SLCO1A2 (solute carrier organic anion transporter family member 1A2)

Gene

• Entrez ID: 6579
• Gene name: Solute carrier organic anion transporter family member 1A2
• Gene symbol: SLCO1A2
• Synonyms (NCBI Gene): OATP, OATP-A, OATP1A2, SLC21A3
• Chromosome: 12
• Chromosome location: 12p12.1
• Summary: This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1369231	hsa-miR-1207-5p	CLIP-seq
MIRT1369232	hsa-miR-1224-3p	CLIP-seq
MIRT1369233	hsa-miR-1236	CLIP-seq
MIRT1369234	hsa-miR-1260	CLIP-seq
MIRT1369235	hsa-miR-1260b	CLIP-seq
MIRT1369236	hsa-miR-128	CLIP-seq
MIRT1369237	hsa-miR-1280	CLIP-seq
MIRT1369238	hsa-miR-1285	CLIP-seq
MIRT1369239	hsa-miR-1302	CLIP-seq
MIRT1369240	hsa-miR-136	CLIP-seq
MIRT1369241	hsa-miR-3145-5p	CLIP-seq
MIRT1369242	hsa-miR-3147	CLIP-seq
MIRT1369243	hsa-miR-3187-5p	CLIP-seq
MIRT1369244	hsa-miR-3667-3p	CLIP-seq
MIRT1369245	hsa-miR-3679-3p	CLIP-seq
MIRT1369246	hsa-miR-3686	CLIP-seq
MIRT1369247	hsa-miR-378g	CLIP-seq
MIRT1369248	hsa-miR-4278	CLIP-seq
MIRT1369249	hsa-miR-4298	CLIP-seq
MIRT1369250	hsa-miR-4314	CLIP-seq
MIRT1369251	hsa-miR-4425	CLIP-seq
MIRT1369252	hsa-miR-4486	CLIP-seq
MIRT1369253	hsa-miR-4648	CLIP-seq
MIRT1369254	hsa-miR-4668-3p	CLIP-seq
MIRT1369255	hsa-miR-4716-5p	CLIP-seq
MIRT1369256	hsa-miR-4724-5p	CLIP-seq
MIRT1369257	hsa-miR-4747-5p	CLIP-seq
MIRT1369258	hsa-miR-4753-3p	CLIP-seq
MIRT1369259	hsa-miR-4763-3p	CLIP-seq
MIRT1369260	hsa-miR-4781-3p	CLIP-seq
MIRT1369261	hsa-miR-4793-5p	CLIP-seq
MIRT1369262	hsa-miR-4795-5p	CLIP-seq
MIRT1369263	hsa-miR-508-5p	CLIP-seq
MIRT1369264	hsa-miR-513a-3p	CLIP-seq
MIRT1369265	hsa-miR-532-3p	CLIP-seq
MIRT1369266	hsa-miR-548c-3p	CLIP-seq
MIRT1369267	hsa-miR-550b	CLIP-seq
MIRT1369268	hsa-miR-612	CLIP-seq
MIRT1369269	hsa-miR-1178	CLIP-seq
MIRT1369231	hsa-miR-1207-5p	CLIP-seq
MIRT1369270	hsa-miR-1208	CLIP-seq
MIRT1369236	hsa-miR-128	CLIP-seq
MIRT1369238	hsa-miR-1285	CLIP-seq
MIRT1369239	hsa-miR-1302	CLIP-seq
MIRT1369271	hsa-miR-18a	CLIP-seq
MIRT1369272	hsa-miR-18b	CLIP-seq
MIRT1369273	hsa-miR-3120-3p	CLIP-seq
MIRT1369274	hsa-miR-3123	CLIP-seq
MIRT1369275	hsa-miR-3150b-3p	CLIP-seq
MIRT1369276	hsa-miR-3154	CLIP-seq
MIRT1369277	hsa-miR-3159	CLIP-seq
MIRT1369278	hsa-miR-3163	CLIP-seq
MIRT1369243	hsa-miR-3187-5p	CLIP-seq
MIRT1369279	hsa-miR-3613-5p	CLIP-seq
MIRT1369280	hsa-miR-3655	CLIP-seq
MIRT1369281	hsa-miR-3692	CLIP-seq
MIRT1369247	hsa-miR-378g	CLIP-seq
MIRT1369282	hsa-miR-382	CLIP-seq
MIRT1369283	hsa-miR-3907	CLIP-seq
MIRT1369249	hsa-miR-4298	CLIP-seq
MIRT1369284	hsa-miR-4303	CLIP-seq
MIRT1369285	hsa-miR-431	CLIP-seq
MIRT1369250	hsa-miR-4314	CLIP-seq
MIRT1369286	hsa-miR-4459	CLIP-seq
MIRT1369287	hsa-miR-4468	CLIP-seq
MIRT1369288	hsa-miR-4474-5p	CLIP-seq
MIRT1369252	hsa-miR-4486	CLIP-seq
MIRT1369253	hsa-miR-4648	CLIP-seq
MIRT1369254	hsa-miR-4668-3p	CLIP-seq
MIRT1369289	hsa-miR-4689	CLIP-seq
MIRT1369290	hsa-miR-4700-3p	CLIP-seq
MIRT1369291	hsa-miR-4722-5p	CLIP-seq
MIRT1369292	hsa-miR-4735-3p	CLIP-seq
MIRT1369259	hsa-miR-4763-3p	CLIP-seq
MIRT1369293	hsa-miR-4784	CLIP-seq
MIRT1369262	hsa-miR-4795-5p	CLIP-seq
MIRT1369294	hsa-miR-5095	CLIP-seq
MIRT1369295	hsa-miR-511	CLIP-seq
MIRT1369264	hsa-miR-513a-3p	CLIP-seq
MIRT1369296	hsa-miR-600	CLIP-seq
MIRT1369297	hsa-miR-605	CLIP-seq
MIRT1369268	hsa-miR-612	CLIP-seq
MIRT1369298	hsa-miR-892a	CLIP-seq
MIRT2109667	hsa-miR-4320	CLIP-seq
MIRT2109668	hsa-miR-4633-5p	CLIP-seq
MIRT2109669	hsa-miR-491-3p	CLIP-seq
MIRT2109670	hsa-miR-520d-5p	CLIP-seq
MIRT2109671	hsa-miR-524-5p	CLIP-seq
MIRT2109672	hsa-miR-532-5p	CLIP-seq
MIRT2332909	hsa-miR-593	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0008514	Function	Organic anion transmembrane transporter activity	TAS	9007731
GO:0015125	Function	Bile acid transmembrane transporter activity	IBA	21873635
GO:0015125	Function	Bile acid transmembrane transporter activity	TAS
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	IBA	21873635
GO:0015711	Process	Organic anion transport	TAS	9007731
GO:0015721	Process	Bile acid and bile salt transport	IBA	21873635
GO:0015721	Process	Bile acid and bile salt transport	TAS
GO:0043252	Process	Sodium-independent organic anion transport	IBA	21873635
GO:0043252	Process	Sodium-independent organic anion transport	TAS
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 602883
• HGNC: 10956
• e!Ensembl: ENSG00000084453

