Gene Gene information from NCBI Gene database.
Entrez ID 6574
Gene name Solute carrier family 20 member 1
Gene symbol SLC20A1
Synonyms (NCBI Gene)
GLVR1Glvr-1PIT1PiT-1
Chromosome 2
Chromosome location 2q14.1
Summary The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retr
miRNA miRNA information provided by mirtarbase database.
465
miRTarBase ID miRNA Experiments Reference
MIRT004960 hsa-let-7a-5p qRT-PCR 17942906
MIRT004945 hsa-miR-98-5p qRT-PCR 17942906
MIRT026069 hsa-miR-196a-5p Sequencing 20371350
MIRT004945 hsa-miR-98-5p Microarray 19088304
MIRT032183 hsa-let-7d-5p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
ATF1 Activation 11722845
CREB1 Activation 11722845
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0005315 Function Phosphate transmembrane transporter activity IBA
GO:0005315 Function Phosphate transmembrane transporter activity IEA
GO:0005316 Function High-affinity phosphate:sodium symporter activity IEA
GO:0005436 Function Sodium:phosphate symporter activity IDA 7929240, 8041748, 11009570, 16790504, 17494632, 19726692
GO:0005436 Function Sodium:phosphate symporter activity TAS 8041748
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
137570 10946 ENSG00000144136
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WUM9
Protein name Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)
Protein function Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:804
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01384 PHO4 39 665 Phosphate transporter family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:2078500}.
Sequence
Sequence length 679
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sodium-coupled phosphate cotransporters
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
SLC20A1-related disorder Benign; Likely benign rs4849091, rs143967365, rs148054695, rs183898160, rs779152045 RCV003979563
RCV003962103
RCV003964007
RCV003924500
RCV003981840
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aortic Dissection Associate 37684281
Aortic Valve Calcification of Associate 23849774
Aortic Valve Disease Associate 23308213
Breast Neoplasms Associate 27986439, 35605014
Calcinosis Associate 23437308
Combined Pituitary Hormone Deficiency Associate 29261175
Fahr's disease Associate 23437308
Growth Hormone Secreting Pituitary Adenoma Associate 31432167
Hepatitis B Associate 35605014
Hypertrophy Associate 15641067