Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64838
Gene name Gene Name - the full gene name approved by the HGNC.	Fibronectin type III domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FNDC4
Synonyms (NCBI Gene) Gene synonyms aliases	FRCP1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.3

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022409	hsa-miR-124-3p	Microarray	18668037
MIRT025717	hsa-miR-7-5p	Sequencing	20371350
MIRT1000573	hsa-miR-130a	CLIP-seq
MIRT1000574	hsa-miR-130b	CLIP-seq
MIRT1000575	hsa-miR-301a	CLIP-seq
MIRT1000576	hsa-miR-301b	CLIP-seq
MIRT1000577	hsa-miR-3198	CLIP-seq
MIRT1000578	hsa-miR-3617	CLIP-seq
MIRT1000579	hsa-miR-3666	CLIP-seq
MIRT1000580	hsa-miR-4295	CLIP-seq
MIRT1000581	hsa-miR-4309	CLIP-seq
MIRT1000582	hsa-miR-454	CLIP-seq
MIRT1000583	hsa-miR-4671-3p	CLIP-seq
MIRT1000584	hsa-miR-641	CLIP-seq
MIRT1000585	hsa-miR-7	CLIP-seq
MIRT2534409	hsa-miR-1178	CLIP-seq
MIRT2534410	hsa-miR-1225-5p	CLIP-seq
MIRT2534411	hsa-miR-1237	CLIP-seq
MIRT2534412	hsa-miR-125a-3p	CLIP-seq
MIRT2534413	hsa-miR-128	CLIP-seq
MIRT2534414	hsa-miR-1302	CLIP-seq
MIRT2534415	hsa-miR-149	CLIP-seq
MIRT2534416	hsa-miR-203	CLIP-seq
MIRT2534417	hsa-miR-2355-5p	CLIP-seq
MIRT2534418	hsa-miR-2392	CLIP-seq
MIRT2534419	hsa-miR-27a	CLIP-seq
MIRT2534420	hsa-miR-27b	CLIP-seq
MIRT2534421	hsa-miR-296-5p	CLIP-seq
MIRT2534422	hsa-miR-3064-5p	CLIP-seq
MIRT2534423	hsa-miR-3122	CLIP-seq
MIRT2534424	hsa-miR-3194-3p	CLIP-seq
MIRT2534425	hsa-miR-3202	CLIP-seq
MIRT2534426	hsa-miR-331-3p	CLIP-seq
MIRT2534427	hsa-miR-3605-5p	CLIP-seq
MIRT2534428	hsa-miR-3649	CLIP-seq
MIRT2534429	hsa-miR-3675-5p	CLIP-seq
MIRT2534430	hsa-miR-3690	CLIP-seq
MIRT2534431	hsa-miR-3913-5p	CLIP-seq
MIRT2534432	hsa-miR-3978	CLIP-seq
MIRT2534433	hsa-miR-4298	CLIP-seq
MIRT2534434	hsa-miR-4308	CLIP-seq
MIRT2534435	hsa-miR-4324	CLIP-seq
MIRT2534436	hsa-miR-4428	CLIP-seq
MIRT2534437	hsa-miR-4522	CLIP-seq
MIRT2534438	hsa-miR-4533	CLIP-seq
MIRT2534439	hsa-miR-4539	CLIP-seq
MIRT2534440	hsa-miR-4650-5p	CLIP-seq
MIRT2534441	hsa-miR-4655-5p	CLIP-seq
MIRT2534442	hsa-miR-4685-5p	CLIP-seq
MIRT2534443	hsa-miR-4688	CLIP-seq
MIRT2534444	hsa-miR-4714-5p	CLIP-seq
MIRT2534445	hsa-miR-4724-3p	CLIP-seq
MIRT2534446	hsa-miR-4726-3p	CLIP-seq
MIRT2534447	hsa-miR-4733-5p	CLIP-seq
MIRT2534448	hsa-miR-4794	CLIP-seq
MIRT2534449	hsa-miR-552	CLIP-seq
MIRT2534450	hsa-miR-583	CLIP-seq
MIRT2534451	hsa-miR-760	CLIP-seq
MIRT2534452	hsa-miR-767-3p	CLIP-seq
