Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6478
Gene name Gene Name - the full gene name approved by the HGNC.	Siah E3 ubiquitin protein ligase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SIAH2
Synonyms (NCBI Gene) Gene synonyms aliases	hSiah2
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047977	hsa-miR-30c-5p	CLASH	23622248
MIRT041115	hsa-miR-503-5p	CLASH	23622248
0	hsa-miR-191-5p	Immunoprecipitation, In situ hybridization, Luciferase assay, Microarray, Northern blot, QRTPCR, Western blot	23505378
MIRT554313	hsa-miR-5692a	PAR-CLIP	20371350
MIRT554312	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT554310	hsa-miR-2278	PAR-CLIP	20371350
MIRT554309	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT554308	hsa-miR-4775	PAR-CLIP	20371350
MIRT554306	hsa-miR-6126	PAR-CLIP	20371350
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT554313	hsa-miR-5692a	PAR-CLIP	21572407
MIRT554312	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT554310	hsa-miR-2278	PAR-CLIP	21572407
MIRT554309	hsa-miR-493-3p	PAR-CLIP	21572407
MIRT554308	hsa-miR-4775	PAR-CLIP	21572407
MIRT554306	hsa-miR-6126	PAR-CLIP	21572407
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	21572407
MIRT439639	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439639	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT554313	hsa-miR-5692a	PAR-CLIP	20371350
MIRT554312	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT554310	hsa-miR-2278	PAR-CLIP	20371350
MIRT554309	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT554308	hsa-miR-4775	PAR-CLIP	20371350
MIRT554306	hsa-miR-6126	PAR-CLIP	20371350
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT554313	hsa-miR-5692a	PAR-CLIP	21572407
MIRT554312	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT554310	hsa-miR-2278	PAR-CLIP	21572407
MIRT554309	hsa-miR-493-3p	PAR-CLIP	21572407
MIRT554308	hsa-miR-4775	PAR-CLIP	21572407
MIRT554306	hsa-miR-6126	PAR-CLIP	21572407
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	21572407
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348186	hsa-miR-1275	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT1348189	hsa-miR-1321	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348192	hsa-miR-146b-3p	CLIP-seq
MIRT1348193	hsa-miR-1914	CLIP-seq
MIRT1348194	hsa-miR-1915	CLIP-seq
MIRT1348195	hsa-miR-19a	CLIP-seq
MIRT1348196	hsa-miR-19b	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348199	hsa-miR-2909	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT1348206	hsa-miR-3121-3p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348208	hsa-miR-3147	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348211	hsa-miR-3162-5p	CLIP-seq
MIRT1348212	hsa-miR-3168	CLIP-seq
MIRT1348213	hsa-miR-3179	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT1348226	hsa-miR-378	CLIP-seq
MIRT1348227	hsa-miR-378b	CLIP-seq
MIRT1348228	hsa-miR-378c	CLIP-seq
MIRT1348229	hsa-miR-378d	CLIP-seq
MIRT1348230	hsa-miR-378e	CLIP-seq
MIRT1348231	hsa-miR-378f	CLIP-seq
MIRT1348232	hsa-miR-378h	CLIP-seq
MIRT1348233	hsa-miR-378i	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348235	hsa-miR-422a	CLIP-seq
MIRT1348236	hsa-miR-425	CLIP-seq
MIRT1348237	hsa-miR-4271	CLIP-seq
MIRT1348238	hsa-miR-4278	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT1348240	hsa-miR-4422	CLIP-seq
MIRT1348241	hsa-miR-4425	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT1348247	hsa-miR-451b	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348249	hsa-miR-4525	CLIP-seq
MIRT1348250	hsa-miR-4638-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT1348252	hsa-miR-4665-5p	CLIP-seq
MIRT1348253	hsa-miR-4666-3p	CLIP-seq
MIRT1348254	hsa-miR-4668-3p	CLIP-seq
MIRT1348255	hsa-miR-4670-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348261	hsa-miR-4723-5p	CLIP-seq
MIRT1348262	hsa-miR-4725-3p	CLIP-seq
MIRT1348263	hsa-miR-4726-3p	CLIP-seq
MIRT1348264	hsa-miR-4739	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT1348267	hsa-miR-4756-5p	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348271	hsa-miR-494	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348273	hsa-miR-569	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348275	hsa-miR-625	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348279	hsa-miR-711	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348186	hsa-miR-1275	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT2103158	hsa-miR-1323	CLIP-seq
