Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6455
Gene name Gene Name - the full gene name approved by the HGNC.	SH3 domain containing GRB2 like 1, endophilin A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SH3GL1
Synonyms (NCBI Gene) Gene synonyms aliases	CNSA1, EEN, SH3D2B, SH3P8
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and

Show/Hide all(252)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028595	hsa-miR-30a-5p	Proteomics	18668040
MIRT044698	hsa-miR-320a	CLASH	23622248
MIRT041509	hsa-miR-193b-3p	CLASH	23622248
MIRT038486	hsa-miR-296-3p	CLASH	23622248
MIRT037699	hsa-miR-744-5p	CLASH	23622248
MIRT037377	hsa-miR-877-5p	CLASH	23622248
MIRT036218	hsa-miR-320b	CLASH	23622248
MIRT438682	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970061
MIRT438682	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970061
MIRT438682	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT438682	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT028595	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726596	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726595	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726594	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726593	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1345054	hsa-miR-1293	CLIP-seq
MIRT1345055	hsa-miR-342-5p	CLIP-seq
MIRT1345056	hsa-miR-4455	CLIP-seq
MIRT1345057	hsa-miR-4483	CLIP-seq
MIRT1345058	hsa-miR-4651	CLIP-seq
MIRT1345059	hsa-miR-4664-5p	CLIP-seq
MIRT1345060	hsa-miR-4731-5p	CLIP-seq
MIRT1345061	hsa-miR-608	CLIP-seq
MIRT1345062	hsa-miR-609	CLIP-seq
MIRT1345063	hsa-miR-3119	CLIP-seq
MIRT1345064	hsa-miR-3141	CLIP-seq
MIRT1345065	hsa-miR-3160-5p	CLIP-seq
MIRT1345066	hsa-miR-320c	CLIP-seq
MIRT1345067	hsa-miR-320d	CLIP-seq
MIRT1345068	hsa-miR-3616-3p	CLIP-seq
MIRT1345069	hsa-miR-3682-5p	CLIP-seq
MIRT1345070	hsa-miR-3940-5p	CLIP-seq
MIRT1345071	hsa-miR-4256	CLIP-seq
MIRT1345072	hsa-miR-4292	CLIP-seq
MIRT1345073	hsa-miR-4303	CLIP-seq
MIRT1345074	hsa-miR-4308	CLIP-seq
MIRT1345075	hsa-miR-4425	CLIP-seq
MIRT1345076	hsa-miR-4429	CLIP-seq
MIRT1345077	hsa-miR-4488	CLIP-seq
MIRT1345078	hsa-miR-4507	CLIP-seq
MIRT1345079	hsa-miR-450b-3p	CLIP-seq
MIRT1345080	hsa-miR-4649-3p	CLIP-seq
MIRT1345081	hsa-miR-4697-5p	CLIP-seq
MIRT1345082	hsa-miR-4721	CLIP-seq
MIRT1345083	hsa-miR-4762-3p	CLIP-seq
MIRT1345084	hsa-miR-486-3p	CLIP-seq
MIRT1345085	hsa-miR-548m	CLIP-seq
MIRT1345086	hsa-miR-769-3p	CLIP-seq
MIRT1345087	hsa-miR-890	CLIP-seq
MIRT1345088	hsa-miR-3125	CLIP-seq
MIRT1345089	hsa-miR-33a	CLIP-seq
MIRT1345090	hsa-miR-33b	CLIP-seq
MIRT1345091	hsa-miR-3916	CLIP-seq
MIRT1345092	hsa-miR-4508	CLIP-seq
MIRT1345093	hsa-miR-450b-5p	CLIP-seq
MIRT1345094	hsa-miR-4649-5p	CLIP-seq
MIRT1345095	hsa-miR-4763-5p	CLIP-seq
MIRT1345096	hsa-miR-507	CLIP-seq
MIRT1345097	hsa-miR-557	CLIP-seq
