Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7014
Gene name	Telomeric repeat binding factor 2
Gene symbol	TERF2
Synonyms (NCBI Gene)	TRBF2TRF2
Chromosome	16
Chromosome location	16q22.1
Summary	This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023208	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT030265	hsa-miR-26b-5p	Microarray	19088304
MIRT049699	hsa-miR-92a-3p	CLASH	23622248
MIRT048736	hsa-miR-96-5p	CLASH	23622248
MIRT046463	hsa-miR-15b-5p	CLASH	23622248
MIRT039036	hsa-miR-766-3p	CLASH	23622248
MIRT698663	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT698662	hsa-miR-3929	HITS-CLIP	23313552
MIRT698661	hsa-miR-4419b	HITS-CLIP	23313552
MIRT698660	hsa-miR-4478	HITS-CLIP	23313552
MIRT698659	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT698658	hsa-miR-4459	HITS-CLIP	23313552
MIRT698657	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT698656	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT698655	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT698654	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT698653	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT698652	hsa-miR-6134	HITS-CLIP	23313552
MIRT698651	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT698650	hsa-miR-4683	HITS-CLIP	23313552
MIRT698649	hsa-miR-541-3p	HITS-CLIP	23313552
MIRT698648	hsa-miR-654-5p	HITS-CLIP	23313552
MIRT698647	hsa-miR-1228-5p	HITS-CLIP	23313552
MIRT698646	hsa-miR-665	HITS-CLIP	23313552
MIRT630055	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630054	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630053	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630052	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630051	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630050	hsa-miR-3666	HITS-CLIP	23824327
MIRT630049	hsa-miR-4295	HITS-CLIP	23824327
MIRT630048	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630047	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630046	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630045	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630044	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630043	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630042	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630041	hsa-miR-3652	HITS-CLIP	23824327
MIRT630040	hsa-miR-4430	HITS-CLIP	23824327
MIRT630039	hsa-miR-572	HITS-CLIP	23824327
MIRT630038	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT664934	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT650097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650096	hsa-miR-764	HITS-CLIP	23824327
MIRT650095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650094	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650093	hsa-miR-1248	HITS-CLIP	23824327
MIRT650092	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT650091	hsa-miR-4635	HITS-CLIP	23824327
MIRT650090	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT650089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT650088	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT650087	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT650086	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT650085	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT630055	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630054	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630053	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630052	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630051	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630050	hsa-miR-3666	HITS-CLIP	23824327
