CLEC7A (C-type lectin domain containing 7A)

Gene

• Entrez ID: 64581
• Gene name: C-type lectin domain containing 7A
• Gene symbol: CLEC7A
• Synonyms (NCBI Gene): BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
• Chromosome: 12
• Chromosome location: 12p13.2
• Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunorec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT675432	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT675431	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT675430	hsa-miR-5693	HITS-CLIP	23824327
MIRT675429	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675428	hsa-miR-4284	HITS-CLIP	23824327
MIRT675427	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT675426	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT675425	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT675424	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT675423	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT675422	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT675421	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT675420	hsa-miR-7977	HITS-CLIP	23824327
MIRT675419	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT675418	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT675417	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT675416	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT675415	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT675414	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT675413	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT675412	hsa-miR-3689c	HITS-CLIP	23824327
MIRT675411	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT675410	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT675409	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540614	hsa-miR-4537	PAR-CLIP	21572407
MIRT540613	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT540612	hsa-miR-6086	PAR-CLIP	21572407
MIRT540610	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT540611	hsa-miR-4792	PAR-CLIP	21572407
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711136	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT711135	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT711134	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT711133	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT675432	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT675431	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT675430	hsa-miR-5693	HITS-CLIP	23824327
MIRT675429	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675428	hsa-miR-4284	HITS-CLIP	23824327
MIRT675427	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT675426	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT675425	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT675424	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT675423	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT675422	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT675421	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT675420	hsa-miR-7977	HITS-CLIP	23824327
MIRT675419	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT675418	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT675417	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT675416	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT675415	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT675414	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT675413	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT675412	hsa-miR-3689c	HITS-CLIP	23824327
MIRT675411	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT675410	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT675409	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540614	hsa-miR-4537	PAR-CLIP	21572407
MIRT540613	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT540612	hsa-miR-6086	PAR-CLIP	21572407
MIRT540610	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT540611	hsa-miR-4792	PAR-CLIP	21572407
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT896167	hsa-miR-24	CLIP-seq
MIRT896168	hsa-miR-3122	CLIP-seq
MIRT896169	hsa-miR-3184	CLIP-seq
MIRT896170	hsa-miR-3197	CLIP-seq
MIRT896171	hsa-miR-323-5p	CLIP-seq
MIRT896172	hsa-miR-3607-3p	CLIP-seq
MIRT896173	hsa-miR-3609	CLIP-seq
MIRT896174	hsa-miR-3613-3p	CLIP-seq
MIRT896175	hsa-miR-3686	CLIP-seq
MIRT896176	hsa-miR-371-5p	CLIP-seq
MIRT896177	hsa-miR-371b-5p	CLIP-seq
