BST1 (bone marrow stromal cell antigen 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
683
Gene name Gene Name - the full gene name approved by the HGNC.
Bone marrow stromal cell antigen 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BST1
Synonyms (NCBI Gene) Gene synonyms aliases
CD157, cADPR2
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p15.32
Summary Summary of gene provided in NCBI Entrez Gene.
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone mar
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT738077 hsa-miR-2276 HITS-CLIP 33718276
MIRT738081 hsa-miR-579 HITS-CLIP 33718276
MIRT826169 hsa-miR-203 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
NFKB1 Unknown 9030974
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
GO ID Ontology Definition Evidence Reference
GO:0001931 Component Uropod IDA 15328157
GO:0001952 Process Regulation of cell-matrix adhesion IDA 15328157
GO:0002691 Process Regulation of cellular extravasation TAS 23576305
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600387 1118 ENSG00000109743
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q10588
Protein name ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157)
Protein function Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracell
PDB 1ISF , 1ISG , 1ISH , 1ISI , 1ISJ , 1ISM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02267 Rib_hydrolayse 40 → 280 ADP-ribosyl cyclase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in various tissues including placenta, lung, liver and kidney. {ECO:0000269|PubMed:8202488}.
Sequence
Sequence length 318
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Nicotinate and nicotinamide metabolism
Metabolic pathways
Salivary secretion
Pancreatic secretion 		  Post-translational modification: synthesis of GPI-anchored proteins
Nicotinate metabolism
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Parkinson Disease Parkinson's disease N/A N/A GWAS
Parkinson disease Age of onset of parkinson disease N/A N/A GWAS
Show/Hide Text Mining Associations (29)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 9691097
Asthma Associate 24634087
Attention Deficit Disorder with Hyperactivity Associate 33155823
Autistic Disorder Associate 24634087
Calcinosis Cutis Associate 22916288
Carcinoma Ovarian Epithelial Associate 20639476, 22916288
Cerebral Infarction Associate 25135788
Cognition Disorders Associate 30656857
Drug Related Side Effects and Adverse Reactions Associate 34707185
Gait Ataxia Associate 30676692