TIMP4 (TIMP metallopeptidase inhibitor 4)

Gene

• Entrez ID: 7079
• Gene name: TIMP metallopeptidase inhibitor 4
• Gene symbol: TIMP4
• Synonyms (NCBI Gene): TIMP-4
• Chromosome: 3
• Chromosome location: 3p25.2
• Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1425431	hsa-miR-1183	CLIP-seq
MIRT1425432	hsa-miR-1237	CLIP-seq
MIRT1425433	hsa-miR-3162-3p	CLIP-seq
MIRT1425434	hsa-miR-4713-5p	CLIP-seq
MIRT1425435	hsa-miR-4762-3p	CLIP-seq
MIRT2349242	hsa-miR-3127-3p	CLIP-seq
MIRT2349243	hsa-miR-3677-5p	CLIP-seq
MIRT2349244	hsa-miR-4312	CLIP-seq
MIRT2349245	hsa-miR-4435	CLIP-seq
MIRT2349246	hsa-miR-4494	CLIP-seq
MIRT2349247	hsa-miR-4645-3p	CLIP-seq
MIRT2349248	hsa-miR-670	CLIP-seq
MIRT2642615	hsa-miR-1184	CLIP-seq
MIRT2642616	hsa-miR-1205	CLIP-seq
MIRT2642617	hsa-miR-125a-3p	CLIP-seq
MIRT2642618	hsa-miR-146a	CLIP-seq
MIRT2642619	hsa-miR-146b-5p	CLIP-seq
MIRT2642620	hsa-miR-1909	CLIP-seq
MIRT2642621	hsa-miR-3158-5p	CLIP-seq
MIRT2642622	hsa-miR-3194-3p	CLIP-seq
MIRT2642623	hsa-miR-3926	CLIP-seq
MIRT2642624	hsa-miR-3934	CLIP-seq
MIRT2642625	hsa-miR-4428	CLIP-seq
MIRT2642626	hsa-miR-4436a	CLIP-seq
MIRT2642627	hsa-miR-451b	CLIP-seq
MIRT2642628	hsa-miR-4533	CLIP-seq
MIRT2642629	hsa-miR-4747-5p	CLIP-seq
MIRT2642630	hsa-miR-548s	CLIP-seq
MIRT2642631	hsa-miR-764	CLIP-seq
MIRT2642632	hsa-miR-885-3p	CLIP-seq
MIRT2642633	hsa-miR-892b	CLIP-seq
MIRT2642615	hsa-miR-1184	CLIP-seq
MIRT2642616	hsa-miR-1205	CLIP-seq
MIRT2642617	hsa-miR-125a-3p	CLIP-seq
MIRT2642618	hsa-miR-146a	CLIP-seq
MIRT2642619	hsa-miR-146b-5p	CLIP-seq
MIRT2642620	hsa-miR-1909	CLIP-seq
MIRT2642621	hsa-miR-3158-5p	CLIP-seq
MIRT2642622	hsa-miR-3194-3p	CLIP-seq
MIRT2642623	hsa-miR-3926	CLIP-seq
MIRT2642624	hsa-miR-3934	CLIP-seq
MIRT2642625	hsa-miR-4428	CLIP-seq
MIRT2642626	hsa-miR-4436a	CLIP-seq
MIRT2642627	hsa-miR-451b	CLIP-seq
MIRT2642628	hsa-miR-4533	CLIP-seq
MIRT2642629	hsa-miR-4747-5p	CLIP-seq
MIRT2642630	hsa-miR-548s	CLIP-seq
MIRT2642631	hsa-miR-764	CLIP-seq
MIRT2642632	hsa-miR-885-3p	CLIP-seq
MIRT2642633	hsa-miR-892b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004857	Function	Enzyme inhibitor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IBA
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IEA
GO:0008191	Function	Metalloendopeptidase inhibitor activity	NAS	8939999
GO:0009725	Process	Response to hormone	IBA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0034097	Process	Response to cytokine	IBA
GO:0034774	Component	Secretory granule lumen	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051045	Process	Negative regulation of membrane protein ectodomain proteolysis	IBA

Other IDs

• MIM: 601915
• HGNC: 11823
• e!Ensembl: ENSG00000157150

Protein

• UniProt ID: Q99727
• Protein name: Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
• Protein function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00965	TIMP	28 → 207	Tissue inhibitor of metalloproteinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Abundant in heart and present at low levels in many other tissues.
• Sequence:

  MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
  SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
  LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
  WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP

• Sequence length: 224