Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
678
Gene name Gene Name - the full gene name approved by the HGNC.
ZFP36 ring finger protein like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZFP36L2
Synonyms (NCBI Gene) Gene synonyms aliases
BRF2, ERF-2, ERF2, OOMD13, OZEMA13, RNF162C, TIS11D
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016129 hsa-miR-421 Sequencing 20371350
MIRT019787 hsa-miR-375 Microarray 20215506
MIRT002907 hsa-miR-124-3p Microarray 18668037
MIRT050676 hsa-miR-18a-5p CLASH 23622248
MIRT047326 hsa-miR-181a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612053 1108 ENSG00000152518
Protein
UniProt ID P47974
Protein name mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)
Protein function Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (Pu
PDB 1RGO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04553 Tis11B_N 1 142 Tis11B like protein, N terminus Family
PF00642 zf-CCCH 154 180 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
PF00642 zf-CCCH 192 217 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
Tissue specificity TISSUE SPECIFICITY: Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in oocytes (PubMed:34611029). {ECO:0000269
Sequence
MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASN
LHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFR
DRSFSENGDRSQHLLHLQQQQK
GGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGF
HELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRD
ALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCS
SSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCAN
NAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQGLAPPAQPPAPPSATLPAG
AAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPG
RRLPIFSRLSISDD
Sequence length 494
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Cellular senescence  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Acute Myeloid Leukemia Acute myeloid leukemia ZFP36L2 is a myeloid leukemia dependency is a myeloid leukemia dependency 33450187 CBGDA
Inflammatory Bowel Disease Inflammatory bowel disease (MTAG) N/A N/A GWAS
Oocyte Maturation Defect oocyte maturation defect 13 N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 36405736
Bone Diseases Metabolic Associate 25565391
Carcinoma Pancreatic Ductal Associate 27862697
Colorectal Neoplasms Associate 33632712, 35343095
Hematologic Neoplasms Associate 34090970
Inflammation Associate 39256536
Job Syndrome Associate 39229272
Leukemia Associate 33450187
Leukemia Myelogenous Chronic BCR ABL Positive Associate 34090970
Leukemia Myeloid Associate 33798415