Gene Gene information from NCBI Gene database.
Entrez ID 7058
Gene name Thrombospondin 2
Gene symbol THBS2
Synonyms (NCBI Gene)
EDSCLL3TSP2
Chromosome 6
Chromosome location 6q27
Summary The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor gr
miRNA miRNA information provided by mirtarbase database.
784
miRTarBase ID miRNA Experiments Reference
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT722595 hsa-miR-3922-5p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
HOXB7 Repression 21183939
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005201 Function Extracellular matrix structural constituent RCA 28327460, 28675934
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 19818485
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
188061 11786 ENSG00000186340
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35442
Protein name Thrombospondin-2
Protein function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
PDB 1YO8 , 2RHP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00093 VWC 320 374 von Willebrand factor type C domain Family
PF00090 TSP_1 385 430 Thrombospondin type 1 domain Domain
PF00090 TSP_1 441 491 Thrombospondin type 1 domain Domain
PF00090 TSP_1 498 548 Thrombospondin type 1 domain Domain
PF07645 EGF_CA 590 646 Calcium-binding EGF domain Domain
PF12947 EGF_3 652 691 EGF domain Domain
PF02412 TSP_3 729 764 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 763 787 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 788 823 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 823 846 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 847 884 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 885 920 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 921 956 Thrombospondin type 3 repeat Repeat
PF05735 TSP_C 974 1171 Thrombospondin C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: High expression in invertebral disk tissue. {ECO:0000269|PubMed:18455130}.
Sequence
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF
DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP
ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY
EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN
TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC
ASPSFVEGECCPSC
LHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI
QTRACSLSKC
DTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG
RETKACQGAPC
PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER
QMCNKRSC
PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVC
EPENPCKDKTHNCH
KHAECIYLGHFSDPMYKCECQTGYAGDGLIC
GEDSDLDGWPNLNLVCATNATYHCIKDNC
PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP
YVHNPAQ
IDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL
VHNPDQ
TDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
DNDGVPDDRDNCRLVFNPDQ
EDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR
NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR
DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN
ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI
YDQTYAGGRLGLFVFSQEMVYFSDLKYECRD
I
Sequence length 1172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cytoskeleton in muscle cells
Malaria
Human papillomavirus infection
  Signaling by PDGF
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
39
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ehlers-Danlos syndrome Pathogenic rs2483451503 RCV003985134
Ehlers-Danlos syndrome, classic-like, 3 Pathogenic rs2483451503 RCV004577965
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign rs59953407, rs76393784 RCV005908626
RCV005910106
Clear cell carcinoma of kidney Benign rs76393784 RCV005910107
Gastric cancer Benign rs59953407 RCV005908627
Lumbar disk herniation, susceptibility to Benign; risk factor rs9406328 RCV000013550
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 27513329
Adenocarcinoma in Situ Associate 40038757
Adenocarcinoma of Lung Stimulate 27513329
Adenocarcinoma of Lung Associate 35547750, 40038757
Alzheimer Disease Associate 26482433
Aortic Aneurysm Abdominal Associate 21593211, 32605321, 34669362
Atrial Fibrillation Associate 34332113, 36335340
Biliary Atresia Associate 36930067
Brain Neoplasms Associate 31888563
Breast Neoplasms Associate 30154546, 30236106