MIRT2103159	hsa-miR-140-5p	CLIP-seq
MIRT2103160	hsa-miR-141	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT2103161	hsa-miR-146a	CLIP-seq
MIRT2103162	hsa-miR-146b-5p	CLIP-seq
MIRT2103163	hsa-miR-200a	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT2103164	hsa-miR-3124-3p	CLIP-seq
MIRT2103165	hsa-miR-3129-3p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT2103166	hsa-miR-3160-5p	CLIP-seq
MIRT2103167	hsa-miR-3187-3p	CLIP-seq
MIRT2103168	hsa-miR-3194-5p	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT2103169	hsa-miR-3545-5p	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103170	hsa-miR-3660	CLIP-seq
MIRT2103171	hsa-miR-3677-5p	CLIP-seq
MIRT2103172	hsa-miR-3685	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT2103174	hsa-miR-384	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT2103175	hsa-miR-3923	CLIP-seq
MIRT2103176	hsa-miR-3926	CLIP-seq
MIRT2103177	hsa-miR-3942-3p	CLIP-seq
MIRT1348237	hsa-miR-4271	CLIP-seq
MIRT2103178	hsa-miR-4276	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT2103179	hsa-miR-4302	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103180	hsa-miR-4460	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT2103182	hsa-miR-4481	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348249	hsa-miR-4525	CLIP-seq
MIRT2103183	hsa-miR-4526	CLIP-seq
MIRT2103184	hsa-miR-4529-5p	CLIP-seq
MIRT2103185	hsa-miR-4645-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT2103186	hsa-miR-4662a-5p	CLIP-seq
MIRT1348252	hsa-miR-4665-5p	CLIP-seq
MIRT2103187	hsa-miR-4666-5p	CLIP-seq
MIRT1348255	hsa-miR-4670-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT2103188	hsa-miR-4676-5p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT2103189	hsa-miR-4710	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348261	hsa-miR-4723-5p	CLIP-seq
MIRT1348262	hsa-miR-4725-3p	CLIP-seq
MIRT2103190	hsa-miR-4745-5p	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT2103191	hsa-miR-4758-5p	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT2103192	hsa-miR-4792	CLIP-seq
MIRT2103193	hsa-miR-4796-5p	CLIP-seq
MIRT2103194	hsa-miR-548o	CLIP-seq
MIRT2103195	hsa-miR-548p	CLIP-seq
MIRT2103196	hsa-miR-548s	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT2103197	hsa-miR-575	CLIP-seq
MIRT2103198	hsa-miR-589	CLIP-seq
MIRT2103199	hsa-miR-603	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348275	hsa-miR-625	CLIP-seq
MIRT2103200	hsa-miR-628-5p	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT2327438	hsa-miR-1207-5p	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT2327439	hsa-miR-1257	CLIP-seq
MIRT2327440	hsa-miR-1260	CLIP-seq
MIRT2327441	hsa-miR-1260b	CLIP-seq
MIRT2327442	hsa-miR-1266	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT2327443	hsa-miR-1273d	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT1348189	hsa-miR-1321	CLIP-seq
MIRT2103158	hsa-miR-1323	CLIP-seq
MIRT2103159	hsa-miR-140-5p	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT2103161	hsa-miR-146a	CLIP-seq
MIRT1348192	hsa-miR-146b-3p	CLIP-seq
MIRT2103162	hsa-miR-146b-5p	CLIP-seq
MIRT2327444	hsa-miR-186	CLIP-seq
MIRT2327445	hsa-miR-188-3p	CLIP-seq
MIRT1348193	hsa-miR-1914	CLIP-seq
MIRT1348194	hsa-miR-1915	CLIP-seq
MIRT2327446	hsa-miR-1972	CLIP-seq
MIRT1348195	hsa-miR-19a	CLIP-seq
MIRT1348196	hsa-miR-19b	CLIP-seq
MIRT2327447	hsa-miR-216a	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT2327448	hsa-miR-2276	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348199	hsa-miR-2909	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT2103165	hsa-miR-3129-3p	CLIP-seq
MIRT2327449	hsa-miR-3130-5p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348208	hsa-miR-3147	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT2327450	hsa-miR-3155	CLIP-seq
MIRT2327451	hsa-miR-3155b	CLIP-seq
MIRT2327452	hsa-miR-3156-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348211	hsa-miR-3162-5p	CLIP-seq
MIRT1348212	hsa-miR-3168	CLIP-seq
MIRT1348213	hsa-miR-3179	CLIP-seq
MIRT2103168	hsa-miR-3194-5p	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT2103169	hsa-miR-3545-5p	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT2327453	hsa-miR-3617	CLIP-seq
MIRT2327454	hsa-miR-3622a-3p	CLIP-seq
MIRT2327455	hsa-miR-3622b-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2327456	hsa-miR-3658	CLIP-seq
