TMOD1 (tropomodulin 1)

Gene

• Entrez ID: 7111
• Gene name: Tropomodulin 1
• Gene symbol: TMOD1
• Synonyms (NCBI Gene): D9S57E, ETMOD, TMOD
• Chromosome: 9
• Chromosome location: 9q22.33
• Summary: This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439420	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439421	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT439419	hsa-miR-544a	HITS-CLIP	24374217
MIRT439418	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT439420	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439421	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT439419	hsa-miR-544a	HITS-CLIP	24374217
MIRT439418	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT1440127	hsa-miR-488	CLIP-seq
MIRT1440128	hsa-miR-15a	CLIP-seq
MIRT1440129	hsa-miR-15b	CLIP-seq
MIRT1440130	hsa-miR-16	CLIP-seq
MIRT1440131	hsa-miR-195	CLIP-seq
MIRT1440132	hsa-miR-214	CLIP-seq
MIRT1440133	hsa-miR-2355-5p	CLIP-seq
MIRT1440134	hsa-miR-3160-5p	CLIP-seq
MIRT1440135	hsa-miR-3194-3p	CLIP-seq
MIRT1440136	hsa-miR-3619-5p	CLIP-seq
MIRT1440137	hsa-miR-3679-3p	CLIP-seq
MIRT1440138	hsa-miR-3974	CLIP-seq
MIRT1440139	hsa-miR-424	CLIP-seq
MIRT1440140	hsa-miR-4291	CLIP-seq
MIRT1440141	hsa-miR-497	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT1440143	hsa-miR-761	CLIP-seq
MIRT1440144	hsa-miR-922	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT1555005	hsa-miR-1237	CLIP-seq
MIRT1555006	hsa-miR-1245b-5p	CLIP-seq
MIRT1555007	hsa-miR-148a	CLIP-seq
MIRT1555008	hsa-miR-148b	CLIP-seq
MIRT1555009	hsa-miR-152	CLIP-seq
MIRT1555010	hsa-miR-3142	CLIP-seq
MIRT1555011	hsa-miR-3152-5p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555016	hsa-miR-4297	CLIP-seq
MIRT1555017	hsa-miR-4310	CLIP-seq
MIRT1555018	hsa-miR-4650-5p	CLIP-seq
MIRT1555019	hsa-miR-4774-3p	CLIP-seq
MIRT1555020	hsa-miR-933	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT1555005	hsa-miR-1237	CLIP-seq
MIRT1555006	hsa-miR-1245b-5p	CLIP-seq
MIRT1555010	hsa-miR-3142	CLIP-seq
MIRT1555011	hsa-miR-3152-5p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555016	hsa-miR-4297	CLIP-seq
MIRT1555017	hsa-miR-4310	CLIP-seq
MIRT1555018	hsa-miR-4650-5p	CLIP-seq
MIRT1555019	hsa-miR-4774-3p	CLIP-seq
MIRT1555020	hsa-miR-933	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2461887	hsa-miR-153	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2461889	hsa-miR-199a-3p	CLIP-seq
MIRT2461890	hsa-miR-199b-3p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461893	hsa-miR-203	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461895	hsa-miR-3065-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2461899	hsa-miR-3129-5p	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2461904	hsa-miR-3184	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT2461906	hsa-miR-320e	CLIP-seq
MIRT2461907	hsa-miR-337-3p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461910	hsa-miR-3685	CLIP-seq
MIRT2461911	hsa-miR-377	CLIP-seq
MIRT2461912	hsa-miR-384	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT2461914	hsa-miR-423-5p	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2461918	hsa-miR-4303	CLIP-seq
MIRT2461919	hsa-miR-4305	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461921	hsa-miR-4328	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461923	hsa-miR-448	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461927	hsa-miR-4640-5p	CLIP-seq
MIRT2461928	hsa-miR-4649-3p	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461935	hsa-miR-4668-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2461938	hsa-miR-4726-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2461940	hsa-miR-4738-3p	CLIP-seq
MIRT2461941	hsa-miR-4760-5p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2461944	hsa-miR-4789-3p	CLIP-seq
MIRT2461945	hsa-miR-4796-5p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2461947	hsa-miR-5096	CLIP-seq
MIRT2461948	hsa-miR-513a-3p	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2461950	hsa-miR-544	CLIP-seq
MIRT2461951	hsa-miR-545	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461952	hsa-miR-548p	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461958	hsa-miR-619	CLIP-seq
MIRT2461959	hsa-miR-622	CLIP-seq
MIRT2461960	hsa-miR-634	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq
MIRT2461967	hsa-miR-885-5p	CLIP-seq
MIRT2461968	hsa-miR-936	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2646717	hsa-miR-1227	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2646718	hsa-miR-1539	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2646719	hsa-miR-199a-5p	CLIP-seq
MIRT2646720	hsa-miR-199b-5p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2646721	hsa-miR-3128	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2646722	hsa-miR-3182	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT2646723	hsa-miR-3188	CLIP-seq
MIRT2646724	hsa-miR-3193	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2646725	hsa-miR-4311	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2646726	hsa-miR-4438	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2646727	hsa-miR-4659a-3p	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2646728	hsa-miR-4659b-3p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2646729	hsa-miR-4720-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2646730	hsa-miR-4755-3p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2646731	hsa-miR-4793-5p	CLIP-seq
MIRT2646732	hsa-miR-4799-3p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2646733	hsa-miR-5095	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2646734	hsa-miR-648	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2646735	hsa-miR-658	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq
MIRT2646736	hsa-miR-885-3p	CLIP-seq
MIRT2646737	hsa-miR-889	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2646717	hsa-miR-1227	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2646718	hsa-miR-1539	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2646719	hsa-miR-199a-5p	CLIP-seq
MIRT2646720	hsa-miR-199b-5p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2646722	hsa-miR-3182	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT2646723	hsa-miR-3188	CLIP-seq
MIRT2646724	hsa-miR-3193	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2646727	hsa-miR-4659a-3p	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2646728	hsa-miR-4659b-3p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2646730	hsa-miR-4755-3p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2646731	hsa-miR-4793-5p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2646734	hsa-miR-648	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2646735	hsa-miR-658	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IDA	26370058
GO:0003779	Function	Actin binding	IEA
GO:0005523	Function	Tropomyosin binding	IBA
GO:0005523	Function	Tropomyosin binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005865	Component	Striated muscle thin filament	IBA
GO:0005865	Component	Striated muscle thin filament	IDA	25250574, 38168645
GO:0005884	Component	Actin filament	IDA	26370058
GO:0006936	Process	Muscle contraction	IBA
GO:0006936	Process	Muscle contraction	IEA
GO:0007015	Process	Actin filament organization	IBA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0016020	Component	Membrane	IEA
GO:0030016	Component	Myofibril	IBA
GO:0030016	Component	Myofibril	IDA	26370058
GO:0030016	Component	Myofibril	IEA
GO:0030017	Component	Sarcomere	IDA	26370058
GO:0030017	Component	Sarcomere	IEA
GO:0030239	Process	Myofibril assembly	IBA
GO:0030239	Process	Myofibril assembly	IEA
GO:0030863	Component	Cortical cytoskeleton	IEA
GO:0051694	Process	Pointed-end actin filament capping	IEA
GO:0070307	Process	Lens fiber cell development	IEA

