Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7031
Gene name Gene Name - the full gene name approved by the HGNC.	Trefoil factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TFF1
Synonyms (NCBI Gene) Gene synonyms aliases	BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are

Show/Hide all(108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053601	hsa-miR-423-5p	Luciferase reporter assay, qRT-PCR, Western blot	24486742
MIRT053601	hsa-miR-423-5p	Luciferase reporter assay, qRT-PCR, Western blot	24486742
MIRT438352	hsa-miR-504-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25015107
MIRT438352	hsa-miR-504-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25015107
MIRT437974	hsa-miR-218-5p	Immunohistochemistry, In situ hybridization, LacZ reporter assay, qRT-PCR, Western blot	25652124
MIRT437974	hsa-miR-218-5p	Immunohistochemistry, In situ hybridization, LacZ reporter assay, qRT-PCR, Western blot	25652124
MIRT438352	hsa-miR-504-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25015107
MIRT438352	hsa-miR-504-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25015107
MIRT437974	hsa-miR-218-5p	Immunohistochemistry, In situ hybridization, LacZ reporter assay, qRT-PCR, Western blot	25652124
MIRT437974	hsa-miR-218-5p	Immunohistochemistry, In situ hybridization, LacZ reporter assay, qRT-PCR, Western blot	25652124
MIRT737180	hsa-miR-326	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, In situ hybridization	31961997
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420563	hsa-miR-4753-3p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq
MIRT1420569	hsa-miR-889	CLIP-seq
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420563	hsa-miR-4753-3p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq
MIRT1420569	hsa-miR-889	CLIP-seq
MIRT1420537	hsa-miR-1295	CLIP-seq
MIRT1420538	hsa-miR-187	CLIP-seq
MIRT1420539	hsa-miR-2278	CLIP-seq
MIRT1420540	hsa-miR-298	CLIP-seq
MIRT1420541	hsa-miR-3144-5p	CLIP-seq
MIRT1420542	hsa-miR-3158-5p	CLIP-seq
MIRT1420543	hsa-miR-3191	CLIP-seq
MIRT1420544	hsa-miR-3192	CLIP-seq
MIRT1420545	hsa-miR-3199	CLIP-seq
MIRT1420546	hsa-miR-330-5p	CLIP-seq
MIRT1420547	hsa-miR-34b	CLIP-seq
MIRT1420548	hsa-miR-3689d	CLIP-seq
MIRT1420549	hsa-miR-3973	CLIP-seq
MIRT1420550	hsa-miR-4274	CLIP-seq
MIRT1420551	hsa-miR-4314	CLIP-seq
MIRT1420552	hsa-miR-4514	CLIP-seq
MIRT1420553	hsa-miR-4537	CLIP-seq
MIRT1420554	hsa-miR-4646-5p	CLIP-seq
MIRT1420555	hsa-miR-4649-3p	CLIP-seq
MIRT1420556	hsa-miR-4652-5p	CLIP-seq
MIRT1420557	hsa-miR-4667-5p	CLIP-seq
MIRT1420558	hsa-miR-4669	CLIP-seq
MIRT1420559	hsa-miR-4692	CLIP-seq
MIRT1420560	hsa-miR-4700-5p	CLIP-seq
MIRT1420561	hsa-miR-4717-5p	CLIP-seq
MIRT1420562	hsa-miR-4731-5p	CLIP-seq
MIRT1420564	hsa-miR-4775	CLIP-seq
MIRT1420565	hsa-miR-520g	CLIP-seq
MIRT1420566	hsa-miR-520h	CLIP-seq
MIRT1420567	hsa-miR-590-3p	CLIP-seq
MIRT1420568	hsa-miR-885-3p	CLIP-seq

Transcription factors

Show/Hide all(20)

Transcription factor	Regulation	Reference
AIP	Repression	21984905
BRCA1	Repression	11244506
ESR1	Activation	11517191;18543253
ESR1	Unknown	10037443;21984905
ESR2	Activation	11517191
ESR2	Unknown	10037443
FOXA1	Unknown	10073575
FOXA2	Unknown	10073575
HDAC1	Repression	19581286
HMGN1	Unknown	17938209
JUN	Unknown	12021387
MECP2	Repression	15870696
MTA1	Unknown	12431981
NCOA4	Unknown	15772083
NELFB	Repression	16452188
NELFB	Unknown	17043641
NFATC3	Activation	16219765
NFKB1	Activation	17565651
RELA	Activation	17565651
SP3	Activation	18543253

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21982860, 24798994, 25416956, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	2303034
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010039	Process	Response to iron ion	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IBA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0043434	Process	Response to peptide hormone	IEA

MIM	HGNC	e!Ensembl
113710	11755	ENSG00000160182

Protein

UniProt ID

P04155

Protein name

Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)

Protein function

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.

PDB

1HI7 , 1PS2 , 6V1D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00088	Trefoil	31 → 71	Trefoil (P-type) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual

Sequence

MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDD
TVRGVPWCFYPNTIDVPPEEECEF

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Estrogen signaling pathway		Estrogen-dependent gene expression

TFF1 (trefoil factor 1)