MIRT896178	hsa-miR-3913-5p	CLIP-seq
MIRT896179	hsa-miR-3934	CLIP-seq
MIRT896180	hsa-miR-423-5p	CLIP-seq
MIRT896181	hsa-miR-4455	CLIP-seq
MIRT896182	hsa-miR-4514	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT896184	hsa-miR-4656	CLIP-seq
MIRT896185	hsa-miR-4692	CLIP-seq
MIRT896186	hsa-miR-4786-5p	CLIP-seq
MIRT896187	hsa-miR-548ah	CLIP-seq
MIRT896188	hsa-miR-550a	CLIP-seq
MIRT896189	hsa-miR-769-5p	CLIP-seq
MIRT896190	hsa-miR-876-3p	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896192	hsa-miR-1273e	CLIP-seq
MIRT896193	hsa-miR-1303	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT896194	hsa-miR-2114	CLIP-seq
MIRT896167	hsa-miR-24	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT896168	hsa-miR-3122	CLIP-seq
MIRT896169	hsa-miR-3184	CLIP-seq
MIRT896172	hsa-miR-3607-3p	CLIP-seq
MIRT896197	hsa-miR-3622b-5p	CLIP-seq
MIRT896198	hsa-miR-3647-3p	CLIP-seq
MIRT896175	hsa-miR-3686	CLIP-seq
MIRT896199	hsa-miR-3691-3p	CLIP-seq
MIRT896178	hsa-miR-3913-5p	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT896180	hsa-miR-423-5p	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT896202	hsa-miR-4433	CLIP-seq
MIRT896203	hsa-miR-4453	CLIP-seq
MIRT896204	hsa-miR-4459	CLIP-seq
MIRT896205	hsa-miR-4470	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT896182	hsa-miR-4514	CLIP-seq
MIRT896207	hsa-miR-4538	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT896208	hsa-miR-4653-3p	CLIP-seq
MIRT896184	hsa-miR-4656	CLIP-seq
MIRT896185	hsa-miR-4692	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT896186	hsa-miR-4786-5p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT896212	hsa-miR-501-3p	CLIP-seq
MIRT896213	hsa-miR-502-3p	CLIP-seq
MIRT896214	hsa-miR-505	CLIP-seq
MIRT896215	hsa-miR-665	CLIP-seq
MIRT896216	hsa-miR-890	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896217	hsa-miR-943	CLIP-seq
MIRT896192	hsa-miR-1273e	CLIP-seq
MIRT1965693	hsa-miR-1285	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT1965694	hsa-miR-1915	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT1965695	hsa-miR-3180	CLIP-seq
MIRT1965696	hsa-miR-3180-3p	CLIP-seq
MIRT1965697	hsa-miR-3187-5p	CLIP-seq
MIRT1965698	hsa-miR-3196	CLIP-seq
MIRT1965699	hsa-miR-335	CLIP-seq
MIRT896173	hsa-miR-3609	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT1965700	hsa-miR-4325	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT896205	hsa-miR-4470	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT1965701	hsa-miR-4480	CLIP-seq
MIRT1965702	hsa-miR-4488	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT1965703	hsa-miR-4697-5p	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT1965704	hsa-miR-495	CLIP-seq
MIRT1965705	hsa-miR-508-5p	CLIP-seq
MIRT1965706	hsa-miR-520g	CLIP-seq
MIRT1965707	hsa-miR-520h	CLIP-seq
MIRT896187	hsa-miR-548ah	CLIP-seq
MIRT1965708	hsa-miR-555	CLIP-seq
MIRT1965709	hsa-miR-612	CLIP-seq
MIRT1965710	hsa-miR-658	CLIP-seq
MIRT1965711	hsa-miR-661	CLIP-seq
MIRT1965712	hsa-miR-766	CLIP-seq
MIRT896216	hsa-miR-890	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896217	hsa-miR-943	CLIP-seq
MIRT2201617	hsa-miR-1227	CLIP-seq
MIRT896192	hsa-miR-1273e	CLIP-seq
MIRT1965693	hsa-miR-1285	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT1965694	hsa-miR-1915	CLIP-seq
MIRT896194	hsa-miR-2114	CLIP-seq
MIRT896167	hsa-miR-24	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT896168	hsa-miR-3122	CLIP-seq
MIRT1965695	hsa-miR-3180	CLIP-seq
MIRT1965696	hsa-miR-3180-3p	CLIP-seq
MIRT896169	hsa-miR-3184	CLIP-seq
MIRT1965697	hsa-miR-3187-5p	CLIP-seq
MIRT1965698	hsa-miR-3196	CLIP-seq
MIRT1965699	hsa-miR-335	CLIP-seq
MIRT896172	hsa-miR-3607-3p	CLIP-seq
MIRT896175	hsa-miR-3686	CLIP-seq
MIRT896178	hsa-miR-3913-5p	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT896180	hsa-miR-423-5p	CLIP-seq
MIRT2201618	hsa-miR-4252	CLIP-seq
MIRT1965700	hsa-miR-4325	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT896202	hsa-miR-4433	CLIP-seq
MIRT896204	hsa-miR-4459	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT1965702	hsa-miR-4488	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT2201619	hsa-miR-4652-3p	CLIP-seq
MIRT896184	hsa-miR-4656	CLIP-seq
MIRT1965703	hsa-miR-4697-5p	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT2201620	hsa-miR-4793-3p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT1965704	hsa-miR-495	CLIP-seq
MIRT1965705	hsa-miR-508-5p	CLIP-seq
MIRT1965708	hsa-miR-555	CLIP-seq
MIRT1965709	hsa-miR-612	CLIP-seq