MIRT630049	hsa-miR-4295	HITS-CLIP	23824327
MIRT630048	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630047	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630046	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630045	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630044	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630043	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630042	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630041	hsa-miR-3652	HITS-CLIP	23824327
MIRT630040	hsa-miR-4430	HITS-CLIP	23824327
MIRT630039	hsa-miR-572	HITS-CLIP	23824327
MIRT630038	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT545572	hsa-miR-5692a	PAR-CLIP	21572407
MIRT545572	hsa-miR-5692a	PAR-CLIP	21572407
MIRT439475	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439475	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT698662	hsa-miR-3929	PAR-CLIP	26701625
MIRT698661	hsa-miR-4419b	PAR-CLIP	26701625
MIRT698660	hsa-miR-4478	PAR-CLIP	26701625
MIRT698659	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT698655	hsa-miR-485-5p	PAR-CLIP	26701625
MIRT698646	hsa-miR-665	PAR-CLIP	26701625
MIRT698654	hsa-miR-6884-5p	PAR-CLIP	26701625
MIRT698651	hsa-miR-7160-5p	PAR-CLIP	26701625
MIRT039036	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT698663	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT698662	hsa-miR-3929	HITS-CLIP	23313552
MIRT698661	hsa-miR-4419b	HITS-CLIP	23313552
MIRT698660	hsa-miR-4478	HITS-CLIP	23313552
MIRT698659	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT698658	hsa-miR-4459	HITS-CLIP	23313552
MIRT698657	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT698656	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT698655	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT698654	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT698653	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT698652	hsa-miR-6134	HITS-CLIP	23313552
MIRT698651	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT698650	hsa-miR-4683	HITS-CLIP	23313552
MIRT698649	hsa-miR-541-3p	HITS-CLIP	23313552
MIRT698648	hsa-miR-654-5p	HITS-CLIP	23313552
MIRT698647	hsa-miR-1228-5p	HITS-CLIP	23313552
MIRT698646	hsa-miR-665	HITS-CLIP	23313552
MIRT630055	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630054	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630053	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630052	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630051	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630050	hsa-miR-3666	HITS-CLIP	23824327
MIRT630049	hsa-miR-4295	HITS-CLIP	23824327
MIRT630048	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630047	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630046	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630045	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630044	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630043	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630042	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630041	hsa-miR-3652	HITS-CLIP	23824327
MIRT630040	hsa-miR-4430	HITS-CLIP	23824327
MIRT630039	hsa-miR-572	HITS-CLIP	23824327