Other IDs

• MIM: 190930
• HGNC: 11871
• e!Ensembl: ENSG00000136842

Protein

• UniProt ID: P28289
• Protein name: Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
• Protein function: Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleto
• PDB: 4PKG, 4PKH, 4PKI, 4Z8G, 4Z94, 8F8T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03250	Tropomodulin	3 → 143	Tropomodulin	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the erythrocyte, heart and skeletal muscle.
• Sequence:

  MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTG
  PFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEAL
  ANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNS
  TDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPV
  AYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEM
  EIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV

• Sequence length: 359

Pathways

KEGG:

Cytoskeleton in muscle cells

Reactome:

Striated Muscle Contraction

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Idiopathic cardiomyopathy	Uncertain significance	rs766826917	RCV003985138

Associations from Text Mining
Disease Name	Relationship Type	References
Cardiomyopathies	Associate	38168645
Cardiomyopathy Restrictive	Associate	38168645
familial dilated cardiomyopathy	Associate	26873245
Muscular Diseases	Associate	28025995
Myopathies Nemaline	Associate	11964245, 37956287
Myotonia Congenita	Associate	30768849
Neoplasms	Associate	14741341, 31364131
Pulmonary Disease Chronic Obstructive	Associate	28025995
Thyroid Neoplasms	Associate	36316666