Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6733
Gene name Gene Name - the full gene name approved by the HGNC.	SRSF protein kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SRPK2
Synonyms (NCBI Gene) Gene synonyms aliases	SFRSK2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.3

Show/Hide all(320)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020912	hsa-miR-155-5p	Proteomics	18668040
MIRT025155	hsa-miR-181a-5p	Microarray	17612493
MIRT030965	hsa-miR-21-5p	Microarray	18591254
MIRT653145	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT653144	hsa-miR-4282	HITS-CLIP	23824327
MIRT653143	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT653142	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT653141	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT653140	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT653139	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT653138	hsa-miR-7977	HITS-CLIP	23824327
MIRT653137	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT653145	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT653144	hsa-miR-4282	HITS-CLIP	23824327
MIRT653143	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT653142	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT653141	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT653140	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT653139	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT653138	hsa-miR-7977	HITS-CLIP	23824327
MIRT653137	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT1389461	hsa-miR-101	CLIP-seq
MIRT1389462	hsa-miR-1261	CLIP-seq
MIRT1389463	hsa-miR-1278	CLIP-seq
MIRT1389464	hsa-miR-128	CLIP-seq
MIRT1389465	hsa-miR-1283	CLIP-seq
MIRT1389466	hsa-miR-1292	CLIP-seq
MIRT1389467	hsa-miR-1298	CLIP-seq
MIRT1389468	hsa-miR-148a	CLIP-seq
MIRT1389469	hsa-miR-148b	CLIP-seq
MIRT1389470	hsa-miR-152	CLIP-seq
MIRT1389471	hsa-miR-181a	CLIP-seq
MIRT1389472	hsa-miR-181b	CLIP-seq
MIRT1389473	hsa-miR-181c	CLIP-seq
MIRT1389474	hsa-miR-181d	CLIP-seq
MIRT1389475	hsa-miR-2053	CLIP-seq
MIRT1389476	hsa-miR-221	CLIP-seq
MIRT1389477	hsa-miR-222	CLIP-seq
MIRT1389478	hsa-miR-27a	CLIP-seq
MIRT1389479	hsa-miR-27b	CLIP-seq
MIRT1389480	hsa-miR-3121-3p	CLIP-seq
MIRT1389481	hsa-miR-3144-3p	CLIP-seq
MIRT1389482	hsa-miR-3153	CLIP-seq
MIRT1389483	hsa-miR-3189-3p	CLIP-seq
MIRT1389484	hsa-miR-330-3p	CLIP-seq
MIRT1389485	hsa-miR-3613-3p	CLIP-seq
MIRT1389486	hsa-miR-3617	CLIP-seq
MIRT1389487	hsa-miR-3692	CLIP-seq
MIRT1389488	hsa-miR-3975	CLIP-seq
MIRT1389489	hsa-miR-4262	CLIP-seq
MIRT1389490	hsa-miR-432	CLIP-seq
MIRT1389491	hsa-miR-4471	CLIP-seq
MIRT1389492	hsa-miR-4646-5p	CLIP-seq
MIRT1389493	hsa-miR-4659a-3p	CLIP-seq
MIRT1389494	hsa-miR-4659b-3p	CLIP-seq
MIRT1389495	hsa-miR-4698	CLIP-seq
MIRT1389496	hsa-miR-4709-5p	CLIP-seq
MIRT1389497	hsa-miR-4722-3p	CLIP-seq
MIRT1389498	hsa-miR-4777-3p	CLIP-seq
MIRT1389499	hsa-miR-4799-5p	CLIP-seq
MIRT1389500	hsa-miR-510	CLIP-seq
MIRT1389501	hsa-miR-512-5p	CLIP-seq
