Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6950
Gene name Gene Name - the full gene name approved by the HGNC.	T-complex 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TCP1
Synonyms (NCBI Gene) Gene synonyms aliases	CCT-alpha, CCT1, CCTa, D6S230E, IDDPMGS, TCP-1-alpha
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different p

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051234	hsa-miR-16-5p	CLASH	23622248
MIRT050683	hsa-miR-18a-5p	CLASH	23622248
MIRT050084	hsa-miR-26a-5p	CLASH	23622248
MIRT048447	hsa-miR-100-5p	CLASH	23622248
MIRT046434	hsa-miR-15b-5p	CLASH	23622248
MIRT046287	hsa-miR-23b-3p	CLASH	23622248
MIRT045307	hsa-miR-186-5p	CLASH	23622248
MIRT044438	hsa-miR-320a	CLASH	23622248
MIRT043872	hsa-miR-378a-3p	CLASH	23622248
MIRT043731	hsa-miR-342-3p	CLASH	23622248
MIRT043392	hsa-miR-331-3p	CLASH	23622248
MIRT039658	hsa-miR-615-3p	CLASH	23622248
MIRT039658	hsa-miR-615-3p	CLASH	23622248
MIRT039480	hsa-miR-652-3p	CLASH	23622248
MIRT732981	hsa-miR-34a-3p	Immunohistochemistry (IHC), Western blotting	33500737
MIRT1416722	hsa-miR-200b	CLIP-seq
MIRT1416723	hsa-miR-200c	CLIP-seq
MIRT1416724	hsa-miR-2054	CLIP-seq
MIRT1416725	hsa-miR-3143	CLIP-seq
MIRT1416726	hsa-miR-33a	CLIP-seq
MIRT1416727	hsa-miR-33b	CLIP-seq
MIRT1416728	hsa-miR-429	CLIP-seq
MIRT1416729	hsa-miR-4761-5p	CLIP-seq
MIRT1416730	hsa-miR-543	CLIP-seq
MIRT1416731	hsa-miR-888	CLIP-seq
MIRT1416722	hsa-miR-200b	CLIP-seq
MIRT1416723	hsa-miR-200c	CLIP-seq
MIRT1416724	hsa-miR-2054	CLIP-seq
MIRT1416725	hsa-miR-3143	CLIP-seq
MIRT1416726	hsa-miR-33a	CLIP-seq
MIRT1416727	hsa-miR-33b	CLIP-seq
MIRT2124963	hsa-miR-340	CLIP-seq
MIRT1416728	hsa-miR-429	CLIP-seq
MIRT1416729	hsa-miR-4761-5p	CLIP-seq
MIRT1416730	hsa-miR-543	CLIP-seq
MIRT1416731	hsa-miR-888	CLIP-seq
MIRT2347440	hsa-miR-3973	CLIP-seq
MIRT2347441	hsa-miR-4257	CLIP-seq
MIRT2347442	hsa-miR-4501	CLIP-seq
MIRT2347443	hsa-miR-4751	CLIP-seq
MIRT2347444	hsa-miR-548k	CLIP-seq

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000242	Component	Pericentriolar material	IEA
GO:0000792	Component	Heterochromatin	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0002199	Component	Zona pellucida receptor complex	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	14532270, 16085932, 16097032, 21098288, 24846140, 25416956, 25467444, 29477555, 30021884, 31470122, 32814053, 33144677, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IDA	20080638
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	1630491
GO:0005832	Component	Chaperonin-containing T-complex	IBA
GO:0005832	Component	Chaperonin-containing T-complex	IDA	23011926, 25467444, 30955883
GO:0005832	Component	Chaperonin-containing T-complex	IEA
GO:0005832	Component	Chaperonin-containing T-complex	IPI	22133715
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	21525035
GO:0005874	Component	Microtubule	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	22133715, 30955883
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	IMP	25467444
GO:0006457	Process	Protein folding	TAS	1630491
GO:0007021	Process	Tubulin complex assembly	NAS	11532003
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	21753002
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IEA
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	25467444
GO:0044183	Function	Protein folding chaperone	IDA	25467444, 30955883
GO:0044183	Function	Protein folding chaperone	IEA
GO:0044297	Component	Cell body	IEA
GO:0050821	Process	Protein stabilization	IEA
GO:0050821	Process	Protein stabilization	IMP	25467444
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051082	Function	Unfolded protein binding	TAS	1630491
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0090666	Process	ScaRNA localization to Cajal body	IMP	25467444
GO:0140535	Component	Intracellular protein-containing complex	IEA
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA
GO:1904851	Process	Positive regulation of establishment of protein localization to telomere	IMP	25467444
GO:1904871	Process	Positive regulation of protein localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	IMP	25467444

MIM	HGNC	e!Ensembl
186980	11655	ENSG00000120438

Protein

UniProt ID

P17987

Protein name

T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)

Protein function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TR

PDB

6NR8 , 6NR9 , 6NRA , 6NRB , 6NRC , 6NRD , 6QB8 , 7LUM , 7LUP , 7NVL , 7NVM , 7NVN , 7NVO , 7TRG , 7TTN , 7TTT , 7TUB , 7WU7 , 7WZ3 , 7X0A , 7X0S , 7X0V , 7X3J , 7X3U , 7X6Q , 7X7Y , 8HKI , 8I1U , 8I9U , 8IB8 , 8SFE , 8SFF , 8SG8 , 8SG9 , 8SGC , 8SGL , 8SGQ , 8SH9 , 8SHA , 8SHD , 8SHE , 8SHF , 8SHG , 8SHL , 8SHN , 8SHO , 8SHP , 8SHQ , 8SHT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00118	Cpn60_TCP1	28 → 535	TCP-1/cpn60 chaperonin family	Family

Sequence

MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGAT
ILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISG
YRLACKEAVRYINENLIVNTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAIK
YTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFS
LQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYF
VEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDE
LILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALS
IYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPER
KNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDD
KHGSYEDAVHSGALND

Sequence length

556

Interactions

View interactions

	Reactome
			Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

TCP1 (t-complex 1)