Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7003
Gene name Gene Name - the full gene name approved by the HGNC.
TEA domain transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TEAD1
Synonyms (NCBI Gene) Gene synonyms aliases
AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
AA
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11567847 T>C Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002701 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT002701 hsa-miR-124-3p Microarray 15685193
MIRT027571 hsa-miR-98-5p Microarray 19088304
MIRT044437 hsa-miR-320a CLASH 23622248
MIRT367734 hsa-miR-1324 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IMP 26045994
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
189967 11714 ENSG00000187079
Protein
UniProt ID P28347
Protein name Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
Protein function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas
PDB 2HZD , 3KYS , 4RE1 , 4Z8E , 5NNX , 6HIL , 6IM5 , 7CMM , 7ZJP , 8Q68 , 9FZA , 9GAX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01285 TEA 31 100 TEA/ATTS domain Domain
PF17725 YBD 214 423 YAP binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Sequence
Sequence length 426
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Hippo signaling pathway
Hippo signaling pathway - multiple species
  YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Helicoid peripapillary chorioretinal degeneration Helicoid peripapillary chorioretinal degeneration rs11567847, rs1249149946
Myopia Myopia rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805
View all (6 more)
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Rheumatic Heart Disease Rheumatic Heart Disease GWAS
Osteoarthritis Of Hip Osteoarthritis Of Hip GWAS
Astrocytoma Astrocytoma GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37723874
Carcinoma Hepatocellular Associate 28349829, 33760147, 36517508, 36680650
Cardiomyopathy Dilated Associate 37058558
Colorectal Neoplasms Associate 24976283, 30649550, 34870557, 36147462
Corneal Endothelial Cell Loss Associate 33456372
Death Associate 25628125
Developmental Disabilities Associate 33509776
Endometrial Neoplasms Associate 28071680
Eye Diseases Associate 30903741
Glioblastoma Associate 30275445