Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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6876
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Transgelin |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TAGLN |
Synonyms (NCBI Gene)
Gene synonyms aliases
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SM22, SM22-alpha, SMCC, TAGLN1, TGLN, WS3-10 |
Chromosome
Chromosome number
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11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q23.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The enc |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Breast carcinoma |
Breast Carcinoma |
rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038 View all (71 more) |
29059430 |
Colonic neoplasms |
Malignant tumor of colon, Colonic Neoplasms |
rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 |
15059925 |
Esophagus neoplasm |
Squamous cell carcinoma of esophagus |
rs28934578, rs121918714, rs1567556006, rs1575166666 |
21517111 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Endometriosis |
Endometriosis |
|
21063030 |
ClinVar |
Breast Cancer |
Breast Cancer |
Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients |
|
GWAS, CBGDA |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Hypothyroidism |
Hypothyroidism |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
19848416 |
Adenoma |
Stimulate
|
37365287 |
Airway Remodeling |
Associate
|
24828686 |
Aortic Dissection |
Inhibit
|
27320219, 33910387 |
Atrial Fibrillation |
Associate
|
34794617, 37967346 |
Bipolar Disorder |
Associate
|
28117838 |
Breast Neoplasms |
Inhibit
|
23936147 |
Breast Neoplasms |
Associate
|
25841305, 28058861, 29059430 |
Breast Neoplasms |
Stimulate
|
37834385 |
Bronchopulmonary Dysplasia |
Associate
|
24828686, 30001393 |
Carcinogenesis |
Associate
|
26344167 |
Carcinoma Hepatocellular |
Associate
|
34001947 |
Carcinoma Non Small Cell Lung |
Stimulate
|
22245152 |
Cardiovascular Diseases |
Associate
|
34902367 |
Chronic Periodontitis |
Associate
|
30922293 |
Colonic Polyps |
Associate
|
37365287 |
Colorectal Neoplasms |
Inhibit
|
19329940, 32353950 |
Colorectal Neoplasms |
Associate
|
19724680, 23138394, 23372686, 27270312, 33096021 |
COVID 19 |
Stimulate
|
39676863 |
Death |
Stimulate
|
39676863 |
Diabetes Gestational |
Stimulate
|
29949406 |
Diabetes Gestational |
Associate
|
35768543 |
Diabetic Nephropathies |
Associate
|
36949528 |
Diaphyseal medullary stenosis with malignant fibrous histiocytoma |
Associate
|
12401825 |
Endometrial Neoplasms |
Associate
|
20236630 |
Endometrial Stromal Tumors |
Associate
|
25991737 |
Erectile Dysfunction |
Associate
|
38111702 |
Esophageal Neoplasms |
Associate
|
26344167 |
Esophageal Squamous Cell Carcinoma |
Associate
|
15986332, 21517111, 26344167 |
Esophageal Squamous Cell Carcinoma |
Stimulate
|
29020885 |
Esophageal Squamous Cell Carcinoma |
Inhibit
|
37203411 |
Fibrosis |
Associate
|
33245228, 36725885 |
Frailty |
Stimulate
|
37697678 |
Gallbladder Neoplasms |
Associate
|
24657443 |
Gallstones |
Stimulate
|
25671835 |
Hamman Rich Syndrome |
Associate
|
35527237 |
Heart Defects Congenital |
Associate
|
30338626 |
Hereditary Breast and Ovarian Cancer Syndrome |
Associate
|
29059430 |
Hypoxia |
Associate
|
15026807 |
Hypoxia |
Stimulate
|
22245152 |
Hypoxia Brain |
Associate
|
22245152 |
Hypoxia Brain |
Inhibit
|
32098916 |
Idiopathic Noncirrhotic Portal Hypertension |
Stimulate
|
19177598 |
Impotence Vasculogenic |
Stimulate
|
29949406 |
Leiomyosarcoma |
Associate
|
23178314, 25991737 |
Liver Failure |
Associate
|
19177598 |
Lung Diseases |
Associate
|
39676863 |
Lupus Erythematosus Systemic |
Inhibit
|
27402083 |
Lymphatic Metastasis |
Associate
|
19724680, 26344167 |
Lymphoma Non Hodgkin |
Associate
|
25991737 |
Mouth Neoplasms |
Associate
|
39308508 |
Necrosis |
Associate
|
38013282 |
Neoplasm Invasiveness |
Associate
|
19848416 |
Neoplasms |
Associate
|
15986332, 19848416, 22245152, 22257561, 24264315, 28058861, 30918060, 37203411, 38013282 |
Neoplasms |
Inhibit
|
19329940, 22506042, 23936147, 24657443, 25841305, 26242444, 33771884, 37365287 |
Neurofibromatosis 1 |
Stimulate
|
25109740 |
Neurofibrosarcoma |
Associate
|
25109740 |
Osteosarcoma |
Associate
|
12401825, 35665757 |
Ovarian Neoplasms |
Associate
|
31315664, 36222710 |
Pelvic Organ Prolapse |
Inhibit
|
26612295 |
Poikiloderma with Neutropenia |
Associate
|
25109740 |
Prostatic Hyperplasia |
Associate
|
37781794 |
Prostatic Neoplasms |
Associate
|
24264315, 28510269, 37781794 |
Prostatic Neoplasms |
Inhibit
|
33771884 |
Pulmonary Arterial Hypertension |
Associate
|
30338626, 32813135 |
Pulmonary Disease Chronic Obstructive |
Associate
|
36411774 |
Rectal Neoplasms |
Associate
|
26861291 |
Retinal Vein Occlusion |
Associate
|
35808901 |
Rhabdoid Tumor |
Associate
|
14662021 |
Sarcoma Endometrial Stromal |
Associate
|
25991737 |
Severe Acute Respiratory Syndrome |
Associate
|
36834879 |
Squamous Cell Carcinoma of Head and Neck |
Stimulate
|
26242444 |
Status Asthmaticus |
Stimulate
|
33245228 |
Stomach Neoplasms |
Associate
|
12923326, 32410620 |
Triple Negative Breast Neoplasms |
Associate
|
25841305, 34326372 |
Ureteral Obstruction |
Associate
|
38013282 |
Urinary Bladder Neoplasms |
Associate
|
21483740, 21672358, 30633156 |
Urinary Incontinence Stress |
Associate
|
22136672 |
Werner Syndrome |
Associate
|
1712899, 8134370 |
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