MIRT2103170	hsa-miR-3660	CLIP-seq
MIRT2327457	hsa-miR-3664-3p	CLIP-seq
MIRT2327458	hsa-miR-3672	CLIP-seq
MIRT2103171	hsa-miR-3677-5p	CLIP-seq
MIRT2327459	hsa-miR-3688-5p	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT2327460	hsa-miR-376c	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348226	hsa-miR-378	CLIP-seq
MIRT1348227	hsa-miR-378b	CLIP-seq
MIRT1348228	hsa-miR-378c	CLIP-seq
MIRT1348229	hsa-miR-378d	CLIP-seq
MIRT1348230	hsa-miR-378e	CLIP-seq
MIRT1348231	hsa-miR-378f	CLIP-seq
MIRT1348232	hsa-miR-378h	CLIP-seq
MIRT1348233	hsa-miR-378i	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT2103175	hsa-miR-3923	CLIP-seq
MIRT2103176	hsa-miR-3926	CLIP-seq
MIRT2327461	hsa-miR-3937	CLIP-seq
MIRT1348235	hsa-miR-422a	CLIP-seq
MIRT2103178	hsa-miR-4276	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT2103179	hsa-miR-4302	CLIP-seq
MIRT1348240	hsa-miR-4422	CLIP-seq
MIRT1348241	hsa-miR-4425	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103180	hsa-miR-4460	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT2103182	hsa-miR-4481	CLIP-seq
MIRT2327462	hsa-miR-4482	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT2327463	hsa-miR-4502	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT2327464	hsa-miR-4518	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT2103183	hsa-miR-4526	CLIP-seq
MIRT1348250	hsa-miR-4638-3p	CLIP-seq
MIRT2103185	hsa-miR-4645-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT2327465	hsa-miR-4662a-3p	CLIP-seq
MIRT2103186	hsa-miR-4662a-5p	CLIP-seq
MIRT2103187	hsa-miR-4666-5p	CLIP-seq
MIRT1348254	hsa-miR-4668-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT2103188	hsa-miR-4676-5p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT2103189	hsa-miR-4710	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348263	hsa-miR-4726-3p	CLIP-seq
MIRT2327466	hsa-miR-4736	CLIP-seq
MIRT1348264	hsa-miR-4739	CLIP-seq
MIRT2103190	hsa-miR-4745-5p	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT1348267	hsa-miR-4756-5p	CLIP-seq
MIRT2103191	hsa-miR-4758-5p	CLIP-seq
MIRT2327467	hsa-miR-4760-5p	CLIP-seq
MIRT2327468	hsa-miR-4762-5p	CLIP-seq
MIRT2327469	hsa-miR-4763-3p	CLIP-seq
MIRT2327470	hsa-miR-4772-3p	CLIP-seq
MIRT2327471	hsa-miR-4773	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT2103192	hsa-miR-4792	CLIP-seq
MIRT2103193	hsa-miR-4796-5p	CLIP-seq
MIRT2327472	hsa-miR-484	CLIP-seq
MIRT2327473	hsa-miR-548ae	CLIP-seq
MIRT2327474	hsa-miR-548aj	CLIP-seq
MIRT2327475	hsa-miR-548am	CLIP-seq
MIRT2103194	hsa-miR-548o	CLIP-seq
MIRT2103195	hsa-miR-548p	CLIP-seq
MIRT2103196	hsa-miR-548s	CLIP-seq
MIRT2327476	hsa-miR-548x	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348273	hsa-miR-569	CLIP-seq
MIRT2103197	hsa-miR-575	CLIP-seq
MIRT2103198	hsa-miR-589	CLIP-seq
MIRT2103199	hsa-miR-603	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT2103200	hsa-miR-628-5p	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT2327477	hsa-miR-653	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348271	hsa-miR-494	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	TAS	10207103
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS
GO:0005515	Function	Protein binding	IPI	21586138, 21659512, 23840749, 25438054, 26392558, 28546513
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	10207103
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA	21586138
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	26392558
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	9334332
GO:0006915	Process	Apoptotic process	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	TAS	10207103
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031396	Process	Regulation of protein ubiquitination	IEA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IBA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IEA
GO:0042752	Process	Regulation of circadian rhythm	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	26392558
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21586138
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IMP	28546513
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	12952940
GO:1990000	Process	Amyloid fibril formation	IEA
GO:1990000	Process	Amyloid fibril formation	TAS
GO:2001233	Process	Regulation of apoptotic signaling pathway	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	21586138

