Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	644
Gene name	Biliverdin reductase A
Gene symbol	BLVRA
Synonyms (NCBI Gene)	BLVRBVRBVRABVRalpha
Chromosome	7
Chromosome location	7p13
Summary	The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternativel

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050960	hsa-miR-17-5p	CLASH	23622248
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT735775	hsa-miR-139-5p	Western blottingqRT-PCR	31758243
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713067	hsa-miR-4688	HITS-CLIP	19536157
MIRT713066	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT713065	hsa-miR-3681-5p	HITS-CLIP	19536157
MIRT713064	hsa-miR-6849-5p	HITS-CLIP	19536157
MIRT713063	hsa-miR-6080	HITS-CLIP	19536157
MIRT713062	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT713061	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT713060	hsa-miR-3138	HITS-CLIP	19536157
MIRT713059	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713058	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT822177	hsa-miR-221	CLIP-seq
MIRT822178	hsa-miR-222	CLIP-seq
MIRT822179	hsa-miR-302a	CLIP-seq
MIRT822180	hsa-miR-302b	CLIP-seq
MIRT822181	hsa-miR-302c	CLIP-seq
MIRT822182	hsa-miR-302d	CLIP-seq
MIRT822183	hsa-miR-302e	CLIP-seq
MIRT822184	hsa-miR-372	CLIP-seq
MIRT822185	hsa-miR-373	CLIP-seq
MIRT822186	hsa-miR-499-3p	CLIP-seq
MIRT822187	hsa-miR-499a-3p	CLIP-seq
MIRT822188	hsa-miR-520a-3p	CLIP-seq
MIRT822189	hsa-miR-520b	CLIP-seq
MIRT822190	hsa-miR-520c-3p	CLIP-seq
MIRT822191	hsa-miR-520d-3p	CLIP-seq
MIRT822192	hsa-miR-520e	CLIP-seq
MIRT822193	hsa-miR-548v	CLIP-seq
MIRT2181753	hsa-miR-105	CLIP-seq
MIRT2181754	hsa-miR-1253	CLIP-seq
MIRT2181755	hsa-miR-138	CLIP-seq
MIRT2181756	hsa-miR-548b-3p	CLIP-seq
MIRT2181757	hsa-miR-548q	CLIP-seq
MIRT2181753	hsa-miR-105	CLIP-seq
MIRT2181755	hsa-miR-138	CLIP-seq
MIRT2181756	hsa-miR-548b-3p	CLIP-seq
MIRT2181757	hsa-miR-548q	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IBA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IDA	7929092, 8424666, 8631357, 10858451
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IEA
GO:0005515	Function	Protein binding	IPI	18463290, 25416956, 29892012, 31515488
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	7929092, 8424666
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032094	Process	Response to food	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034440	Process	Lipid oxidation	IEA
GO:0038178	Process	Complement component C5a signaling pathway	IEA
GO:0042167	Process	Heme catabolic process	IDA	10858451
GO:0042167	Process	Heme catabolic process	IEA
GO:0042440	Process	Pigment metabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0106276	Function	Biliberdin reductase (NADH) activity	IDA	7929092, 8424666, 8631357
GO:0106276	Function	Biliberdin reductase (NADH) activity	IEA
GO:0106277	Function	Biliverdin reductase (NADPH) activity	IEA
GO:0160025	Process	Sensory perception of itch	IEA
GO:1905237	Process	Response to cyclosporin A	IEA

MIM	HGNC	e!Ensembl
109750	1062	ENSG00000106605

P53004

Protein name

Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)

Protein function

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin I

PDB

2H63

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01408	GFO_IDH_MocA	9 → 125	Oxidoreductase family, NAD-binding Rossmann fold	Family
PF09166	Biliv-reduc_cat	133 → 245	Biliverdin reductase, catalytic	Domain

Tissue specificity

TISSUE SPECIFICITY: Liver. {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.

Sequence

MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Porphyrin metabolism Metabolic pathways		Heme degradation

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hyperbiliverdinemia	Likely pathogenic; Pathogenic	rs747902950, rs387906595, rs387906596	RCV001331360 RCV000022451 RCV000022452

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
BLVRA-related disorder	Benign; Likely benign	rs1131372, rs7738, rs146389616, rs1802846, rs140295067	RCV003973491 RCV003973492 RCV003961176 RCV003973625 RCV003937411

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Stimulate	21241799
Alzheimer Disease	Associate	22549002, 34367470
Carcinoma Hepatocellular	Stimulate	27740521
Cataract	Inhibit	35910837
Cataract Age Related Nuclear	Inhibit	35910837
Cholangitis Sclerosing	Associate	39683940
Cognition Disorders	Associate	21241799
Cognitive Dysfunction	Associate	22549002
Colitis Ulcerative	Associate	39596612
Diabetes Mellitus Type 2	Associate	31065010
Essential Hypertension	Associate	21721974
Fatty Liver	Associate	30826467, 33260451
Gilbert Disease	Associate	28389660
Glucose Metabolism Disorders	Associate	33260451
HAIR AN syndrome	Inhibit	30826467
Heart Diseases	Associate	33260451
Hyperbilirubinemia Neonatal	Associate	38279097
Inflammation	Associate	30826467
Inflammation	Inhibit	33260451
Insulin Resistance	Associate	21721974, 30826467
Liver Cirrhosis	Associate	39683940
Metabolic Syndrome	Associate	30826467
Mitochondrial Diseases	Associate	35910837
Neoplasms	Associate	39683940
Neoplasms Adipose Tissue	Associate	33260451
Non alcoholic Fatty Liver Disease	Associate	33260451
Obesity	Inhibit	30826467
Obesity	Associate	33260451
Pneumothorax	Associate	20526373

BLVRA (biliverdin reductase A)