Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6670
Gene name Gene Name - the full gene name approved by the HGNC.	Sp3 transcription factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SP3
Synonyms (NCBI Gene) Gene synonyms aliases	SPR2
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q31.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several

Show/Hide all(296)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002402	hsa-miR-27a-3p	Western blot	18006846
MIRT006249	hsa-miR-223-3p	Luciferase reporter assay, Western blot	22080513
MIRT022933	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT002402	hsa-miR-27a-3p	Western blot;qRT-PCR	20382698
MIRT042140	hsa-miR-484	CLASH	23622248
MIRT052769	hsa-miR-1260b	CLASH	23622248
MIRT439556	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439556	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1381293	hsa-miR-105	CLIP-seq
MIRT1381294	hsa-miR-1226	CLIP-seq
MIRT1381295	hsa-miR-1261	CLIP-seq
MIRT1381296	hsa-miR-129-5p	CLIP-seq
MIRT1381297	hsa-miR-1297	CLIP-seq
MIRT1381298	hsa-miR-1298	CLIP-seq
MIRT1381299	hsa-miR-1304	CLIP-seq
MIRT1381300	hsa-miR-1305	CLIP-seq
MIRT1381301	hsa-miR-133a	CLIP-seq
MIRT1381302	hsa-miR-133b	CLIP-seq
MIRT1381303	hsa-miR-135a	CLIP-seq
MIRT1381304	hsa-miR-135b	CLIP-seq
MIRT1381305	hsa-miR-151-3p	CLIP-seq
MIRT1381306	hsa-miR-153	CLIP-seq
MIRT1381307	hsa-miR-190	CLIP-seq
MIRT1381308	hsa-miR-190b	CLIP-seq
MIRT1381309	hsa-miR-1976	CLIP-seq
MIRT1381310	hsa-miR-203	CLIP-seq
MIRT1381311	hsa-miR-208a	CLIP-seq
MIRT1381312	hsa-miR-208b	CLIP-seq
MIRT1381313	hsa-miR-21	CLIP-seq
MIRT1381314	hsa-miR-2117	CLIP-seq
MIRT1381315	hsa-miR-26a	CLIP-seq
MIRT1381316	hsa-miR-26b	CLIP-seq
MIRT1381317	hsa-miR-297	CLIP-seq
MIRT1381318	hsa-miR-302a	CLIP-seq
MIRT1381319	hsa-miR-302b	CLIP-seq
MIRT1381320	hsa-miR-302c	CLIP-seq
MIRT1381321	hsa-miR-302d	CLIP-seq
MIRT1381322	hsa-miR-302e	CLIP-seq
MIRT1381323	hsa-miR-3145-3p	CLIP-seq
MIRT1381324	hsa-miR-3160-5p	CLIP-seq
MIRT1381325	hsa-miR-3166	CLIP-seq
MIRT1381326	hsa-miR-3168	CLIP-seq
MIRT1381327	hsa-miR-3180-5p	CLIP-seq
MIRT1381328	hsa-miR-3198	CLIP-seq
MIRT1381329	hsa-miR-323-5p	CLIP-seq
MIRT1381330	hsa-miR-338-5p	CLIP-seq
MIRT1381331	hsa-miR-33a	CLIP-seq
MIRT1381332	hsa-miR-33b	CLIP-seq
MIRT1381333	hsa-miR-34b	CLIP-seq
MIRT1381334	hsa-miR-3545-3p	CLIP-seq
MIRT1381335	hsa-miR-3613-3p	CLIP-seq
MIRT1381336	hsa-miR-3614-3p	CLIP-seq
MIRT1381337	hsa-miR-3646	CLIP-seq
MIRT1381338	hsa-miR-3647-3p	CLIP-seq
MIRT1381339	hsa-miR-3653	CLIP-seq
MIRT1381340	hsa-miR-3658	CLIP-seq
MIRT1381341	hsa-miR-3662	CLIP-seq
MIRT1381342	hsa-miR-3671	CLIP-seq
MIRT1381343	hsa-miR-3688-3p	CLIP-seq
MIRT1381344	hsa-miR-369-3p	CLIP-seq
MIRT1381345	hsa-miR-372	CLIP-seq
MIRT1381346	hsa-miR-373	CLIP-seq
MIRT1381347	hsa-miR-374a	CLIP-seq