MIRT1389502	hsa-miR-515-5p	CLIP-seq
MIRT1389503	hsa-miR-520d-5p	CLIP-seq
MIRT1389504	hsa-miR-524-5p	CLIP-seq
MIRT1389505	hsa-miR-548ad	CLIP-seq
MIRT1389506	hsa-miR-548l	CLIP-seq
MIRT1389507	hsa-miR-548p	CLIP-seq
MIRT1389508	hsa-miR-569	CLIP-seq
MIRT1389509	hsa-miR-583	CLIP-seq
MIRT1389510	hsa-miR-617	CLIP-seq
MIRT1389511	hsa-miR-621	CLIP-seq
MIRT1389512	hsa-miR-641	CLIP-seq
MIRT1389513	hsa-miR-875-5p	CLIP-seq
MIRT1389464	hsa-miR-128	CLIP-seq
MIRT1389468	hsa-miR-148a	CLIP-seq
MIRT1389469	hsa-miR-148b	CLIP-seq
MIRT1389470	hsa-miR-152	CLIP-seq
MIRT1389471	hsa-miR-181a	CLIP-seq
MIRT1389472	hsa-miR-181b	CLIP-seq
MIRT1389473	hsa-miR-181c	CLIP-seq
MIRT1389474	hsa-miR-181d	CLIP-seq
MIRT1389514	hsa-miR-186	CLIP-seq
MIRT1389515	hsa-miR-2054	CLIP-seq
MIRT1389516	hsa-miR-208a	CLIP-seq
MIRT1389517	hsa-miR-208b	CLIP-seq
MIRT1389518	hsa-miR-2276	CLIP-seq
MIRT1389519	hsa-miR-2355-5p	CLIP-seq
MIRT1389520	hsa-miR-23a	CLIP-seq
MIRT1389521	hsa-miR-23b	CLIP-seq
MIRT1389522	hsa-miR-23c	CLIP-seq
MIRT1389478	hsa-miR-27a	CLIP-seq
MIRT1389479	hsa-miR-27b	CLIP-seq
MIRT1389523	hsa-miR-302f	CLIP-seq
MIRT1389524	hsa-miR-3133	CLIP-seq
MIRT1389481	hsa-miR-3144-3p	CLIP-seq
MIRT1389525	hsa-miR-3149	CLIP-seq
MIRT1389526	hsa-miR-3614-5p	CLIP-seq
MIRT1389486	hsa-miR-3617	CLIP-seq
MIRT1389527	hsa-miR-3658	CLIP-seq
MIRT1389528	hsa-miR-371-5p	CLIP-seq
MIRT1389488	hsa-miR-3975	CLIP-seq
MIRT1389489	hsa-miR-4262	CLIP-seq
MIRT1389529	hsa-miR-4267	CLIP-seq
MIRT1389530	hsa-miR-4693-3p	CLIP-seq
MIRT1389495	hsa-miR-4698	CLIP-seq
MIRT1389531	hsa-miR-4712-3p	CLIP-seq
MIRT1389532	hsa-miR-4774-3p	CLIP-seq
MIRT1389533	hsa-miR-4778-3p	CLIP-seq
MIRT1389534	hsa-miR-4786-3p	CLIP-seq
MIRT1389499	hsa-miR-4799-5p	CLIP-seq
MIRT1389535	hsa-miR-499-5p	CLIP-seq
MIRT1389536	hsa-miR-500a	CLIP-seq
MIRT1389537	hsa-miR-548k	CLIP-seq
MIRT1389538	hsa-miR-548n	CLIP-seq
MIRT1389507	hsa-miR-548p	CLIP-seq
MIRT1389539	hsa-miR-548t	CLIP-seq
MIRT1389540	hsa-miR-548u	CLIP-seq
MIRT1389541	hsa-miR-549	CLIP-seq
MIRT1389542	hsa-miR-584	CLIP-seq
MIRT1389512	hsa-miR-641	CLIP-seq
MIRT1389543	hsa-miR-656	CLIP-seq
MIRT1389513	hsa-miR-875-5p	CLIP-seq
MIRT2116719	hsa-miR-3688-3p	CLIP-seq
MIRT2116720	hsa-miR-3163	CLIP-seq
MIRT1389484	hsa-miR-330-3p	CLIP-seq
MIRT2116721	hsa-miR-3668	CLIP-seq
MIRT2116722	hsa-miR-374a	CLIP-seq
MIRT2116723	hsa-miR-374b	CLIP-seq
MIRT2116724	hsa-miR-3924	CLIP-seq
MIRT1389484	hsa-miR-330-3p	CLIP-seq
MIRT2116721	hsa-miR-3668	CLIP-seq
MIRT1389503	hsa-miR-520d-5p	CLIP-seq
MIRT1389504	hsa-miR-524-5p	CLIP-seq
MIRT2339116	hsa-miR-3613-5p	CLIP-seq
MIRT2116719	hsa-miR-3688-3p	CLIP-seq
MIRT2339117	hsa-miR-513b	CLIP-seq
MIRT2440801	hsa-miR-377	CLIP-seq
MIRT2440802	hsa-miR-4731-3p	CLIP-seq
MIRT2440803	hsa-miR-4801	CLIP-seq
MIRT2632791	hsa-miR-1	CLIP-seq
MIRT2632792	hsa-miR-1273d	CLIP-seq
MIRT1389464	hsa-miR-128	CLIP-seq
MIRT1389465	hsa-miR-1283	CLIP-seq
MIRT2632793	hsa-miR-1288	CLIP-seq
MIRT2632794	hsa-miR-1289	CLIP-seq
MIRT2632795	hsa-miR-1303	CLIP-seq
MIRT2632796	hsa-miR-1323	CLIP-seq
