Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7178
Gene name Gene Name - the full gene name approved by the HGNC.
Tumor protein, translationally-controlled 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TPT1
Synonyms (NCBI Gene) Gene synonyms aliases
HRF, TCTP, p02, p23
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5`-TOP) in its 5` untranslated region that functions to repress its translation under quiescent cond
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031462 hsa-miR-16-5p Proteomics 18668040
MIRT052061 hsa-let-7b-5p CLASH 23622248
MIRT048923 hsa-miR-92a-3p CLASH 23622248
MIRT048923 hsa-miR-92a-3p CLASH 23622248
MIRT048369 hsa-miR-29b-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
VDR Activation 19815065
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IDA 15162379
GO:0003723 Function RNA binding HDA 22658674
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IDA 15162379, 15958728
GO:0005515 Function Protein binding IPI 16730713, 17301792, 18325344, 21081126, 21278788, 22451927, 25277244, 25416956, 27607350
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600763 12022 ENSG00000133112
Protein
UniProt ID P13693
Protein name Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)
Protein function Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:183253
PDB 1YZ1 , 2HR9 , 3EBM , 4Z9V , 5O9L , 5O9M , 6IZB , 6IZE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00838 TCTP 1 168 Translationally controlled tumour protein Domain
Tissue specificity TISSUE SPECIFICITY: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal
Sequence
Sequence length 172
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Stimulate 28143584
Astrocytoma Associate 36714975
Atherosclerosis Associate 34626801
Breast Neoplasms Associate 17127214, 25779659
Carcinogenesis Associate 26425551, 32792860
Carcinoma Hepatocellular Associate 34498708
Carcinoma Non Small Cell Lung Associate 24761856, 32046740
Carcinoma Pancreatic Ductal Associate 35534983
Carcinoma Renal Cell Associate 26425551
Cardiomyopathies Stimulate 38025678