Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	6565
Gene name	Solute carrier family 15 member 2
Gene symbol	SLC15A2
Synonyms (NCBI Gene)	PEPT2
Chromosome	3
Chromosome location	3q13.33
Summary	The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023364	hsa-miR-122-5p	Microarray	17612493
MIRT631111	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631110	hsa-miR-764	HITS-CLIP	23824327
MIRT631109	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631108	hsa-miR-4421	HITS-CLIP	23824327
MIRT631107	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631106	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT643111	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT643110	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT643109	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631105	hsa-miR-640	HITS-CLIP	23824327
MIRT631111	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631110	hsa-miR-764	HITS-CLIP	23824327
MIRT631109	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631108	hsa-miR-4421	HITS-CLIP	23824327
MIRT631107	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631106	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631105	hsa-miR-640	HITS-CLIP	23824327
MIRT631111	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631110	hsa-miR-764	HITS-CLIP	23824327
MIRT631109	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631108	hsa-miR-4421	HITS-CLIP	23824327
MIRT631107	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631106	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT643111	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT643110	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT643109	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631105	hsa-miR-640	HITS-CLIP	23824327
MIRT631111	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631110	hsa-miR-764	HITS-CLIP	23824327
MIRT631109	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631108	hsa-miR-4421	HITS-CLIP	23824327
MIRT631107	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631106	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631105	hsa-miR-640	HITS-CLIP	23824327
MIRT1352679	hsa-miR-197	CLIP-seq
MIRT1352680	hsa-miR-3145-3p	CLIP-seq
MIRT1352681	hsa-miR-3170	CLIP-seq
MIRT1352682	hsa-miR-3187-3p	CLIP-seq
MIRT1352683	hsa-miR-3613-3p	CLIP-seq
MIRT1352684	hsa-miR-3647-3p	CLIP-seq
MIRT1352685	hsa-miR-3655	CLIP-seq
MIRT1352686	hsa-miR-3663-5p	CLIP-seq
MIRT1352687	hsa-miR-3714	CLIP-seq
MIRT1352688	hsa-miR-3918	CLIP-seq
MIRT1352689	hsa-miR-3922-5p	CLIP-seq
MIRT1352690	hsa-miR-3934	CLIP-seq
MIRT1352691	hsa-miR-3977	CLIP-seq
MIRT1352692	hsa-miR-4282	CLIP-seq
MIRT1352693	hsa-miR-4435	CLIP-seq
MIRT1352694	hsa-miR-4640-5p	CLIP-seq
MIRT1352695	hsa-miR-4701-5p	CLIP-seq
MIRT1352696	hsa-miR-4712-5p	CLIP-seq
MIRT1352697	hsa-miR-4716-5p	CLIP-seq
MIRT1352698	hsa-miR-4726-5p	CLIP-seq
MIRT1352699	hsa-miR-4755-3p	CLIP-seq
MIRT1352700	hsa-miR-4781-3p	CLIP-seq
MIRT1352701	hsa-miR-5096	CLIP-seq
MIRT1352702	hsa-miR-513a-3p	CLIP-seq
MIRT1352703	hsa-miR-522	CLIP-seq
MIRT1352704	hsa-miR-548s	CLIP-seq
MIRT1352705	hsa-miR-588	CLIP-seq
MIRT1352706	hsa-miR-606	CLIP-seq
MIRT1352707	hsa-miR-615-5p	CLIP-seq
MIRT1352708	hsa-miR-645	CLIP-seq
MIRT1352709	hsa-miR-770-5p	CLIP-seq
MIRT1352710	hsa-miR-936	CLIP-seq
MIRT1352711	hsa-miR-1910	CLIP-seq
MIRT1352679	hsa-miR-197	CLIP-seq
MIRT1352712	hsa-miR-3148	CLIP-seq
MIRT1352713	hsa-miR-3163	CLIP-seq
MIRT1352714	hsa-miR-3182	CLIP-seq
MIRT1352682	hsa-miR-3187-3p	CLIP-seq
MIRT1352715	hsa-miR-340	CLIP-seq
MIRT1352686	hsa-miR-3663-5p	CLIP-seq
MIRT1352716	hsa-miR-3690	CLIP-seq
MIRT1352687	hsa-miR-3714	CLIP-seq
MIRT1352689	hsa-miR-3922-5p	CLIP-seq
MIRT1352690	hsa-miR-3934	CLIP-seq
MIRT1352717	hsa-miR-409-3p	CLIP-seq
MIRT1352718	hsa-miR-411	CLIP-seq
MIRT1352719	hsa-miR-4254	CLIP-seq
MIRT1352720	hsa-miR-4307	CLIP-seq
MIRT1352721	hsa-miR-4317	CLIP-seq
MIRT1352722	hsa-miR-433	CLIP-seq
