SIAH2 (siah E3 ubiquitin protein ligase 2)

Gene

• Entrez ID: 6478
• Gene name: Siah E3 ubiquitin protein ligase 2
• Gene symbol: SIAH2
• Synonyms (NCBI Gene): hSiah2
• Chromosome: 3
• Chromosome location: 3q25.1
• Summary: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047977	hsa-miR-30c-5p	CLASH	23622248
MIRT041115	hsa-miR-503-5p	CLASH	23622248
0	hsa-miR-191-5p	Immunoprecipitation, In situ hybridization, Luciferase assay, Microarray, Northern blot, QRTPCR, Western blot	23505378
MIRT554313	hsa-miR-5692a	PAR-CLIP	20371350
MIRT554312	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT554310	hsa-miR-2278	PAR-CLIP	20371350
MIRT554309	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT554308	hsa-miR-4775	PAR-CLIP	20371350
MIRT554306	hsa-miR-6126	PAR-CLIP	20371350
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT554313	hsa-miR-5692a	PAR-CLIP	21572407
MIRT554312	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT554310	hsa-miR-2278	PAR-CLIP	21572407
MIRT554309	hsa-miR-493-3p	PAR-CLIP	21572407
MIRT554308	hsa-miR-4775	PAR-CLIP	21572407
MIRT554306	hsa-miR-6126	PAR-CLIP	21572407
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	21572407
MIRT439639	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439639	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT554313	hsa-miR-5692a	PAR-CLIP	20371350
MIRT554312	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT554310	hsa-miR-2278	PAR-CLIP	20371350
MIRT554309	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT554308	hsa-miR-4775	PAR-CLIP	20371350
MIRT554306	hsa-miR-6126	PAR-CLIP	20371350
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	20371350
MIRT554313	hsa-miR-5692a	PAR-CLIP	21572407
MIRT554312	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT554311	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT554310	hsa-miR-2278	PAR-CLIP	21572407
MIRT554309	hsa-miR-493-3p	PAR-CLIP	21572407
MIRT554308	hsa-miR-4775	PAR-CLIP	21572407
MIRT554306	hsa-miR-6126	PAR-CLIP	21572407
MIRT554307	hsa-miR-6864-5p	PAR-CLIP	21572407
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348186	hsa-miR-1275	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT1348189	hsa-miR-1321	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348192	hsa-miR-146b-3p	CLIP-seq
MIRT1348193	hsa-miR-1914	CLIP-seq
MIRT1348194	hsa-miR-1915	CLIP-seq
MIRT1348195	hsa-miR-19a	CLIP-seq
MIRT1348196	hsa-miR-19b	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348199	hsa-miR-2909	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT1348206	hsa-miR-3121-3p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348208	hsa-miR-3147	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348211	hsa-miR-3162-5p	CLIP-seq
MIRT1348212	hsa-miR-3168	CLIP-seq
MIRT1348213	hsa-miR-3179	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT1348226	hsa-miR-378	CLIP-seq
MIRT1348227	hsa-miR-378b	CLIP-seq
MIRT1348228	hsa-miR-378c	CLIP-seq
MIRT1348229	hsa-miR-378d	CLIP-seq
MIRT1348230	hsa-miR-378e	CLIP-seq
MIRT1348231	hsa-miR-378f	CLIP-seq
MIRT1348232	hsa-miR-378h	CLIP-seq
MIRT1348233	hsa-miR-378i	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348235	hsa-miR-422a	CLIP-seq
MIRT1348236	hsa-miR-425	CLIP-seq
MIRT1348237	hsa-miR-4271	CLIP-seq
MIRT1348238	hsa-miR-4278	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT1348240	hsa-miR-4422	CLIP-seq
MIRT1348241	hsa-miR-4425	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT1348247	hsa-miR-451b	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348249	hsa-miR-4525	CLIP-seq
MIRT1348250	hsa-miR-4638-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT1348252	hsa-miR-4665-5p	CLIP-seq
MIRT1348253	hsa-miR-4666-3p	CLIP-seq
MIRT1348254	hsa-miR-4668-3p	CLIP-seq
MIRT1348255	hsa-miR-4670-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348261	hsa-miR-4723-5p	CLIP-seq
MIRT1348262	hsa-miR-4725-3p	CLIP-seq
MIRT1348263	hsa-miR-4726-3p	CLIP-seq
