Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6522
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 4 member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC4A2
Synonyms (NCBI Gene) Gene synonyms aliases
AE2, BND3L, EPB3L1, HKB3, NBND3, OPTB9
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OPTB9
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q36.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary bil
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051300 hsa-miR-16-5p CLASH 23622248
MIRT049380 hsa-miR-92a-3p CLASH 23622248
MIRT042083 hsa-miR-484 CLASH 23622248
MIRT042083 hsa-miR-484 CLASH 23622248
MIRT042083 hsa-miR-484 CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
EGR1 Activation 22228178
EGR1 Unknown 23121767
SP1 Unknown 23121767
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005452 Function Inorganic anion exchanger activity IEA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005925 Component Focal adhesion HDA 21423176
GO:0006820 Process Anion transport TAS 3015590
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
109280 11028 ENSG00000164889
Protein
UniProt ID P04920
Protein name Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)
Protein function Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMe
PDB 8GV8 , 8GV9 , 8GVA , 8GVC , 8GVE , 8GVF , 8GVH , 8JNI , 8JNJ , 8ZLE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07565 Band_3_cyto 352 620 Band 3 cytoplasmic domain Domain
PF00955 HCO3_cotransp 675 1169 HCO3- transporter family Family
Tissue specificity TISSUE SPECIFICITY: [Isoform A]: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. {ECO:0000269|PubMed:10623603}.; TISSUE SPECIFICITY: [Isoform B1]: Expressed in the liver and kidney. {ECO:0000269|PubMed:10623603}.; TISSUE SPECIFICITY
Sequence
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE
EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT
IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ
EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR
IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW
GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV
ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA
VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
AINAFLDCSVVLPPSEVQGE
ELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL
LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL
SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS
FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS
KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK
PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH
LLLMPPKHHPDVTYVKKVRTLRMHLFTAL
QLLCLALLWAVMSTAASLAFPFILILTVPLR
MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Sequence length 1241
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
  Bicarbonate transporters
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Polycystic kidney disease Autosomal Recessive Polycystic Kidney Disease rs119103233, rs886041027, rs886041028, rs137852944, rs28937907, rs137852947, rs137852948, rs137852949, rs137852950, rs267607048, rs2147483647, rs199476094, rs1567154953, rs199476095, rs199476096
View all (740 more)
18988797
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29610475
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Renal Tubular Associate 31959358
Adenocarcinoma Associate 17760565
Autoimmune Diseases Associate 34944008
Carcinogenesis Associate 22228178
Cholelithiasis Associate 31538484
Cholestasis Associate 8985258
Colorectal Neoplasms Associate 22228178
Hypertension Associate 19562039
Liver Cirrhosis Biliary Associate 19491853, 22383162
Liver Cirrhosis Biliary Inhibit 22383162, 26991014, 8985258