MIRT1345098	hsa-miR-877	CLIP-seq
MIRT2102081	hsa-miR-1291	CLIP-seq
MIRT2102082	hsa-miR-1908	CLIP-seq
MIRT2102083	hsa-miR-1913	CLIP-seq
MIRT2102084	hsa-miR-24	CLIP-seq
MIRT1345063	hsa-miR-3119	CLIP-seq
MIRT1345088	hsa-miR-3125	CLIP-seq
MIRT1345064	hsa-miR-3141	CLIP-seq
MIRT1345065	hsa-miR-3160-5p	CLIP-seq
MIRT2102085	hsa-miR-3189-5p	CLIP-seq
MIRT2102086	hsa-miR-324-3p	CLIP-seq
MIRT2102087	hsa-miR-3591-5p	CLIP-seq
MIRT1345068	hsa-miR-3616-3p	CLIP-seq
MIRT1345091	hsa-miR-3916	CLIP-seq
MIRT2102088	hsa-miR-3928	CLIP-seq
MIRT2102089	hsa-miR-4255	CLIP-seq
MIRT1345073	hsa-miR-4303	CLIP-seq
MIRT2102090	hsa-miR-4505	CLIP-seq
MIRT1345080	hsa-miR-4649-3p	CLIP-seq
MIRT2102091	hsa-miR-4701-5p	CLIP-seq
MIRT2102092	hsa-miR-4716-5p	CLIP-seq
MIRT1345082	hsa-miR-4721	CLIP-seq
MIRT2102093	hsa-miR-4758-3p	CLIP-seq
MIRT1345083	hsa-miR-4762-3p	CLIP-seq
MIRT2102094	hsa-miR-545	CLIP-seq
MIRT2102095	hsa-miR-588	CLIP-seq
MIRT2102096	hsa-miR-663	CLIP-seq
MIRT1345087	hsa-miR-890	CLIP-seq
MIRT2102097	hsa-miR-939	CLIP-seq
MIRT2326527	hsa-miR-1207-3p	CLIP-seq
MIRT1345054	hsa-miR-1293	CLIP-seq
MIRT2326528	hsa-miR-1294	CLIP-seq
MIRT2326529	hsa-miR-1912	CLIP-seq
MIRT2102083	hsa-miR-1913	CLIP-seq
MIRT2326530	hsa-miR-30a	CLIP-seq
MIRT2326531	hsa-miR-30b	CLIP-seq
MIRT2326532	hsa-miR-30c	CLIP-seq
MIRT2326533	hsa-miR-30d	CLIP-seq
MIRT2326534	hsa-miR-30e	CLIP-seq
MIRT2326535	hsa-miR-3150a-3p	CLIP-seq
MIRT2326536	hsa-miR-3175	CLIP-seq
MIRT2102086	hsa-miR-324-3p	CLIP-seq
MIRT2326537	hsa-miR-324-5p	CLIP-seq
MIRT1345055	hsa-miR-342-5p	CLIP-seq
MIRT2102087	hsa-miR-3591-5p	CLIP-seq
MIRT2326538	hsa-miR-3652	CLIP-seq
MIRT2326539	hsa-miR-3689a-3p	CLIP-seq
MIRT2326540	hsa-miR-3689c	CLIP-seq
MIRT1345070	hsa-miR-3940-5p	CLIP-seq
MIRT2326541	hsa-miR-3943	CLIP-seq
MIRT2102089	hsa-miR-4255	CLIP-seq
MIRT2326542	hsa-miR-4259	CLIP-seq
MIRT2326543	hsa-miR-4280	CLIP-seq
MIRT2326544	hsa-miR-4286	CLIP-seq
MIRT1345075	hsa-miR-4425	CLIP-seq
MIRT2326545	hsa-miR-4430	CLIP-seq
MIRT1345056	hsa-miR-4455	CLIP-seq
MIRT1345057	hsa-miR-4483	CLIP-seq
MIRT2326546	hsa-miR-4486	CLIP-seq
MIRT1345077	hsa-miR-4488	CLIP-seq
MIRT2102090	hsa-miR-4505	CLIP-seq
MIRT1345078	hsa-miR-4507	CLIP-seq
MIRT1345079	hsa-miR-450b-3p	CLIP-seq
MIRT1345094	hsa-miR-4649-5p	CLIP-seq
MIRT1345058	hsa-miR-4651	CLIP-seq
MIRT1345059	hsa-miR-4664-5p	CLIP-seq
MIRT2326547	hsa-miR-4695-5p	CLIP-seq
MIRT1345081	hsa-miR-4697-5p	CLIP-seq
MIRT2326548	hsa-miR-4723-5p	CLIP-seq
MIRT1345060	hsa-miR-4731-5p	CLIP-seq
MIRT2326549	hsa-miR-4781-5p	CLIP-seq
MIRT1345084	hsa-miR-486-3p	CLIP-seq
MIRT1345061	hsa-miR-608	CLIP-seq
MIRT1345062	hsa-miR-609	CLIP-seq
MIRT2326550	hsa-miR-765	CLIP-seq
MIRT1345086	hsa-miR-769-3p	CLIP-seq
MIRT2102097	hsa-miR-939	CLIP-seq
MIRT2326529	hsa-miR-1912	CLIP-seq
MIRT2326530	hsa-miR-30a	CLIP-seq
MIRT2326531	hsa-miR-30b	CLIP-seq