MIRT630038	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT664934	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT650097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650096	hsa-miR-764	HITS-CLIP	23824327
MIRT650095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650094	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650093	hsa-miR-1248	HITS-CLIP	23824327
MIRT650092	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT650091	hsa-miR-4635	HITS-CLIP	23824327
MIRT650090	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT650089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT650088	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT650087	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT650086	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT650085	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT630055	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630054	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630053	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630052	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630051	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630050	hsa-miR-3666	HITS-CLIP	23824327
MIRT630049	hsa-miR-4295	HITS-CLIP	23824327
MIRT630048	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630047	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630046	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630045	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630044	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630043	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630042	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630041	hsa-miR-3652	HITS-CLIP	23824327
MIRT630040	hsa-miR-4430	HITS-CLIP	23824327
MIRT630039	hsa-miR-572	HITS-CLIP	23824327
MIRT630038	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT545572	hsa-miR-5692a	PAR-CLIP	21572407
MIRT545572	hsa-miR-5692a	PAR-CLIP	21572407
MIRT756220	hsa-miR-182-3p	Luciferase reporter assayWestern blotting	36426578
MIRT1418282	hsa-miR-101	CLIP-seq
MIRT1418283	hsa-miR-105	CLIP-seq
MIRT1418284	hsa-miR-1233	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT1418286	hsa-miR-1268	CLIP-seq
MIRT1418287	hsa-miR-1268b	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT1418289	hsa-miR-1324	CLIP-seq
MIRT1418290	hsa-miR-3120-3p	CLIP-seq
MIRT1418291	hsa-miR-3154	CLIP-seq
MIRT1418292	hsa-miR-3166	CLIP-seq
MIRT1418293	hsa-miR-3194-3p	CLIP-seq
MIRT1418294	hsa-miR-3613-3p	CLIP-seq
MIRT1418295	hsa-miR-3714	CLIP-seq
MIRT1418296	hsa-miR-371-5p	CLIP-seq
MIRT1418297	hsa-miR-371b-5p	CLIP-seq
MIRT1418298	hsa-miR-4428	CLIP-seq
MIRT1418299	hsa-miR-4434	CLIP-seq
MIRT1418300	hsa-miR-4480	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT1418302	hsa-miR-4516	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT1418304	hsa-miR-4727-5p	CLIP-seq
MIRT1418305	hsa-miR-4769-3p	CLIP-seq
MIRT1418306	hsa-miR-550a	CLIP-seq
MIRT1418307	hsa-miR-601	CLIP-seq
MIRT1418308	hsa-miR-760	CLIP-seq
MIRT1418282	hsa-miR-101	CLIP-seq
MIRT2125463	hsa-miR-103b	CLIP-seq
MIRT1418284	hsa-miR-1233	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT2125464	hsa-miR-1289	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT2125465	hsa-miR-138	CLIP-seq
MIRT2125466	hsa-miR-200b	CLIP-seq
MIRT2125467	hsa-miR-200c	CLIP-seq
MIRT2125468	hsa-miR-23a	CLIP-seq
MIRT2125469	hsa-miR-23b	CLIP-seq
MIRT2125470	hsa-miR-23c	CLIP-seq
MIRT2125471	hsa-miR-24	CLIP-seq
MIRT1418290	hsa-miR-3120-3p	CLIP-seq
MIRT2125472	hsa-miR-3122	CLIP-seq