MIRT1965710	hsa-miR-658	CLIP-seq
MIRT1965711	hsa-miR-661	CLIP-seq
MIRT1965712	hsa-miR-766	CLIP-seq
MIRT896216	hsa-miR-890	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT1965700	hsa-miR-4325	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT1965705	hsa-miR-508-5p	CLIP-seq
MIRT896188	hsa-miR-550a	CLIP-seq
MIRT1965712	hsa-miR-766	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT2504481	hsa-miR-10a	CLIP-seq
MIRT2504482	hsa-miR-10b	CLIP-seq
MIRT896192	hsa-miR-1273e	CLIP-seq
MIRT1965693	hsa-miR-1285	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT1965694	hsa-miR-1915	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT2504483	hsa-miR-3120-5p	CLIP-seq
MIRT896168	hsa-miR-3122	CLIP-seq
MIRT1965697	hsa-miR-3187-5p	CLIP-seq
MIRT1965699	hsa-miR-335	CLIP-seq
MIRT2504484	hsa-miR-339-5p	CLIP-seq
MIRT896172	hsa-miR-3607-3p	CLIP-seq
MIRT896173	hsa-miR-3609	CLIP-seq
MIRT896174	hsa-miR-3613-3p	CLIP-seq
MIRT2504485	hsa-miR-3664-5p	CLIP-seq
MIRT896175	hsa-miR-3686	CLIP-seq
MIRT896176	hsa-miR-371-5p	CLIP-seq
MIRT896177	hsa-miR-371b-5p	CLIP-seq
MIRT896178	hsa-miR-3913-5p	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT1965700	hsa-miR-4325	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT2504486	hsa-miR-4421	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT896182	hsa-miR-4514	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT2504487	hsa-miR-4684-5p	CLIP-seq
MIRT896185	hsa-miR-4692	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT896186	hsa-miR-4786-5p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT1965704	hsa-miR-495	CLIP-seq
MIRT1965705	hsa-miR-508-5p	CLIP-seq
MIRT1965706	hsa-miR-520g	CLIP-seq
MIRT1965707	hsa-miR-520h	CLIP-seq
MIRT896187	hsa-miR-548ah	CLIP-seq
MIRT2504488	hsa-miR-593	CLIP-seq
MIRT1965709	hsa-miR-612	CLIP-seq
MIRT1965711	hsa-miR-661	CLIP-seq
MIRT1965712	hsa-miR-766	CLIP-seq
MIRT896189	hsa-miR-769-5p	CLIP-seq
MIRT896216	hsa-miR-890	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896217	hsa-miR-943	CLIP-seq
MIRT2504481	hsa-miR-10a	CLIP-seq
MIRT2504482	hsa-miR-10b	CLIP-seq
MIRT896192	hsa-miR-1273e	CLIP-seq
MIRT1965693	hsa-miR-1285	CLIP-seq
MIRT896166	hsa-miR-1827	CLIP-seq
MIRT896195	hsa-miR-2964a-3p	CLIP-seq
MIRT896196	hsa-miR-302f	CLIP-seq
MIRT2504483	hsa-miR-3120-5p	CLIP-seq
MIRT896168	hsa-miR-3122	CLIP-seq
MIRT1965697	hsa-miR-3187-5p	CLIP-seq
MIRT1965699	hsa-miR-335	CLIP-seq
MIRT2504484	hsa-miR-339-5p	CLIP-seq
MIRT896172	hsa-miR-3607-3p	CLIP-seq
MIRT896173	hsa-miR-3609	CLIP-seq
MIRT896174	hsa-miR-3613-3p	CLIP-seq
MIRT2504485	hsa-miR-3664-5p	CLIP-seq
MIRT896175	hsa-miR-3686	CLIP-seq
MIRT896176	hsa-miR-371-5p	CLIP-seq
MIRT896177	hsa-miR-371b-5p	CLIP-seq
MIRT896178	hsa-miR-3913-5p	CLIP-seq
MIRT896200	hsa-miR-3929	CLIP-seq
MIRT1965700	hsa-miR-4325	CLIP-seq
MIRT896201	hsa-miR-4419b	CLIP-seq
MIRT2504486	hsa-miR-4421	CLIP-seq
MIRT896206	hsa-miR-4478	CLIP-seq
MIRT896183	hsa-miR-4649-3p	CLIP-seq
MIRT2504487	hsa-miR-4684-5p	CLIP-seq
MIRT896209	hsa-miR-4722-5p	CLIP-seq
MIRT896210	hsa-miR-4768-3p	CLIP-seq
MIRT896186	hsa-miR-4786-5p	CLIP-seq
MIRT896211	hsa-miR-485-5p	CLIP-seq
MIRT1965704	hsa-miR-495	CLIP-seq
MIRT1965705	hsa-miR-508-5p	CLIP-seq
MIRT1965706	hsa-miR-520g	CLIP-seq
MIRT1965707	hsa-miR-520h	CLIP-seq
MIRT896187	hsa-miR-548ah	CLIP-seq
MIRT2504488	hsa-miR-593	CLIP-seq
MIRT1965709	hsa-miR-612	CLIP-seq
MIRT1965711	hsa-miR-661	CLIP-seq
MIRT1965712	hsa-miR-766	CLIP-seq
MIRT896189	hsa-miR-769-5p	CLIP-seq
MIRT896216	hsa-miR-890	CLIP-seq
MIRT896191	hsa-miR-940	CLIP-seq
MIRT896217	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001775	Process	Cell activation	ISS
GO:0001872	Function	(1->3)-beta-D-glucan binding	IBA
GO:0001872	Function	(1->3)-beta-D-glucan binding	IDA	22267217, 24721111
GO:0001872	Function	(1->3)-beta-D-glucan binding	IEA
GO:0001872	Function	(1->3)-beta-D-glucan binding	ISS
GO:0001872	Function	(1->3)-beta-D-glucan binding	TAS	25251945
GO:0001878	Process	Response to yeast	ISS
GO:0001879	Process	Detection of yeast	ISS
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	ISS
GO:0002376	Process	Immune system process	IEA
GO:0002720	Process	Positive regulation of cytokine production involved in immune response	IBA
GO:0002732	Process	Positive regulation of dendritic cell cytokine production	ISS
GO:0002752	Process	Cell surface pattern recognition receptor signaling pathway	IDA	19358895
