Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7162
Gene name Gene Name - the full gene name approved by the HGNC.	Trophoblast glycoprotein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TPBG
Synonyms (NCBI Gene) Gene synonyms aliases	5T4, 5T4AG, M6P1, WAIF1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q14.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is ass

Show/Hide all(169)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020868	hsa-miR-155-5p	Proteomics	18668040
MIRT028555	hsa-miR-30a-5p	Proteomics	18668040
MIRT031878	hsa-miR-16-5p	Proteomics	18668040
MIRT032386	hsa-let-7b-5p	Proteomics	18668040
MIRT041063	hsa-miR-505-3p	CLASH	23622248
MIRT528648	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT528647	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT528645	hsa-miR-6830-5p	PAR-CLIP	22012620
MIRT361344	hsa-miR-208a-5p	PAR-CLIP	24398324
MIRT361346	hsa-miR-208b-5p	PAR-CLIP	24398324
MIRT361349	hsa-miR-1827	PAR-CLIP	24398324
MIRT361350	hsa-miR-3140-3p	PAR-CLIP	24398324
MIRT499259	hsa-miR-516a-5p	PAR-CLIP	24398324
MIRT499258	hsa-miR-6765-5p	PAR-CLIP	24398324
MIRT392440	hsa-miR-653-5p	PAR-CLIP	24398324
MIRT361347	hsa-miR-1304-5p	PAR-CLIP	24398324
MIRT528648	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT528647	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT528645	hsa-miR-6830-5p	PAR-CLIP	22012620
MIRT361344	hsa-miR-208a-5p	PAR-CLIP	24398324
MIRT361346	hsa-miR-208b-5p	PAR-CLIP	24398324
MIRT361349	hsa-miR-1827	PAR-CLIP	24398324
MIRT361350	hsa-miR-3140-3p	PAR-CLIP	24398324
MIRT499259	hsa-miR-516a-5p	PAR-CLIP	24398324
MIRT499258	hsa-miR-6765-5p	PAR-CLIP	24398324
MIRT392440	hsa-miR-653-5p	PAR-CLIP	24398324
MIRT361347	hsa-miR-1304-5p	PAR-CLIP	24398324
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448921	hsa-miR-1324	CLIP-seq
MIRT1448922	hsa-miR-298	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448926	hsa-miR-3605-5p	CLIP-seq
MIRT1448927	hsa-miR-3613-3p	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448929	hsa-miR-3944-5p	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448931	hsa-miR-452	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448933	hsa-miR-4676-3p	CLIP-seq
MIRT1448934	hsa-miR-4796-3p	CLIP-seq
MIRT1448935	hsa-miR-548a-5p	CLIP-seq
MIRT1448936	hsa-miR-548ab	CLIP-seq
MIRT1448937	hsa-miR-548ak	CLIP-seq
MIRT1448938	hsa-miR-548b-5p	CLIP-seq
MIRT1448939	hsa-miR-548c-5p	CLIP-seq
MIRT1448940	hsa-miR-548d-5p	CLIP-seq
MIRT1448941	hsa-miR-548g	CLIP-seq
MIRT1448942	hsa-miR-548h	CLIP-seq
MIRT1448943	hsa-miR-548i	CLIP-seq
MIRT1448944	hsa-miR-548j	CLIP-seq
MIRT1448945	hsa-miR-548n	CLIP-seq
MIRT1448946	hsa-miR-548w	CLIP-seq
MIRT1448947	hsa-miR-548y	CLIP-seq
MIRT1448948	hsa-miR-559	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT1448952	hsa-miR-1304	CLIP-seq
MIRT1448921	hsa-miR-1324	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT1448961	hsa-miR-653	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448922	hsa-miR-298	CLIP-seq
MIRT2134329	hsa-miR-607	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT2134330	hsa-miR-3614-3p	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2355529	hsa-miR-221	CLIP-seq
MIRT2355530	hsa-miR-222	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448926	hsa-miR-3605-5p	CLIP-seq
MIRT2355531	hsa-miR-3681	CLIP-seq
MIRT2355532	hsa-miR-3973	CLIP-seq
MIRT2355533	hsa-miR-4420	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT2355534	hsa-miR-520g	CLIP-seq
MIRT2355535	hsa-miR-520h	CLIP-seq
MIRT2355536	hsa-miR-548v	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2355537	hsa-miR-765	CLIP-seq
MIRT2434300	hsa-miR-3127-3p	CLIP-seq
MIRT2355533	hsa-miR-4420	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2649136	hsa-miR-142-5p	CLIP-seq
MIRT2649137	hsa-miR-1470	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT2649138	hsa-miR-3145-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2649139	hsa-miR-4667-3p	CLIP-seq
MIRT2649140	hsa-miR-4668-3p	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT1448935	hsa-miR-548a-5p	CLIP-seq
MIRT1448936	hsa-miR-548ab	CLIP-seq
MIRT1448937	hsa-miR-548ak	CLIP-seq
MIRT1448938	hsa-miR-548b-5p	CLIP-seq
MIRT2649141	hsa-miR-548c-3p	CLIP-seq
MIRT1448939	hsa-miR-548c-5p	CLIP-seq
MIRT1448940	hsa-miR-548d-5p	CLIP-seq
MIRT1448942	hsa-miR-548h	CLIP-seq
MIRT1448943	hsa-miR-548i	CLIP-seq
MIRT1448944	hsa-miR-548j	CLIP-seq
MIRT2649142	hsa-miR-548k	CLIP-seq
MIRT2649143	hsa-miR-548l	CLIP-seq
MIRT1448946	hsa-miR-548w	CLIP-seq
MIRT1448947	hsa-miR-548y	CLIP-seq
MIRT1448948	hsa-miR-559	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2649137	hsa-miR-1470	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2649139	hsa-miR-4667-3p	CLIP-seq
MIRT2649140	hsa-miR-4668-3p	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT2649141	hsa-miR-548c-3p	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10366710
GO:0007155	Process	Cell adhesion	NAS	10366710
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008355	Process	Olfactory learning	IEA
GO:0009986	Component	Cell surface	HDA	19581412
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0050921	Process	Positive regulation of chemotaxis	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0060326	Process	Cell chemotaxis	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA
GO:0090497	Process	Mesenchymal cell migration	IEA
GO:0140059	Process	Dendrite arborization	IEA