MIRT2125473	hsa-miR-3145-5p	CLIP-seq
MIRT1418291	hsa-miR-3154	CLIP-seq
MIRT2125474	hsa-miR-3165	CLIP-seq
MIRT2125475	hsa-miR-3198	CLIP-seq
MIRT2125476	hsa-miR-3651	CLIP-seq
MIRT2125477	hsa-miR-3680	CLIP-seq
MIRT2125478	hsa-miR-3689a-3p	CLIP-seq
MIRT2125479	hsa-miR-3689c	CLIP-seq
MIRT2125480	hsa-miR-369-3p	CLIP-seq
MIRT2125481	hsa-miR-3913-5p	CLIP-seq
MIRT2125482	hsa-miR-4259	CLIP-seq
MIRT2125483	hsa-miR-4284	CLIP-seq
MIRT2125484	hsa-miR-429	CLIP-seq
MIRT2125485	hsa-miR-4294	CLIP-seq
MIRT2125486	hsa-miR-4309	CLIP-seq
MIRT2125487	hsa-miR-4433	CLIP-seq
MIRT1418299	hsa-miR-4434	CLIP-seq
MIRT2125488	hsa-miR-4457	CLIP-seq
MIRT1418300	hsa-miR-4480	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT1418302	hsa-miR-4516	CLIP-seq
MIRT2125489	hsa-miR-4699-3p	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT1418304	hsa-miR-4727-5p	CLIP-seq
MIRT2125490	hsa-miR-4728-5p	CLIP-seq
MIRT2125491	hsa-miR-4755-3p	CLIP-seq
MIRT1418305	hsa-miR-4769-3p	CLIP-seq
MIRT2125492	hsa-miR-4786-5p	CLIP-seq
MIRT2125493	hsa-miR-4798-3p	CLIP-seq
MIRT2125494	hsa-miR-490-3p	CLIP-seq
MIRT2125495	hsa-miR-490-5p	CLIP-seq
MIRT2125496	hsa-miR-513b	CLIP-seq
MIRT1418306	hsa-miR-550a	CLIP-seq
MIRT2125497	hsa-miR-571	CLIP-seq
MIRT2125498	hsa-miR-766	CLIP-seq
MIRT1418282	hsa-miR-101	CLIP-seq
MIRT2125463	hsa-miR-103b	CLIP-seq
MIRT1418283	hsa-miR-105	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT2347817	hsa-miR-1276	CLIP-seq
MIRT2125464	hsa-miR-1289	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT1418289	hsa-miR-1324	CLIP-seq
MIRT2125465	hsa-miR-138	CLIP-seq
MIRT2347818	hsa-miR-185	CLIP-seq
MIRT2347819	hsa-miR-2277-3p	CLIP-seq
MIRT2347820	hsa-miR-296-3p	CLIP-seq
MIRT2347821	hsa-miR-2964a-5p	CLIP-seq
MIRT1418290	hsa-miR-3120-3p	CLIP-seq
MIRT2347822	hsa-miR-3128	CLIP-seq
MIRT2125474	hsa-miR-3165	CLIP-seq
MIRT1418292	hsa-miR-3166	CLIP-seq
MIRT1418293	hsa-miR-3194-3p	CLIP-seq
MIRT2125475	hsa-miR-3198	CLIP-seq
MIRT2125476	hsa-miR-3651	CLIP-seq
MIRT1418295	hsa-miR-3714	CLIP-seq
MIRT2347823	hsa-miR-376c	CLIP-seq
MIRT2125482	hsa-miR-4259	CLIP-seq
MIRT2125485	hsa-miR-4294	CLIP-seq
MIRT2347824	hsa-miR-4306	CLIP-seq
MIRT2125486	hsa-miR-4309	CLIP-seq
MIRT2347825	hsa-miR-4311	CLIP-seq
MIRT2125488	hsa-miR-4457	CLIP-seq
MIRT1418300	hsa-miR-4480	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT2347826	hsa-miR-4497	CLIP-seq
MIRT2347827	hsa-miR-4530	CLIP-seq
MIRT2347828	hsa-miR-4537	CLIP-seq
MIRT2347829	hsa-miR-4644	CLIP-seq
MIRT2347830	hsa-miR-4669	CLIP-seq
MIRT2347831	hsa-miR-4695-3p	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT2347832	hsa-miR-4720-5p	CLIP-seq
MIRT1418304	hsa-miR-4727-5p	CLIP-seq
MIRT2347833	hsa-miR-4744	CLIP-seq
MIRT1418305	hsa-miR-4769-3p	CLIP-seq
MIRT2347834	hsa-miR-4794	CLIP-seq
MIRT2347835	hsa-miR-4795-5p	CLIP-seq
MIRT2347836	hsa-miR-4799-3p	CLIP-seq
MIRT2125495	hsa-miR-490-5p	CLIP-seq
MIRT2125496	hsa-miR-513b	CLIP-seq
MIRT2347837	hsa-miR-545	CLIP-seq
MIRT1418306	hsa-miR-550a	CLIP-seq
MIRT2125497	hsa-miR-571	CLIP-seq
MIRT2347838	hsa-miR-583	CLIP-seq
MIRT1418308	hsa-miR-760	CLIP-seq
MIRT2125498	hsa-miR-766	CLIP-seq
MIRT2347839	hsa-miR-892b	CLIP-seq
MIRT2347840	hsa-miR-922	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT2125474	hsa-miR-3165	CLIP-seq
MIRT2125482	hsa-miR-4259	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT2125497	hsa-miR-571	CLIP-seq
MIRT1418294	hsa-miR-3613-3p	CLIP-seq
MIRT1418296	hsa-miR-371-5p	CLIP-seq
MIRT1418297	hsa-miR-371b-5p	CLIP-seq
