Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6780
Gene name Gene Name - the full gene name approved by the HGNC.
Staufen double-stranded RNA binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STAU1
Synonyms (NCBI Gene) Gene synonyms aliases
PPP1R150, STAU
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021842 hsa-miR-132-3p Microarray 17612493
MIRT028692 hsa-miR-27a-3p Sequencing 20371350
MIRT031669 hsa-miR-16-5p Proteomics 18668040
MIRT044157 hsa-miR-30e-5p CLASH 23622248
MIRT037250 hsa-miR-877-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000512 Process LncRNA-mediated post-transcriptional gene silencing TAS 31048766
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IEA
GO:0003725 Function Double-stranded RNA binding IBA
GO:0003725 Function Double-stranded RNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601716 11370 ENSG00000124214
Protein
UniProt ID O95793
Protein name Double-stranded RNA-binding protein Staufen homolog 1
Protein function Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.;
PDB 4DKK , 6HTU , 6SDW , 6SDY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00035 dsrm 76 160 Double-stranded RNA binding motif Domain
PF00035 dsrm 185 249 Double-stranded RNA binding motif Domain
PF00035 dsrm 287 352 Double-stranded RNA binding motif Domain
PF16482 Staufen_C 446 557 Staufen C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
Sequence
MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPSENAGRPIQNSALPSAS
ITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPF
PVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRIL
QNEPLPERLEVNGRESEEEN
LNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKN
AAIAVLEEL
KKLPPLPAVERVKPRIKKKTKPIVKPQTSPEYGQGINPISRLAQIQQAKKE
KEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTGTNKKVAKRNAAENMLEIL
GFKVPQAQ
PTKPALKSEEKTPIKKPGDGRKVTFFEPGSGDENGTSNKEDEFRMPYLSHQQLPAGILPM
VPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNISSGH
VPHGPLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVES
CHDMAALNILKLLSELD
QQSTEMPRTGNGPMSVCGRC
Sequence length 577
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Hypertension Hypertension (confirmatory factor analysis Factor 12) N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Agnosia Associate 37672513
Carcinogenesis Associate 37847286
Colorectal Neoplasms Associate 28004750, 37749132
Leukemia Myeloid Acute Associate 33762305
Mitochondrial Diseases Associate 37847286
Myelodysplastic Syndromes Associate 33762305
Neoplasm Metastasis Associate 34163032
Neoplasms Associate 34163032, 35806349, 37847286
Pulmonary Disease Chronic Obstructive Associate 35350787
Rhabdomyosarcoma Embryonal Associate 37847286