TLE3 (TLE family member 3, transcriptional corepressor)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7090 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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TLE family member 3, transcriptional corepressor |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TLE3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ESG, ESG3, GRG3, HsT18976 |
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Chromosome
Chromosome number
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15 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q23 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expr |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q04726 | ||||||||||||||||||||
| Protein name | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | ||||||||||||||||||||
| Protein function | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE f | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Placenta and lung. {ECO:0000269|PubMed:1303260}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 772 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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