TCEA2 (transcription elongation factor A2)

Gene

• Entrez ID: 6919
• Gene name: Transcription elongation factor A2
• Gene symbol: TCEA2
• Synonyms (NCBI Gene): TFIIS
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051001	hsa-miR-17-5p	CLASH	23622248
MIRT050731	hsa-miR-18a-5p	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 21516116, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005813	Component	Centrosome	IDA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006354	Process	DNA-templated transcription elongation	NAS	8566795
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006368	Process	Transcription elongation by RNA polymerase II	IEA
GO:0008023	Component	Transcription elongation factor complex	NAS	8566795
GO:0008270	Function	Zinc ion binding	IEA
GO:0032784	Process	Regulation of DNA-templated transcription elongation	NAS	8566795
GO:0036064	Component	Ciliary basal body	IDA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604784
• HGNC: 11614
• e!Ensembl: ENSG00000171703

Protein

• UniProt ID: Q15560
• Protein name: Transcription elongation factor A protein 2 (Testis-specific S-II) (Transcription elongation factor S-II protein 2) (Transcription elongation factor TFIIS.l)
• Protein function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in l
• PDB: 2LW4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08711	Med26	29 → 80	TFIIS helical bundle-like domain	Domain
  PF07500	TFIIS_M	136 → 246	Transcription factor S-II (TFIIS), central domain	Domain
  PF01096	TFIIS_C	259 → 297	Transcription factor S-II (TFIIS)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis and ovary specific. {ECO:0000269|PubMed:8566795}.
• Sequence:

  MMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQS
  SDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAP
  STPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGN
  TDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTK
  EAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC

• Sequence length: 299