TCEA2 (transcription elongation factor A2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6919
Gene name Gene Name - the full gene name approved by the HGNC.
Transcription elongation factor A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TCEA2
Synonyms (NCBI Gene) Gene synonyms aliases
TFIIS
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT051001 hsa-miR-17-5p CLASH 23622248
MIRT050731 hsa-miR-18a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 16169070, 16189514, 21516116, 25416956, 31515488, 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
604784 11614 ENSG00000171703
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q15560
Protein name Transcription elongation factor A protein 2 (Testis-specific S-II) (Transcription elongation factor S-II protein 2) (Transcription elongation factor TFIIS.l)
Protein function Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in l
PDB 2LW4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08711 Med26 29 → 80 TFIIS helical bundle-like domain Domain
PF07500 TFIIS_M 136 → 246 Transcription factor S-II (TFIIS), central domain Domain
PF01096 TFIIS_C 259 → 297 Transcription factor S-II (TFIIS) Domain
Tissue specificity TISSUE SPECIFICITY: Testis and ovary specific. {ECO:0000269|PubMed:8566795}.
Sequence
Sequence length 299
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anxiety Disorder Anxiety N/A N/A GWAS
Diabetes Type 2 diabetes (adjusted for BMI) N/A N/A GWAS
Show/Hide Text Mining Associations (3)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 23680185
Hereditary Breast and Ovarian Cancer Syndrome Associate 25184681
Renal Insufficiency Chronic Associate 39333727