Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64946
Gene name	Centromere protein H
Gene symbol	CENPH
Synonyms (NCBI Gene)	-
Chromosome	5
Chromosome location	5q13.2
Summary	Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interpha

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miRTarBase ID	miRNA	Experiments	Reference
MIRT714732	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT714731	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT714730	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT714729	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714728	hsa-miR-8063	HITS-CLIP	19536157
MIRT714727	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT714726	hsa-miR-4470	HITS-CLIP	19536157
MIRT714725	hsa-miR-3688-5p	HITS-CLIP	19536157
MIRT714732	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT714731	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT714730	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT714729	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714728	hsa-miR-8063	HITS-CLIP	19536157
MIRT714727	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT714726	hsa-miR-4470	HITS-CLIP	19536157
MIRT714725	hsa-miR-3688-5p	HITS-CLIP	19536157
MIRT884911	hsa-miR-105	CLIP-seq
MIRT884912	hsa-miR-1246	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT884916	hsa-miR-219-1-3p	CLIP-seq
MIRT884917	hsa-miR-3065-5p	CLIP-seq
MIRT884918	hsa-miR-3138	CLIP-seq
MIRT884919	hsa-miR-3140-3p	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT884921	hsa-miR-3201	CLIP-seq
MIRT884922	hsa-miR-3689a-3p	CLIP-seq
MIRT884923	hsa-miR-3689c	CLIP-seq
MIRT884924	hsa-miR-371-5p	CLIP-seq
MIRT884925	hsa-miR-371b-5p	CLIP-seq
MIRT884926	hsa-miR-378g	CLIP-seq
MIRT884927	hsa-miR-3925-3p	CLIP-seq
MIRT884928	hsa-miR-3929	CLIP-seq
MIRT884929	hsa-miR-4252	CLIP-seq
MIRT884930	hsa-miR-4263	CLIP-seq
MIRT884931	hsa-miR-4282	CLIP-seq
MIRT884932	hsa-miR-4290	CLIP-seq
MIRT884933	hsa-miR-4419b	CLIP-seq
MIRT884934	hsa-miR-4478	CLIP-seq
MIRT884935	hsa-miR-4486	CLIP-seq
MIRT884936	hsa-miR-4520a-3p	CLIP-seq
MIRT884937	hsa-miR-4537	CLIP-seq
MIRT884938	hsa-miR-4649-3p	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884940	hsa-miR-4728-5p	CLIP-seq
MIRT884941	hsa-miR-4791	CLIP-seq
MIRT884942	hsa-miR-4799-5p	CLIP-seq
MIRT884943	hsa-miR-485-5p	CLIP-seq
MIRT884944	hsa-miR-576-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884946	hsa-miR-622	CLIP-seq
MIRT884947	hsa-miR-890	CLIP-seq
MIRT884927	hsa-miR-3925-3p	CLIP-seq
MIRT884932	hsa-miR-4290	CLIP-seq
MIRT884946	hsa-miR-622	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT2198840	hsa-miR-2467-3p	CLIP-seq
MIRT2198841	hsa-miR-3607-3p	CLIP-seq
MIRT2198842	hsa-miR-3612	CLIP-seq
MIRT2198843	hsa-miR-3686	CLIP-seq
MIRT2198844	hsa-miR-4257	CLIP-seq
MIRT2198845	hsa-miR-4433	CLIP-seq
MIRT2198846	hsa-miR-500a	CLIP-seq
MIRT2198847	hsa-miR-650	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT2198840	hsa-miR-2467-3p	CLIP-seq
MIRT2198841	hsa-miR-3607-3p	CLIP-seq
MIRT2198842	hsa-miR-3612	CLIP-seq
MIRT2198843	hsa-miR-3686	CLIP-seq
MIRT2198844	hsa-miR-4257	CLIP-seq
MIRT884937	hsa-miR-4537	CLIP-seq
MIRT2385936	hsa-miR-4798-5p	CLIP-seq
MIRT2198846	hsa-miR-500a	CLIP-seq
MIRT2198847	hsa-miR-650	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2501644	hsa-miR-3622b-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2501644	hsa-miR-3622b-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
SP1	Activation	22682030
SP3	Activation	22682030

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IBA
GO:0000776	Component	Kinetochore	IDA	11092768
GO:0000776	Component	Kinetochore	IEA
GO:0000776	Component	Kinetochore	IMP	20212317
GO:0000776	Component	Kinetochore	NAS	11092768
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005515	Function	Protein binding	IPI	11092768, 15713649, 24981860, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11092768
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007052	Process	Mitotic spindle organization	IBA
GO:0007059	Process	Chromosome segregation	IBA
GO:0007059	Process	Chromosome segregation	NAS	36085283
GO:0043515	Function	Kinetochore binding	IBA
GO:0043515	Function	Kinetochore binding	IDA	11092768
GO:0043515	Function	Kinetochore binding	IEA
GO:0051382	Process	Kinetochore assembly	IEA
GO:0051383	Process	Kinetochore organization	TAS	11092768

MIM	HGNC	e!Ensembl
605607	17268	ENSG00000153044

Q9H3R5

Protein name

Centromere protein H (CENP-H) (Interphase centromere complex protein 35)

Protein function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal)

PDB

7PB4 , 7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05837	CENP-H	126 → 239	Centromere protein H (CENP-H)	Domain

Sequence

MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM

Sequence length

247

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Recurrent spontaneous abortion	Uncertain significance	rs1748193764	RCV001250899

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	18700042
Adenocarcinoma of Lung	Associate	31731374
Allan Herndon Dudley syndrome	Associate	18700042
Breast Neoplasms	Associate	21880184
Carcinogenesis	Associate	19500341
Carcinoma Non Small Cell Lung	Associate	19170237
Colorectal Neoplasms	Associate	30658502, 37328854
Esophageal Neoplasms	Associate	18700042
Lung Neoplasms	Stimulate	19170237
Nasopharyngeal Carcinoma	Associate	22682030
Neoplasms	Associate	18700042, 19500341, 22631655, 22682030
Squamous Cell Carcinoma of Head and Neck	Associate	22631655
Tongue Neoplasms	Associate	19500341

CENPH (centromere protein H)