GO:0002752	Process	Cell surface pattern recognition receptor signaling pathway	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 23674515, 25416956, 31515488, 31875558, 32296183
GO:0005737	Component	Cytoplasm	IDA	24721111
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA	25251945
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006910	Process	Phagocytosis, recognition	IBA
GO:0006910	Process	Phagocytosis, recognition	IDA	11567029
GO:0006910	Process	Phagocytosis, recognition	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0008037	Process	Cell recognition	IDA	11567029
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	24721111
GO:0009756	Process	Carbohydrate mediated signaling	TAS	11567029
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	24721111, 25251945
GO:0009986	Component	Cell surface	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	19358895
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	11567029
GO:0016046	Process	Detection of fungus	IDA	19358895
GO:0016046	Process	Detection of fungus	IEA
GO:0030246	Function	Carbohydrate binding	IDA	11567029
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	24721111
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IMP	22267217
GO:0032491	Process	Detection of molecule of fungal origin	IDA	19358895
GO:0032491	Process	Detection of molecule of fungal origin	IEA
GO:0032491	Process	Detection of molecule of fungal origin	ISS
GO:0032729	Process	Positive regulation of type II interferon production	IDA	19358895
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IDA	22267217
GO:0032733	Process	Positive regulation of interleukin-10 production	IDA	19358895
GO:0032733	Process	Positive regulation of interleukin-10 production	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	IDA	19358895
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	19358895
GO:0032743	Process	Positive regulation of interleukin-2 production	IEA
GO:0032743	Process	Positive regulation of interleukin-2 production	ISS
GO:0032747	Process	Positive regulation of interleukin-23 production	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	19358895
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	25251945
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IDA	19358895
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0032930	Process	Positive regulation of superoxide anion generation	IDA	19358895
GO:0038187	Function	Pattern recognition receptor activity	IBA
GO:0038187	Function	Pattern recognition receptor activity	IDA	11567029
GO:0038187	Function	Pattern recognition receptor activity	IEA
GO:0038187	Function	Pattern recognition receptor activity	ISS
GO:0042110	Process	T cell activation	TAS	11567029
GO:0042287	Function	MHC protein binding	NAS	11567029
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0042832	Process	Defense response to protozoan	NAS	11567029
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IBA
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	ISS
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	11053425, 18223652, 18287044
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045321	Process	Leukocyte activation	IEA
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	IDA	19358895
GO:0046872	Function	Metal ion binding	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IDA	19358895
GO:0050766	Process	Positive regulation of phagocytosis	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	ISS
GO:0051251	Process	Positive regulation of lymphocyte activation	IDA	19358895
GO:0060267	Process	Positive regulation of respiratory burst	IDA	19358895
GO:0061760	Process	Antifungal innate immune response	ISS
GO:0070884	Process	Regulation of calcineurin-NFAT signaling cascade	ISS
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	ISS
GO:0071226	Process	Cellular response to molecule of fungal origin	IDA	22267217
GO:0071226	Process	Cellular response to molecule of fungal origin	IEA
GO:0071226	Process	Cellular response to molecule of fungal origin	ISS
GO:0071639	Process	Positive regulation of monocyte chemotactic protein-1 production	IMP	25251945
GO:0090303	Process	Positive regulation of wound healing	IMP	24721111
GO:0097190	Process	Apoptotic signaling pathway	IMP	22267217
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	IDA	22267217
GO:1903431	Process	Positive regulation of cell maturation	IDA	19358895
GO:2000318	Process	Positive regulation of T-helper 17 type immune response	ISS

