Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6546
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 8 member A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC8A1
Synonyms (NCBI Gene) Gene synonyms aliases	NCX1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006819	hsa-miR-1-3p	Luciferase reporter assay, Western blot	22362515
MIRT510749	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510745	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510744	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510742	hsa-miR-3924	HITS-CLIP	21572407
MIRT510743	hsa-miR-590-3p	HITS-CLIP	21572407
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT641916	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT641915	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636223	hsa-miR-6124	HITS-CLIP	23824327
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT636224	hsa-miR-4282	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636223	hsa-miR-6124	HITS-CLIP	23824327
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT510749	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT510743	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT554159	hsa-miR-4775	PAR-CLIP	21572407
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510742	hsa-miR-3924	PAR-CLIP	21572407
MIRT534184	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT534183	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT534182	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT534181	hsa-miR-4766-5p	PAR-CLIP	22012620
MIRT534180	hsa-miR-3135a	PAR-CLIP	22012620
MIRT534179	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT534178	hsa-miR-760	PAR-CLIP	22012620
MIRT534177	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT534176	hsa-miR-8057	PAR-CLIP	22012620
MIRT534175	hsa-miR-5693	PAR-CLIP	22012620
MIRT534174	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT534173	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534172	hsa-miR-6847-5p	PAR-CLIP	22012620
MIRT534171	hsa-miR-1825	PAR-CLIP	22012620
MIRT534170	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT534169	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT534168	hsa-miR-494-3p	PAR-CLIP	22012620
MIRT534167	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT534166	hsa-miR-4784	PAR-CLIP	22012620
MIRT534165	hsa-miR-4683	PAR-CLIP	22012620
MIRT510749	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510748	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT510747	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT510746	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521019	hsa-miR-4699-3p	PAR-CLIP	23446348
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510742	hsa-miR-3924	PAR-CLIP	23446348
MIRT510743	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT510749	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510748	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT510747	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT510746	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510742	hsa-miR-3924	PAR-CLIP	23446348
