Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6760
Gene name Gene Name - the full gene name approved by the HGNC.
SS18 subunit of BAF chromatin remodeling complex
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SS18
Synonyms (NCBI Gene) Gene synonyms aliases
SMARCL1, SSXT, SYT
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q11.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021673 hsa-miR-140-3p Sequencing 20371350
MIRT024343 hsa-miR-215-5p Microarray 19074876
MIRT026660 hsa-miR-192-5p Microarray 19074876
MIRT046813 hsa-miR-222-3p CLASH 23622248
MIRT043346 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IEA
GO:0000785 Component Chromatin NAS 29374058
GO:0000902 Process Cell morphogenesis IEA
GO:0003713 Function Transcription coactivator activity IBA
GO:0003713 Function Transcription coactivator activity IDA 15919756
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600192 11340 ENSG00000141380
Protein
UniProt ID Q15532
Protein name Protein SSXT (Protein SYT) (Synovial sarcoma translocated to X chromosome protein)
Protein function Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF ch
PDB 7VRB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05030 SSXT 13 74 SSXT protein (N-terminal region) Family
Tissue specificity TISSUE SPECIFICITY: Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
Sequence
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVY
LATIADSNQNMQSL
LPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQ
NQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQ
GNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY
QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
Sequence length 418
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  ATP-dependent chromatin remodeling
Transcriptional misregulation in cancer
 
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Neuroticism Neuroticism N/A N/A GWAS
Rhegmatogenous retinal detachment Rhegmatogenous retinal detachment N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 33878706, 33982215, 35710690
Adenoma Associate 25267074
Adenosarcoma Associate 25267074
Calcinosis Cutis Associate 35639915
Carcinogenesis Associate 24130893
Carcinoma Associate 30206413, 33648512, 36456921
Head and Neck Neoplasms Stimulate 28249647
Liposarcoma Myxoid Associate 32557980
Lymphoma Non Hodgkin Associate 35521683
Myoepithelioma Associate 32557980