MIRT1389468	hsa-miR-148a	CLIP-seq
MIRT1389469	hsa-miR-148b	CLIP-seq
MIRT1389470	hsa-miR-152	CLIP-seq
MIRT1389471	hsa-miR-181a	CLIP-seq
MIRT1389472	hsa-miR-181b	CLIP-seq
MIRT1389473	hsa-miR-181c	CLIP-seq
MIRT1389474	hsa-miR-181d	CLIP-seq
MIRT2632797	hsa-miR-1912	CLIP-seq
MIRT2632798	hsa-miR-19a	CLIP-seq
MIRT2632799	hsa-miR-19b	CLIP-seq
MIRT2632800	hsa-miR-206	CLIP-seq
MIRT1389476	hsa-miR-221	CLIP-seq
MIRT1389477	hsa-miR-222	CLIP-seq
MIRT1389519	hsa-miR-2355-5p	CLIP-seq
MIRT1389520	hsa-miR-23a	CLIP-seq
MIRT1389521	hsa-miR-23b	CLIP-seq
MIRT1389522	hsa-miR-23c	CLIP-seq
MIRT1389478	hsa-miR-27a	CLIP-seq
MIRT1389479	hsa-miR-27b	CLIP-seq
MIRT1389523	hsa-miR-302f	CLIP-seq
MIRT1389481	hsa-miR-3144-3p	CLIP-seq
MIRT1389525	hsa-miR-3149	CLIP-seq
MIRT2632801	hsa-miR-3180-5p	CLIP-seq
MIRT1389483	hsa-miR-3189-3p	CLIP-seq
MIRT2632802	hsa-miR-3198	CLIP-seq
MIRT2632803	hsa-miR-3199	CLIP-seq
MIRT1389484	hsa-miR-330-3p	CLIP-seq
MIRT2632804	hsa-miR-3612	CLIP-seq
MIRT2632805	hsa-miR-3618	CLIP-seq
MIRT2632806	hsa-miR-3673	CLIP-seq
MIRT2116719	hsa-miR-3688-3p	CLIP-seq
MIRT2632807	hsa-miR-3690	CLIP-seq
MIRT2632808	hsa-miR-3713	CLIP-seq
MIRT2116722	hsa-miR-374a	CLIP-seq
MIRT2116723	hsa-miR-374b	CLIP-seq
MIRT2440801	hsa-miR-377	CLIP-seq
MIRT2632809	hsa-miR-3913-3p	CLIP-seq
MIRT1389488	hsa-miR-3975	CLIP-seq
MIRT2632810	hsa-miR-4254	CLIP-seq
MIRT1389489	hsa-miR-4262	CLIP-seq
MIRT2632811	hsa-miR-4294	CLIP-seq
MIRT2632812	hsa-miR-4309	CLIP-seq
MIRT1389490	hsa-miR-432	CLIP-seq
MIRT2632813	hsa-miR-4477b	CLIP-seq
MIRT2632814	hsa-miR-448	CLIP-seq
MIRT2632815	hsa-miR-4668-3p	CLIP-seq
MIRT2632816	hsa-miR-4695-5p	CLIP-seq
MIRT1389495	hsa-miR-4698	CLIP-seq
MIRT2632817	hsa-miR-4719	CLIP-seq
MIRT2440802	hsa-miR-4731-3p	CLIP-seq
MIRT1389532	hsa-miR-4774-3p	CLIP-seq
MIRT2632818	hsa-miR-4775	CLIP-seq
MIRT1389533	hsa-miR-4778-3p	CLIP-seq
MIRT1389499	hsa-miR-4799-5p	CLIP-seq
MIRT2440803	hsa-miR-4801	CLIP-seq
MIRT2632819	hsa-miR-489	CLIP-seq
MIRT2632820	hsa-miR-494	CLIP-seq
MIRT2632821	hsa-miR-507	CLIP-seq
MIRT2632822	hsa-miR-518a-5p	CLIP-seq
MIRT2632823	hsa-miR-520a-5p	CLIP-seq
MIRT1389503	hsa-miR-520d-5p	CLIP-seq
MIRT2632824	hsa-miR-522	CLIP-seq
MIRT1389504	hsa-miR-524-5p	CLIP-seq
MIRT2632825	hsa-miR-525-5p	CLIP-seq
MIRT2632826	hsa-miR-527	CLIP-seq
MIRT2632827	hsa-miR-539	CLIP-seq
MIRT2632828	hsa-miR-548a-3p	CLIP-seq
MIRT2632829	hsa-miR-548e	CLIP-seq
MIRT2632830	hsa-miR-548f	CLIP-seq
MIRT2632831	hsa-miR-548g	CLIP-seq
MIRT1389537	hsa-miR-548k	CLIP-seq
MIRT1389538	hsa-miR-548n	CLIP-seq
MIRT2632832	hsa-miR-548o	CLIP-seq
MIRT1389507	hsa-miR-548p	CLIP-seq
MIRT1389539	hsa-miR-548t	CLIP-seq
MIRT1389540	hsa-miR-548u	CLIP-seq
MIRT2632833	hsa-miR-557	CLIP-seq
MIRT2632834	hsa-miR-561	CLIP-seq
MIRT1389509	hsa-miR-583	CLIP-seq
MIRT1389542	hsa-miR-584	CLIP-seq
MIRT2632835	hsa-miR-590-3p	CLIP-seq
MIRT2632836	hsa-miR-606	CLIP-seq
MIRT2632837	hsa-miR-613	CLIP-seq
MIRT1389510	hsa-miR-617	CLIP-seq
MIRT2632838	hsa-miR-650	CLIP-seq
MIRT1389543	hsa-miR-656	CLIP-seq
