Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6468
Gene name Gene Name - the full gene name approved by the HGNC.	F-box and WD repeat domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FBXW4
Synonyms (NCBI Gene) Gene synonyms aliases	DAC, FBW4, FBWD4, SHFM3, SHSF3
Disease Acronyms (UniProt) Disease acronyms from UniProt database	SHFM3
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for mainta

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miRTarBase ID	miRNA	Experiments
MIRT993427	hsa-miR-1288	CLIP-seq
MIRT993428	hsa-miR-1343	CLIP-seq
MIRT993429	hsa-miR-15a	CLIP-seq
MIRT993430	hsa-miR-15b	CLIP-seq
MIRT993431	hsa-miR-16	CLIP-seq
MIRT993432	hsa-miR-195	CLIP-seq
MIRT993433	hsa-miR-214	CLIP-seq
MIRT993434	hsa-miR-217	CLIP-seq
MIRT993435	hsa-miR-3126-5p	CLIP-seq
MIRT993436	hsa-miR-3179	CLIP-seq
MIRT993437	hsa-miR-3192	CLIP-seq
MIRT993438	hsa-miR-3199	CLIP-seq
MIRT993439	hsa-miR-326	CLIP-seq
MIRT993440	hsa-miR-330-5p	CLIP-seq
MIRT993441	hsa-miR-3619-5p	CLIP-seq
MIRT993442	hsa-miR-3689a-3p	CLIP-seq
MIRT993443	hsa-miR-3689c	CLIP-seq
MIRT993444	hsa-miR-3914	CLIP-seq
MIRT993445	hsa-miR-424	CLIP-seq
MIRT993446	hsa-miR-4314	CLIP-seq
MIRT993447	hsa-miR-4422	CLIP-seq
MIRT993448	hsa-miR-4490	CLIP-seq
MIRT993449	hsa-miR-4646-5p	CLIP-seq
MIRT993450	hsa-miR-4677-3p	CLIP-seq
MIRT993451	hsa-miR-4679	CLIP-seq
MIRT993452	hsa-miR-4688	CLIP-seq
MIRT993453	hsa-miR-4722-3p	CLIP-seq
MIRT993454	hsa-miR-4728-5p	CLIP-seq
MIRT993455	hsa-miR-4747-5p	CLIP-seq
MIRT993456	hsa-miR-4774-5p	CLIP-seq
MIRT993457	hsa-miR-486-3p	CLIP-seq
MIRT993458	hsa-miR-497	CLIP-seq
MIRT993459	hsa-miR-515-5p	CLIP-seq
MIRT993460	hsa-miR-761	CLIP-seq
MIRT1994671	hsa-miR-4732-3p	CLIP-seq
MIRT1994672	hsa-miR-4755-5p	CLIP-seq
MIRT1994673	hsa-miR-670	CLIP-seq
MIRT2228765	hsa-miR-128	CLIP-seq
MIRT2228766	hsa-miR-1915	CLIP-seq
MIRT2228767	hsa-miR-1972	CLIP-seq
MIRT2228768	hsa-miR-3137	CLIP-seq
MIRT2228769	hsa-miR-330-3p	CLIP-seq
MIRT2228770	hsa-miR-371b-3p	CLIP-seq
MIRT2228771	hsa-miR-4433	CLIP-seq
MIRT2228772	hsa-miR-4645-5p	CLIP-seq
MIRT2228773	hsa-miR-4673	CLIP-seq
MIRT2228774	hsa-miR-4717-5p	CLIP-seq
MIRT2228775	hsa-miR-4726-3p	CLIP-seq
MIRT2228776	hsa-miR-665	CLIP-seq
MIRT2532315	hsa-miR-204	CLIP-seq
MIRT2532316	hsa-miR-211	CLIP-seq
MIRT2532317	hsa-miR-3121-5p	CLIP-seq
MIRT2228769	hsa-miR-330-3p	CLIP-seq
MIRT2532318	hsa-miR-4731-5p	CLIP-seq
MIRT1994672	hsa-miR-4755-5p	CLIP-seq
MIRT2532319	hsa-miR-548aa	CLIP-seq
MIRT2532320	hsa-miR-548p	CLIP-seq
MIRT2532321	hsa-miR-578	CLIP-seq
MIRT2532322	hsa-miR-607	CLIP-seq
MIRT2532323	hsa-miR-623	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	NAS	10945468
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0005515	Function	Protein binding	IPI	22632967, 27705803, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	NAS	10945468
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA	21873635
GO:0030326	Process	Embryonic limb morphogenesis	NAS	10405324
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0043687	Process	Post-translational protein modification	TAS

MIM	HGNC	e!Ensembl
608071	10847	ENSG00000107829

Protein

UniProt ID

P57775

Protein name

F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)

Protein function

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12937	F-box-like	28 → 74	F-box-like	Domain
PF00400	WD40	192 → 227	WD domain, G-beta repeat	Repeat
PF00400	WD40	326 → 365	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, kidney, lung and liver. {ECO:0000269|PubMed:10405324}.

Sequence

MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR
FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ
MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG
GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT
IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM
YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV
VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Sequence length

412

Interactions

View interactions

	Reactome
			Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Split-hand-foot malformation	SPLIT-HAND/FOOT MALFORMATION 3	rs121908836, rs121908838, rs121908839, rs121918349, rs763548858, rs398122527, rs587777842, rs863225437, rs763991433, rs1163162816, rs776938956, rs1592252556, rs1718026198	21485001, 18067070

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Split-Hand-Foot Malformation	split hand-foot malformation 3	GenCC
Schizophrenia	Schizophrenia	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	35589867
Colorectal Neoplasms	Associate	34373442
Glioma	Associate	39377096
Neoplasms	Associate	39377096

FBXW4 (F-box and WD repeat domain containing 4)