Other IDs

• MIM: 606264
• HGNC: 14558
• e!Ensembl: ENSG00000172243

Protein

• UniProt ID: Q9BXN2
• Protein name: C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
• Protein function: Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00059	Lectin_C	137 → 243	Lectin C-type domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:00002
• Sequence:

  MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVI
  AVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPC
  PPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFW
  IGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSI
  CEKKFSM

• Sequence length: 247

Pathways

KEGG:

Phagosome
Neutrophil extracellular trap formation
C-type lectin receptor signaling pathway
Tuberculosis

Reactome:

CLEC7A (Dectin-1) signaling

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Aspergillosis, susceptibility to	Benign; Likely benign; Uncertain significance	rs16910526, rs143893294, rs144190589	RCV000023528 RCV003224435 RCV002503078
CLEC7A-related disorder	Benign; Likely benign	rs16910526, rs369160278, rs191421705, rs151164069	RCV003974796 RCV003912231 RCV003941582 RCV003968136
Familial chronic mucocutaneous candidiasis	Uncertain significance; Benign; Likely benign	rs1948157159, rs16910526, rs143893294, rs144190589	RCV001329912 RCV000004721 RCV000768185 RCV002503078

Associations from Text Mining
Disease Name	Relationship Type	References
Arthritis Psoriatic	Stimulate	20631729
Arthritis Rheumatoid	Associate	20158887
Asperger Syndrome	Associate	26352598
Aspergillosis	Associate	29118175
Autism Spectrum Disorder	Associate	26352598
Autoimmune Diseases	Stimulate	25474109
Bone Diseases	Associate	20158887
Brain Injuries Traumatic	Associate	35819574
Bronchiolitis Obliterans Syndrome	Associate	31613800
Carcinoma Pancreatic Ductal	Associate	40269781
Carcinoma Renal Cell	Associate	27600310
Communicable Diseases	Associate	26963509
Crohn Disease	Associate	32476786
Cytokine Release Syndrome	Associate	36139454
Death	Associate	31613800, 36248807
Diabetes Mellitus Type 2	Associate	36078084
Diverticulitis	Associate	19915667
Glioblastoma	Associate	35185876
Glut1 Deficiency Syndrome	Associate	35819574
Graft vs Host Disease	Associate	21178438
HIV Infections	Associate	20577092, 37606991
Hyperacusis	Associate	21876553
Infections	Inhibit	22396727
Infections	Associate	31613800
Inflammation	Associate	19915667, 36078084, 36139454, 36463168, 37606991
Inflammatory Bowel Diseases	Associate	19915667
Insulin Resistance	Stimulate	36078084
Intracranial Aneurysm	Associate	36248807
Invasive Fungal Infections	Associate	26963509
Invasive Pulmonary Aspergillosis	Associate	22384201, 23817424, 24712925
Leukemia Myeloid Acute	Associate	26963509
Lung Diseases Fungal	Associate	26963509
Lupus Nephritis	Associate	31638917
Melanoma	Associate	36353633
Mycoses	Associate	25883525, 31613800
Neoplasms	Associate	27600310, 35185876, 36353633
Neuroinflammatory Diseases	Associate	35819574
Obesity	Associate	32188105, 36078084
Obesity	Stimulate	36139454
Oropharyngeal Neoplasms	Associate	20577092
Osteogenesis imperfecta type 1A	Associate	29118175
Periodic fever familial autosomal dominant	Associate	35819574
Pneumonia	Associate	26963509
Primary Graft Dysfunction	Associate	31613800
Psoriasis	Stimulate	20631729
Retinoblastoma	Associate	31207142
Urinary Bladder Neoplasms	Associate	36131933
Vaginosis Bacterial	Associate	29616193
Vulvovaginitis	Associate	29616193