Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6574
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 20 member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC20A1
Synonyms (NCBI Gene) Gene synonyms aliases
GLVR1, Glvr-1, PIT1, PiT-1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004960 hsa-let-7a-5p qRT-PCR 17942906
MIRT004945 hsa-miR-98-5p qRT-PCR 17942906
MIRT026069 hsa-miR-196a-5p Sequencing 20371350
MIRT004945 hsa-miR-98-5p Microarray 19088304
MIRT032183 hsa-let-7d-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
ATF1 Activation 11722845
CREB1 Activation 11722845
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005315 Function Phosphate transmembrane transporter activity IBA
GO:0005315 Function Phosphate transmembrane transporter activity IEA
GO:0005316 Function High-affinity phosphate:sodium symporter activity IEA
GO:0005436 Function Sodium:phosphate symporter activity IDA 7929240, 8041748, 11009570, 16790504, 17494632, 19726692
GO:0005436 Function Sodium:phosphate symporter activity TAS 8041748
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
137570 10946 ENSG00000144136
Protein
UniProt ID Q8WUM9
Protein name Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)
Protein function Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:804
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01384 PHO4 39 665 Phosphate transporter family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:2078500}.
Sequence
Sequence length 679
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sodium-coupled phosphate cotransporters
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aortic Dissection Associate 37684281
Aortic Valve Calcification of Associate 23849774
Aortic Valve Disease Associate 23308213
Breast Neoplasms Associate 27986439, 35605014
Calcinosis Associate 23437308
Combined Pituitary Hormone Deficiency Associate 29261175
Fahr's disease Associate 23437308
Growth Hormone Secreting Pituitary Adenoma Associate 31432167
Hepatitis B Associate 35605014
Hypertrophy Associate 15641067