Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7033
Gene name Gene Name - the full gene name approved by the HGNC.	Trefoil factor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TFF3
Synonyms (NCBI Gene) Gene synonyms aliases	ITF, P1B, TFI
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are

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miRTarBase ID	miRNA	Experiments
MIRT1420576	hsa-miR-1254	CLIP-seq
MIRT1420577	hsa-miR-1273f	CLIP-seq
MIRT1420578	hsa-miR-143	CLIP-seq
MIRT1420579	hsa-miR-208a	CLIP-seq
MIRT1420580	hsa-miR-208b	CLIP-seq
MIRT1420581	hsa-miR-214	CLIP-seq
MIRT1420582	hsa-miR-298	CLIP-seq
MIRT1420583	hsa-miR-3116	CLIP-seq
MIRT1420584	hsa-miR-3155	CLIP-seq
MIRT1420585	hsa-miR-3155b	CLIP-seq
MIRT1420586	hsa-miR-3617	CLIP-seq
MIRT1420587	hsa-miR-3619-5p	CLIP-seq
MIRT1420588	hsa-miR-3649	CLIP-seq
MIRT1420589	hsa-miR-3913-3p	CLIP-seq
MIRT1420590	hsa-miR-4291	CLIP-seq
MIRT1420591	hsa-miR-4705	CLIP-seq
MIRT1420592	hsa-miR-4708-5p	CLIP-seq
MIRT1420593	hsa-miR-4770	CLIP-seq
MIRT1420594	hsa-miR-484	CLIP-seq
MIRT1420595	hsa-miR-499-5p	CLIP-seq
MIRT1420596	hsa-miR-515-3p	CLIP-seq
MIRT1420597	hsa-miR-519e	CLIP-seq
MIRT1420598	hsa-miR-550a	CLIP-seq
MIRT1420599	hsa-miR-641	CLIP-seq
MIRT1420600	hsa-miR-661	CLIP-seq
MIRT1420601	hsa-miR-761	CLIP-seq
MIRT1420602	hsa-miR-885-3p	CLIP-seq
MIRT1420603	hsa-miR-922	CLIP-seq
MIRT1420577	hsa-miR-1273f	CLIP-seq
MIRT2126311	hsa-miR-1285	CLIP-seq
MIRT2126312	hsa-miR-1304	CLIP-seq
MIRT1420578	hsa-miR-143	CLIP-seq
MIRT1420579	hsa-miR-208a	CLIP-seq
MIRT1420580	hsa-miR-208b	CLIP-seq
MIRT1420581	hsa-miR-214	CLIP-seq
MIRT1420582	hsa-miR-298	CLIP-seq
MIRT1420584	hsa-miR-3155	CLIP-seq
MIRT1420585	hsa-miR-3155b	CLIP-seq
MIRT2126313	hsa-miR-3187-5p	CLIP-seq
MIRT2126314	hsa-miR-320a	CLIP-seq
MIRT2126315	hsa-miR-320b	CLIP-seq
MIRT2126316	hsa-miR-320c	CLIP-seq
MIRT2126317	hsa-miR-320d	CLIP-seq
MIRT1420586	hsa-miR-3617	CLIP-seq
MIRT1420587	hsa-miR-3619-5p	CLIP-seq
MIRT1420588	hsa-miR-3649	CLIP-seq
MIRT1420589	hsa-miR-3913-3p	CLIP-seq
MIRT1420590	hsa-miR-4291	CLIP-seq
MIRT2126318	hsa-miR-4328	CLIP-seq
MIRT2126319	hsa-miR-4429	CLIP-seq
MIRT2126320	hsa-miR-4475	CLIP-seq
MIRT1420592	hsa-miR-4708-5p	CLIP-seq
MIRT1420593	hsa-miR-4770	CLIP-seq
MIRT2126321	hsa-miR-4771	CLIP-seq
MIRT2126322	hsa-miR-4780	CLIP-seq
MIRT1420594	hsa-miR-484	CLIP-seq
MIRT1420595	hsa-miR-499-5p	CLIP-seq
MIRT2126323	hsa-miR-518e	CLIP-seq
MIRT2126324	hsa-miR-612	CLIP-seq
MIRT1420599	hsa-miR-641	CLIP-seq
MIRT1420600	hsa-miR-661	CLIP-seq
MIRT2126325	hsa-miR-7	CLIP-seq
MIRT1420601	hsa-miR-761	CLIP-seq
MIRT1420603	hsa-miR-922	CLIP-seq
MIRT2126326	hsa-miR-938	CLIP-seq
MIRT2348302	hsa-miR-1207-3p	CLIP-seq
MIRT1420576	hsa-miR-1254	CLIP-seq
MIRT1420577	hsa-miR-1273f	CLIP-seq
MIRT2348303	hsa-miR-1273g	CLIP-seq
MIRT2348304	hsa-miR-140-5p	CLIP-seq
MIRT1420578	hsa-miR-143	CLIP-seq
