Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64946
Gene name Gene Name - the full gene name approved by the HGNC.	Centromere protein H
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CENPH
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interpha

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miRTarBase ID	miRNA	Experiments	Reference
MIRT714732	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT714731	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT714730	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT714729	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714728	hsa-miR-8063	HITS-CLIP	19536157
MIRT714727	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT714726	hsa-miR-4470	HITS-CLIP	19536157
MIRT714725	hsa-miR-3688-5p	HITS-CLIP	19536157
MIRT714732	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT714731	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT714730	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT714729	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714728	hsa-miR-8063	HITS-CLIP	19536157
MIRT714727	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT714726	hsa-miR-4470	HITS-CLIP	19536157
MIRT714725	hsa-miR-3688-5p	HITS-CLIP	19536157
MIRT884911	hsa-miR-105	CLIP-seq
MIRT884912	hsa-miR-1246	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT884916	hsa-miR-219-1-3p	CLIP-seq
MIRT884917	hsa-miR-3065-5p	CLIP-seq
MIRT884918	hsa-miR-3138	CLIP-seq
MIRT884919	hsa-miR-3140-3p	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT884921	hsa-miR-3201	CLIP-seq
MIRT884922	hsa-miR-3689a-3p	CLIP-seq
MIRT884923	hsa-miR-3689c	CLIP-seq
MIRT884924	hsa-miR-371-5p	CLIP-seq
MIRT884925	hsa-miR-371b-5p	CLIP-seq
MIRT884926	hsa-miR-378g	CLIP-seq
MIRT884927	hsa-miR-3925-3p	CLIP-seq
MIRT884928	hsa-miR-3929	CLIP-seq
MIRT884929	hsa-miR-4252	CLIP-seq
MIRT884930	hsa-miR-4263	CLIP-seq
MIRT884931	hsa-miR-4282	CLIP-seq
MIRT884932	hsa-miR-4290	CLIP-seq
MIRT884933	hsa-miR-4419b	CLIP-seq
MIRT884934	hsa-miR-4478	CLIP-seq
MIRT884935	hsa-miR-4486	CLIP-seq
MIRT884936	hsa-miR-4520a-3p	CLIP-seq
MIRT884937	hsa-miR-4537	CLIP-seq
MIRT884938	hsa-miR-4649-3p	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884940	hsa-miR-4728-5p	CLIP-seq
MIRT884941	hsa-miR-4791	CLIP-seq
MIRT884942	hsa-miR-4799-5p	CLIP-seq
MIRT884943	hsa-miR-485-5p	CLIP-seq
MIRT884944	hsa-miR-576-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884946	hsa-miR-622	CLIP-seq
MIRT884947	hsa-miR-890	CLIP-seq
MIRT884927	hsa-miR-3925-3p	CLIP-seq
MIRT884932	hsa-miR-4290	CLIP-seq
MIRT884946	hsa-miR-622	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT2198840	hsa-miR-2467-3p	CLIP-seq
MIRT2198841	hsa-miR-3607-3p	CLIP-seq
MIRT2198842	hsa-miR-3612	CLIP-seq
MIRT2198843	hsa-miR-3686	CLIP-seq
MIRT2198844	hsa-miR-4257	CLIP-seq
MIRT2198845	hsa-miR-4433	CLIP-seq
MIRT2198846	hsa-miR-500a	CLIP-seq
MIRT2198847	hsa-miR-650	CLIP-seq
MIRT884913	hsa-miR-1273e	CLIP-seq
MIRT884915	hsa-miR-1827	CLIP-seq
MIRT2198840	hsa-miR-2467-3p	CLIP-seq
MIRT2198841	hsa-miR-3607-3p	CLIP-seq
MIRT2198842	hsa-miR-3612	CLIP-seq
MIRT2198843	hsa-miR-3686	CLIP-seq
MIRT2198844	hsa-miR-4257	CLIP-seq
MIRT884937	hsa-miR-4537	CLIP-seq
MIRT2385936	hsa-miR-4798-5p	CLIP-seq
MIRT2198846	hsa-miR-500a	CLIP-seq
MIRT2198847	hsa-miR-650	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2501644	hsa-miR-3622b-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq
MIRT884914	hsa-miR-1285	CLIP-seq
MIRT884920	hsa-miR-3187-5p	CLIP-seq
MIRT2501644	hsa-miR-3622b-5p	CLIP-seq
MIRT2446848	hsa-miR-3945	CLIP-seq
MIRT2446849	hsa-miR-4253	CLIP-seq
MIRT884939	hsa-miR-4684-5p	CLIP-seq
MIRT884945	hsa-miR-612	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SP1	Activation	22682030
SP3	Activation	22682030

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IBA
GO:0000776	Component	Kinetochore	IDA	11092768
GO:0000776	Component	Kinetochore	IEA
GO:0000776	Component	Kinetochore	IMP	20212317
GO:0000776	Component	Kinetochore	NAS	11092768
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005515	Function	Protein binding	IPI	11092768, 15713649, 24981860, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11092768
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007052	Process	Mitotic spindle organization	IBA
GO:0007059	Process	Chromosome segregation	IBA
GO:0007059	Process	Chromosome segregation	NAS	36085283
GO:0043515	Function	Kinetochore binding	IBA
GO:0043515	Function	Kinetochore binding	IDA	11092768
GO:0043515	Function	Kinetochore binding	IEA
GO:0051382	Process	Kinetochore assembly	IEA
GO:0051383	Process	Kinetochore organization	TAS	11092768

MIM	HGNC	e!Ensembl
605607	17268	ENSG00000153044

Protein

UniProt ID

Q9H3R5

Protein name

Centromere protein H (CENP-H) (Interphase centromere complex protein 35)

Protein function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal)

PDB

7PB4 , 7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05837	CENP-H	126 → 239	Centromere protein H (CENP-H)	Domain

Sequence

MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM

Sequence length

247

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

CENPH (centromere protein H)