MIRT510743	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT450666	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448463	hsa-miR-507	PAR-CLIP	22100165
MIRT448462	hsa-miR-557	PAR-CLIP	22100165
MIRT448463	hsa-miR-507	PAR-CLIP	22100165
MIRT448462	hsa-miR-557	PAR-CLIP	22100165
MIRT510749	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510745	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510744	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510742	hsa-miR-3924	HITS-CLIP	21572407
MIRT510743	hsa-miR-590-3p	HITS-CLIP	21572407
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT641916	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT641915	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636223	hsa-miR-6124	HITS-CLIP	23824327
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT636224	hsa-miR-4282	HITS-CLIP	23824327
MIRT636225	hsa-miR-3148	HITS-CLIP	23824327
MIRT636223	hsa-miR-6124	HITS-CLIP	23824327
MIRT636222	hsa-miR-3161	HITS-CLIP	23824327
MIRT636221	hsa-miR-3978	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT622180	hsa-miR-599	HITS-CLIP	23824327
MIRT622179	hsa-miR-1305	HITS-CLIP	23824327
MIRT622178	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT510749	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT510743	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT554159	hsa-miR-4775	PAR-CLIP	21572407
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510742	hsa-miR-3924	PAR-CLIP	21572407
MIRT534184	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT534183	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT534182	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT534181	hsa-miR-4766-5p	PAR-CLIP	22012620
MIRT534180	hsa-miR-3135a	PAR-CLIP	22012620
MIRT534179	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT534178	hsa-miR-760	PAR-CLIP	22012620
MIRT534177	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT534176	hsa-miR-8057	PAR-CLIP	22012620
MIRT534175	hsa-miR-5693	PAR-CLIP	22012620
MIRT534174	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT534173	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534172	hsa-miR-6847-5p	PAR-CLIP	22012620
MIRT534171	hsa-miR-1825	PAR-CLIP	22012620
MIRT534170	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT534169	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT534168	hsa-miR-494-3p	PAR-CLIP	22012620
MIRT534167	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT534166	hsa-miR-4784	PAR-CLIP	22012620
MIRT534165	hsa-miR-4683	PAR-CLIP	22012620
MIRT510749	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510748	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT510747	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT510746	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521019	hsa-miR-4699-3p	PAR-CLIP	23446348
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510742	hsa-miR-3924	PAR-CLIP	23446348