MIRT1389513	hsa-miR-875-5p	CLIP-seq
MIRT2632839	hsa-miR-892a	CLIP-seq
MIRT2632791	hsa-miR-1	CLIP-seq
MIRT2632792	hsa-miR-1273d	CLIP-seq
MIRT1389464	hsa-miR-128	CLIP-seq
MIRT1389465	hsa-miR-1283	CLIP-seq
MIRT2632793	hsa-miR-1288	CLIP-seq
MIRT2632794	hsa-miR-1289	CLIP-seq
MIRT2632795	hsa-miR-1303	CLIP-seq
MIRT2632796	hsa-miR-1323	CLIP-seq
MIRT1389468	hsa-miR-148a	CLIP-seq
MIRT1389469	hsa-miR-148b	CLIP-seq
MIRT1389470	hsa-miR-152	CLIP-seq
MIRT1389471	hsa-miR-181a	CLIP-seq
MIRT1389472	hsa-miR-181b	CLIP-seq
MIRT1389473	hsa-miR-181c	CLIP-seq
MIRT1389474	hsa-miR-181d	CLIP-seq
MIRT2632797	hsa-miR-1912	CLIP-seq
MIRT2632798	hsa-miR-19a	CLIP-seq
MIRT2632799	hsa-miR-19b	CLIP-seq
MIRT2632800	hsa-miR-206	CLIP-seq
MIRT1389519	hsa-miR-2355-5p	CLIP-seq
MIRT1389520	hsa-miR-23a	CLIP-seq
MIRT1389521	hsa-miR-23b	CLIP-seq
MIRT1389522	hsa-miR-23c	CLIP-seq
MIRT1389478	hsa-miR-27a	CLIP-seq
MIRT1389479	hsa-miR-27b	CLIP-seq
MIRT1389523	hsa-miR-302f	CLIP-seq
MIRT1389481	hsa-miR-3144-3p	CLIP-seq
MIRT1389525	hsa-miR-3149	CLIP-seq
MIRT2632801	hsa-miR-3180-5p	CLIP-seq
MIRT1389483	hsa-miR-3189-3p	CLIP-seq
MIRT2632802	hsa-miR-3198	CLIP-seq
MIRT2632803	hsa-miR-3199	CLIP-seq
MIRT2632805	hsa-miR-3618	CLIP-seq
MIRT2632806	hsa-miR-3673	CLIP-seq
MIRT2116719	hsa-miR-3688-3p	CLIP-seq
MIRT2632807	hsa-miR-3690	CLIP-seq
MIRT2632808	hsa-miR-3713	CLIP-seq
MIRT2116722	hsa-miR-374a	CLIP-seq
MIRT2116723	hsa-miR-374b	CLIP-seq
MIRT2440801	hsa-miR-377	CLIP-seq
MIRT2632809	hsa-miR-3913-3p	CLIP-seq
MIRT1389488	hsa-miR-3975	CLIP-seq
MIRT2632810	hsa-miR-4254	CLIP-seq
MIRT1389489	hsa-miR-4262	CLIP-seq
MIRT2632811	hsa-miR-4294	CLIP-seq
MIRT2632812	hsa-miR-4309	CLIP-seq
MIRT1389490	hsa-miR-432	CLIP-seq
MIRT2632813	hsa-miR-4477b	CLIP-seq
MIRT2632814	hsa-miR-448	CLIP-seq
MIRT2632815	hsa-miR-4668-3p	CLIP-seq
MIRT1389495	hsa-miR-4698	CLIP-seq
MIRT2632817	hsa-miR-4719	CLIP-seq
MIRT2440802	hsa-miR-4731-3p	CLIP-seq
MIRT1389532	hsa-miR-4774-3p	CLIP-seq
MIRT2632818	hsa-miR-4775	CLIP-seq
MIRT1389533	hsa-miR-4778-3p	CLIP-seq
MIRT1389499	hsa-miR-4799-5p	CLIP-seq
MIRT2440803	hsa-miR-4801	CLIP-seq
MIRT2632819	hsa-miR-489	CLIP-seq
MIRT2632821	hsa-miR-507	CLIP-seq
MIRT2632823	hsa-miR-520a-5p	CLIP-seq
MIRT2632824	hsa-miR-522	CLIP-seq
MIRT2632825	hsa-miR-525-5p	CLIP-seq
MIRT2632828	hsa-miR-548a-3p	CLIP-seq
MIRT2632829	hsa-miR-548e	CLIP-seq
MIRT2632830	hsa-miR-548f	CLIP-seq
MIRT2632831	hsa-miR-548g	CLIP-seq
MIRT1389537	hsa-miR-548k	CLIP-seq
MIRT1389538	hsa-miR-548n	CLIP-seq
MIRT2632832	hsa-miR-548o	CLIP-seq
MIRT1389507	hsa-miR-548p	CLIP-seq
MIRT1389539	hsa-miR-548t	CLIP-seq
MIRT1389540	hsa-miR-548u	CLIP-seq
MIRT2632833	hsa-miR-557	CLIP-seq
MIRT2632834	hsa-miR-561	CLIP-seq
MIRT1389509	hsa-miR-583	CLIP-seq
MIRT1389542	hsa-miR-584	CLIP-seq
MIRT2632835	hsa-miR-590-3p	CLIP-seq
MIRT2632836	hsa-miR-606	CLIP-seq
MIRT2632837	hsa-miR-613	CLIP-seq
MIRT1389510	hsa-miR-617	CLIP-seq
MIRT1389543	hsa-miR-656	CLIP-seq
MIRT1389513	hsa-miR-875-5p	CLIP-seq
MIRT2632839	hsa-miR-892a	CLIP-seq

