Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6876
Gene name Gene Name - the full gene name approved by the HGNC.
Transgelin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAGLN
Synonyms (NCBI Gene) Gene synonyms aliases
SM22, SM22-alpha, SMCC, TAGLN1, TGLN, WS3-10
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The enc
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021406 hsa-miR-9-5p Microarray 17612493
MIRT022018 hsa-miR-128-3p Microarray 17612493
MIRT023899 hsa-miR-1-3p Other 20458751
MIRT025891 hsa-miR-7-5p Microarray 17612493
MIRT030313 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Transcription factor Regulation Reference
KLF4 Unknown 19486889
MKL1 Activation 14970199
SRF Activation 14970199
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21044950, 22245152, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0007517 Process Muscle organ development TAS 9615232
GO:0030855 Process Epithelial cell differentiation IDA 21492153
GO:0051015 Function Actin filament binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600818 11553 ENSG00000149591
Protein
UniProt ID Q01995
Protein name Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)
Protein function Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 24 139 Calponin homology (CH) domain Domain
PF00402 Calponin 175 199 Calponin family repeat Repeat
Sequence
Sequence length 201
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059430
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 15059925
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 21063030 ClinVar
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Metabolic Syndrome Metabolic Syndrome GWAS
Hypothyroidism Hypothyroidism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 19848416
Adenoma Stimulate 37365287
Airway Remodeling Associate 24828686
Aortic Dissection Inhibit 27320219, 33910387
Atrial Fibrillation Associate 34794617, 37967346
Bipolar Disorder Associate 28117838
Breast Neoplasms Inhibit 23936147
Breast Neoplasms Associate 25841305, 28058861, 29059430
Breast Neoplasms Stimulate 37834385
Bronchopulmonary Dysplasia Associate 24828686, 30001393