MIRT510743	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT510749	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510748	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT510747	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT510746	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT510745	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510744	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510742	hsa-miR-3924	PAR-CLIP	23446348
MIRT510743	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT450666	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448463	hsa-miR-507	PAR-CLIP	22100165
MIRT448462	hsa-miR-557	PAR-CLIP	22100165
MIRT448463	hsa-miR-507	PAR-CLIP	22100165
MIRT448462	hsa-miR-557	PAR-CLIP	22100165
MIRT006819	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR	36035156
MIRT1368403	hsa-miR-1193	CLIP-seq
MIRT1368404	hsa-miR-1225-5p	CLIP-seq
MIRT1368405	hsa-miR-1227	CLIP-seq
MIRT1368406	hsa-miR-1275	CLIP-seq
MIRT1368407	hsa-miR-1324	CLIP-seq
MIRT1368408	hsa-miR-148a	CLIP-seq
MIRT1368409	hsa-miR-148b	CLIP-seq
MIRT1368410	hsa-miR-152	CLIP-seq
MIRT1368411	hsa-miR-186	CLIP-seq
MIRT1368412	hsa-miR-197	CLIP-seq
MIRT1368413	hsa-miR-218	CLIP-seq
MIRT1368414	hsa-miR-3133	CLIP-seq
MIRT1368415	hsa-miR-3140-3p	CLIP-seq
MIRT1368416	hsa-miR-3152-5p	CLIP-seq
MIRT1368417	hsa-miR-3160-5p	CLIP-seq
MIRT1368418	hsa-miR-3170	CLIP-seq
MIRT1368419	hsa-miR-3183	CLIP-seq
MIRT1368420	hsa-miR-3184	CLIP-seq
MIRT1368421	hsa-miR-3674	CLIP-seq
MIRT1368422	hsa-miR-3689d	CLIP-seq
MIRT1368423	hsa-miR-3692	CLIP-seq
MIRT1368424	hsa-miR-378g	CLIP-seq
MIRT1368425	hsa-miR-423-5p	CLIP-seq
MIRT1368426	hsa-miR-4279	CLIP-seq
MIRT1368427	hsa-miR-4426	CLIP-seq
MIRT1368428	hsa-miR-4525	CLIP-seq
MIRT1368429	hsa-miR-4647	CLIP-seq
MIRT1368430	hsa-miR-4662b	CLIP-seq
MIRT1368431	hsa-miR-4665-5p	CLIP-seq
MIRT1368432	hsa-miR-4703-3p	CLIP-seq
MIRT1368433	hsa-miR-4710	CLIP-seq
MIRT1368434	hsa-miR-4716-3p	CLIP-seq
MIRT1368435	hsa-miR-4723-3p	CLIP-seq
MIRT1368436	hsa-miR-4723-5p	CLIP-seq
MIRT1368437	hsa-miR-4763-5p	CLIP-seq
MIRT1368438	hsa-miR-4774-3p	CLIP-seq
MIRT1368439	hsa-miR-4790-3p	CLIP-seq
MIRT1368440	hsa-miR-485-3p	CLIP-seq
MIRT1368441	hsa-miR-509-3p	CLIP-seq
MIRT1368442	hsa-miR-5096	CLIP-seq
MIRT1368443	hsa-miR-570	CLIP-seq
MIRT1368444	hsa-miR-625	CLIP-seq
MIRT1368445	hsa-miR-635	CLIP-seq
MIRT1368446	hsa-miR-636	CLIP-seq
MIRT1368406	hsa-miR-1275	CLIP-seq
MIRT1368447	hsa-miR-3163	CLIP-seq
MIRT1368420	hsa-miR-3184	CLIP-seq
MIRT1368448	hsa-miR-3646	CLIP-seq
MIRT1368449	hsa-miR-3647-3p	CLIP-seq
MIRT1368450	hsa-miR-3662	CLIP-seq
MIRT1368422	hsa-miR-3689d	CLIP-seq
MIRT1368425	hsa-miR-423-5p	CLIP-seq
MIRT1368428	hsa-miR-4525	CLIP-seq
MIRT1368431	hsa-miR-4665-5p	CLIP-seq
MIRT1368433	hsa-miR-4710	CLIP-seq
MIRT1368434	hsa-miR-4716-3p	CLIP-seq
MIRT1368436	hsa-miR-4723-5p	CLIP-seq
MIRT1368451	hsa-miR-4773	CLIP-seq
MIRT1368452	hsa-miR-495	CLIP-seq
MIRT1368444	hsa-miR-625	CLIP-seq
MIRT2109505	hsa-miR-4291	CLIP-seq
MIRT2109506	hsa-miR-4528	CLIP-seq
MIRT2109507	hsa-miR-4659a-3p	CLIP-seq
MIRT2109508	hsa-miR-4659b-3p	CLIP-seq
MIRT2109509	hsa-miR-885-5p	CLIP-seq
MIRT1368405	hsa-miR-1227	CLIP-seq
MIRT2332619	hsa-miR-1303	CLIP-seq
MIRT1368407	hsa-miR-1324	CLIP-seq
MIRT1368408	hsa-miR-148a	CLIP-seq
MIRT1368409	hsa-miR-148b	CLIP-seq
MIRT1368410	hsa-miR-152	CLIP-seq
MIRT1368412	hsa-miR-197	CLIP-seq
MIRT2332620	hsa-miR-4502	CLIP-seq
MIRT2332621	hsa-miR-455-3p	CLIP-seq
MIRT2332622	hsa-miR-4646-5p	CLIP-seq
MIRT2332623	hsa-miR-4757-5p	CLIP-seq
MIRT1368442	hsa-miR-5096	CLIP-seq
MIRT2332624	hsa-miR-877	CLIP-seq
MIRT2332625	hsa-miR-892a	CLIP-seq
MIRT2459927	hsa-miR-2392	CLIP-seq
MIRT2459928	hsa-miR-4533	CLIP-seq
MIRT2459929	hsa-miR-4747-5p	CLIP-seq
MIRT2627055	hsa-miR-106a	CLIP-seq
MIRT2627056	hsa-miR-106b	CLIP-seq
MIRT2627057	hsa-miR-1203	CLIP-seq
MIRT2627058	hsa-miR-1207-5p	CLIP-seq
MIRT2627059	hsa-miR-130a	CLIP-seq
MIRT2627060	hsa-miR-130b	CLIP-seq
MIRT2627061	hsa-miR-1343	CLIP-seq
MIRT2627062	hsa-miR-137	CLIP-seq
MIRT2627063	hsa-miR-149	CLIP-seq
MIRT2627064	hsa-miR-150	CLIP-seq
MIRT2627065	hsa-miR-153	CLIP-seq
MIRT2627066	hsa-miR-155	CLIP-seq
MIRT2627067	hsa-miR-17	CLIP-seq
MIRT1368411	hsa-miR-186	CLIP-seq
MIRT2627068	hsa-miR-188-5p	CLIP-seq
MIRT2627069	hsa-miR-19a	CLIP-seq
MIRT2627070	hsa-miR-19b	CLIP-seq
MIRT2627071	hsa-miR-2053	CLIP-seq
MIRT2627072	hsa-miR-20a	CLIP-seq
MIRT2627073	hsa-miR-20b	CLIP-seq
MIRT1368413	hsa-miR-218	CLIP-seq
MIRT2627074	hsa-miR-219-2-3p	CLIP-seq
MIRT2627075	hsa-miR-23a	CLIP-seq
MIRT2627076	hsa-miR-23b	CLIP-seq
MIRT2627077	hsa-miR-23c	CLIP-seq
MIRT2627078	hsa-miR-298	CLIP-seq
MIRT2627079	hsa-miR-301a	CLIP-seq
MIRT2627080	hsa-miR-301b	CLIP-seq
MIRT2627081	hsa-miR-3065-5p	CLIP-seq
MIRT2627082	hsa-miR-3074-3p	CLIP-seq
MIRT2627083	hsa-miR-3074-5p	CLIP-seq
MIRT2627084	hsa-miR-3138	CLIP-seq
MIRT1368415	hsa-miR-3140-3p	CLIP-seq
MIRT2627085	hsa-miR-3167	CLIP-seq
MIRT1368418	hsa-miR-3170	CLIP-seq
MIRT2627086	hsa-miR-338-3p	CLIP-seq
MIRT2627087	hsa-miR-3609	CLIP-seq
MIRT2627088	hsa-miR-3613-3p	CLIP-seq
MIRT2627089	hsa-miR-3614-3p	CLIP-seq
MIRT2627090	hsa-miR-361-5p	CLIP-seq
MIRT2627091	hsa-miR-3617	CLIP-seq
MIRT1368448	hsa-miR-3646	CLIP-seq
MIRT1368450	hsa-miR-3662	CLIP-seq
MIRT2627092	hsa-miR-3665	CLIP-seq
MIRT2627093	hsa-miR-3666	CLIP-seq
MIRT2627094	hsa-miR-3688-3p	CLIP-seq
MIRT2627095	hsa-miR-371b-5p	CLIP-seq
MIRT2627096	hsa-miR-374c	CLIP-seq
MIRT2627097	hsa-miR-3928	CLIP-seq
MIRT2627098	hsa-miR-3944-5p	CLIP-seq
MIRT2627099	hsa-miR-3977	CLIP-seq
MIRT2627100	hsa-miR-4265	CLIP-seq
MIRT1368426	hsa-miR-4279	CLIP-seq
MIRT2627101	hsa-miR-4295	CLIP-seq
MIRT2627102	hsa-miR-4296	CLIP-seq
MIRT2627103	hsa-miR-4310	CLIP-seq
MIRT2627104	hsa-miR-4317	CLIP-seq
MIRT2627105	hsa-miR-4322	CLIP-seq
MIRT2627106	hsa-miR-4417	CLIP-seq
MIRT1368427	hsa-miR-4426	CLIP-seq
MIRT2627107	hsa-miR-4437	CLIP-seq
MIRT2627108	hsa-miR-4459	CLIP-seq
MIRT2627109	hsa-miR-4477a	CLIP-seq
MIRT2627110	hsa-miR-448	CLIP-seq
MIRT2627111	hsa-miR-4494	CLIP-seq
MIRT2627112	hsa-miR-452	CLIP-seq
MIRT2627113	hsa-miR-4520a-3p	CLIP-seq
MIRT2627114	hsa-miR-4522	CLIP-seq
MIRT2627115	hsa-miR-454	CLIP-seq
MIRT2627116	hsa-miR-4640-5p	CLIP-seq
MIRT2627117	hsa-miR-4643	CLIP-seq
MIRT2627118	hsa-miR-4645-3p	CLIP-seq
MIRT1368429	hsa-miR-4647	CLIP-seq
MIRT2109507	hsa-miR-4659a-3p	CLIP-seq
MIRT2109508	hsa-miR-4659b-3p	CLIP-seq
MIRT1368430	hsa-miR-4662b	CLIP-seq
MIRT2627119	hsa-miR-4676-3p	CLIP-seq
MIRT2627120	hsa-miR-4693-5p	CLIP-seq
MIRT2627121	hsa-miR-4694-3p	CLIP-seq
MIRT2627122	hsa-miR-4698	CLIP-seq
MIRT2627123	hsa-miR-4704-3p	CLIP-seq
MIRT2627124	hsa-miR-4713-5p	CLIP-seq
MIRT2627125	hsa-miR-4717-3p	CLIP-seq
MIRT2627126	hsa-miR-4726-5p	CLIP-seq
MIRT2627127	hsa-miR-4736	CLIP-seq
MIRT2627128	hsa-miR-4755-3p	CLIP-seq
MIRT2627129	hsa-miR-4763-3p	CLIP-seq
MIRT2627130	hsa-miR-4777-5p	CLIP-seq
MIRT2627131	hsa-miR-4778-3p	CLIP-seq
MIRT1368439	hsa-miR-4790-3p	CLIP-seq
MIRT2627132	hsa-miR-4796-3p	CLIP-seq
MIRT1368452	hsa-miR-495	CLIP-seq
MIRT2627133	hsa-miR-499a-5p	CLIP-seq
MIRT2627134	hsa-miR-518d-5p	CLIP-seq
MIRT2627135	hsa-miR-519b-5p	CLIP-seq
MIRT2627136	hsa-miR-519c-5p	CLIP-seq
MIRT2627137	hsa-miR-519d	CLIP-seq
MIRT2627138	hsa-miR-520c-5p	CLIP-seq
MIRT2627139	hsa-miR-526a	CLIP-seq
MIRT2627140	hsa-miR-532-3p	CLIP-seq
MIRT2627141	hsa-miR-548ad	CLIP-seq
MIRT2627142	hsa-miR-548ah	CLIP-seq
MIRT2627143	hsa-miR-550b	CLIP-seq
MIRT2627144	hsa-miR-555	CLIP-seq
MIRT2627145	hsa-miR-569	CLIP-seq
MIRT2627146	hsa-miR-577	CLIP-seq
MIRT2627147	hsa-miR-595	CLIP-seq
MIRT2627148	hsa-miR-628-3p	CLIP-seq
MIRT2627149	hsa-miR-634	CLIP-seq
MIRT1368446	hsa-miR-636	CLIP-seq
MIRT2627150	hsa-miR-641	CLIP-seq
MIRT2627151	hsa-miR-642b	CLIP-seq
MIRT2627152	hsa-miR-655	CLIP-seq
MIRT2627153	hsa-miR-876-5p	CLIP-seq
MIRT2627154	hsa-miR-9	CLIP-seq
MIRT2627155	hsa-miR-93	CLIP-seq
MIRT2627075	hsa-miR-23a	CLIP-seq
MIRT2627076	hsa-miR-23b	CLIP-seq
MIRT2627077	hsa-miR-23c	CLIP-seq
MIRT2627098	hsa-miR-3944-5p	CLIP-seq
MIRT1368427	hsa-miR-4426	CLIP-seq
MIRT1368429	hsa-miR-4647	CLIP-seq
MIRT2109507	hsa-miR-4659a-3p	CLIP-seq
MIRT2109508	hsa-miR-4659b-3p	CLIP-seq
MIRT1368430	hsa-miR-4662b	CLIP-seq
MIRT2627131	hsa-miR-4778-3p	CLIP-seq
MIRT1368405	hsa-miR-1227	CLIP-seq
MIRT1368407	hsa-miR-1324	CLIP-seq
MIRT1368408	hsa-miR-148a	CLIP-seq
MIRT1368409	hsa-miR-148b	CLIP-seq
MIRT1368410	hsa-miR-152	CLIP-seq
MIRT2627066	hsa-miR-155	CLIP-seq
MIRT2627069	hsa-miR-19a	CLIP-seq
MIRT2627070	hsa-miR-19b	CLIP-seq
MIRT2627071	hsa-miR-2053	CLIP-seq
MIRT1368413	hsa-miR-218	CLIP-seq
MIRT1368415	hsa-miR-3140-3p	CLIP-seq
MIRT1368418	hsa-miR-3170	CLIP-seq
MIRT1368448	hsa-miR-3646	CLIP-seq
MIRT1368450	hsa-miR-3662	CLIP-seq
MIRT2627094	hsa-miR-3688-3p	CLIP-seq
MIRT2627112	hsa-miR-452	CLIP-seq
MIRT2627117	hsa-miR-4643	CLIP-seq
MIRT2627119	hsa-miR-4676-3p	CLIP-seq
MIRT2627120	hsa-miR-4693-5p	CLIP-seq
MIRT2627121	hsa-miR-4694-3p	CLIP-seq
MIRT2627125	hsa-miR-4717-3p	CLIP-seq
MIRT2627128	hsa-miR-4755-3p	CLIP-seq
MIRT1368439	hsa-miR-4790-3p	CLIP-seq
MIRT2627141	hsa-miR-548ad	CLIP-seq
MIRT2627143	hsa-miR-550b	CLIP-seq
MIRT2627145	hsa-miR-569	CLIP-seq
MIRT2691308	hsa-miR-576-3p	CLIP-seq
MIRT1368446	hsa-miR-636	CLIP-seq
MIRT2627151	hsa-miR-642b	CLIP-seq

Show/Hide all(85)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002026	Process	Regulation of the force of heart contraction	IC	19481548
GO:0002026	Process	Regulation of the force of heart contraction	ISS
GO:0002027	Process	Regulation of heart rate	ISS
GO:0005432	Function	Calcium:sodium antiporter activity	IBA
GO:0005432	Function	Calcium:sodium antiporter activity	IDA	1374913, 19481548
GO:0005432	Function	Calcium:sodium antiporter activity	IEA
GO:0005432	Function	Calcium:sodium antiporter activity	IMP	25589784
GO:0005432	Function	Calcium:sodium antiporter activity	TAS
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	16292983, 25589784, 31837246
GO:0005516	Function	Calmodulin binding	IDA	26421717
GO:0005516	Function	Calmodulin binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	1374913, 26421717
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	19095005
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006814	Process	Sodium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0006883	Process	Intracellular sodium ion homeostasis	IDA	1374913
GO:0006936	Process	Muscle contraction	TAS	1374913
GO:0007154	Process	Cell communication	IEA
GO:0008092	Function	Cytoskeletal protein binding	IDA	16292983
GO:0010468	Process	Regulation of gene expression	ISS
GO:0010649	Process	Regulation of cell communication by electrical coupling	TAS	17614935
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	TAS	23608603
GO:0010882	Process	Regulation of cardiac muscle contraction by calcium ion signaling	TAS	23224879
GO:0014069	Component	Postsynaptic density	ISS
GO:0014704	Component	Intercalated disc	ISS
GO:0014704	Component	Intercalated disc	TAS	17614935
GO:0014829	Process	Vascular associated smooth muscle contraction	ISS
GO:0015297	Function	Antiporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0030018	Component	Z disc	ISS
GO:0030315	Component	T-tubule	ISS
GO:0030315	Component	T-tubule	TAS	17614935
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	ISS
GO:0030501	Process	Positive regulation of bone mineralization	IMP	25589784
GO:0030506	Function	Ankyrin binding	IPI	17178715
GO:0030506	Function	Ankyrin binding	ISS
GO:0034614	Process	Cellular response to reactive oxygen species	IDA	19481548
GO:0035725	Process	Sodium ion transmembrane transport	IBA
GO:0035725	Process	Sodium ion transmembrane transport	IGI	25589784
GO:0035725	Process	Sodium ion transmembrane transport	IMP	25589784
GO:0035994	Process	Response to muscle stretch	IMP	15105296
GO:0036376	Process	Sodium ion export across plasma membrane	IDA	19481548
GO:0042383	Component	Sarcolemma	IBA
GO:0042383	Component	Sarcolemma	ISS
GO:0043025	Component	Neuronal cell body	ISS
GO:0043679	Component	Axon terminus	ISS
GO:0044325	Function	Transmembrane transporter binding	ISS
GO:0044557	Process	Relaxation of smooth muscle	ISS
GO:0045202	Component	Synapse	IDA	21382638
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051481	Process	Negative regulation of cytosolic calcium ion concentration	ISS
GO:0055013	Process	Cardiac muscle cell development	ISS
GO:0055074	Process	Calcium ion homeostasis	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0055119	Process	Relaxation of cardiac muscle	IC	19481548
GO:0055119	Process	Relaxation of cardiac muscle	TAS	23224879
GO:0060048	Process	Cardiac muscle contraction	TAS	23224879
GO:0060402	Process	Calcium ion transport into cytosol	ISS
GO:0070509	Process	Calcium ion import	IDA	1374913, 19481548
GO:0070588	Process	Calcium ion transmembrane transport	IGI	25589784
GO:0070588	Process	Calcium ion transmembrane transport	ISS
GO:0071313	Process	Cellular response to caffeine	ISS
GO:0071944	Component	Cell periphery	IDA	21321244
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	TAS	23608603
GO:0086064	Process	Cell communication by electrical coupling involved in cardiac conduction	ISS
GO:0097553	Process	Calcium ion transmembrane import into cytosol	TAS	19095005
GO:0098703	Process	Calcium ion import across plasma membrane	IBA
GO:0098719	Process	Sodium ion import across plasma membrane	IDA	1374913
GO:0098735	Process	Positive regulation of the force of heart contraction	IMP	15105296
GO:0098794	Component	Postsynapse	IBA
GO:1901660	Process	Calcium ion export	IDA	19481548
GO:1902532	Process	Negative regulation of intracellular signal transduction	ISS
GO:1903779	Process	Regulation of cardiac conduction	IEA
GO:1903779	Process	Regulation of cardiac conduction	TAS