MIRT1352693	hsa-miR-4435	CLIP-seq
MIRT1352723	hsa-miR-4462	CLIP-seq
MIRT1352724	hsa-miR-4532	CLIP-seq
MIRT1352695	hsa-miR-4701-5p	CLIP-seq
MIRT1352697	hsa-miR-4716-5p	CLIP-seq
MIRT1352699	hsa-miR-4755-3p	CLIP-seq
MIRT1352700	hsa-miR-4781-3p	CLIP-seq
MIRT1352725	hsa-miR-498	CLIP-seq
MIRT1352701	hsa-miR-5096	CLIP-seq
MIRT1352702	hsa-miR-513a-3p	CLIP-seq
MIRT1352703	hsa-miR-522	CLIP-seq
MIRT1352726	hsa-miR-548aa	CLIP-seq
MIRT1352704	hsa-miR-548s	CLIP-seq
MIRT1352727	hsa-miR-580	CLIP-seq
MIRT1352705	hsa-miR-588	CLIP-seq
MIRT1352728	hsa-miR-591	CLIP-seq
MIRT1352708	hsa-miR-645	CLIP-seq
MIRT2104421	hsa-miR-105	CLIP-seq
MIRT2104422	hsa-miR-106a	CLIP-seq
MIRT2104423	hsa-miR-106b	CLIP-seq
MIRT2104424	hsa-miR-1228	CLIP-seq
MIRT2104425	hsa-miR-1305	CLIP-seq
MIRT2104426	hsa-miR-150	CLIP-seq
MIRT2104427	hsa-miR-17	CLIP-seq
MIRT1352679	hsa-miR-197	CLIP-seq
MIRT2104428	hsa-miR-20a	CLIP-seq
MIRT2104429	hsa-miR-20b	CLIP-seq
MIRT2104430	hsa-miR-2276	CLIP-seq
MIRT2104431	hsa-miR-302a	CLIP-seq
MIRT2104432	hsa-miR-302b	CLIP-seq
MIRT2104433	hsa-miR-302c	CLIP-seq
MIRT2104434	hsa-miR-302d	CLIP-seq
MIRT2104435	hsa-miR-302e	CLIP-seq
MIRT1352682	hsa-miR-3187-3p	CLIP-seq
MIRT2104436	hsa-miR-361-3p	CLIP-seq
MIRT2104437	hsa-miR-3646	CLIP-seq
MIRT1352686	hsa-miR-3663-5p	CLIP-seq
MIRT2104438	hsa-miR-3671	CLIP-seq
MIRT2104439	hsa-miR-372	CLIP-seq
MIRT2104440	hsa-miR-373	CLIP-seq
MIRT1352690	hsa-miR-3934	CLIP-seq
MIRT1352693	hsa-miR-4435	CLIP-seq
MIRT2104441	hsa-miR-4438	CLIP-seq
MIRT2104442	hsa-miR-4639-3p	CLIP-seq
MIRT1352695	hsa-miR-4701-5p	CLIP-seq
MIRT1352697	hsa-miR-4716-5p	CLIP-seq
MIRT2104443	hsa-miR-4731-5p	CLIP-seq
MIRT2104444	hsa-miR-4735-5p	CLIP-seq
MIRT1352699	hsa-miR-4755-3p	CLIP-seq
MIRT2104445	hsa-miR-4760-5p	CLIP-seq
MIRT2104446	hsa-miR-4769-3p	CLIP-seq
MIRT2104447	hsa-miR-4772-3p	CLIP-seq
MIRT2104448	hsa-miR-4775	CLIP-seq
MIRT2104449	hsa-miR-4778-5p	CLIP-seq
MIRT1352700	hsa-miR-4781-3p	CLIP-seq
MIRT2104450	hsa-miR-4794	CLIP-seq
MIRT1352701	hsa-miR-5096	CLIP-seq
MIRT2104451	hsa-miR-512-3p	CLIP-seq
MIRT2104452	hsa-miR-519d	CLIP-seq
MIRT2104453	hsa-miR-520a-3p	CLIP-seq
MIRT2104454	hsa-miR-520b	CLIP-seq
MIRT2104455	hsa-miR-520c-3p	CLIP-seq
MIRT2104456	hsa-miR-520d-3p	CLIP-seq
MIRT2104457	hsa-miR-520e	CLIP-seq
MIRT2104458	hsa-miR-520g	CLIP-seq
MIRT2104459	hsa-miR-520h	CLIP-seq
MIRT2104460	hsa-miR-544	CLIP-seq
MIRT1352704	hsa-miR-548s	CLIP-seq
MIRT1352705	hsa-miR-588	CLIP-seq
MIRT2104461	hsa-miR-590-3p	CLIP-seq
MIRT2104462	hsa-miR-593	CLIP-seq
MIRT2104463	hsa-miR-607	CLIP-seq
MIRT2104464	hsa-miR-93	CLIP-seq
MIRT2328852	hsa-miR-1307	CLIP-seq
MIRT1352721	hsa-miR-4317	CLIP-seq
MIRT2104441	hsa-miR-4438	CLIP-seq
MIRT1352724	hsa-miR-4532	CLIP-seq
MIRT2328853	hsa-miR-4638-5p	CLIP-seq
MIRT2328854	hsa-miR-4695-3p	CLIP-seq
MIRT2328855	hsa-miR-5095	CLIP-seq
MIRT1352714	hsa-miR-3182	CLIP-seq
MIRT2328856	hsa-miR-4659a-3p	CLIP-seq
MIRT2328857	hsa-miR-4659b-3p	CLIP-seq
MIRT2459494	hsa-miR-3157-5p	CLIP-seq
MIRT1352714	hsa-miR-3182	CLIP-seq
MIRT1352691	hsa-miR-3977	CLIP-seq
MIRT1352724	hsa-miR-4532	CLIP-seq
MIRT2328856	hsa-miR-4659a-3p	CLIP-seq
MIRT2328857	hsa-miR-4659b-3p	CLIP-seq
MIRT2459495	hsa-miR-4740-3p	CLIP-seq
MIRT1352725	hsa-miR-498	CLIP-seq
MIRT2104424	hsa-miR-1228	CLIP-seq
MIRT2623252	hsa-miR-3619-3p	CLIP-seq
MIRT2623253	hsa-miR-4722-3p	CLIP-seq
MIRT2104444	hsa-miR-4735-5p	CLIP-seq
MIRT2104446	hsa-miR-4769-3p	CLIP-seq
MIRT2104448	hsa-miR-4775	CLIP-seq
MIRT2623254	hsa-miR-4776-5p	CLIP-seq
MIRT2104450	hsa-miR-4794	CLIP-seq
MIRT2623255	hsa-miR-485-3p	CLIP-seq
MIRT2623256	hsa-miR-487a	CLIP-seq
MIRT2104461	hsa-miR-590-3p	CLIP-seq
MIRT2104424	hsa-miR-1228	CLIP-seq
MIRT2623252	hsa-miR-3619-3p	CLIP-seq
MIRT2104444	hsa-miR-4735-5p	CLIP-seq
MIRT2104448	hsa-miR-4775	CLIP-seq
MIRT2623254	hsa-miR-4776-5p	CLIP-seq
MIRT2104450	hsa-miR-4794	CLIP-seq
MIRT2623255	hsa-miR-485-3p	CLIP-seq
MIRT2623256	hsa-miR-487a	CLIP-seq
MIRT2104461	hsa-miR-590-3p	CLIP-seq