MIRT2461315	hsa-miR-4684-5p	CLIP-seq
MIRT2461316	hsa-miR-548c-3p	CLIP-seq
MIRT1418283	hsa-miR-105	CLIP-seq
MIRT1418284	hsa-miR-1233	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT1418286	hsa-miR-1268	CLIP-seq
MIRT1418287	hsa-miR-1268b	CLIP-seq
MIRT2347817	hsa-miR-1276	CLIP-seq
MIRT2125464	hsa-miR-1289	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT1418289	hsa-miR-1324	CLIP-seq
MIRT2125465	hsa-miR-138	CLIP-seq
MIRT2640646	hsa-miR-139-5p	CLIP-seq
MIRT2640647	hsa-miR-186	CLIP-seq
MIRT2640648	hsa-miR-1908	CLIP-seq
MIRT2640649	hsa-miR-197	CLIP-seq
MIRT2640650	hsa-miR-2114	CLIP-seq
MIRT2347819	hsa-miR-2277-3p	CLIP-seq
MIRT2125468	hsa-miR-23a	CLIP-seq
MIRT2125469	hsa-miR-23b	CLIP-seq
MIRT2125470	hsa-miR-23c	CLIP-seq
MIRT2125471	hsa-miR-24	CLIP-seq
MIRT2347820	hsa-miR-296-3p	CLIP-seq
MIRT2347821	hsa-miR-2964a-5p	CLIP-seq
MIRT1418290	hsa-miR-3120-3p	CLIP-seq
MIRT2640651	hsa-miR-3121-5p	CLIP-seq
MIRT2125472	hsa-miR-3122	CLIP-seq
MIRT2347822	hsa-miR-3128	CLIP-seq
MIRT2640652	hsa-miR-3133	CLIP-seq
MIRT2640653	hsa-miR-3145-3p	CLIP-seq
MIRT1418291	hsa-miR-3154	CLIP-seq
MIRT2125474	hsa-miR-3165	CLIP-seq
MIRT1418292	hsa-miR-3166	CLIP-seq
MIRT2640654	hsa-miR-3169	CLIP-seq
MIRT1418293	hsa-miR-3194-3p	CLIP-seq
MIRT2125475	hsa-miR-3198	CLIP-seq
MIRT2640655	hsa-miR-33a	CLIP-seq
MIRT2640656	hsa-miR-33b	CLIP-seq
MIRT1418294	hsa-miR-3613-3p	CLIP-seq
MIRT2640657	hsa-miR-361-3p	CLIP-seq
MIRT2640658	hsa-miR-3616-5p	CLIP-seq
MIRT2640659	hsa-miR-3647-5p	CLIP-seq
MIRT2640660	hsa-miR-3649	CLIP-seq
MIRT2640661	hsa-miR-3663-5p	CLIP-seq
MIRT2640662	hsa-miR-3685	CLIP-seq
MIRT2125478	hsa-miR-3689a-3p	CLIP-seq
MIRT2125479	hsa-miR-3689c	CLIP-seq
MIRT2640663	hsa-miR-3692	CLIP-seq
MIRT1418295	hsa-miR-3714	CLIP-seq
MIRT1418296	hsa-miR-371-5p	CLIP-seq
MIRT1418297	hsa-miR-371b-5p	CLIP-seq
MIRT2640664	hsa-miR-384	CLIP-seq
MIRT2125481	hsa-miR-3913-5p	CLIP-seq
MIRT2640665	hsa-miR-412	CLIP-seq
MIRT2125482	hsa-miR-4259	CLIP-seq
MIRT2125483	hsa-miR-4284	CLIP-seq
MIRT2125485	hsa-miR-4294	CLIP-seq
MIRT2125486	hsa-miR-4309	CLIP-seq
MIRT2347825	hsa-miR-4311	CLIP-seq
MIRT2125487	hsa-miR-4433	CLIP-seq
MIRT1418299	hsa-miR-4434	CLIP-seq
MIRT2125488	hsa-miR-4457	CLIP-seq
MIRT2640666	hsa-miR-4477b	CLIP-seq
MIRT1418300	hsa-miR-4480	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT2640667	hsa-miR-4493	CLIP-seq
MIRT2640668	hsa-miR-4503	CLIP-seq
MIRT2640669	hsa-miR-4515	CLIP-seq
MIRT1418302	hsa-miR-4516	CLIP-seq
MIRT2640670	hsa-miR-4527	CLIP-seq
MIRT2640671	hsa-miR-4639-5p	CLIP-seq
MIRT2461315	hsa-miR-4684-5p	CLIP-seq
MIRT2347831	hsa-miR-4695-3p	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT2640672	hsa-miR-4709-5p	CLIP-seq
MIRT2640673	hsa-miR-4711-5p	CLIP-seq
MIRT2640674	hsa-miR-4714-3p	CLIP-seq
MIRT2347832	hsa-miR-4720-5p	CLIP-seq
MIRT1418304	hsa-miR-4727-5p	CLIP-seq
MIRT2125490	hsa-miR-4728-5p	CLIP-seq
MIRT2347833	hsa-miR-4744	CLIP-seq
MIRT2640675	hsa-miR-4753-5p	CLIP-seq
MIRT2125491	hsa-miR-4755-3p	CLIP-seq
MIRT2640676	hsa-miR-4767	CLIP-seq
MIRT1418305	hsa-miR-4769-3p	CLIP-seq
MIRT2640677	hsa-miR-4778-5p	CLIP-seq
MIRT2125492	hsa-miR-4786-5p	CLIP-seq
MIRT2640678	hsa-miR-4793-5p	CLIP-seq
MIRT2347834	hsa-miR-4794	CLIP-seq
MIRT2347835	hsa-miR-4795-5p	CLIP-seq
MIRT2347836	hsa-miR-4799-3p	CLIP-seq
MIRT2125494	hsa-miR-490-3p	CLIP-seq
MIRT2125495	hsa-miR-490-5p	CLIP-seq
MIRT2640679	hsa-miR-513a-3p	CLIP-seq
MIRT2125496	hsa-miR-513b	CLIP-seq
MIRT2640680	hsa-miR-515-5p	CLIP-seq
