Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7058
Gene name Gene Name - the full gene name approved by the HGNC.
Thrombospondin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
THBS2
Synonyms (NCBI Gene) Gene synonyms aliases
EDSCLL3, TSP2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
EDSCLL3
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q27
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor gr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT722595 hsa-miR-3922-5p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
HOXB7 Repression 21183939
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005201 Function Extracellular matrix structural constituent RCA 28327460, 28675934
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 19818485
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
188061 11786 ENSG00000186340
Protein
UniProt ID P35442
Protein name Thrombospondin-2
Protein function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
PDB 1YO8 , 2RHP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00093 VWC 320 374 von Willebrand factor type C domain Family
PF00090 TSP_1 385 430 Thrombospondin type 1 domain Domain
PF00090 TSP_1 441 491 Thrombospondin type 1 domain Domain
PF00090 TSP_1 498 548 Thrombospondin type 1 domain Domain
PF07645 EGF_CA 590 646 Calcium-binding EGF domain Domain
PF12947 EGF_3 652 691 EGF domain Domain
PF02412 TSP_3 729 764 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 763 787 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 788 823 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 823 846 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 847 884 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 885 920 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 921 956 Thrombospondin type 3 repeat Repeat
PF05735 TSP_C 974 1171 Thrombospondin C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: High expression in invertebral disk tissue. {ECO:0000269|PubMed:18455130}.
Sequence
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF
DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP
ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY
EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN
TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC
ASPSFVEGECCPSC
LHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI
QTRACSLSKC
DTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG
RETKACQGAPC
PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER
QMCNKRSC
PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVC
EPENPCKDKTHNCH
KHAECIYLGHFSDPMYKCECQTGYAGDGLIC
GEDSDLDGWPNLNLVCATNATYHCIKDNC
PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP
YVHNPAQ
IDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL
VHNPDQ
TDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
DNDGVPDDRDNCRLVFNPDQ
EDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR
NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR
DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN
ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI
YDQTYAGGRLGLFVFSQEMVYFSDLKYECRD
I
Sequence length 1172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cytoskeleton in muscle cells
Malaria
Human papillomavirus infection
  Signaling by PDGF
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23723366
Unknown
Disease term Disease name Evidence References Source
Ehlers-Danlos Syndrome Ehlers-Danlos syndrome, classic-like, 3 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 27513329
Adenocarcinoma in Situ Associate 40038757
Adenocarcinoma of Lung Stimulate 27513329
Adenocarcinoma of Lung Associate 35547750, 40038757
Alzheimer Disease Associate 26482433
Aortic Aneurysm Abdominal Associate 21593211, 32605321, 34669362
Atrial Fibrillation Associate 34332113, 36335340
Biliary Atresia Associate 36930067
Brain Neoplasms Associate 31888563
Breast Neoplasms Associate 30154546, 30236106