MIRT1381348	hsa-miR-374b	CLIP-seq
MIRT1381349	hsa-miR-374c	CLIP-seq
MIRT1381350	hsa-miR-3908	CLIP-seq
MIRT1381351	hsa-miR-3924	CLIP-seq
MIRT1381352	hsa-miR-409-3p	CLIP-seq
MIRT1381353	hsa-miR-4273	CLIP-seq
MIRT1381354	hsa-miR-4282	CLIP-seq
MIRT1381355	hsa-miR-4305	CLIP-seq
MIRT1381356	hsa-miR-4307	CLIP-seq
MIRT1381357	hsa-miR-4309	CLIP-seq
MIRT1381358	hsa-miR-4317	CLIP-seq
MIRT1381359	hsa-miR-4465	CLIP-seq
MIRT1381360	hsa-miR-448	CLIP-seq
MIRT1381361	hsa-miR-4490	CLIP-seq
MIRT1381362	hsa-miR-4494	CLIP-seq
MIRT1381363	hsa-miR-4499	CLIP-seq
MIRT1381364	hsa-miR-4513	CLIP-seq
MIRT1381365	hsa-miR-4639-5p	CLIP-seq
MIRT1381366	hsa-miR-4659a-3p	CLIP-seq
MIRT1381367	hsa-miR-4659b-3p	CLIP-seq
MIRT1381368	hsa-miR-4666-5p	CLIP-seq
MIRT1381369	hsa-miR-4704-5p	CLIP-seq
MIRT1381370	hsa-miR-4722-3p	CLIP-seq
MIRT1381371	hsa-miR-4753-3p	CLIP-seq
MIRT1381372	hsa-miR-4762-5p	CLIP-seq
MIRT1381373	hsa-miR-4764-3p	CLIP-seq
MIRT1381374	hsa-miR-4769-3p	CLIP-seq
MIRT1381375	hsa-miR-4771	CLIP-seq
MIRT1381376	hsa-miR-4789-5p	CLIP-seq
MIRT1381377	hsa-miR-487a	CLIP-seq
MIRT1381378	hsa-miR-489	CLIP-seq
MIRT1381379	hsa-miR-495	CLIP-seq
MIRT1381380	hsa-miR-498	CLIP-seq
MIRT1381381	hsa-miR-5096	CLIP-seq
MIRT1381382	hsa-miR-513a-3p	CLIP-seq
MIRT1381383	hsa-miR-519a	CLIP-seq
MIRT1381384	hsa-miR-519b-3p	CLIP-seq
MIRT1381385	hsa-miR-519c-3p	CLIP-seq
MIRT1381386	hsa-miR-520a-3p	CLIP-seq
MIRT1381387	hsa-miR-520a-5p	CLIP-seq
MIRT1381388	hsa-miR-520b	CLIP-seq
MIRT1381389	hsa-miR-520c-3p	CLIP-seq
MIRT1381390	hsa-miR-520d-3p	CLIP-seq
MIRT1381391	hsa-miR-520d-5p	CLIP-seq
MIRT1381392	hsa-miR-520e	CLIP-seq
MIRT1381393	hsa-miR-524-5p	CLIP-seq
MIRT1381394	hsa-miR-525-5p	CLIP-seq
MIRT1381395	hsa-miR-543	CLIP-seq
MIRT1381396	hsa-miR-548a-3p	CLIP-seq
MIRT1381397	hsa-miR-548aa	CLIP-seq
MIRT1381398	hsa-miR-548ag	CLIP-seq
MIRT1381399	hsa-miR-548ai	CLIP-seq
MIRT1381400	hsa-miR-548c-3p	CLIP-seq
MIRT1381401	hsa-miR-548e	CLIP-seq
MIRT1381402	hsa-miR-548f	CLIP-seq
MIRT1381403	hsa-miR-548u	CLIP-seq
MIRT1381404	hsa-miR-567	CLIP-seq
MIRT1381405	hsa-miR-584	CLIP-seq
MIRT1381406	hsa-miR-586	CLIP-seq
MIRT1381407	hsa-miR-590-5p	CLIP-seq
MIRT1381408	hsa-miR-600	CLIP-seq
MIRT1381409	hsa-miR-607	CLIP-seq
MIRT740204	hsa-miR-634	CLIP-seq
MIRT1381410	hsa-miR-655	CLIP-seq
MIRT1381411	hsa-miR-659	CLIP-seq
MIRT1381412	hsa-miR-664	CLIP-seq
MIRT1381413	hsa-miR-889	CLIP-seq
MIRT1381414	hsa-miR-891b	CLIP-seq
MIRT1381415	hsa-miR-944	CLIP-seq
MIRT1381293	hsa-miR-105	CLIP-seq
MIRT1381416	hsa-miR-124	CLIP-seq
MIRT1381306	hsa-miR-153	CLIP-seq
MIRT1381417	hsa-miR-219-2-3p	CLIP-seq
MIRT1381418	hsa-miR-2964a-3p	CLIP-seq
MIRT1381419	hsa-miR-3143	CLIP-seq
MIRT1381335	hsa-miR-3613-3p	CLIP-seq
MIRT1381338	hsa-miR-3647-3p	CLIP-seq
MIRT1381343	hsa-miR-3688-3p	CLIP-seq