MIM	HGNC	e!Ensembl
602213	10858	ENSG00000181788

Protein

UniProt ID

O43255

Protein name

E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme

PDB

5H9M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03145	Sina	122 → 318	Seven in absentia protein family	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low level. {ECO:0000269|PubMed:9403064}.

Sequence

MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG
GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP
SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS
LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE
GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD
TAIAHLFADNGNLGINVTISTCCP

Sequence length

324

Interactions

View interactions

	Reactome
			Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Childhood asthma exacerbations in long-acting beta2-agonist treatment	N/A	N/A	GWAS
Breast cancer	Breast cancer	N/A	N/A	GWAS
Breast Cancer	BRCA1/2-negative high-risk breast cancer	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Stimulate	26580787
Adenocarcinoma of Lung	Stimulate	26580787
Adenomatous Polyposis Coli	Inhibit	17463182
Breast Neoplasms	Associate	21306611, 22037769, 23208506, 24244489, 24656476, 26654769, 33727952, 35309179, 35913115, 36077333, 40004017, 40696656
Breast Neoplasms	Stimulate	40442365
Carcinogenesis	Associate	35154166, 35816252
Carcinoma Intraductal Noninfiltrating	Stimulate	21306611
Carcinoma Non Small Cell Lung	Associate	24833526, 26580787
Carcinoma Ovarian Epithelial	Associate	26512788
Carcinoma Squamous Cell	Stimulate	24833526
Cell Transformation Neoplastic	Associate	26654769
Cholangiocarcinoma	Associate	35154166
Colorectal Neoplasms	Associate	35994813
Drug Related Side Effects and Adverse Reactions	Associate	35154166
Fever	Associate	36216898
Helicobacter Infections	Associate	27048589
Hypoglycemia	Associate	25807533
hypoglycemic encephalopathy	Stimulate	25807533
Hypoxia	Associate	21659512, 28515325, 29400343, 35309179, 35913115, 36481701
Hypoxia Brain	Associate	21306611, 28515325, 29400343, 35913115
Leukemia	Associate	29400343
Leukemia Myelogenous Chronic BCR ABL Positive	Stimulate	29400343
Liposarcoma	Associate	35313831
Lung Neoplasms	Associate	24833526
Lung Neoplasms	Stimulate	26580787
Lymphatic Metastasis	Stimulate	26512788
Melanoma	Associate	21659512
Metabolic Diseases	Associate	40004017
Mitochondrial Diseases	Associate	35816252
Neoplasm Metastasis	Stimulate	21306611
Neoplasms	Associate	26512788, 26654769, 27048589, 27058417, 35154166, 35913115
Neoplasms	Stimulate	36846090
Neoplasms Squamous Cell	Stimulate	26580787
Osteoarthritis	Associate	39258983
Prostate Cancer Hereditary 7	Associate	24708576
Prostatic Neoplasms	Associate	27058417, 34897998
Stomach Neoplasms	Stimulate	27048589
Stomach Neoplasms	Associate	35816252
Vascular Diseases	Associate	25807533

SIAH2 (siah E3 ubiquitin protein ligase 2)