Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7031
Gene name	Trefoil factor 1
Gene symbol	TFF1
Synonyms (NCBI Gene)	BCEID21S21HP1.AHPS2pNR-2pS2
Chromosome	21
Chromosome location	21q22.3
Summary	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053601	hsa-miR-423-5p	Luciferase reporter assayqRT-PCRWestern blot	24486742
MIRT053601	hsa-miR-423-5p	Luciferase reporter assayqRT-PCRWestern blot	24486742
MIRT438352	hsa-miR-504-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	25015107
MIRT438352	hsa-miR-504-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	25015107
MIRT437974	hsa-miR-218-5p	ImmunohistochemistryIn situ hybridizationLacZ reporter assayqRT-PCRWestern blot	25652124
MIRT437974	hsa-miR-218-5p	ImmunohistochemistryIn situ hybridizationLacZ reporter assayqRT-PCRWestern blot	25652124
MIRT438352	hsa-miR-504-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	25015107
MIRT438352	hsa-miR-504-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	25015107
MIRT437974	hsa-miR-218-5p	ImmunohistochemistryIn situ hybridizationLacZ reporter assayqRT-PCRWestern blot	25652124
MIRT437974	hsa-miR-218-5p	ImmunohistochemistryIn situ hybridizationLacZ reporter assayqRT-PCRWestern blot	25652124
MIRT737180	hsa-miR-326	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCRIn situ hybridization	31961997
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420563	hsa-miR-4753-3p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq
MIRT1420569	hsa-miR-889	CLIP-seq
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420563	hsa-miR-4753-3p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq
MIRT1420569	hsa-miR-889	CLIP-seq
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq

Show/Hide all (20)

Transcription factor	Regulation	Reference
AIP	Repression	21984905
BRCA1	Repression	11244506
ESR1	Activation	11517191;18543253
ESR1	Unknown	10037443;21984905
ESR2	Activation	11517191
ESR2	Unknown	10037443
FOXA1	Unknown	10073575
FOXA2	Unknown	10073575
HDAC1	Repression	19581286
HMGN1	Unknown	17938209
JUN	Unknown	12021387
MECP2	Repression	15870696
MTA1	Unknown	12431981
NCOA4	Unknown	15772083
NELFB	Repression	16452188
NELFB	Unknown	17043641
NFATC3	Activation	16219765
NFKB1	Activation	17565651
RELA	Activation	17565651
SP3	Activation	18543253

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21982860, 24798994, 25416956, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	2303034
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010039	Process	Response to iron ion	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IBA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0043434	Process	Response to peptide hormone	IEA

MIM	HGNC	e!Ensembl
113710	11755	ENSG00000160182

P04155

Protein name

Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)

Protein function

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.

PDB

1HI7 , 1PS2 , 6V1D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00088	Trefoil	31 → 71	Trefoil (P-type) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual

Sequence

MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDD
TVRGVPWCFYPNTIDVPPEEECEF

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Estrogen signaling pathway		Estrogen-dependent gene expression

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Benign	rs72561490	RCV005910193
Gastric cancer	Benign	rs72561490	RCV005910194
Lung cancer	Benign	rs72561490	RCV005910195