Protein

• UniProt ID: P46721
• Protein name: Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
• Protein function: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at t
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03137	OATP	21 → 597	Organic Anion Transporter Polypeptide (OATP) family	Family
  PF07648	Kazal_2	440 → 486	Kazal-type serine protease inhibitor domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Higher expression in the brain than in liver and kidney (PubMed:15632119, PubMed:7557095, PubMed:9539145). Expressed in brain neurons in both cortex and hippocampus (PubMed:10873595, PubMed:25132355). Expressed in placental trophoblast
• Sequence:

  MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGF
  INGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVS
  VSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI
  SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTR
  WVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYG
  ITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGI
  YNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT
  SYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV
  FQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
  SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYI
  YLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTV
  LKDDELKTKL

• Sequence length: 670

Pathways

KEGG:

Bile secretion

Reactome:

Recycling of bile acids and salts
Transport of organic anions

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease term	Disease name	Evidence	References	Source
Progressive Supranuclear Palsy	Progressive Supranuclear Palsy			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Anemia Sickle Cell	Associate	26146896
Bile Duct Diseases	Associate	28084414
Breast Neoplasms	Associate	19010908
Carcinoma Hepatocellular	Associate	21383546, 23142319
Cardiotoxicity	Associate	34230586
Cholelithiasis	Associate	26146896
Cognition Disorders	Associate	27021820
Colonic Neoplasms	Associate	37543674
Gallstones	Associate	26146896, 32597704
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	21633340, 25056761, 32027818
Neoplasms	Associate	21383546, 37543674
Nervous System Diseases	Associate	37174648
Prostatic Neoplasms	Associate	22864060, 30890759
Squamous Cell Carcinoma of Head and Neck	Associate	23137910
Supranuclear Palsy Progressive	Associate	29986742, 30089514, 35842134, 39251599