Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6665
Gene name Gene Name - the full gene name approved by the HGNC.	SRY-box transcription factor 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SOX15
Synonyms (NCBI Gene) Gene synonyms aliases	SOX20, SOX26, SOX27
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after for

Show/Hide all(13)

miRTarBase ID	miRNA	Experiments
MIRT2336842	hsa-miR-1323	CLIP-seq
MIRT2336843	hsa-miR-200b	CLIP-seq
MIRT2336844	hsa-miR-200c	CLIP-seq
MIRT2336845	hsa-miR-374c	CLIP-seq
MIRT2336846	hsa-miR-429	CLIP-seq
MIRT2336847	hsa-miR-452	CLIP-seq
MIRT2336848	hsa-miR-4676-3p	CLIP-seq
MIRT2336849	hsa-miR-548a-3p	CLIP-seq
MIRT2336850	hsa-miR-548e	CLIP-seq
MIRT2336851	hsa-miR-548f	CLIP-seq
MIRT2336852	hsa-miR-548g	CLIP-seq
MIRT2336853	hsa-miR-548o	CLIP-seq
MIRT2336854	hsa-miR-655	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS	17363903
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	NAS	8332506
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	8332506
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	NAS	8332506
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006325	Process	Chromatin organization	NAS	8332506
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	8332506
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9540826
GO:0008584	Process	Male gonad development	TAS	9540826
GO:0009653	Process	Anatomical structure morphogenesis	IBA	21873635
GO:0014718	Process	Positive regulation of satellite cell activation involved in skeletal muscle regeneration	ISS	17363903
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030154	Process	Cell differentiation	ISS	16759287
GO:0043403	Process	Skeletal muscle tissue regeneration	IEA
GO:0045843	Process	Negative regulation of striated muscle tissue development	ISS	10821863
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	17363903
GO:0048627	Process	Myoblast development	ISS	15367664
GO:0060707	Process	Trophoblast giant cell differentiation	ISS
GO:0070318	Process	Positive regulation of G0 to G1 transition	ISS	17363903
GO:2000288	Process	Positive regulation of myoblast proliferation	ISS	17363903

MIM	HGNC	e!Ensembl
601297	11196	ENSG00000129194

Protein

UniProt ID

O60248

Protein name

Transcription factor SOX-15 (Protein SOX-12) (Protein SOX-20) (SRY-box transcription factor 15)

Protein function

Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Bind

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00505	HMG_box	49 → 117	HMG (high mobility group) box	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. {ECO:0000269|PubMed:8978787, ECO:0000269|PubMed:9880678}.

Sequence

MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWS
SAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRP
RRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSS
HCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL

Sequence length

233

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	30061737

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation		30061737	ClinVar

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Abnormalities Drug Induced	Associate	36672963
Adenocarcinoma	Associate	35328735
Campomelic Dysplasia	Associate	36672963
Carcinoma Embryonal	Associate	18182846
Cardiovascular Diseases	Associate	36672963
Central Nervous System Diseases	Associate	36672963
Endometrial Neoplasms	Associate	27881125, 28821564, 30935961
Endometriosis	Associate	27881125
Infertility Male	Associate	36446526
Intellectual Disability	Associate	36672963
Neoplasms	Associate	23300844
Neoplasms	Inhibit	34603557
Prostatic Neoplasms	Associate	35922412
Seizures	Associate	36672963
Testicular Germ Cell Tumor	Associate	23300844
Thyroid Cancer Papillary	Associate	34603557

SOX15 (SRY-box transcription factor 15)