MIRT1420579	hsa-miR-208a	CLIP-seq
MIRT1420580	hsa-miR-208b	CLIP-seq
MIRT1420581	hsa-miR-214	CLIP-seq
MIRT1420582	hsa-miR-298	CLIP-seq
MIRT1420583	hsa-miR-3116	CLIP-seq
MIRT2348305	hsa-miR-3135b	CLIP-seq
MIRT1420584	hsa-miR-3155	CLIP-seq
MIRT1420585	hsa-miR-3155b	CLIP-seq
MIRT2126314	hsa-miR-320a	CLIP-seq
MIRT2126315	hsa-miR-320b	CLIP-seq
MIRT2126316	hsa-miR-320c	CLIP-seq
MIRT2126317	hsa-miR-320d	CLIP-seq
MIRT2348306	hsa-miR-323b-5p	CLIP-seq
MIRT2348307	hsa-miR-324-5p	CLIP-seq
MIRT2348308	hsa-miR-3611	CLIP-seq
MIRT1420586	hsa-miR-3617	CLIP-seq
MIRT1420587	hsa-miR-3619-5p	CLIP-seq
MIRT1420588	hsa-miR-3649	CLIP-seq
MIRT2348309	hsa-miR-3689d	CLIP-seq
MIRT2348310	hsa-miR-3907	CLIP-seq
MIRT2348311	hsa-miR-3909	CLIP-seq
MIRT1420589	hsa-miR-3913-3p	CLIP-seq
MIRT1420590	hsa-miR-4291	CLIP-seq
MIRT2126318	hsa-miR-4328	CLIP-seq
MIRT2126319	hsa-miR-4429	CLIP-seq
MIRT2126320	hsa-miR-4475	CLIP-seq
MIRT2348312	hsa-miR-4511	CLIP-seq
MIRT2348313	hsa-miR-4693-3p	CLIP-seq
MIRT1420591	hsa-miR-4705	CLIP-seq
MIRT2348314	hsa-miR-4707-5p	CLIP-seq
MIRT1420592	hsa-miR-4708-5p	CLIP-seq
MIRT1420593	hsa-miR-4770	CLIP-seq
MIRT1420594	hsa-miR-484	CLIP-seq
MIRT2348315	hsa-miR-486-3p	CLIP-seq
MIRT1420595	hsa-miR-499-5p	CLIP-seq
MIRT1420596	hsa-miR-515-3p	CLIP-seq
MIRT2126323	hsa-miR-518e	CLIP-seq
MIRT1420597	hsa-miR-519e	CLIP-seq
MIRT1420598	hsa-miR-550a	CLIP-seq
MIRT2348316	hsa-miR-615-3p	CLIP-seq
MIRT1420599	hsa-miR-641	CLIP-seq
MIRT1420600	hsa-miR-661	CLIP-seq
MIRT2126325	hsa-miR-7	CLIP-seq
MIRT1420601	hsa-miR-761	CLIP-seq
MIRT1420602	hsa-miR-885-3p	CLIP-seq
MIRT1420603	hsa-miR-922	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
CDX2	Activation	17182120
CEBPB	Unknown	12297725
ERG	Unknown	21170267
NFKB1	Activation	12912861
NFKB1	Unknown	12297725
RELA	Activation	12912861
RELA	Unknown	12297725

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20423149, 25416956, 31658587, 32296183
GO:0005576	Component	Extracellular region	IDA	8454642
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0010906	Process	Regulation of glucose metabolic process	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IBA
GO:0042802	Function	Identical protein binding	IPI	20423149, 31658587

MIM	HGNC	e!Ensembl
600633	11757	ENSG00000160180

Protein

UniProt ID

Q07654

Protein name

Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)

Protein function

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

PDB

1E9T , 1PE3 , 6V1C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00088	Trefoil	46 → 86	Trefoil (P-type) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricu

Sequence

MKRVLSCVPEPTVVMAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGYPH
VTPKECNNRGCCFDSRIPGVPWCFKPLQEAECTF

Sequence length

Interactions

View interactions

	Reactome
			Estrogen-dependent gene expression

TFF3 (trefoil factor 3)