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000245	Process	Spliceosomal complex assembly	IBA	21873635
GO:0000245	Process	Spliceosomal complex assembly	IDA	9472028
GO:0000287	Function	Magnesium ion binding	IDA	9472028
GO:0000785	Component	Chromatin	IDA	28076779
GO:0001525	Process	Angiogenesis	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9472028
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	26167880
GO:0005515	Function	Protein binding	IPI	16189514, 19592491, 22365833, 23602568, 25416956, 28076779, 32296183
GO:0005524	Function	ATP binding	IDA	9472028
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	9472028
GO:0005654	Component	Nucleoplasm	IDA	28076779
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	9472028, 28076779
GO:0005829	Component	Cytosol	IDA
GO:0006468	Process	Protein phosphorylation	IDA	9472028
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	18559500
GO:0008380	Process	RNA splicing	IDA	9472028
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016607	Component	Nuclear speck	IDA	28076779
GO:0018105	Process	Peptidyl-serine phosphorylation	IGI	26167880
GO:0030154	Process	Cell differentiation	IEA
GO:0035063	Process	Nuclear speck organization	ISS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	IDA	9472028
GO:0043525	Process	Positive regulation of neuron apoptotic process	ISS
GO:0045070	Process	Positive regulation of viral genome replication	IDA	20498328
GO:0045071	Process	Negative regulation of viral genome replication	IDA	12417631
GO:0045087	Process	Innate immune response	IC	12417631
GO:0045787	Process	Positive regulation of cell cycle	ISS
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	TAS	21205200
GO:0050684	Process	Regulation of mRNA processing	IBA	21873635
GO:0062176	Process	R-loop disassembly	IDA	28076779
GO:0071889	Function	14-3-3 protein binding	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

