Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	6504
Gene name	Signaling lymphocytic activation molecule family member 1
Gene symbol	SLAMF1
Synonyms (NCBI Gene)	CD150CDw150IPO3SLAM
Chromosome	1
Chromosome location	1q23.3

Show/Hide all (58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030083	hsa-miR-26b-5p	Microarray	19088304
MIRT641305	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT641304	hsa-miR-3921	HITS-CLIP	23824327
MIRT641303	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT641302	hsa-miR-4682	HITS-CLIP	23824327
MIRT641301	hsa-miR-496	HITS-CLIP	23824327
MIRT641300	hsa-miR-4448	HITS-CLIP	23824327
MIRT641305	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT641304	hsa-miR-3921	HITS-CLIP	23824327
MIRT641303	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT641302	hsa-miR-4682	HITS-CLIP	23824327
MIRT641301	hsa-miR-496	HITS-CLIP	23824327
MIRT641300	hsa-miR-4448	HITS-CLIP	23824327
MIRT641299	hsa-miR-194-5p	HITS-CLIP	23824327
MIRT641298	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT641297	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT641296	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT641295	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT641294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641293	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT641292	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT641291	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT641290	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641289	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT641288	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT641287	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT641305	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT641304	hsa-miR-3921	HITS-CLIP	23824327
MIRT641303	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT641302	hsa-miR-4682	HITS-CLIP	23824327
MIRT641301	hsa-miR-496	HITS-CLIP	23824327
MIRT641300	hsa-miR-4448	HITS-CLIP	23824327
MIRT641305	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT641304	hsa-miR-3921	HITS-CLIP	23824327
MIRT641303	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT641302	hsa-miR-4682	HITS-CLIP	23824327
MIRT641301	hsa-miR-496	HITS-CLIP	23824327
MIRT641300	hsa-miR-4448	HITS-CLIP	23824327
MIRT641299	hsa-miR-194-5p	HITS-CLIP	23824327
MIRT641298	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT641297	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT641296	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT641295	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT641294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641293	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT641292	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT641291	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT641290	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641289	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT641288	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT641287	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT1351471	hsa-miR-1825	CLIP-seq
MIRT1351472	hsa-miR-199a-5p	CLIP-seq
MIRT1351473	hsa-miR-199b-5p	CLIP-seq
MIRT1351474	hsa-miR-323-5p	CLIP-seq
MIRT1351475	hsa-miR-4302	CLIP-seq
MIRT1351476	hsa-miR-4456	CLIP-seq
MIRT1351477	hsa-miR-876-3p	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IDA	10972291
GO:0001618	Function	Virus receptor activity	IEA
GO:0001779	Process	Natural killer cell differentiation	IEA
GO:0001787	Process	Natural killer cell proliferation	IEA
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0002232	Process	Leukocyte chemotaxis involved in inflammatory response	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002277	Process	Myeloid dendritic cell activation involved in immune response	IDA	16317102
GO:0002376	Process	Immune system process	IEA
GO:0002725	Process	Negative regulation of T cell cytokine production	IEA
GO:0003823	Function	Antigen binding	TAS	7617038
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	7617038
GO:0005515	Function	Protein binding	IPI	9774102, 10549287, 11389028, 11477068, 11806999, 11823424, 12225753, 12545174, 14674764, 15841490, 16983070, 20231852, 22048310
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IDA	10972291
GO:0005886	Component	Plasma membrane	IEA
GO:0006909	Process	Phagocytosis	IEA
GO:0006955	Process	Immune response	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	7617038
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010759	Process	Positive regulation of macrophage chemotaxis	IEA
GO:0016020	Component	Membrane	IEA
GO:0031338	Process	Regulation of vesicle fusion	IEA
GO:0032689	Process	Negative regulation of type II interferon production	IEA
GO:0032695	Process	Negative regulation of interleukin-12 production	IDA	16317102
GO:0032715	Process	Negative regulation of interleukin-6 production	IDA	16317102
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	16317102
GO:0032729	Process	Positive regulation of type II interferon production	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042104	Process	Positive regulation of activated T cell proliferation	IEA
GO:0042169	Function	SH2 domain binding	IDA	9774102
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	21217702, 21982860
GO:0045087	Process	Innate immune response	IEA
GO:0045321	Process	Leukocyte activation	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IDA	20231852
GO:0046649	Process	Lymphocyte activation	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	20231852
GO:2000349	Process	Negative regulation of CD40 signaling pathway	IDA	16317102
GO:2000510	Process	Positive regulation of dendritic cell chemotaxis	IEA
GO:2000556	Process	Positive regulation of T-helper 1 cell cytokine production	IEA

MIM	HGNC	e!Ensembl
603492	10903	ENSG00000117090

Q13291

Protein name

Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)

Protein function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and

PDB

1D4T , 1D4W , 1I3Z , 1KA6 , 1KA7 , 1M27

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06214	SLAM	1 → 125	Signaling lymphocytic activation molecule (SLAM) protein	Family

Tissue specificity

TISSUE SPECIFICITY: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1

Sequence

MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYERINKSMNKSI
HIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLM
TLEKNVSVQRFCLQLRLYEQVSTPEIKVLNKTQENGTCTLILGCTVEKGDHVAYSWSEKA
GTHPLNPANSSHLLSLTLGPQHADNIYICTVSNPISNNSQTFSPWPGCRTDPSETKPWAV
YAGLLGGVIMILIMVVILQLRRRGKTNHYQTTVEKKSLTIYAQVQKPGPLQKKLDSFPAQ
DPCTTIYVAATEPVPESVQETNSITVYASVTLPES

Sequence length

335

Interactions

View interactions

	KEGG
	Virion - Ebolavirus, Lyssavirus and Morbillivirus Measles

SLAMF1 (signaling lymphocytic activation molecule family member 1)