MIRT1348264	hsa-miR-4739	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT1348267	hsa-miR-4756-5p	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348271	hsa-miR-494	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348273	hsa-miR-569	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348275	hsa-miR-625	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348279	hsa-miR-711	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348186	hsa-miR-1275	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT2103158	hsa-miR-1323	CLIP-seq
MIRT2103159	hsa-miR-140-5p	CLIP-seq
MIRT2103160	hsa-miR-141	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT2103161	hsa-miR-146a	CLIP-seq
MIRT2103162	hsa-miR-146b-5p	CLIP-seq
MIRT2103163	hsa-miR-200a	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT2103164	hsa-miR-3124-3p	CLIP-seq
MIRT2103165	hsa-miR-3129-3p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT2103166	hsa-miR-3160-5p	CLIP-seq
MIRT2103167	hsa-miR-3187-3p	CLIP-seq
MIRT2103168	hsa-miR-3194-5p	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT2103169	hsa-miR-3545-5p	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103170	hsa-miR-3660	CLIP-seq
MIRT2103171	hsa-miR-3677-5p	CLIP-seq
MIRT2103172	hsa-miR-3685	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT2103174	hsa-miR-384	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT2103175	hsa-miR-3923	CLIP-seq
MIRT2103176	hsa-miR-3926	CLIP-seq
MIRT2103177	hsa-miR-3942-3p	CLIP-seq
MIRT1348237	hsa-miR-4271	CLIP-seq
MIRT2103178	hsa-miR-4276	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT2103179	hsa-miR-4302	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103180	hsa-miR-4460	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT2103182	hsa-miR-4481	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348249	hsa-miR-4525	CLIP-seq
MIRT2103183	hsa-miR-4526	CLIP-seq
MIRT2103184	hsa-miR-4529-5p	CLIP-seq
MIRT2103185	hsa-miR-4645-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT2103186	hsa-miR-4662a-5p	CLIP-seq
MIRT1348252	hsa-miR-4665-5p	CLIP-seq
MIRT2103187	hsa-miR-4666-5p	CLIP-seq
MIRT1348255	hsa-miR-4670-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT2103188	hsa-miR-4676-5p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT2103189	hsa-miR-4710	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348261	hsa-miR-4723-5p	CLIP-seq
MIRT1348262	hsa-miR-4725-3p	CLIP-seq
MIRT2103190	hsa-miR-4745-5p	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT2103191	hsa-miR-4758-5p	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT2103192	hsa-miR-4792	CLIP-seq
MIRT2103193	hsa-miR-4796-5p	CLIP-seq
MIRT2103194	hsa-miR-548o	CLIP-seq
MIRT2103195	hsa-miR-548p	CLIP-seq
MIRT2103196	hsa-miR-548s	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT2103197	hsa-miR-575	CLIP-seq
MIRT2103198	hsa-miR-589	CLIP-seq
MIRT2103199	hsa-miR-603	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348275	hsa-miR-625	CLIP-seq
MIRT2103200	hsa-miR-628-5p	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348181	hsa-miR-1206	CLIP-seq
MIRT2327438	hsa-miR-1207-5p	CLIP-seq
MIRT1348182	hsa-miR-1208	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT2327439	hsa-miR-1257	CLIP-seq
MIRT2327440	hsa-miR-1260	CLIP-seq
MIRT2327441	hsa-miR-1260b	CLIP-seq
MIRT2327442	hsa-miR-1266	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT2327443	hsa-miR-1273d	CLIP-seq
MIRT1348187	hsa-miR-1302	CLIP-seq
MIRT1348188	hsa-miR-1304	CLIP-seq
MIRT1348189	hsa-miR-1321	CLIP-seq
MIRT2103158	hsa-miR-1323	CLIP-seq
MIRT2103159	hsa-miR-140-5p	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT2103161	hsa-miR-146a	CLIP-seq
MIRT1348192	hsa-miR-146b-3p	CLIP-seq
MIRT2103162	hsa-miR-146b-5p	CLIP-seq
MIRT2327444	hsa-miR-186	CLIP-seq
MIRT2327445	hsa-miR-188-3p	CLIP-seq
MIRT1348193	hsa-miR-1914	CLIP-seq
MIRT1348194	hsa-miR-1915	CLIP-seq
MIRT2327446	hsa-miR-1972	CLIP-seq
MIRT1348195	hsa-miR-19a	CLIP-seq
MIRT1348196	hsa-miR-19b	CLIP-seq
MIRT2327447	hsa-miR-216a	CLIP-seq
MIRT1348197	hsa-miR-218	CLIP-seq
