Gene Gene information from NCBI Gene database.
Entrez ID 65264
Gene name Ubiquitin conjugating enzyme E2 Z
Gene symbol UBE2Z
Synonyms (NCBI Gene)
HOYS7USE1
Chromosome 17
Chromosome location 17q21.32
Summary This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
miRNA miRNA information provided by mirtarbase database.
1103
miRTarBase ID miRNA Experiments Reference
MIRT019617 hsa-miR-340-5p Sequencing 20371350
MIRT028379 hsa-miR-32-5p Sequencing 20371350
MIRT051172 hsa-miR-16-5p CLASH 23622248
MIRT048167 hsa-miR-196a-5p CLASH 23622248
MIRT047613 hsa-miR-10a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 16189514, 24528925, 25416956, 32296183
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 17464193
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611362 25847 ENSG00000159202
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H832
Protein name Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)
Protein function Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed
PDB 5A4P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00179 UQ_con 103 250 Ubiquitin-conjugating enzyme Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly in placenta, pancreas, spleen and testis. {ECO:0000269|PubMed:17160626, ECO:0000269|PubMed:17597759}.
Sequence
MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGS
GLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMF
VVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPN
FYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNY
NECIRHETIR
VAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDP
FGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV
Sequence length 354
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ubiquitin mediated proteolysis   Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation