Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	65110
Gene name	UPF3A regulator of nonsense mediated mRNA decay
Gene symbol	UPF3A
Synonyms (NCBI Gene)	HUPF3ARENT3AUPF3
Chromosome	13
Chromosome location	13q34
Summary	This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs wit

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miRTarBase ID	miRNA	Experiments	Reference
MIRT042322	hsa-miR-484	CLASH	23622248
MIRT042322	hsa-miR-484	CLASH	23622248
MIRT662870	hsa-miR-888-3p	HITS-CLIP	23824327
MIRT662869	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT662868	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT662867	hsa-miR-3660	HITS-CLIP	23824327
MIRT662866	hsa-miR-4526	HITS-CLIP	23824327
MIRT662865	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT662864	hsa-miR-4513	HITS-CLIP	23824327
MIRT662863	hsa-miR-6855-3p	HITS-CLIP	23824327
MIRT662862	hsa-miR-6857-3p	HITS-CLIP	23824327
MIRT662861	hsa-miR-1236-5p	HITS-CLIP	23824327
MIRT662860	hsa-miR-4268	HITS-CLIP	23824327
MIRT662859	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT662858	hsa-miR-3118	HITS-CLIP	23824327
MIRT662857	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT662856	hsa-miR-3136-5p	HITS-CLIP	23824327
MIRT662855	hsa-miR-4439	HITS-CLIP	23824327
MIRT662870	hsa-miR-888-3p	HITS-CLIP	23824327
MIRT662869	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT662868	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT662867	hsa-miR-3660	HITS-CLIP	23824327
MIRT662866	hsa-miR-4526	HITS-CLIP	23824327
MIRT662865	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT662864	hsa-miR-4513	HITS-CLIP	23824327
MIRT662863	hsa-miR-6855-3p	HITS-CLIP	23824327
MIRT662862	hsa-miR-6857-3p	HITS-CLIP	23824327
MIRT662861	hsa-miR-1236-5p	HITS-CLIP	23824327
MIRT662860	hsa-miR-4268	HITS-CLIP	23824327
MIRT662859	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT662858	hsa-miR-3118	HITS-CLIP	23824327
MIRT662857	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT662856	hsa-miR-3136-5p	HITS-CLIP	23824327
MIRT662855	hsa-miR-4439	HITS-CLIP	23824327
MIRT1476191	hsa-miR-299-5p	CLIP-seq
MIRT1476192	hsa-miR-520d-5p	CLIP-seq
MIRT1476193	hsa-miR-524-5p	CLIP-seq
MIRT1476194	hsa-miR-1229	CLIP-seq
MIRT1476195	hsa-miR-24	CLIP-seq
MIRT1476196	hsa-miR-3177-3p	CLIP-seq
MIRT1476197	hsa-miR-3192	CLIP-seq
MIRT1476198	hsa-miR-342-3p	CLIP-seq
MIRT1476199	hsa-miR-3681	CLIP-seq
MIRT1476200	hsa-miR-3691-5p	CLIP-seq
MIRT1476201	hsa-miR-4257	CLIP-seq
MIRT1476202	hsa-miR-4284	CLIP-seq
MIRT1476203	hsa-miR-4314	CLIP-seq
MIRT1476204	hsa-miR-4523	CLIP-seq
MIRT1476205	hsa-miR-4646-5p	CLIP-seq
MIRT1476206	hsa-miR-4717-5p	CLIP-seq
MIRT1476207	hsa-miR-4764-5p	CLIP-seq
MIRT1476208	hsa-miR-4796-3p	CLIP-seq
MIRT1476192	hsa-miR-520d-5p	CLIP-seq
MIRT1476209	hsa-miR-520g	CLIP-seq
MIRT1476210	hsa-miR-520h	CLIP-seq
MIRT1476193	hsa-miR-524-5p	CLIP-seq
MIRT1476211	hsa-miR-938	CLIP-seq
MIRT2143483	hsa-miR-1825	CLIP-seq
MIRT2143484	hsa-miR-188-5p	CLIP-seq
MIRT2143485	hsa-miR-198	CLIP-seq
MIRT2143486	hsa-miR-199a-5p	CLIP-seq
MIRT2143487	hsa-miR-199b-5p	CLIP-seq
MIRT2143488	hsa-miR-2052	CLIP-seq
MIRT2143489	hsa-miR-3620	CLIP-seq
MIRT2143490	hsa-miR-3667-3p	CLIP-seq
MIRT2143491	hsa-miR-3676	CLIP-seq
MIRT2143492	hsa-miR-4279	CLIP-seq
MIRT2143493	hsa-miR-4282	CLIP-seq
MIRT2143494	hsa-miR-4520a-5p	CLIP-seq
MIRT2143495	hsa-miR-4520b-5p	CLIP-seq
MIRT2143496	hsa-miR-4652-3p	CLIP-seq
MIRT2143497	hsa-miR-4704-3p	CLIP-seq
MIRT2143498	hsa-miR-4790-3p	CLIP-seq
MIRT1476192	hsa-miR-520d-5p	CLIP-seq
MIRT1476193	hsa-miR-524-5p	CLIP-seq
MIRT2143499	hsa-miR-598	CLIP-seq
MIRT2363682	hsa-miR-1323	CLIP-seq
MIRT1476195	hsa-miR-24	CLIP-seq
MIRT2363683	hsa-miR-3688-5p	CLIP-seq
MIRT1476201	hsa-miR-4257	CLIP-seq
MIRT1476202	hsa-miR-4284	CLIP-seq
MIRT2363684	hsa-miR-4470	CLIP-seq
MIRT1476204	hsa-miR-4523	CLIP-seq
MIRT2363685	hsa-miR-4697-3p	CLIP-seq
MIRT1476206	hsa-miR-4717-5p	CLIP-seq
MIRT2363686	hsa-miR-4742-3p	CLIP-seq
MIRT2363687	hsa-miR-548a-3p	CLIP-seq
MIRT2363688	hsa-miR-548e	CLIP-seq
MIRT2363689	hsa-miR-548f	CLIP-seq
MIRT2363690	hsa-miR-548g	CLIP-seq
MIRT2363691	hsa-miR-548o	CLIP-seq
MIRT2657321	hsa-miR-106a	CLIP-seq
MIRT2657322	hsa-miR-106b	CLIP-seq
MIRT1476194	hsa-miR-1229	CLIP-seq
MIRT2657323	hsa-miR-1267	CLIP-seq
MIRT2657324	hsa-miR-127-5p	CLIP-seq
MIRT2363682	hsa-miR-1323	CLIP-seq
MIRT2657325	hsa-miR-1537	CLIP-seq
MIRT2657326	hsa-miR-17	CLIP-seq
MIRT2143483	hsa-miR-1825	CLIP-seq
MIRT2657327	hsa-miR-194	CLIP-seq
MIRT2143485	hsa-miR-198	CLIP-seq
MIRT2143486	hsa-miR-199a-5p	CLIP-seq
MIRT2143487	hsa-miR-199b-5p	CLIP-seq
MIRT2143488	hsa-miR-2052	CLIP-seq
MIRT2657328	hsa-miR-20a	CLIP-seq
MIRT2657329	hsa-miR-20b	CLIP-seq
MIRT1476195	hsa-miR-24	CLIP-seq
MIRT2657330	hsa-miR-302a	CLIP-seq
MIRT2657331	hsa-miR-302b	CLIP-seq
MIRT2657332	hsa-miR-302c	CLIP-seq
MIRT2657333	hsa-miR-302d	CLIP-seq
MIRT2657334	hsa-miR-302e	CLIP-seq
MIRT2657335	hsa-miR-3065-5p	CLIP-seq
MIRT2657336	hsa-miR-3147	CLIP-seq
MIRT2657337	hsa-miR-323b-3p	CLIP-seq
MIRT1476198	hsa-miR-342-3p	CLIP-seq
MIRT2657338	hsa-miR-3622b-5p	CLIP-seq
MIRT1476199	hsa-miR-3681	CLIP-seq