MIRT2534409	hsa-miR-1178	CLIP-seq
MIRT2534410	hsa-miR-1225-5p	CLIP-seq
MIRT2534411	hsa-miR-1237	CLIP-seq
MIRT2534413	hsa-miR-128	CLIP-seq
MIRT2534415	hsa-miR-149	CLIP-seq
MIRT2534417	hsa-miR-2355-5p	CLIP-seq
MIRT2534418	hsa-miR-2392	CLIP-seq
MIRT2534419	hsa-miR-27a	CLIP-seq
MIRT2534420	hsa-miR-27b	CLIP-seq
MIRT2534422	hsa-miR-3064-5p	CLIP-seq
MIRT2534424	hsa-miR-3194-3p	CLIP-seq
MIRT2534425	hsa-miR-3202	CLIP-seq
MIRT2534426	hsa-miR-331-3p	CLIP-seq
MIRT2534427	hsa-miR-3605-5p	CLIP-seq
MIRT2534430	hsa-miR-3690	CLIP-seq
MIRT2534432	hsa-miR-3978	CLIP-seq
MIRT2534434	hsa-miR-4308	CLIP-seq
MIRT2534435	hsa-miR-4324	CLIP-seq
MIRT2534436	hsa-miR-4428	CLIP-seq
MIRT2534437	hsa-miR-4522	CLIP-seq
MIRT2534438	hsa-miR-4533	CLIP-seq
MIRT2534439	hsa-miR-4539	CLIP-seq
MIRT2534440	hsa-miR-4650-5p	CLIP-seq
MIRT2534441	hsa-miR-4655-5p	CLIP-seq
MIRT2534442	hsa-miR-4685-5p	CLIP-seq
MIRT2534443	hsa-miR-4688	CLIP-seq
MIRT2534444	hsa-miR-4714-5p	CLIP-seq
MIRT2534445	hsa-miR-4724-3p	CLIP-seq
MIRT2534446	hsa-miR-4726-3p	CLIP-seq
MIRT2534447	hsa-miR-4733-5p	CLIP-seq
MIRT2534448	hsa-miR-4794	CLIP-seq
MIRT2534450	hsa-miR-583	CLIP-seq
MIRT2534451	hsa-miR-760	CLIP-seq
MIRT2534452	hsa-miR-767-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IBA	21873635
GO:0005615	Component	Extracellular space	ISS
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IBA	21873635
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0071559	Process	Response to transforming growth factor beta	IEP	27066907

MIM	HGNC	e!Ensembl
611905	20239	ENSG00000115226

Protein

UniProt ID

Q9H6D8

Protein name

Fibronectin type III domain-containing protein 4 (Fibronectin type III repeat-containing protein 1) [Cleaved into: Soluble FNDC4 (sFNDC4)]

Protein function

[Soluble FNDC4]: Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	48 → 130	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the liver and the brain, including in the cortex, hypothalamus and hippocampus (PubMed:34016966). Also expressed in adipose tissue (PubMed:34016966). {ECO:0000269|PubMed:34016966}.

Sequence

MPSGCHSSPPSGLRGDMASLVPLSPYLSPTVLLLVSCDLGFVRADRPPSPVNVTVTHLRA
NSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRS
IGLRGESPPGPRVHFRTLKGSDRLPSNSSSPGDITVEGLDGERPLQTGEVVIIVVVLLMW
AAVIGLFCRQYDIIKDNDSNNNPKEKGKGPEQSPQGRPVGTRQKKSPSINTIDV

Sequence length

234

Interactions

View interactions

FNDC4 (fibronectin type III domain containing 4)