MIM	HGNC	e!Ensembl
182305	11068	ENSG00000183023

Protein

UniProt ID

P32418

Protein name

Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)

Protein function

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, P

PDB

8JP0 , 8SGI , 8SGJ , 8SGT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01699	Na_Ca_ex	80 → 251	Sodium/calcium exchanger protein	Family
PF16494	Na_Ca_ex_C	254 → 390	C-terminal extension of sodium/calcium exchanger domain	Family
PF03160	Calx-beta	396 → 496	Calx-beta domain	Domain
PF03160	Calx-beta	527 → 627	Calx-beta domain	Domain
PF01699	Na_Ca_ex	799 → 964	Sodium/calcium exchanger protein	Family

Tissue specificity

TISSUE SPECIFICITY: Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165). {ECO:0000269|PubMed:1374913, ECO:0000269|P

Sequence

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPV
FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSLEAYCHIKGF

Sequence length

973

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cGMP-PKG signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Olfactory transduction Endocrine and other factor-regulated calcium reabsorption Protein digestion and absorption Mineral absorption Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma, Asthma (childhood onset)	N/A	N/A	GWAS
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Associate	28544176, 37074453
Alzheimer Disease	Associate	21382638
Basal Ganglia Diseases	Associate	15148385
Bipolar Disorder	Associate	27063557
Bone Diseases	Associate	36251145
Carcinogenesis	Associate	27588478
Carcinoma Non Small Cell Lung	Associate	34724864, 36042596
Carcinoma Pancreatic Ductal	Associate	37566113
Colorectal Neoplasms	Associate	34127021, 37438612
Crisponi syndrome	Associate	38255780
Diabetes Mellitus	Associate	28804970
Diabetes Mellitus Type 2	Stimulate	28804970
Drug Hypersensitivity	Associate	37966164
Endometrial Neoplasms	Associate	36231119
Esophageal Squamous Cell Carcinoma	Associate	27588478
Essential Hypertension	Associate	15785003
Familial Primary Pulmonary Hypertension	Associate	17192285
Glioblastoma	Associate	24641279
Heart Arrest	Stimulate	17192285
Heart Diseases	Associate	10898440
Heart Failure Diastolic	Associate	32330487
Hypertension	Associate	15785003, 19562039, 25168954
Intervertebral Disc Degeneration	Associate	38492610
Juvenile gout	Associate	39216982
Lung Diseases	Associate	17192285
Medulloblastoma	Associate	28683437
Mitral Valve Insufficiency	Associate	17347034
Mucocutaneous Lymph Node Syndrome	Associate	28753597
Multiple Myeloma	Associate	36251145
Multiple Sclerosis	Associate	15148385
Nasopharyngeal Carcinoma	Associate	37151882
Neoplasms	Associate	20861471, 28544176, 34127021, 37151882, 39731939
Neoplasms	Stimulate	27588478
Neoplasms	Inhibit	33869627, 34724864
Nerve Degeneration	Associate	15148385
Osteoarthritis	Associate	35894157
Ovarian Neoplasms	Associate	26584285
Overtraining Syndrome	Stimulate	27591218
Pain	Associate	33573686
Pancreatic Neoplasms	Associate	20861471
Pancreatitis	Associate	37566113
Parkinson Disease	Associate	32899900, 38255780
Prostatic Neoplasms	Inhibit	33869627
Pulmonary Disease Chronic Obstructive	Associate	34588774
Sciatica	Associate	33573686
Stomach Neoplasms	Associate	39731939
Thyroid Cancer Papillary	Associate	35599603
Uveal melanoma	Associate	37966164
Ventricular Dysfunction Left	Associate	17347034

SLC8A1 (solute carrier family 8 member A1)