Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6541
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC7A1
Synonyms (NCBI Gene) Gene synonyms aliases
ATRC1, CAT-1, ERR, HCAT1, REC1L
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
MIRT003105 hsa-miR-122-5p Luciferase reporter assay, Western blot 17179747
Transcription factors
Transcription factor Regulation Reference
NRIP1 Activation 17056252
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000064 Function L-ornithine transmembrane transporter activity IBA 21873635
GO:0005290 Function L-histidine transmembrane transporter activity IDA 11591158
GO:0005515 Function Protein binding IPI 25416956, 28514442, 30956113, 32296183
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA 28112518
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
104615 11057 ENSG00000139514
Protein
UniProt ID P30825
Protein name High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
Protein function High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 32 446 Amino acid permease Family
PF13906 AA_permease_C 558 608 C-terminus of AA_permease Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:1718082}.
Sequence
Sequence length 629
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MicroRNAs in cancer   Amino acid transport across the plasma membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 11401523
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 30176945, 33399102, 35839757
Colorectal Neoplasms Associate 23373973
Diabetes Gestational Stimulate 15272035, 26710791
Diabetes Gestational Associate 29155213
Epilepsy Associate 38366765
Heart Diseases Associate 23841815
Hypertension Associate 23841815
Inflammation Associate 26449889
Liver Neoplasms Associate 30176945
Neoplasm Metastasis Associate 23373973, 39844299