Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	645
Gene name Gene Name - the full gene name approved by the HGNC.	Biliverdin reductase B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BLVRB
Synonyms (NCBI Gene) Gene synonyms aliases	BVRB, FLR, HEL-S-10, SDR43U1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029434	hsa-miR-26b-5p	Microarray	19088304
MIRT732044	hsa-miR-127-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	26708147
MIRT732044	hsa-miR-127-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	26708147
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822195	hsa-miR-24	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822200	hsa-miR-4284	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT822203	hsa-miR-4729	CLIP-seq
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822195	hsa-miR-24	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822200	hsa-miR-4284	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT822203	hsa-miR-4729	CLIP-seq
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT2485427	hsa-miR-3144-5p	CLIP-seq
MIRT2485428	hsa-miR-3191	CLIP-seq
MIRT2485429	hsa-miR-4652-5p	CLIP-seq
MIRT2485430	hsa-miR-4715-3p	CLIP-seq
MIRT2485431	hsa-miR-4797-5p	CLIP-seq
MIRT2485432	hsa-miR-759	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IBA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IDA	7929092, 10858451
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IEA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	TAS	8117274
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	38056462
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	7929092
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0008286	Process	Insulin receptor signaling pathway	IDA	8440175, 38056462
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030219	Process	Megakaryocyte differentiation	IMP	27207795
GO:0035605	Function	Peptidyl-cysteine S-nitrosylase activity	IDA	38056462
GO:0035605	Function	Peptidyl-cysteine S-nitrosylase activity	IEA
GO:0042167	Process	Heme catabolic process	IDA	7929092, 10858451
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IBA
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IDA	11224564
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IEA
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IMP	27207795
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	38056462
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0052873	Function	FMN reductase (NADPH) activity	IEA
GO:0052874	Function	FMN reductase (NADH) activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
600941	1063	ENSG00000090013

Protein

UniProt ID

P30043

Protein name

Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransf

Protein function

Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development

PDB

1HDO , 1HE2 , 1HE3 , 1HE4 , 1HE5 , 5OOG , 5OOH , 6OPL , 7ER6 , 7ER7 , 7ER8 , 7ER9 , 7ERA , 7ERB , 7ERC , 7ERD , 7ERE , 8ELL , 8ELM , 8K4K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13460	NAD_binding_10	10 → 192	NAD(P)H-binding	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in liver and erythrocytes (PubMed:7929092). At lower levels in heart, lung, adrenal gland and cerebrum (PubMed:7929092). Expressed in adult red blood cells (PubMed:29932944). {ECO:0000269|PubMed:29932944, ECO:00

Sequence

MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ

Sequence length

206

Interactions

View interactions

	KEGG		Reactome
	Riboflavin metabolism Porphyrin metabolism Metabolic pathways		Heme degradation

BLVRB (biliverdin reductase B)