Gene Gene information from NCBI Gene database.
Entrez ID 6780
Gene name Staufen double-stranded RNA binding protein 1
Gene symbol STAU1
Synonyms (NCBI Gene)
PPP1R150STAU
Chromosome 20
Chromosome location 20q13.13
Summary Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple
miRNA miRNA information provided by mirtarbase database.
389
miRTarBase ID miRNA Experiments Reference
MIRT021842 hsa-miR-132-3p Microarray 17612493
MIRT028692 hsa-miR-27a-3p Sequencing 20371350
MIRT031669 hsa-miR-16-5p Proteomics 18668040
MIRT044157 hsa-miR-30e-5p CLASH 23622248
MIRT037250 hsa-miR-877-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0000512 Process LncRNA-mediated post-transcriptional gene silencing TAS 31048766
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IEA
GO:0003725 Function Double-stranded RNA binding IBA
GO:0003725 Function Double-stranded RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601716 11370 ENSG00000124214
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95793
Protein name Double-stranded RNA-binding protein Staufen homolog 1
Protein function Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.;
PDB 4DKK , 6HTU , 6SDW , 6SDY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00035 dsrm 76 160 Double-stranded RNA binding motif Domain
PF00035 dsrm 185 249 Double-stranded RNA binding motif Domain
PF00035 dsrm 287 352 Double-stranded RNA binding motif Domain
PF16482 Staufen_C 446 557 Staufen C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
Sequence
MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPSENAGRPIQNSALPSAS
ITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPF
PVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRIL
QNEPLPERLEVNGRESEEEN
LNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKN
AAIAVLEEL
KKLPPLPAVERVKPRIKKKTKPIVKPQTSPEYGQGINPISRLAQIQQAKKE
KEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTGTNKKVAKRNAAENMLEIL
GFKVPQAQ
PTKPALKSEEKTPIKKPGDGRKVTFFEPGSGDENGTSNKEDEFRMPYLSHQQLPAGILPM
VPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNISSGH
VPHGPLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVES
CHDMAALNILKLLSELD
QQSTEMPRTGNGPMSVCGRC
Sequence length 577
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Agnosia Associate 37672513
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 37847286
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 28004750, 37749132
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Associate 33762305
★☆☆☆☆
Found in Text Mining only
Mitochondrial Diseases Associate 37847286
★☆☆☆☆
Found in Text Mining only
Myelodysplastic Syndromes Associate 33762305
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 34163032
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 34163032, 35806349, 37847286
★☆☆☆☆
Found in Text Mining only
Pulmonary Disease Chronic Obstructive Associate 35350787
★☆☆☆☆
Found in Text Mining only
Rhabdomyosarcoma Embryonal Associate 37847286
★☆☆☆☆
Found in Text Mining only