Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6753
Gene name Gene Name - the full gene name approved by the HGNC.	Somatostatin receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SSTR3
Synonyms (NCBI Gene) Gene synonyms aliases	SS-3-R, SS3-R, SS3R, SSR-28, SST3
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT714170	hsa-miR-3918	HITS-CLIP	19536157
MIRT714169	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT714168	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT495173	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT495171	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714167	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714166	hsa-miR-6749-5p	HITS-CLIP	19536157
MIRT714165	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT714164	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT714163	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT714162	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	22291592
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT495175	hsa-miR-5685	PAR-CLIP	22291592
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	22291592
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT495172	hsa-miR-3926	PAR-CLIP	22291592
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT495168	hsa-miR-328-5p	PAR-CLIP	22291592
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	22291592
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	23708386
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495175	hsa-miR-5685	PAR-CLIP	23708386
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	23708386
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	23708386
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	23708386
MIRT495172	hsa-miR-3926	PAR-CLIP	23708386
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	23708386
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	23708386
MIRT495168	hsa-miR-328-5p	PAR-CLIP	23708386
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	23708386
MIRT714170	hsa-miR-3918	HITS-CLIP	19536157
MIRT714169	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT714168	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT495173	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT495171	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714167	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714166	hsa-miR-6749-5p	HITS-CLIP	19536157
MIRT714165	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT714164	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT714163	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT714162	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT647420	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647418	hsa-miR-4761-3p	HITS-CLIP	23824327
MIRT647419	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT647417	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT647416	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647415	hsa-miR-4780	HITS-CLIP	23824327
MIRT647414	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647413	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647412	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647411	hsa-miR-4287	HITS-CLIP	23824327
MIRT647410	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647408	hsa-miR-4493	HITS-CLIP	23824327
MIRT647409	hsa-miR-711	HITS-CLIP	23824327
MIRT647407	hsa-miR-623	HITS-CLIP	23824327
MIRT647406	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT647405	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT647403	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT647404	hsa-miR-4776-5p	HITS-CLIP	23824327
MIRT647402	hsa-miR-4535	HITS-CLIP	23824327
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	22291592
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT495175	hsa-miR-5685	PAR-CLIP	22291592
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	22291592
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT495172	hsa-miR-3926	PAR-CLIP	22291592
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT495168	hsa-miR-328-5p	PAR-CLIP	22291592
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	22291592
MIRT495177	hsa-miR-6854-5p	PAR-CLIP	23708386
MIRT495176	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495175	hsa-miR-5685	PAR-CLIP	23708386
MIRT495174	hsa-miR-6798-5p	PAR-CLIP	23708386
MIRT495173	hsa-miR-1915-3p	PAR-CLIP	23708386
MIRT495171	hsa-miR-6764-5p	PAR-CLIP	23708386
MIRT495172	hsa-miR-3926	PAR-CLIP	23708386
MIRT495170	hsa-miR-6762-5p	PAR-CLIP	23708386
MIRT495169	hsa-miR-6845-5p	PAR-CLIP	23708386
MIRT495168	hsa-miR-328-5p	PAR-CLIP	23708386
MIRT495167	hsa-miR-6885-5p	PAR-CLIP	23708386
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq
MIRT2339883	hsa-miR-3120-3p	CLIP-seq
MIRT1392869	hsa-miR-3152-5p	CLIP-seq
MIRT1392870	hsa-miR-3157-5p	CLIP-seq
MIRT2339884	hsa-miR-377	CLIP-seq
MIRT2339885	hsa-miR-3974	CLIP-seq
MIRT2339886	hsa-miR-451b	CLIP-seq
MIRT1392871	hsa-miR-4691-3p	CLIP-seq
MIRT2339887	hsa-miR-4714-3p	CLIP-seq
MIRT1392872	hsa-miR-4763-5p	CLIP-seq
MIRT1392873	hsa-miR-4774-3p	CLIP-seq
MIRT1392874	hsa-miR-767-3p	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004994	Function	Somatostatin receptor activity	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	19071123, 22651821, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005929	Component	Cilium	IDA	28154160
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8405411
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	1337145
GO:0007283	Process	Spermatogenesis	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	8961277
GO:0008628	Process	Hormone-mediated apoptotic signaling pathway	TAS	8961277
GO:0021549	Process	Cerebellum development	IEA
GO:0030900	Process	Forebrain development	IEA
GO:0038170	Process	Somatostatin signaling pathway	IEA
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042594	Process	Response to starvation	IEA
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0060170	Component	Ciliary membrane	TAS
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IEA
GO:0071392	Process	Cellular response to estradiol stimulus	IEA
GO:0097730	Component	Non-motile cilium	ISS

MIM	HGNC	e!Ensembl
182453	11332	ENSG00000278195

Protein

UniProt ID

P32745

Protein name

Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)

Protein function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

PDB

8XIQ , 8XIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	61 → 313	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Brain, pituitary and pancreas. {ECO:0000269|PubMed:1337145}.

Sequence

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLL
GNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVM
AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV
FSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV
WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA
LPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEE
SREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action		Peptide ligand-binding receptors G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431	17625444

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining
ACTH Secreting Pituitary Adenoma	Associate	25536318
Adenocarcinoma	Associate	20966542
Adenoma	Associate	25536318, 26607296
Carcinoid Tumor	Associate	11772967
Carcinoma Hepatocellular	Associate	15456543, 29282035
Carcinoma Merkel Cell	Associate	37540574
Colorectal Neoplasms	Associate	16610049
Endocrine Gland Neoplasms	Associate	16508627
Gallbladder Neoplasms	Associate	23991955
Glioma	Associate	34114970
Growth Hormone Deficiency With Pituitary Anomalies	Associate	26391562
Growth Hormone Secreting Pituitary Adenoma	Associate	24098585, 26607296
Hyperpituitarism	Associate	17420609
Meningioma	Associate	33899156
Neoplasm Metastasis	Associate	16508627
Neoplasms	Associate	11772967, 15456543, 17159301, 30529752, 31381461, 32429652, 33491286
Neoplasms	Stimulate	34601710
Neuroendocrine Tumors	Associate	20529830, 20682006, 22558472, 27101376, 27622342, 37033229
Neuroma Acoustic	Associate	14747443
Pancreatic Neoplasms	Associate	25890201
Pancreatitis	Associate	25890201
Pigmented Nodular Adrenocortical Disease Primary 1	Associate	24512486
Pituitary Neoplasms	Associate	24098585, 25536318
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	33297556
Prostatic Intraepithelial Neoplasia	Associate	20646346, 20966542
Prostatic Neoplasms	Associate	20646346, 21151154, 32665998
Retinitis Pigmentosa	Associate	20646346
Rhabdomyosarcoma	Associate	33297556
Spherocytosis Hereditary	Associate	33297556
Stomach Neoplasms	Inhibit	15197339, 15326367
Thyroid Neoplasms	Associate	10768564
Thyroiditis	Associate	23672766
Uveal melanoma	Associate	29949880

SSTR3 (somatostatin receptor 3)