MIRT2347837	hsa-miR-545	CLIP-seq
MIRT2461316	hsa-miR-548c-3p	CLIP-seq
MIRT1418306	hsa-miR-550a	CLIP-seq
MIRT2640681	hsa-miR-566	CLIP-seq
MIRT2125497	hsa-miR-571	CLIP-seq
MIRT2640682	hsa-miR-573	CLIP-seq
MIRT2347838	hsa-miR-583	CLIP-seq
MIRT1418307	hsa-miR-601	CLIP-seq
MIRT2640683	hsa-miR-603	CLIP-seq
MIRT2640684	hsa-miR-662	CLIP-seq
MIRT2640685	hsa-miR-663	CLIP-seq
MIRT1418308	hsa-miR-760	CLIP-seq
MIRT2125498	hsa-miR-766	CLIP-seq
MIRT2347839	hsa-miR-892b	CLIP-seq
MIRT1418283	hsa-miR-105	CLIP-seq
MIRT1418284	hsa-miR-1233	CLIP-seq
MIRT1418285	hsa-miR-1262	CLIP-seq
MIRT1418286	hsa-miR-1268	CLIP-seq
MIRT1418287	hsa-miR-1268b	CLIP-seq
MIRT2347817	hsa-miR-1276	CLIP-seq
MIRT2125464	hsa-miR-1289	CLIP-seq
MIRT1418288	hsa-miR-1293	CLIP-seq
MIRT1418289	hsa-miR-1324	CLIP-seq
MIRT2125465	hsa-miR-138	CLIP-seq
MIRT2640646	hsa-miR-139-5p	CLIP-seq
MIRT2640647	hsa-miR-186	CLIP-seq
MIRT2640648	hsa-miR-1908	CLIP-seq
MIRT2640649	hsa-miR-197	CLIP-seq
MIRT2640650	hsa-miR-2114	CLIP-seq
MIRT2347819	hsa-miR-2277-3p	CLIP-seq
MIRT2125468	hsa-miR-23a	CLIP-seq
MIRT2125469	hsa-miR-23b	CLIP-seq
MIRT2125470	hsa-miR-23c	CLIP-seq
MIRT2347820	hsa-miR-296-3p	CLIP-seq
MIRT2347821	hsa-miR-2964a-5p	CLIP-seq
MIRT1418290	hsa-miR-3120-3p	CLIP-seq
MIRT2640651	hsa-miR-3121-5p	CLIP-seq
MIRT2125472	hsa-miR-3122	CLIP-seq
MIRT2640652	hsa-miR-3133	CLIP-seq
MIRT2640653	hsa-miR-3145-3p	CLIP-seq
MIRT1418291	hsa-miR-3154	CLIP-seq
MIRT2125474	hsa-miR-3165	CLIP-seq
MIRT1418292	hsa-miR-3166	CLIP-seq
MIRT2640654	hsa-miR-3169	CLIP-seq
MIRT2125475	hsa-miR-3198	CLIP-seq
MIRT2640655	hsa-miR-33a	CLIP-seq
MIRT2640656	hsa-miR-33b	CLIP-seq
MIRT1418294	hsa-miR-3613-3p	CLIP-seq
MIRT2640661	hsa-miR-3663-5p	CLIP-seq
MIRT2640662	hsa-miR-3685	CLIP-seq
MIRT2125478	hsa-miR-3689a-3p	CLIP-seq
MIRT2125479	hsa-miR-3689c	CLIP-seq
MIRT2640663	hsa-miR-3692	CLIP-seq
MIRT1418295	hsa-miR-3714	CLIP-seq
MIRT1418296	hsa-miR-371-5p	CLIP-seq
MIRT1418297	hsa-miR-371b-5p	CLIP-seq
MIRT2640664	hsa-miR-384	CLIP-seq
MIRT2125481	hsa-miR-3913-5p	CLIP-seq
MIRT2640665	hsa-miR-412	CLIP-seq
MIRT2125482	hsa-miR-4259	CLIP-seq
MIRT2125485	hsa-miR-4294	CLIP-seq
MIRT2125486	hsa-miR-4309	CLIP-seq
MIRT2347825	hsa-miR-4311	CLIP-seq
MIRT2125487	hsa-miR-4433	CLIP-seq
MIRT1418299	hsa-miR-4434	CLIP-seq
MIRT2125488	hsa-miR-4457	CLIP-seq
MIRT1418300	hsa-miR-4480	CLIP-seq
MIRT1418301	hsa-miR-4483	CLIP-seq
MIRT2640667	hsa-miR-4493	CLIP-seq
MIRT2640668	hsa-miR-4503	CLIP-seq
MIRT2640669	hsa-miR-4515	CLIP-seq
MIRT1418302	hsa-miR-4516	CLIP-seq
MIRT2640670	hsa-miR-4527	CLIP-seq
MIRT2461315	hsa-miR-4684-5p	CLIP-seq
MIRT1418303	hsa-miR-4701-3p	CLIP-seq
MIRT2640673	hsa-miR-4711-5p	CLIP-seq
MIRT2640674	hsa-miR-4714-3p	CLIP-seq
MIRT2125490	hsa-miR-4728-5p	CLIP-seq
MIRT2347833	hsa-miR-4744	CLIP-seq
MIRT2640675	hsa-miR-4753-5p	CLIP-seq
MIRT2640676	hsa-miR-4767	CLIP-seq
MIRT2125492	hsa-miR-4786-5p	CLIP-seq
MIRT2640678	hsa-miR-4793-5p	CLIP-seq
MIRT2347834	hsa-miR-4794	CLIP-seq
MIRT2125494	hsa-miR-490-3p	CLIP-seq
MIRT2125495	hsa-miR-490-5p	CLIP-seq
MIRT2640679	hsa-miR-513a-3p	CLIP-seq
MIRT2125496	hsa-miR-513b	CLIP-seq
MIRT2347837	hsa-miR-545	CLIP-seq
MIRT2461316	hsa-miR-548c-3p	CLIP-seq
MIRT2640681	hsa-miR-566	CLIP-seq
MIRT2125497	hsa-miR-571	CLIP-seq
MIRT2347838	hsa-miR-583	CLIP-seq
MIRT1418307	hsa-miR-601	CLIP-seq
MIRT2640685	hsa-miR-663	CLIP-seq
MIRT2125498	hsa-miR-766	CLIP-seq
MIRT2347839	hsa-miR-892b	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
SP1	Activation	19783902

Show/Hide all (91)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000723	Process	Telomere maintenance	IDA	28216226
GO:0000723	Process	Telomere maintenance	IEA
GO:0000723	Process	Telomere maintenance	IEA
GO:0000723	Process	Telomere maintenance	IMP	20655466
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000781	Component	Chromosome, telomeric region	IDA	28216226
GO:0000781	Component	Chromosome, telomeric region	IDA	12768206, 15109494, 20479256, 20655466, 23685356, 24012755, 24270157
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000782	Component	Telomere cap complex	IEA
GO:0000783	Component	Nuclear telomere cap complex	IDA	15181449, 16880378
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003691	Function	Double-stranded telomeric DNA binding	IBA
GO:0003691	Function	Double-stranded telomeric DNA binding	IDA	18812185, 21852327, 28216226
GO:0003691	Function	Double-stranded telomeric DNA binding	IEA
GO:0003691	Function	Double-stranded telomeric DNA binding	ISS	9326950
GO:0003720	Function	Telomerase activity	IBA
GO:0003720	Function	Telomerase activity	IDA	23685356
GO:0005515	Function	Protein binding	IPI	10984620, 12181313, 14690602, 15181449, 15229185, 15314656, 15383534, 15657433, 16730175, 16799465, 16880378, 17055345, 18202258, 19287395, 19596235, 19596236, 19651898, 20360068, 20479256, 20655466, 21044950, 21217703, 21824286, 21829167, 22039056, 22157895, 24012755, 24095731, 249
GO:0005634	Component	Nucleus	IDA	17055345
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0016233	Process	Telomere capping	IDA	21852327
GO:0016233	Process	Telomere capping	IMP	12768206, 14690602, 15657433
GO:0016233	Process	Telomere capping	NAS	17395247
GO:0016233	Process	Telomere capping	TAS	24095731
GO:0016604	Component	Nuclear body	IDA
GO:0019899	Function	Enzyme binding	IPI	20479256
GO:0030424	Component	Axon	IEA
GO:0031627	Process	Telomeric loop formation	IBA
GO:0031627	Process	Telomeric loop formation	IDA	10338214
GO:0031627	Process	Telomeric loop formation	IEA
GO:0031848	Process	Protection from non-homologous end joining at telomere	IBA
GO:0031848	Process	Protection from non-homologous end joining at telomere	IEA
GO:0031848	Process	Protection from non-homologous end joining at telomere	IEA
GO:0031848	Process	Protection from non-homologous end joining at telomere	IMP	14690602, 17499040
GO:0031848	Process	Protection from non-homologous end joining at telomere	IPI	24095731
GO:0032204	Process	Regulation of telomere maintenance	IMP	22536324
GO:0032205	Process	Negative regulation of telomere maintenance	IMP	11971978
GO:0032206	Process	Positive regulation of telomere maintenance	IDA	24012755
GO:0032206	Process	Positive regulation of telomere maintenance	IEA
GO:0032206	Process	Positive regulation of telomere maintenance	IEA
GO:0032206	Process	Positive regulation of telomere maintenance	NAS	15383534
GO:0032208	Process	Negative regulation of telomere maintenance via recombination	IBA
GO:0032208	Process	Negative regulation of telomere maintenance via recombination	IEA
GO:0032208	Process	Negative regulation of telomere maintenance via recombination	IMP	15507207
GO:0032208	Process	Negative regulation of telomere maintenance via recombination	ISS
GO:0032210	Process	Regulation of telomere maintenance via telomerase	IBA
GO:0032210	Process	Regulation of telomere maintenance via telomerase	IDA	23685356
GO:0032210	Process	Regulation of telomere maintenance via telomerase	IMP	19864690
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IC	15657433
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IDA	17055345
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IEA
GO:0032214	Process	Negative regulation of telomere maintenance via semi-conservative replication	NAS	15007108
GO:0042162	Function	Telomeric DNA binding	IDA	19854130, 20655466, 23685356
GO:0042162	Function	Telomeric DNA binding	IEA
GO:0042162	Function	Telomeric DNA binding	TAS	9476899
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	9326950
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0044877	Function	Protein-containing complex binding	IPI	14690602, 24095731
GO:0061820	Process	Telomeric D-loop disassembly	IBA
GO:0061820	Process	Telomeric D-loop disassembly	IEA
GO:0061820	Process	Telomeric D-loop disassembly	IGI	22039056
GO:0070187	Component	Shelterin complex	IBA
GO:0070187	Component	Shelterin complex	IDA	15383534, 23685356
GO:0070187	Component	Shelterin complex	IEA
GO:0070187	Component	Shelterin complex	IMP	21852327
GO:0070187	Component	Shelterin complex	IPI	15383534
GO:0070187	Component	Shelterin complex	TAS	18202258
GO:0070198	Process	Protein localization to chromosome, telomeric region	IBA
GO:0070198	Process	Protein localization to chromosome, telomeric region	IMP	17499040
GO:0090398	Process	Cellular senescence	NAS	17395247
GO:0098505	Function	G-rich strand telomeric DNA binding	IBA
GO:0098505	Function	G-rich strand telomeric DNA binding	IDA	17694070
GO:0098505	Function	G-rich strand telomeric DNA binding	IEA
GO:0099088	Process	Axonal transport of messenger ribonucleoprotein complex	IEA
GO:1903824	Process	Negative regulation of telomere single strand break repair	NAS	17395247
GO:1904354	Process	Negative regulation of telomere capping	IMP	24270157
GO:1904357	Process	Negative regulation of telomere maintenance via telomere lengthening	IMP	24012755
GO:1904430	Process	Negative regulation of t-circle formation	IMP	15507207
GO:1904430	Process	Negative regulation of t-circle formation	TAS	19581589
GO:1905839	Process	Negative regulation of telomeric D-loop disassembly	IBA
GO:1905839	Process	Negative regulation of telomeric D-loop disassembly	IDA	15200954
GO:1905839	Process	Negative regulation of telomeric D-loop disassembly	IEA
GO:2000773	Process	Negative regulation of cellular senescence	IMP	11927518

MIM	HGNC	e!Ensembl
602027	11729	ENSG00000132604

Q15554

Protein name

Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)

Protein function

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950,

PDB

1H6P , 1VF9 , 1VFC , 1W0U , 1XG1 , 3BU8 , 3BUA , 3K6G , 3SJM , 4M7C , 4RQI , 5WQD , 5XYF , 6J67 , 7C5D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08558	TRF	94 → 293	Telomere repeat binding factor (TRF)	Domain
PF16772	TERF2_RBM	318 → 358	Telomeric repeat-binding factor 2 Rap1-binding motif	Domain
PF00249	Myb_DNA-binding	489 → 537	Myb-like DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9326950}.

Sequence

MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRR
ASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQ
IRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEM
IKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNI
IREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDK
QPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQ
ALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLN
SSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDE
DSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLG
MN

Sequence length

542

Interactions

View interactions

	Reactome
			Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Benign	rs35439397, rs12325060	RCV005921812 RCV005923375
Lung cancer	Benign	rs9925538	RCV005922079
Malignant lymphoma, large B-cell, diffuse	Benign	rs35439397, rs12325060	RCV005921810 RCV005923373
Malignant tumor of esophagus	Benign	rs9925538	RCV005922078
Nonpapillary renal cell carcinoma	Benign	rs12325060	RCV005923372
TERF2-related disorder	Benign; Uncertain significance; Likely benign	rs34415214, rs2543397056, rs996291216, rs371717517, rs2014176824, rs1030818017	RCV003980811 RCV003410605 RCV003937255 RCV003936929 RCV003922280 RCV003976849
Uterine carcinosarcoma	Benign	rs35439397, rs12325060	RCV005921811 RCV005923374
Uterine corpus endometrial carcinoma	Benign	rs9925538	RCV005922080
Uveal melanoma	Benign	rs35439397	RCV005921809

Show/Hide Text Mining Associations (63)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	27165744
Alternating hemiplegia of childhood	Associate	23708666, 25609072
Anodontia	Associate	28436953
Astrocytoma	Inhibit	23691191
Bloom Syndrome	Associate	12181313
Brain Neoplasms	Associate	23691191
Breast Neoplasms	Associate	15735711, 20625812, 22527105, 23342266, 23629941, 29328377, 37858982, 40352198
Carcinogenesis	Associate	15735711, 18641004, 23570868, 27923994
Carcinoma Hepatocellular	Associate	27782152, 29725012
Carcinoma Renal Cell	Associate	25730259
Chromosome Aberrations	Associate	28404540, 28436953
Cockayne Syndrome	Associate	22904069
Colorectal Neoplasms	Associate	11556843, 19783902, 27923994, 29870526, 35240232, 36834938
Colorectal Neoplasms	Stimulate	32539869
Diabetes Mellitus Type 2	Associate	21665207, 32296102
DNA Virus Infections	Associate	16287861
Dyskeratosis Congenita	Associate	29581185
Dysplastic Nevus Syndrome	Associate	23300679
Endometrial Neoplasms	Associate	35054812
Esophageal Squamous Cell Carcinoma	Associate	16437597
Glioblastoma	Inhibit	23691191
Glioblastoma	Associate	32970185, 34010660
Heart Diseases	Associate	16539655
Heart Failure	Associate	36719921
Hereditary leiomyomatosis and renal cell cancer	Associate	28436953
HIV Infections	Inhibit	22398292
HIV Infections	Associate	35660868
Hodgkin Disease	Associate	28436953
Kidney Calculi	Inhibit	34745087
Leukemia Biphenotypic Acute	Associate	21056083
Leukemia Lymphocytic Chronic B Cell	Associate	18077792, 27528712
Leukemia Lymphoma Adult T Cell	Associate	17643074
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	36871092
Leukemia Myeloid Acute	Associate	11123427, 15982341
Leukemia T Cell	Associate	17643074
Lung Neoplasms	Associate	19285750
Lymphoma	Associate	12915884
Lymphoma Non Hodgkin	Associate	12915884
Lymphoma Non Hodgkin	Inhibit	18641004
Macular Degeneration	Associate	24648608, 36497103
Melanoma	Associate	23300679, 25505254, 26945789, 33796413
Melanoma Cutaneous Malignant	Associate	33796413
Mitochondrial Diseases	Associate	37231173
Monoclonal Gammopathy of Undetermined Significance	Associate	20644899
Multiple Myeloma	Associate	20644899
Muscular Dystrophy Duchenne	Associate	36719921
Myelodysplastic Syndromes	Inhibit	28404540
Neoplasm Invasiveness	Associate	20625812
Neoplasm Metastasis	Associate	25654471
Neoplasms	Associate	11123427, 16280054, 16437597, 16539655, 17643074, 18818083, 19783902, 20625812, 25609072, 25654471, 26108857, 26640040, 26945789, 30907229, 34010660, 35240232, 40352198 View all (2 more)
Neoplasms	Inhibit	19748686
Neoplasms	Stimulate	32539869
Nevus	Associate	23300679
Oncogene Addiction	Stimulate	36494469
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	15982341
Prostatic Neoplasms	Associate	21777411, 28808664, 32784507
Stomach Neoplasms	Associate	16760674
Telomeric 22q13 Monosomy Syndrome	Associate	16539655, 19596784, 21394098, 32970185, 35261172
Thyroid Nodule	Associate	15632001
Triple Negative Breast Neoplasms	Associate	37858982
Uterine Cervical Neoplasms	Associate	25654471
Virus Diseases	Associate	35660868
Werner Syndrome	Associate	15200954, 18212065, 20215438

TERF2 (telomeric repeat binding factor 2)