MIRT1381420	hsa-miR-3714	CLIP-seq
MIRT1381421	hsa-miR-3910	CLIP-seq
MIRT1381422	hsa-miR-4276	CLIP-seq
MIRT1381423	hsa-miR-4302	CLIP-seq
MIRT1381355	hsa-miR-4305	CLIP-seq
MIRT1381356	hsa-miR-4307	CLIP-seq
MIRT740205	hsa-miR-4445	CLIP-seq
MIRT1381424	hsa-miR-4452	CLIP-seq
MIRT1381360	hsa-miR-448	CLIP-seq
MIRT1381361	hsa-miR-4490	CLIP-seq
MIRT1381368	hsa-miR-4666-5p	CLIP-seq
MIRT1381371	hsa-miR-4753-3p	CLIP-seq
MIRT1381425	hsa-miR-4760-3p	CLIP-seq
MIRT1381376	hsa-miR-4789-5p	CLIP-seq
MIRT1381426	hsa-miR-506	CLIP-seq
MIRT1381395	hsa-miR-543	CLIP-seq
MIRT1381403	hsa-miR-548u	CLIP-seq
MIRT1381427	hsa-miR-568	CLIP-seq
MIRT740204	hsa-miR-634	CLIP-seq
MIRT1381335	hsa-miR-3613-3p	CLIP-seq
MIRT1381293	hsa-miR-105	CLIP-seq
MIRT2114117	hsa-miR-1183	CLIP-seq
MIRT2114118	hsa-miR-1229	CLIP-seq
MIRT2114119	hsa-miR-1236	CLIP-seq
MIRT2114120	hsa-miR-1243	CLIP-seq
MIRT2114121	hsa-miR-1273d	CLIP-seq
MIRT2114122	hsa-miR-1283	CLIP-seq
MIRT1381300	hsa-miR-1305	CLIP-seq
MIRT1381306	hsa-miR-153	CLIP-seq
MIRT2114123	hsa-miR-194	CLIP-seq
MIRT2114124	hsa-miR-223	CLIP-seq
MIRT2114125	hsa-miR-23a	CLIP-seq
MIRT2114126	hsa-miR-23b	CLIP-seq
MIRT2114127	hsa-miR-23c	CLIP-seq
MIRT2114128	hsa-miR-3163	CLIP-seq
MIRT1381327	hsa-miR-3180-5p	CLIP-seq
MIRT2114129	hsa-miR-323b-3p	CLIP-seq
MIRT1381330	hsa-miR-338-5p	CLIP-seq
MIRT1381337	hsa-miR-3646	CLIP-seq
MIRT2114130	hsa-miR-3654	CLIP-seq
MIRT1381341	hsa-miR-3662	CLIP-seq
MIRT1381342	hsa-miR-3671	CLIP-seq
MIRT1381343	hsa-miR-3688-3p	CLIP-seq
MIRT1381347	hsa-miR-374a	CLIP-seq
MIRT1381348	hsa-miR-374b	CLIP-seq
MIRT1381349	hsa-miR-374c	CLIP-seq
MIRT1381352	hsa-miR-409-3p	CLIP-seq
MIRT2114131	hsa-miR-421	CLIP-seq
MIRT2114132	hsa-miR-4272	CLIP-seq
MIRT1381354	hsa-miR-4282	CLIP-seq
MIRT1381362	hsa-miR-4494	CLIP-seq
MIRT2114133	hsa-miR-4495	CLIP-seq
MIRT1381366	hsa-miR-4659a-3p	CLIP-seq
MIRT1381367	hsa-miR-4659b-3p	CLIP-seq
MIRT2114134	hsa-miR-4691-5p	CLIP-seq
MIRT2114135	hsa-miR-4693-5p	CLIP-seq
MIRT2114136	hsa-miR-4697-3p	CLIP-seq
MIRT1381369	hsa-miR-4704-5p	CLIP-seq
MIRT2114137	hsa-miR-4716-5p	CLIP-seq
MIRT1381371	hsa-miR-4753-3p	CLIP-seq
MIRT1381425	hsa-miR-4760-3p	CLIP-seq
MIRT1381372	hsa-miR-4762-5p	CLIP-seq
MIRT2114138	hsa-miR-488	CLIP-seq
MIRT2114139	hsa-miR-491-3p	CLIP-seq
MIRT2114140	hsa-miR-518d-5p	CLIP-seq
MIRT2114141	hsa-miR-519b-5p	CLIP-seq
MIRT2114142	hsa-miR-519c-5p	CLIP-seq
MIRT1381387	hsa-miR-520a-5p	CLIP-seq
MIRT2114143	hsa-miR-520c-5p	CLIP-seq
MIRT1381391	hsa-miR-520d-5p	CLIP-seq
MIRT1381393	hsa-miR-524-5p	CLIP-seq
MIRT1381394	hsa-miR-525-5p	CLIP-seq
MIRT2114144	hsa-miR-526a	CLIP-seq
MIRT1381395	hsa-miR-543	CLIP-seq
MIRT1381400	hsa-miR-548c-3p	CLIP-seq
MIRT2114145	hsa-miR-548k	CLIP-seq
MIRT2114146	hsa-miR-548n	CLIP-seq
MIRT1381427	hsa-miR-568	CLIP-seq
MIRT1381406	hsa-miR-586	CLIP-seq
MIRT2114147	hsa-miR-590-3p	CLIP-seq
MIRT1381409	hsa-miR-607	CLIP-seq
MIRT1381410	hsa-miR-655	CLIP-seq
MIRT1381411	hsa-miR-659	CLIP-seq
MIRT2114148	hsa-miR-935	CLIP-seq
MIRT2114149	hsa-miR-942	CLIP-seq
MIRT1381339	hsa-miR-3653	CLIP-seq
MIRT1381340	hsa-miR-3658	CLIP-seq
MIRT2337074	hsa-miR-3973	CLIP-seq
MIRT1381368	hsa-miR-4666-5p	CLIP-seq
MIRT2114134	hsa-miR-4691-5p	CLIP-seq
MIRT2114135	hsa-miR-4693-5p	CLIP-seq
MIRT2114146	hsa-miR-548n	CLIP-seq
MIRT2337075	hsa-miR-548t	CLIP-seq
MIRT1381406	hsa-miR-586	CLIP-seq
MIRT1381293	hsa-miR-105	CLIP-seq
MIRT1381296	hsa-miR-129-5p	CLIP-seq
MIRT1381301	hsa-miR-133a	CLIP-seq
MIRT1381302	hsa-miR-133b	CLIP-seq
MIRT1381310	hsa-miR-203	CLIP-seq
MIRT1381419	hsa-miR-3143	CLIP-seq
MIRT2114129	hsa-miR-323b-3p	CLIP-seq
MIRT1381330	hsa-miR-338-5p	CLIP-seq
MIRT1381334	hsa-miR-3545-3p	CLIP-seq
MIRT1381343	hsa-miR-3688-3p	CLIP-seq
MIRT2337076	hsa-miR-3913-3p	CLIP-seq
MIRT1381356	hsa-miR-4307	CLIP-seq
MIRT2114134	hsa-miR-4691-5p	CLIP-seq
MIRT1381371	hsa-miR-4753-3p	CLIP-seq
MIRT1381372	hsa-miR-4762-5p	CLIP-seq
MIRT1381378	hsa-miR-489	CLIP-seq
MIRT2337077	hsa-miR-5095	CLIP-seq
MIRT1381395	hsa-miR-543	CLIP-seq
MIRT2337078	hsa-miR-552	CLIP-seq
MIRT1381411	hsa-miR-659	CLIP-seq
MIRT2114148	hsa-miR-935	CLIP-seq
MIRT1381415	hsa-miR-944	CLIP-seq
MIRT1381305	hsa-miR-151-3p	CLIP-seq
MIRT1381328	hsa-miR-3198	CLIP-seq
MIRT1381357	hsa-miR-4309	CLIP-seq
MIRT1381405	hsa-miR-584	CLIP-seq
MIRT1381406	hsa-miR-586	CLIP-seq
MIRT1381411	hsa-miR-659	CLIP-seq
MIRT2114118	hsa-miR-1229	CLIP-seq
MIRT1381296	hsa-miR-129-5p	CLIP-seq
MIRT2630552	hsa-miR-186	CLIP-seq
MIRT2630553	hsa-miR-2355-5p	CLIP-seq
MIRT1381330	hsa-miR-338-5p	CLIP-seq
MIRT2630554	hsa-miR-3617	CLIP-seq
MIRT1381341	hsa-miR-3662	CLIP-seq
MIRT2630555	hsa-miR-3914	CLIP-seq
MIRT1381354	hsa-miR-4282	CLIP-seq
MIRT2630556	hsa-miR-450b-5p	CLIP-seq
MIRT2630557	hsa-miR-4511	CLIP-seq
MIRT1381366	hsa-miR-4659a-3p	CLIP-seq
MIRT1381367	hsa-miR-4659b-3p	CLIP-seq
MIRT1381376	hsa-miR-4789-5p	CLIP-seq
MIRT2114138	hsa-miR-488	CLIP-seq
MIRT2630558	hsa-miR-507	CLIP-seq
MIRT2630559	hsa-miR-548b-3p	CLIP-seq
MIRT2630560	hsa-miR-557	CLIP-seq
MIRT2630561	hsa-miR-641	CLIP-seq
MIRT2114149	hsa-miR-942	CLIP-seq
MIRT2691795	hsa-miR-1271	CLIP-seq
MIRT1381296	hsa-miR-129-5p	CLIP-seq
MIRT2691796	hsa-miR-182	CLIP-seq
MIRT2630552	hsa-miR-186	CLIP-seq
MIRT2630554	hsa-miR-3617	CLIP-seq
MIRT2691797	hsa-miR-4470	CLIP-seq
MIRT2630556	hsa-miR-450b-5p	CLIP-seq
MIRT1381376	hsa-miR-4789-5p	CLIP-seq
MIRT2114138	hsa-miR-488	CLIP-seq
MIRT2630558	hsa-miR-507	CLIP-seq
MIRT2630560	hsa-miR-557	CLIP-seq
MIRT2630561	hsa-miR-641	CLIP-seq
MIRT2691798	hsa-miR-96	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
MYB	Unknown	18342022
NF1	Unknown	18342022
NFYA	Activation	16024108
SP1	Activation	16024108