MIRT2326532	hsa-miR-30c	CLIP-seq
MIRT2326533	hsa-miR-30d	CLIP-seq
MIRT2326534	hsa-miR-30e	CLIP-seq
MIRT2326537	hsa-miR-324-5p	CLIP-seq
MIRT2326539	hsa-miR-3689a-3p	CLIP-seq
MIRT2326540	hsa-miR-3689c	CLIP-seq
MIRT2326543	hsa-miR-4280	CLIP-seq
MIRT2326544	hsa-miR-4286	CLIP-seq
MIRT1345074	hsa-miR-4308	CLIP-seq
MIRT1345075	hsa-miR-4425	CLIP-seq
MIRT2459280	hsa-miR-1266	CLIP-seq
MIRT2459281	hsa-miR-1911	CLIP-seq
MIRT2459282	hsa-miR-4270	CLIP-seq
MIRT2459283	hsa-miR-4441	CLIP-seq
MIRT2459284	hsa-miR-4518	CLIP-seq
MIRT2459285	hsa-miR-4777-3p	CLIP-seq
MIRT2459286	hsa-miR-767-3p	CLIP-seq
MIRT2622088	hsa-miR-1224-5p	CLIP-seq
MIRT2102081	hsa-miR-1291	CLIP-seq
MIRT2326528	hsa-miR-1294	CLIP-seq
MIRT2622089	hsa-miR-1296	CLIP-seq
MIRT2622090	hsa-miR-146b-3p	CLIP-seq
MIRT2622091	hsa-miR-1538	CLIP-seq
MIRT2102082	hsa-miR-1908	CLIP-seq
MIRT2102083	hsa-miR-1913	CLIP-seq
MIRT2622092	hsa-miR-214	CLIP-seq
MIRT2622093	hsa-miR-2277-3p	CLIP-seq
MIRT1345063	hsa-miR-3119	CLIP-seq
MIRT1345064	hsa-miR-3141	CLIP-seq
MIRT2622094	hsa-miR-3150b-3p	CLIP-seq
MIRT1345065	hsa-miR-3160-5p	CLIP-seq
MIRT2622095	hsa-miR-3173-5p	CLIP-seq
MIRT2622096	hsa-miR-3176	CLIP-seq
MIRT2622097	hsa-miR-3197	CLIP-seq
MIRT1345066	hsa-miR-320c	CLIP-seq
MIRT1345067	hsa-miR-320d	CLIP-seq
MIRT2102086	hsa-miR-324-3p	CLIP-seq
MIRT2622098	hsa-miR-328	CLIP-seq
MIRT1345089	hsa-miR-33a	CLIP-seq
MIRT1345090	hsa-miR-33b	CLIP-seq
MIRT1345055	hsa-miR-342-5p	CLIP-seq
MIRT1345068	hsa-miR-3616-3p	CLIP-seq
MIRT2622099	hsa-miR-3619-5p	CLIP-seq
MIRT2326539	hsa-miR-3689a-3p	CLIP-seq
MIRT2326540	hsa-miR-3689c	CLIP-seq
MIRT2622100	hsa-miR-3915	CLIP-seq
MIRT2622101	hsa-miR-3918	CLIP-seq
MIRT2622102	hsa-miR-3922-3p	CLIP-seq
MIRT1345070	hsa-miR-3940-5p	CLIP-seq
MIRT2622103	hsa-miR-4254	CLIP-seq
MIRT1345072	hsa-miR-4292	CLIP-seq
MIRT1345073	hsa-miR-4303	CLIP-seq
MIRT1345074	hsa-miR-4308	CLIP-seq
MIRT2622104	hsa-miR-4316	CLIP-seq
MIRT1345075	hsa-miR-4425	CLIP-seq
MIRT1345076	hsa-miR-4429	CLIP-seq
MIRT2622105	hsa-miR-4434	CLIP-seq
MIRT1345077	hsa-miR-4488	CLIP-seq
MIRT1345078	hsa-miR-4507	CLIP-seq
MIRT1345092	hsa-miR-4508	CLIP-seq
MIRT1345079	hsa-miR-450b-3p	CLIP-seq
MIRT2622106	hsa-miR-4512	CLIP-seq
MIRT2622107	hsa-miR-4516	CLIP-seq
MIRT2622108	hsa-miR-4640-5p	CLIP-seq
MIRT1345080	hsa-miR-4649-3p	CLIP-seq
MIRT2622109	hsa-miR-4650-5p	CLIP-seq
MIRT1345059	hsa-miR-4664-5p	CLIP-seq
MIRT2622110	hsa-miR-4685-5p	CLIP-seq
MIRT2622111	hsa-miR-4689	CLIP-seq
MIRT2622112	hsa-miR-4690-5p	CLIP-seq
MIRT1345081	hsa-miR-4697-5p	CLIP-seq
MIRT2622113	hsa-miR-4710	CLIP-seq
MIRT1345082	hsa-miR-4721	CLIP-seq
MIRT2622114	hsa-miR-4726-5p	CLIP-seq
MIRT2622115	hsa-miR-4745-3p	CLIP-seq
MIRT2622116	hsa-miR-4747-3p	CLIP-seq
MIRT1345083	hsa-miR-4762-3p	CLIP-seq
MIRT2622117	hsa-miR-4784	CLIP-seq
MIRT2622118	hsa-miR-4787-5p	CLIP-seq