MIM	HGNC	e!Ensembl
190920	12004	ENSG00000146242

Protein

UniProt ID

Q13641

Protein name

Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)

Protein function

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

PDB

4CNC , 4CNM , 6HBY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	61 → 90	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	91 → 154	Leucine rich repeat	Repeat
PF13855	LRR_8	118 → 168	Leucine rich repeat	Repeat
PF13855	LRR_8	210 → 270	Leucine rich repeat	Repeat
PF13855	LRR_8	239 → 294	Leucine rich repeat	Repeat
PF01463	LRRCT	320 → 345	Leucine rich repeat C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a va

Sequence

MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

Sequence length

420

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35452205
Alzheimer Disease	Associate	28183528
Atypical Squamous Cells of the Cervix	Associate	2404512
Breast Neoplasms	Associate	37495592
Carcinoma Non Small Cell Lung	Associate	30736848
Carcinoma Renal Cell	Associate	16222313, 31686124
Colorectal Neoplasms	Associate	1419629, 16630022, 19221742, 31686124, 8132670, 8180020
Glioblastoma	Associate	33553434
Idiopathic Pulmonary Fibrosis	Associate	36601116
Inflammation	Associate	34580602, 36601116
Kidney Neoplasms	Associate	16222313
Lymphoma Non Hodgkin	Associate	29216196
Mesothelioma	Associate	29959059
Mesothelioma Malignant	Associate	22498111
Nasopharyngeal Carcinoma	Associate	28687750
Neoplasm Metastasis	Associate	8132670
Neoplasms	Associate	1419629, 16222313, 16630022, 18004564, 19138409, 19221742, 2404511, 24194959, 27323861, 28630212, 31686124, 36271507, 8132670, 8180020
Neoplasms	Stimulate	28481180
Ovarian Neoplasms	Associate	27323861
Pre Eclampsia	Associate	26388242
Preeclamptic toxemia	Stimulate	28481180
Prostatic Neoplasms	Associate	32591433
Small Cell Lung Carcinoma	Associate	18004564
Stomach Ulcer	Associate	18004564
Urinary Bladder Neoplasms	Associate	20224111
Uterine Cervical Neoplasms	Associate	2404512
Wolf Hirschhorn Syndrome	Associate	17576924

TPBG (trophoblast glycoprotein)