Show/Hide Text Mining Associations (102)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Inhibit	10737716, 18927283, 21829465
Adenocarcinoma	Associate	15849833, 17143957
Adenocarcinoma Mucinous	Associate	1911216, 32781417
Adenocarcinoma of Lung	Associate	30539871, 32237253, 32930112
Allergic Fungal Sinusitis	Associate	31683988
Alzheimer Disease	Associate	18768471
Astrocytoma	Associate	24843314
Barrett Esophagus	Associate	10190312, 24550372
Bone Diseases	Associate	28143986
Brain Neoplasms	Associate	29287594
Breast Neoplasms	Associate	10535357, 11438468, 1347193, 1850611, 1911216, 19129556, 19153192, 20126581, 20132413, 20525369, 20619646, 21505052, 2153395, 2185238, 2194831 View all (18 more)
Breast Neoplasms	Stimulate	28687783, 31986408
Carcinogenesis	Associate	10737716, 12379766, 16437709, 17143957, 23329884
Carcinoma	Associate	1911216
Carcinoma Ductal Breast	Associate	19153192
Carcinoma Lobular	Associate	21228366
Carcinoma Non Small Cell Lung	Associate	32587780
Carcinoma Pancreatic Ductal	Associate	12377812, 26240291, 36459568
Cholangiocarcinoma	Inhibit	14563942
Cholangiocarcinoma	Stimulate	21472131
Cholangiocarcinoma	Associate	22476540
Cholestasis Intrahepatic	Associate	24406866
Colitis Ulcerative	Associate	16924127, 23691218
Colonic Polyps	Associate	28430953
Colorectal Neoplasms	Associate	28104986
Colorectal Neoplasms	Stimulate	31432157
Craniocerebral Trauma	Inhibit	16718800
Crohn Disease	Associate	23691218
Depressive Disorder Major	Associate	32093803
Diabetic Retinopathy	Associate	31455213
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	14563942
Duodenal Ulcer	Stimulate	15849833
Duodenal Ulcer	Associate	7557569
Early Onset Glaucoma	Inhibit	23329884
Endometrial Neoplasms	Associate	23530112
Endometrial Neoplasms	Inhibit	28745797
Esophageal Neoplasms	Inhibit	29296124
Esophageal Squamous Cell Carcinoma	Associate	21946330
Esophageal Squamous Cell Carcinoma	Inhibit	29296124
Gastritis	Stimulate	15849833
Gastritis Atrophic	Inhibit	16718800
Gastrointestinal Diseases	Stimulate	12377807
Gastrointestinal Neoplasms	Associate	7531128
Glaucoma	Associate	16809382
Glycogen Storage Disease Type IV	Associate	35216615
Helicobacter Infections	Inhibit	36514982
Hermanski Pudlak Syndrome	Associate	33536261
Hypoxia Brain	Stimulate	29997345
Inflammation	Inhibit	36514982
Inflammatory Bowel Diseases	Associate	31322753
Intestinal Diseases	Associate	10737716
Irritable Bowel Syndrome	Associate	24763552, 33843785
Kidney Calculi	Inhibit	35987613
Lung Neoplasms	Associate	1911216, 22246423
Lymphatic Metastasis	Stimulate	1850611
Lymphatic Metastasis	Associate	26240479
Lymphatic Metastasis	Inhibit	28745797
Lymphoma Non Hodgkin	Associate	18927283
Mandibuloacral dysplasia with type A lipodystrophy	Inhibit	18927283
Mental Disorders	Associate	32093803
Metaplasia	Associate	14563942, 7557569
Mouth Diseases	Associate	35749918
Neoplasm Metastasis	Associate	18722547, 21283680
Neoplasms	Associate	10535357, 17143957, 1850611, 1911216, 19153192, 23530112, 25287138, 26510686, 28104986, 28150071, 29296124, 30431719, 30457247, 7531128
Neoplasms	Stimulate	10835496, 11438468, 31432157
Neoplasms	Inhibit	12377807, 16474375, 36514982
Neoplasms Cystic Mucinous and Serous	Associate	12377812
Neoplasms Glandular and Epithelial	Associate	1911216
Nephrolithiasis	Associate	35987613
Neuroendocrine Tumors	Associate	15588310
Obesity	Stimulate	29546532
Ovarian Neoplasms	Associate	1911216, 26617749
Pancreatic Intraductal Neoplasms	Associate	12000726, 12377812
Pancreatic Neoplasms	Stimulate	36812168
Peptic Ulcer	Associate	15849833
Polyps	Stimulate	28430953
Polyps	Associate	35749918
Pouchitis	Associate	11358897
Precancerous Conditions	Inhibit	16718800
Prostatic Neoplasms	Associate	15588310
Prostatitis	Associate	1911216
Pulmonary Fibrosis	Stimulate	33536261
Retinal Dysplasia	Stimulate	21472131
Retinoblastoma	Associate	25199519
Sjogren's Syndrome	Associate	9844061
Stomach Diseases	Associate	15849833, 16718800, 29997345
Stomach Neoplasms	Associate	10737716, 12379766, 14601088, 15849833, 16437709, 16474375, 17143957, 18593995, 18722547, 18938748, 22642590, 26240479, 27598141, 28150071, 30612555, 36514982 View all (1 more)
Stomach Neoplasms	Inhibit	16718800, 23329884, 24236136, 26617749
Stomach Ulcer	Stimulate	15849833
Stomach Ulcer	Inhibit	16718800
Stomach Ulcer	Associate	17143957
Tertiary Lymphoid Structures	Associate	18722547
Tertiary Lymphoid Structures	Stimulate	30431719, 30457247
Thyroid Cancer Papillary	Associate	36917092
Triple Negative Breast Neoplasms	Inhibit	31986408
Triple Negative Breast Neoplasms	Associate	36157217
Ulcer	Stimulate	15849833
Ulcer	Associate	17143957, 20191040, 7557569
Urinary Bladder Neoplasms	Associate	1911216
Uterine Cervical Neoplasms	Associate	1911216
Weight Loss	Associate	24141897
Wounds and Injuries	Stimulate	24236136

TFF1 (trefoil factor 1)