MIRT2657339	hsa-miR-3685	CLIP-seq
MIRT2363683	hsa-miR-3688-5p	CLIP-seq
MIRT1476200	hsa-miR-3691-5p	CLIP-seq
MIRT2657340	hsa-miR-372	CLIP-seq
MIRT2657341	hsa-miR-373	CLIP-seq
MIRT2657342	hsa-miR-3923	CLIP-seq
MIRT2657343	hsa-miR-3940-5p	CLIP-seq
MIRT2657344	hsa-miR-3941	CLIP-seq
MIRT2657345	hsa-miR-3977	CLIP-seq
MIRT2657346	hsa-miR-412	CLIP-seq
MIRT2657347	hsa-miR-4253	CLIP-seq
MIRT1476201	hsa-miR-4257	CLIP-seq
MIRT1476202	hsa-miR-4284	CLIP-seq
MIRT2657348	hsa-miR-4425	CLIP-seq
MIRT2657349	hsa-miR-4436a	CLIP-seq
MIRT2363684	hsa-miR-4470	CLIP-seq
MIRT2657350	hsa-miR-4507	CLIP-seq
MIRT2657351	hsa-miR-451	CLIP-seq
MIRT2657352	hsa-miR-4511	CLIP-seq
MIRT1476204	hsa-miR-4523	CLIP-seq
MIRT2657353	hsa-miR-4637	CLIP-seq
MIRT2657354	hsa-miR-4643	CLIP-seq
MIRT2143496	hsa-miR-4652-3p	CLIP-seq
MIRT2657355	hsa-miR-4659a-3p	CLIP-seq
MIRT2657356	hsa-miR-4659b-3p	CLIP-seq
MIRT2657357	hsa-miR-466	CLIP-seq
MIRT2657358	hsa-miR-4668-3p	CLIP-seq
MIRT2657359	hsa-miR-4672	CLIP-seq
MIRT2657360	hsa-miR-4680-5p	CLIP-seq
MIRT2363685	hsa-miR-4697-3p	CLIP-seq
MIRT2657361	hsa-miR-4714-5p	CLIP-seq
MIRT1476206	hsa-miR-4717-5p	CLIP-seq
MIRT2657362	hsa-miR-4719	CLIP-seq
MIRT2657363	hsa-miR-4759	CLIP-seq
MIRT1476207	hsa-miR-4764-5p	CLIP-seq
MIRT2657364	hsa-miR-4766-5p	CLIP-seq
MIRT2657365	hsa-miR-4767	CLIP-seq
MIRT2657366	hsa-miR-4789-3p	CLIP-seq
MIRT2143498	hsa-miR-4790-3p	CLIP-seq
MIRT1476208	hsa-miR-4796-3p	CLIP-seq
MIRT2657367	hsa-miR-488	CLIP-seq
MIRT2657368	hsa-miR-495	CLIP-seq
MIRT2657369	hsa-miR-519d	CLIP-seq
MIRT2657370	hsa-miR-520a-3p	CLIP-seq
MIRT2657371	hsa-miR-520b	CLIP-seq
MIRT2657372	hsa-miR-520c-3p	CLIP-seq
MIRT2657373	hsa-miR-520d-3p	CLIP-seq
MIRT1476192	hsa-miR-520d-5p	CLIP-seq
MIRT2657374	hsa-miR-520e	CLIP-seq
MIRT2657375	hsa-miR-520f	CLIP-seq
MIRT1476209	hsa-miR-520g	CLIP-seq
MIRT1476210	hsa-miR-520h	CLIP-seq
MIRT1476193	hsa-miR-524-5p	CLIP-seq
MIRT2363687	hsa-miR-548a-3p	CLIP-seq
MIRT2363688	hsa-miR-548e	CLIP-seq
MIRT2363689	hsa-miR-548f	CLIP-seq
MIRT2363690	hsa-miR-548g	CLIP-seq
MIRT2363691	hsa-miR-548o	CLIP-seq
MIRT2657376	hsa-miR-606	CLIP-seq
MIRT2657377	hsa-miR-629	CLIP-seq
MIRT2657378	hsa-miR-640	CLIP-seq
MIRT2657379	hsa-miR-648	CLIP-seq
MIRT2657380	hsa-miR-653	CLIP-seq
MIRT2657381	hsa-miR-93	CLIP-seq
MIRT2657321	hsa-miR-106a	CLIP-seq
MIRT2657322	hsa-miR-106b	CLIP-seq
MIRT1476194	hsa-miR-1229	CLIP-seq
MIRT2657323	hsa-miR-1267	CLIP-seq
MIRT2657324	hsa-miR-127-5p	CLIP-seq
MIRT2363682	hsa-miR-1323	CLIP-seq
MIRT2657325	hsa-miR-1537	CLIP-seq
MIRT2657326	hsa-miR-17	CLIP-seq
MIRT2143483	hsa-miR-1825	CLIP-seq
MIRT2657327	hsa-miR-194	CLIP-seq
MIRT2143485	hsa-miR-198	CLIP-seq
MIRT2143486	hsa-miR-199a-5p	CLIP-seq
MIRT2143487	hsa-miR-199b-5p	CLIP-seq
MIRT2143488	hsa-miR-2052	CLIP-seq
MIRT2657328	hsa-miR-20a	CLIP-seq
MIRT2657329	hsa-miR-20b	CLIP-seq
MIRT1476195	hsa-miR-24	CLIP-seq
MIRT2657330	hsa-miR-302a	CLIP-seq
MIRT2657331	hsa-miR-302b	CLIP-seq
MIRT2657332	hsa-miR-302c	CLIP-seq
MIRT2657333	hsa-miR-302d	CLIP-seq
MIRT2657334	hsa-miR-302e	CLIP-seq
MIRT2657335	hsa-miR-3065-5p	CLIP-seq
MIRT2657336	hsa-miR-3147	CLIP-seq
MIRT2657337	hsa-miR-323b-3p	CLIP-seq
MIRT1476198	hsa-miR-342-3p	CLIP-seq
MIRT2657338	hsa-miR-3622b-5p	CLIP-seq
MIRT1476199	hsa-miR-3681	CLIP-seq
MIRT2657339	hsa-miR-3685	CLIP-seq
MIRT2363683	hsa-miR-3688-5p	CLIP-seq
MIRT1476200	hsa-miR-3691-5p	CLIP-seq
MIRT2657340	hsa-miR-372	CLIP-seq
MIRT2657341	hsa-miR-373	CLIP-seq
MIRT2657342	hsa-miR-3923	CLIP-seq
MIRT2657343	hsa-miR-3940-5p	CLIP-seq
MIRT2657344	hsa-miR-3941	CLIP-seq
MIRT2657345	hsa-miR-3977	CLIP-seq
MIRT2657346	hsa-miR-412	CLIP-seq
MIRT2657347	hsa-miR-4253	CLIP-seq
MIRT1476201	hsa-miR-4257	CLIP-seq
MIRT1476202	hsa-miR-4284	CLIP-seq
MIRT2657348	hsa-miR-4425	CLIP-seq
MIRT2657349	hsa-miR-4436a	CLIP-seq
MIRT2363684	hsa-miR-4470	CLIP-seq
MIRT2657350	hsa-miR-4507	CLIP-seq
MIRT2657351	hsa-miR-451	CLIP-seq
MIRT2657352	hsa-miR-4511	CLIP-seq
MIRT1476204	hsa-miR-4523	CLIP-seq
MIRT2657353	hsa-miR-4637	CLIP-seq
MIRT2657354	hsa-miR-4643	CLIP-seq
MIRT2143496	hsa-miR-4652-3p	CLIP-seq
MIRT2657355	hsa-miR-4659a-3p	CLIP-seq
MIRT2657356	hsa-miR-4659b-3p	CLIP-seq
MIRT2657357	hsa-miR-466	CLIP-seq
MIRT2657359	hsa-miR-4672	CLIP-seq
MIRT2657360	hsa-miR-4680-5p	CLIP-seq
MIRT2363685	hsa-miR-4697-3p	CLIP-seq
MIRT2657361	hsa-miR-4714-5p	CLIP-seq
MIRT1476206	hsa-miR-4717-5p	CLIP-seq
MIRT2657362	hsa-miR-4719	CLIP-seq
MIRT2657363	hsa-miR-4759	CLIP-seq
MIRT1476207	hsa-miR-4764-5p	CLIP-seq
MIRT2657364	hsa-miR-4766-5p	CLIP-seq
MIRT2657365	hsa-miR-4767	CLIP-seq
MIRT2657366	hsa-miR-4789-3p	CLIP-seq
MIRT1476208	hsa-miR-4796-3p	CLIP-seq
MIRT2657367	hsa-miR-488	CLIP-seq
MIRT2657368	hsa-miR-495	CLIP-seq
MIRT2657369	hsa-miR-519d	CLIP-seq
MIRT2657370	hsa-miR-520a-3p	CLIP-seq
MIRT2657371	hsa-miR-520b	CLIP-seq
MIRT2657372	hsa-miR-520c-3p	CLIP-seq
MIRT2657373	hsa-miR-520d-3p	CLIP-seq
MIRT1476192	hsa-miR-520d-5p	CLIP-seq
MIRT2657374	hsa-miR-520e	CLIP-seq
MIRT2657375	hsa-miR-520f	CLIP-seq
MIRT1476209	hsa-miR-520g	CLIP-seq
MIRT1476210	hsa-miR-520h	CLIP-seq
MIRT1476193	hsa-miR-524-5p	CLIP-seq
MIRT2363687	hsa-miR-548a-3p	CLIP-seq
MIRT2363688	hsa-miR-548e	CLIP-seq
MIRT2363689	hsa-miR-548f	CLIP-seq
MIRT2363690	hsa-miR-548g	CLIP-seq
MIRT2363691	hsa-miR-548o	CLIP-seq
MIRT2657376	hsa-miR-606	CLIP-seq
MIRT2657377	hsa-miR-629	CLIP-seq
MIRT2657378	hsa-miR-640	CLIP-seq
MIRT2657379	hsa-miR-648	CLIP-seq
MIRT2657380	hsa-miR-653	CLIP-seq
MIRT2657381	hsa-miR-93	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA	16601204
GO:0001701	Process	In utero embryonic development	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IDA	11163187
GO:0005515	Function	Protein binding	IPI	11163187, 11546873, 11546874, 12417715, 14636577, 19503078, 20479275, 25220460
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	11163187
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	11163187
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0007283	Process	Spermatogenesis	IEA
GO:0035145	Component	Exon-exon junction complex	IDA	16601204
GO:0035145	Component	Exon-exon junction complex	IEA
GO:0035145	Component	Exon-exon junction complex	TAS	11546873
GO:0042162	Function	Telomeric DNA binding	IBA
GO:0042162	Function	Telomeric DNA binding	IDA	17916692
GO:0043005	Component	Neuron projection	IEA
GO:0045727	Process	Positive regulation of translation	IBA
GO:0045727	Process	Positive regulation of translation	IDA	16601204
GO:0045727	Process	Positive regulation of translation	IEA
GO:0051028	Process	MRNA transport	IEA
GO:1905746	Process	Positive regulation of mRNA cis splicing, via spliceosome	IEA
GO:2000623	Process	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA

MIM	HGNC	e!Ensembl
605530	20332	ENSG00000169062

Q9H1J1

Protein name

Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

Protein function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of

PDB

2L08 , 7QG6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03467	Smg4_UPF3	65 → 226	Smg-4/UPF3 family	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}.

Sequence

MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR
EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN
PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF
LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR
RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE
RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR
YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC
DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE

Sequence length

476

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

UPF3A (UPF3A regulator of nonsense mediated mRNA decay)