TLE3 (TLE family member 3, transcriptional corepressor)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 7090 |
| Gene name | TLE family member 3, transcriptional corepressor |
| Gene symbol | TLE3 |
| Synonyms (NCBI Gene) |
ESGESG3GRG3HsT18976
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| Chromosome | 15 |
| Chromosome location | 15q23 |
| Summary | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expr |
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miRNA
miRNA information provided by mirtarbase database.
617
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q04726 | ||||||||||||||||||||
| Protein name | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | ||||||||||||||||||||
| Protein function | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE f | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Placenta and lung. {ECO:0000269|PubMed:1303260}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 772 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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