Show/Hide all(56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	14979875
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS	10362258
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IEA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001503	Process	Ossification	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0001779	Process	Natural killer cell differentiation	IEA
GO:0001829	Process	Trophectodermal cell differentiation	IEA
GO:0001889	Process	Liver development	IEA
GO:0001892	Process	Embryonic placenta development	IEA
GO:0002318	Process	Myeloid progenitor cell differentiation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	10391891, 10816575, 12176973, 17500595, 31527615, 32296183, 32814053
GO:0005634	Component	Nucleus	IC	12560508
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	12560508
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016605	Component	PML body	IEA
GO:0017053	Component	Transcription repressor complex	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0030217	Process	T cell differentiation	IEA
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0030219	Process	Megakaryocyte differentiation	IEA
GO:0030224	Process	Monocyte differentiation	IEA
GO:0030324	Process	Lung development	IEA
GO:0030851	Process	Granulocyte differentiation	IEA
GO:0032993	Component	Protein-DNA complex	ISS	10362258
GO:0043353	Process	Enucleate erythrocyte differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	20091743
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	9278495
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	12771217
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	9278495
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	14979875
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	14979875
GO:0046872	Function	Metal ion binding	IEA
GO:0048596	Process	Embryonic camera-type eye morphogenesis	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA
GO:0060136	Process	Embryonic process involved in female pregnancy	IEA
GO:0060216	Process	Definitive hemopoiesis	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	17130167
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
601804	11208	ENSG00000172845