MIRT1345084	hsa-miR-486-3p	CLIP-seq
MIRT1345085	hsa-miR-548m	CLIP-seq
MIRT2622119	hsa-miR-642b	CLIP-seq
MIRT2102096	hsa-miR-663	CLIP-seq
MIRT2622120	hsa-miR-744	CLIP-seq
MIRT2622121	hsa-miR-761	CLIP-seq
MIRT1345086	hsa-miR-769-3p	CLIP-seq
MIRT2622122	hsa-miR-874	CLIP-seq
MIRT1345087	hsa-miR-890	CLIP-seq
MIRT1345063	hsa-miR-3119	CLIP-seq
MIRT1345065	hsa-miR-3160-5p	CLIP-seq
MIRT1345066	hsa-miR-320c	CLIP-seq
MIRT1345067	hsa-miR-320d	CLIP-seq
MIRT1345068	hsa-miR-3616-3p	CLIP-seq
MIRT1345070	hsa-miR-3940-5p	CLIP-seq
MIRT1345072	hsa-miR-4292	CLIP-seq
MIRT1345073	hsa-miR-4303	CLIP-seq
MIRT1345074	hsa-miR-4308	CLIP-seq
MIRT1345075	hsa-miR-4425	CLIP-seq
MIRT1345076	hsa-miR-4429	CLIP-seq
MIRT1345077	hsa-miR-4488	CLIP-seq
MIRT1345078	hsa-miR-4507	CLIP-seq
MIRT1345079	hsa-miR-450b-3p	CLIP-seq
MIRT1345080	hsa-miR-4649-3p	CLIP-seq
MIRT2622109	hsa-miR-4650-5p	CLIP-seq
MIRT1345081	hsa-miR-4697-5p	CLIP-seq
MIRT1345082	hsa-miR-4721	CLIP-seq
MIRT1345083	hsa-miR-4762-3p	CLIP-seq
MIRT1345084	hsa-miR-486-3p	CLIP-seq
MIRT1345085	hsa-miR-548m	CLIP-seq
MIRT2622119	hsa-miR-642b	CLIP-seq
MIRT1345086	hsa-miR-769-3p	CLIP-seq
MIRT1345087	hsa-miR-890	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002102	Component	Podosome	IEA
GO:0005515	Function	Protein binding	IPI	16115810, 16169070, 16189514, 19060904, 21516116, 21900206, 22998870, 25036101, 28514442, 31046837, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006897	Process	Endocytosis	IEA
GO:0007165	Process	Signal transduction	TAS	9169142
GO:0007417	Process	Central nervous system development	IEA
GO:0007417	Process	Central nervous system development	TAS	9169142
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	16115810, 16189514, 21900206, 32296183
GO:0042995	Component	Cell projection	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070161	Component	Anchoring junction	IEA
GO:0098793	Component	Presynapse	IBA
GO:0098978	Component	Glutamatergic synapse	IBA

MIM	HGNC	e!Ensembl
601768	10830	ENSG00000141985

Protein

UniProt ID

Q99961

Protein name

Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)

Protein function

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03114	BAR	6 → 242	BAR domain	Domain
PF00018	SH3_1	312 → 357	SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

Sequence

MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
EVLVPLPQ

Sequence length

368

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Immunodeficiency	immunodeficiency disease	N/A	N/A	GenCC

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Squamous Cell	Associate	33960436
Colorectal Neoplasms	Associate	27220321
Neoplasm Metastasis	Associate	27220321
Neoplasms	Associate	27220321, 33960436
Scoliosis	Associate	22183150
Tuberculosis Multidrug Resistant	Associate	27220321

SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2)