MIRT2327448	hsa-miR-2276	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348199	hsa-miR-2909	CLIP-seq
MIRT1348200	hsa-miR-296-3p	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT2103165	hsa-miR-3129-3p	CLIP-seq
MIRT2327449	hsa-miR-3130-5p	CLIP-seq
MIRT1348207	hsa-miR-3140-3p	CLIP-seq
MIRT1348208	hsa-miR-3147	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT2327450	hsa-miR-3155	CLIP-seq
MIRT2327451	hsa-miR-3155b	CLIP-seq
MIRT2327452	hsa-miR-3156-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348211	hsa-miR-3162-5p	CLIP-seq
MIRT1348212	hsa-miR-3168	CLIP-seq
MIRT1348213	hsa-miR-3179	CLIP-seq
MIRT2103168	hsa-miR-3194-5p	CLIP-seq
MIRT1348214	hsa-miR-3202	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT2103169	hsa-miR-3545-5p	CLIP-seq
MIRT1348221	hsa-miR-3607-5p	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT2327453	hsa-miR-3617	CLIP-seq
MIRT2327454	hsa-miR-3622a-3p	CLIP-seq
MIRT2327455	hsa-miR-3622b-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2327456	hsa-miR-3658	CLIP-seq
MIRT2103170	hsa-miR-3660	CLIP-seq
MIRT2327457	hsa-miR-3664-3p	CLIP-seq
MIRT2327458	hsa-miR-3672	CLIP-seq
MIRT2103171	hsa-miR-3677-5p	CLIP-seq
MIRT2327459	hsa-miR-3688-5p	CLIP-seq
MIRT1348224	hsa-miR-3691-5p	CLIP-seq
MIRT1348225	hsa-miR-3714	CLIP-seq
MIRT2327460	hsa-miR-376c	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348226	hsa-miR-378	CLIP-seq
MIRT1348227	hsa-miR-378b	CLIP-seq
MIRT1348228	hsa-miR-378c	CLIP-seq
MIRT1348229	hsa-miR-378d	CLIP-seq
MIRT1348230	hsa-miR-378e	CLIP-seq
MIRT1348231	hsa-miR-378f	CLIP-seq
MIRT1348232	hsa-miR-378h	CLIP-seq
MIRT1348233	hsa-miR-378i	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT2103175	hsa-miR-3923	CLIP-seq
MIRT2103176	hsa-miR-3926	CLIP-seq
MIRT2327461	hsa-miR-3937	CLIP-seq
MIRT1348235	hsa-miR-422a	CLIP-seq
MIRT2103178	hsa-miR-4276	CLIP-seq
MIRT1348239	hsa-miR-4298	CLIP-seq
MIRT2103179	hsa-miR-4302	CLIP-seq
MIRT1348240	hsa-miR-4422	CLIP-seq
MIRT1348241	hsa-miR-4425	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103180	hsa-miR-4460	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348243	hsa-miR-4475	CLIP-seq
MIRT1348244	hsa-miR-4476	CLIP-seq
MIRT2103182	hsa-miR-4481	CLIP-seq
MIRT2327462	hsa-miR-4482	CLIP-seq
MIRT1348245	hsa-miR-4491	CLIP-seq
MIRT2327463	hsa-miR-4502	CLIP-seq
MIRT1348246	hsa-miR-4514	CLIP-seq
MIRT2327464	hsa-miR-4518	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT2103183	hsa-miR-4526	CLIP-seq
MIRT1348250	hsa-miR-4638-3p	CLIP-seq
MIRT2103185	hsa-miR-4645-3p	CLIP-seq
MIRT1348251	hsa-miR-4657	CLIP-seq
MIRT2327465	hsa-miR-4662a-3p	CLIP-seq
MIRT2103186	hsa-miR-4662a-5p	CLIP-seq
MIRT2103187	hsa-miR-4666-5p	CLIP-seq
MIRT1348254	hsa-miR-4668-3p	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT2103188	hsa-miR-4676-5p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348258	hsa-miR-4692	CLIP-seq
MIRT1348259	hsa-miR-4704-3p	CLIP-seq
MIRT2103189	hsa-miR-4710	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348263	hsa-miR-4726-3p	CLIP-seq
MIRT2327466	hsa-miR-4736	CLIP-seq
MIRT1348264	hsa-miR-4739	CLIP-seq
MIRT2103190	hsa-miR-4745-5p	CLIP-seq
MIRT1348265	hsa-miR-4747-5p	CLIP-seq
MIRT1348266	hsa-miR-4752	CLIP-seq
MIRT1348267	hsa-miR-4756-5p	CLIP-seq
MIRT2103191	hsa-miR-4758-5p	CLIP-seq
MIRT2327467	hsa-miR-4760-5p	CLIP-seq
MIRT2327468	hsa-miR-4762-5p	CLIP-seq
MIRT2327469	hsa-miR-4763-3p	CLIP-seq
MIRT2327470	hsa-miR-4772-3p	CLIP-seq
MIRT2327471	hsa-miR-4773	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT2103192	hsa-miR-4792	CLIP-seq
MIRT2103193	hsa-miR-4796-5p	CLIP-seq
MIRT2327472	hsa-miR-484	CLIP-seq
MIRT2327473	hsa-miR-548ae	CLIP-seq
MIRT2327474	hsa-miR-548aj	CLIP-seq
MIRT2327475	hsa-miR-548am	CLIP-seq
MIRT2103194	hsa-miR-548o	CLIP-seq
MIRT2103195	hsa-miR-548p	CLIP-seq
MIRT2103196	hsa-miR-548s	CLIP-seq
MIRT2327476	hsa-miR-548x	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348273	hsa-miR-569	CLIP-seq
MIRT2103197	hsa-miR-575	CLIP-seq
MIRT2103198	hsa-miR-589	CLIP-seq
MIRT2103199	hsa-miR-603	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT2103200	hsa-miR-628-5p	CLIP-seq
MIRT1348276	hsa-miR-636	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT2327477	hsa-miR-653	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348281	hsa-miR-940	CLIP-seq
MIRT1348201	hsa-miR-30a	CLIP-seq
MIRT1348202	hsa-miR-30b	CLIP-seq
MIRT1348203	hsa-miR-30c	CLIP-seq
MIRT1348204	hsa-miR-30d	CLIP-seq
MIRT1348205	hsa-miR-30e	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348272	hsa-miR-553	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq
MIRT1348183	hsa-miR-1224-5p	CLIP-seq
MIRT1348184	hsa-miR-1226	CLIP-seq
MIRT2103157	hsa-miR-1228	CLIP-seq
MIRT1348185	hsa-miR-1267	CLIP-seq
MIRT1348190	hsa-miR-142-5p	CLIP-seq
MIRT1348191	hsa-miR-144	CLIP-seq
MIRT1348198	hsa-miR-2467-3p	CLIP-seq
MIRT1348209	hsa-miR-3150b-3p	CLIP-seq
MIRT1348210	hsa-miR-3158-3p	CLIP-seq
MIRT1348215	hsa-miR-320a	CLIP-seq
MIRT1348216	hsa-miR-320b	CLIP-seq
MIRT1348217	hsa-miR-320c	CLIP-seq
MIRT1348218	hsa-miR-320d	CLIP-seq
MIRT1348219	hsa-miR-329	CLIP-seq
MIRT1348220	hsa-miR-340	CLIP-seq
MIRT1348222	hsa-miR-3616-3p	CLIP-seq
MIRT1348223	hsa-miR-362-3p	CLIP-seq
MIRT2103173	hsa-miR-377	CLIP-seq
MIRT1348234	hsa-miR-3915	CLIP-seq
MIRT1348242	hsa-miR-4429	CLIP-seq
MIRT2103181	hsa-miR-4474-5p	CLIP-seq
MIRT1348248	hsa-miR-452	CLIP-seq
MIRT1348256	hsa-miR-4676-3p	CLIP-seq
MIRT1348257	hsa-miR-4689	CLIP-seq
MIRT1348260	hsa-miR-4721	CLIP-seq
MIRT1348268	hsa-miR-4779	CLIP-seq
MIRT1348269	hsa-miR-4784	CLIP-seq
MIRT1348270	hsa-miR-4786-3p	CLIP-seq
MIRT1348271	hsa-miR-494	CLIP-seq
MIRT1348274	hsa-miR-618	CLIP-seq
MIRT1348277	hsa-miR-642b	CLIP-seq
MIRT1348278	hsa-miR-671-5p	CLIP-seq
MIRT1348280	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	TAS	10207103
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS
GO:0005515	Function	Protein binding	IPI	21586138, 21659512, 23840749, 25438054, 26392558, 28546513
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	10207103
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA	21586138
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	26392558
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	9334332
GO:0006915	Process	Apoptotic process	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	TAS	10207103
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031396	Process	Regulation of protein ubiquitination	IEA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IBA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IEA
GO:0042752	Process	Regulation of circadian rhythm	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	26392558
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21586138
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IMP	28546513
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	12952940
GO:1990000	Process	Amyloid fibril formation	IEA
GO:1990000	Process	Amyloid fibril formation	TAS
GO:2001233	Process	Regulation of apoptotic signaling pathway	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	21586138

Other IDs

• MIM: 602213
• HGNC: 10858
• e!Ensembl: ENSG00000181788

Protein

• UniProt ID: O43255
• Protein name: E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)
• Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme
• PDB: 5H9M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03145	Sina	122 → 318	Seven in absentia protein family	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed at low level. {ECO:0000269|PubMed:9403064}.
• Sequence:

  MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG
  GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP
  SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS
  LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE
  GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD
  TAIAHLFADNGNLGINVTISTCCP

• Sequence length: 324

Pathways

Reactome:

Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation