TRB (T cell receptor beta locus)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 6957
Gene name T cell receptor beta locus
Gene symbol TRB
Synonyms (NCBI Gene)
TCRBTRB@
Chromosome 7
Chromosome location 7q34
Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
ETS1 Repression 1409722
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0002355 Process Detection of tumor cell IDA 31959982
GO:0002376 Process Immune system process IEA
GO:0002419 Process T cell mediated cytotoxicity directed against tumor cell target IDA 31959982
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC 12155 N/A
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0DSE2
Protein name M1-specific T cell receptor beta chain (TR beta chain TRBV19*01J2S7*01C*02)
Protein function The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a publ
PDB 1OGA , 2VLJ , 2VLK , 2VLR , 5HHM , 5HHO , 6JXR , 7FJD , 7FJE , 7FJF
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in M/matrix protein 1-specific effector memory CD8-positive T cells readily detectable in the peripheral blood, secondary lymphoid organs and lung (primary site of infection) of IAV infected individuals. {ECO:0000269|PubMed:2
Sequence 
MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQ
GLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSIRSSYEQ
YFGPGTRLTVTEDLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNG
KEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEW
TQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLM
AMVKRKDSRG
Sequence length 310
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0DTU4
Protein name T cell receptor beta chain MC.7.G5 (TR beta chain TRBV25-1*01J2S3*01C2*01) (MC.7.G5 TRB)
Protein function The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-
PDB 8T4Z , 8TW4 , 8Y6X , 8YIV , 8YJ2 , 8YJ3 , 9C3E
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in MR1-restricted CD8-positive T cells. {ECO:0000269|PubMed:31959982}.
Sequence 
MTIRLLCYMGFYFLGAGLMEADIYQTPRYLVIGTGKKITLECSQTMGHDKMYWYQQDPGM
ELHLIHYSYGVNSTEKGDLSSESTVSRIRTEHFPLTLESARPSHTSQYLCASSEARGLAE
FTDTQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELS
WWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLS
ENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVS
ALVLMAMVKRKDSRG
Sequence length 315
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (3)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
KERATOCONUS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PANCREATIC TRYPSINOGEN DEFICIENCY — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VITAMIN D-DEPENDENT RICKETS, TYPE 2A — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (121)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Coronary Syndrome Associate 32460698
★★★★★
★☆☆☆☆
Found in Text Mining only
Antiphospholipid Syndrome Associate 11895785
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Associate 17404318
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Psoriatic Associate 28835222, 31677365
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 10460187, 1352153, 1386608, 9741318
★★★★★
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Associate 2529926
★★★★★
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Associate 37604642, 7717407
★★★★★
★☆☆☆☆
Found in Text Mining only
Autoimmune Lymphoproliferative Syndrome Associate 19176318
★★★★★
★☆☆☆☆
Found in Text Mining only
Axial Spondyloarthritis Associate 30029674
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 16282247, 23292282, 27452728, 34534367
★★★★★
★☆☆☆☆
Found in Text Mining only