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	16738539, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IC	7756356, 18367661, 18762712
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	7756356
GO:0006857	Process	Oligopeptide transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015293	Function	Symporter activity	IEA
GO:0015333	Function	Peptide:proton symporter activity	IDA	7756356, 18367661, 31073693
GO:0015333	Function	Peptide:proton symporter activity	IEA
GO:0015333	Function	Peptide:proton symporter activity	TAS	7756356
GO:0015833	Process	Peptide transport	IEA
GO:0015835	Process	Peptidoglycan transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	RCA	7756356
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IDA	20406817
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035673	Function	Oligopeptide transmembrane transporter activity	IEA
GO:0042908	Process	Xenobiotic transport	ISS
GO:0042937	Function	Tripeptide transmembrane transporter activity	ISS
GO:0042938	Process	Dipeptide transport	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708
GO:0070293	Process	Renal absorption	ISS
GO:0070424	Process	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISS
GO:0071916	Function	Dipeptide transmembrane transporter activity	IBA
GO:0071916	Function	Dipeptide transmembrane transporter activity	IDA	7756356, 18367661, 18762712, 31073693
GO:0071916	Function	Dipeptide transmembrane transporter activity	IEA
GO:0140206	Process	Dipeptide import across plasma membrane	IBA
GO:0140206	Process	Dipeptide import across plasma membrane	IDA	7756356, 18367661, 18762712, 31073693
GO:0140206	Process	Dipeptide import across plasma membrane	IEA
GO:0140207	Process	Tripeptide import across plasma membrane	ISS
GO:0140367	Process	Antibacterial innate immune response	IDA	20406817
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1990961	Process	Xenobiotic detoxification by transmembrane export across the plasma membrane	NAS	16738539

MIM	HGNC	e!Ensembl
602339	10921	ENSG00000163406

Q16348

Protein name

Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)

Protein function

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356). Transports neutral and anionic dipeptides with a proton to peptide sto

PDB

6EZI , 7PMY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00854	PTR2	111 → 487	POT family	Family
PF00854	PTR2	566 → 675	POT family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney (PubMed:7756356). Not detected in intestine (PubMed:7756356). Highly expressed in macrophages (PubMed:20406817). {ECO:0000269|PubMed:20406817, ECO:0000269|PubMed:7756356}.

Sequence

MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSY
YGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLV
YVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEER
TRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSK
IYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALT
RVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFD
FVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLN
LADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHS
VQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVG
EDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIED
IPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIV
LVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMI
KLETKKTKL

Sequence length

729

Interactions

View interactions

	Reactome
			Proton/oligopeptide cotransporters

SLC15A2 (solute carrier family 15 member 2)