Protein

UniProt ID

Q02447

Protein name

Transcription factor Sp3 (SPR-2)

Protein function

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcriptio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	621 → 645	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	651 → 675	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	681 → 703	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLA
LLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIK
DEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSAD
GQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVA
IGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTG
QAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSS
GQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQT
IHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQ
NTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGE
NADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVAC
TCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGK
RFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVE
AARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETM
E

Sequence length

781

Interactions

View interactions

	Reactome
			SUMOylation of transcription factors

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Multiple myeloma	Multiple myeloma	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (50)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	36889558
Astrocytoma	Associate	26689994
Atypical Squamous Cells of the Cervix	Associate	19309563
Breast Neoplasms	Associate	12176973, 12733991, 12837748, 15987735, 17511886
Carcinoma Hepatocellular	Associate	26317792
Colonic Diseases	Associate	21156786
Colonic Neoplasms	Associate	26807725
Colorectal Neoplasms	Associate	11027677, 20068171, 21156786, 21919647, 23194063, 24948597, 37786278
Congenital myasthenic syndrome ib	Associate	12393509
Diabetes Mellitus Type 2	Associate	29207083
Down Syndrome	Associate	11415440, 11562358, 12393509
Endometrial Neoplasms	Associate	10816575
Esophageal Squamous Cell Carcinoma	Associate	23280018
Gastroesophageal Reflux	Associate	21323962
Glioblastoma	Associate	26689994
Glioma	Associate	26689994
Glomerulonephritis IGA	Associate	26063800
Infections	Associate	15270850
Inflammation	Associate	12218073
Keratoconus	Associate	16275928
Kidney Diseases	Associate	24029427
Leukemia	Associate	11476892
Leukemia Promyelocytic Acute	Associate	2491776
Lung Neoplasms	Associate	23996530
Lymphoma	Associate	35019687
Lymphoma Large B Cell Diffuse	Associate	40128844
Melanoma	Associate	11742542
Multiple Myeloma	Associate	30115673
Multiple Sclerosis	Inhibit	10814800, 12218073
Myocardial Infarction	Associate	15466927
Nasopharyngeal Carcinoma	Associate	22682030, 24214394
Neoplasm Metastasis	Associate	23326307
Neoplasms	Associate	16901903, 17690209, 20442780, 26063800, 35019687
Neuroblastoma	Associate	14645238, 33504757
Neuroblastoma	Inhibit	22975311
Neurofibromatoses	Associate	2491776
Osteoarthritis	Associate	23825960, 24861163
Ovarian Neoplasms	Inhibit	31362717
Pancreatic Neoplasms	Associate	15760841, 27835861
Prostatic Neoplasms	Associate	23028678
Prostatitis	Associate	25816367
Pulmonary Disease Chronic Obstructive	Associate	22140090
Pulmonary Fibrosis	Associate	17881752
Sarcoma	Associate	23326307
Sarcoma Kaposi	Associate	35019687
Sarcoma Small Cell	Associate	17690209
Scleroderma Systemic	Associate	17881752
Stomach Neoplasms	Associate	24151362, 27668303, 36553500
Thyroid Carcinoma Anaplastic	Associate	27796151
Thyroid Neoplasms	Associate	21268135

SP3 (Sp3 transcription factor)