MIM	HGNC	e!Ensembl
602980	11306	ENSG00000135250

Protein

UniProt ID

P78362

Protein name

SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]

Protein function

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing fac

PDB

2X7G , 5MYV , 7ZKX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	81 → 230	Protein kinase domain	Domain
PF00069	Pkinase	511 → 686	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269|PubMed:9472028}.

Sequence

MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP
ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE
TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ
KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK
IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE
KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN
AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ
EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH
FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA
HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT
DFLIPMLEMVPEKRASAGECLRHPWLNS

Sequence length

688

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Age-related macular degeneration	Age related macular degeneration	rs199474657, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152 View all (20 more)	26691988
Myopia	Myopia, Degenerative	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805 View all (6 more)	23049088
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	30285260, 28991256, 26198764, 29483656, 31268507, 28540026, 25056061

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Bipolar Disorder	Bipolar Disorder		GWAS
Melanoma	Melanoma	SMAD3 and SLC9A5 gain?of?function increases invasion capability of melanoma cells.	GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma		GWAS
Diabetes	Diabetes		GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	23071587
Autism Spectrum Disorder	Associate	37907504
Carcinoma Non Small Cell Lung	Associate	23071587
Carcinoma Squamous Cell	Stimulate	23071587
Cholangiocarcinoma	Associate	39344395
Colorectal Neoplasms	Associate	31898732
COVID 19	Associate	35967328
Infertility Male	Associate	31103287
Leukemia	Associate	18559500, 26244849
Leukemia Myeloid Acute	Associate	18559500
Nasopharyngeal Carcinoma	Associate	32671994
Neoplasms	Stimulate	26244849
Neoplasms	Associate	30724469, 31898732, 32671994
Pancreatic Neoplasms	Associate	30724469, 31898732
Squamous Cell Carcinoma of Head and Neck	Associate	26853621

SRPK2 (SRSF protein kinase 2)