Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64581
Gene name Gene Name - the full gene name approved by the HGNC.
C-type lectin domain containing 7A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLEC7A
Synonyms (NCBI Gene) Gene synonyms aliases
BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CANDF4
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunorec
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT711136 hsa-miR-4777-3p HITS-CLIP 19536157
MIRT711135 hsa-miR-4768-5p HITS-CLIP 19536157
MIRT711134 hsa-miR-6833-3p HITS-CLIP 19536157
MIRT711133 hsa-miR-6809-3p HITS-CLIP 19536157
MIRT711136 hsa-miR-4777-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001872 Function (1->3)-beta-D-glucan binding IBA 21873635
GO:0001872 Function (1->3)-beta-D-glucan binding IDA 22267217, 24721111
GO:0001872 Function (1->3)-beta-D-glucan binding TAS 25251945
GO:0002366 Process Leukocyte activation involved in immune response IEA
GO:0002732 Process Positive regulation of dendritic cell cytokine production IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606264 14558 ENSG00000172243
Protein
UniProt ID Q9BXN2
Protein name C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
Protein function Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 137 243 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:00002
Sequence
MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVI
AVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPC
PPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFW
IGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSI
CEK
KFSM
Sequence length 247
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phagosome
Neutrophil extracellular trap formation
C-type lectin receptor signaling pathway
Tuberculosis
  CLEC7A (Dectin-1) signaling