Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7003
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
TEA domain transcription factor 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TEAD1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
|
AA |
Chromosome
Chromosome number
|
11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
11p15.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations |
UniProt ID |
P28347
|
Protein name |
Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) |
Protein function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas |
PDB |
2HZD
,
3KYS
,
4RE1
,
4Z8E
,
5NNX
,
6HIL
,
6IM5
,
7CMM
,
7ZJP
,
8Q68
,
9FZA
,
9GAX
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01285
|
TEA |
31 → 100 |
TEA/ATTS domain |
Domain |
PF17725
|
YBD |
214 → 423 |
YAP binding domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
Sequence |
|
Sequence length |
426 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Helicoid peripapillary chorioretinal degeneration |
Helicoid peripapillary chorioretinal degeneration |
rs11567847, rs1249149946 |
|
Myopia |
Myopia |
rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023 View all (6 more) |
|
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
31374203 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Rheumatic Heart Disease |
Rheumatic Heart Disease |
|
|
GWAS |
Osteoarthritis Of Hip |
Osteoarthritis Of Hip |
|
|
GWAS |
Astrocytoma |
Astrocytoma |
|
|
GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
|
GWAS, CBGDA |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
37723874 |
Carcinoma Hepatocellular |
Associate
|
28349829, 33760147, 36517508, 36680650 |
Cardiomyopathy Dilated |
Associate
|
37058558 |
Colorectal Neoplasms |
Associate
|
24976283, 30649550, 34870557, 36147462 |
Corneal Endothelial Cell Loss |
Associate
|
33456372 |
Death |
Associate
|
25628125 |
Developmental Disabilities |
Associate
|
33509776 |
Endometrial Neoplasms |
Associate
|
28071680 |
Eye Diseases |
Associate
|
30903741 |
Glioblastoma |
Associate
|
30275445 |
Glioma |
Associate
|
31894297 |
Heart Diseases |
Associate
|
37058558 |
Inflammation |
Associate
|
33456372 |
Lymphatic Metastasis |
Associate
|
24175801 |
Melanoma |
Associate
|
25628125 |
Melanoma Cutaneous Malignant |
Associate
|
25628125 |
Neoplasm Metastasis |
Associate
|
36147462 |
Neoplasms |
Associate
|
21288909, 24175801, 30275445, 34657158, 36680650 |
Neoplasms |
Inhibit
|
36484096 |
Odontogenic Tumors |
Associate
|
28512636 |
Oncogene Addiction |
Associate
|
37578237 |
Osteosarcoma |
Associate
|
37752588 |
Prostatic Neoplasms |
Associate
|
19002168 |
Stomach Neoplasms |
Stimulate
|
24175801 |
Sveinsson Chorioretinal Atrophy |
Associate
|
23029054, 30903741 |
Trisomy 18 Syndrome |
Associate
|
33509776 |
Uterine Cervical Neoplasms |
Associate
|
1318197, 32132238 |
|