Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	642
Gene name	Bleomycin hydrolase
Gene symbol	BLMH
Synonyms (NCBI Gene)	BHBMH
Chromosome	17
Chromosome location	17q11.2
Summary	Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination c

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048998	hsa-miR-92a-3p	CLASH	23622248
MIRT047889	hsa-miR-30c-5p	CLASH	23622248
MIRT042229	hsa-miR-484	CLASH	23622248
MIRT036413	hsa-miR-1226-3p	CLASH	23622248
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT559226	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT559225	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT559224	hsa-miR-2115-3p	PAR-CLIP	21572407
MIRT559223	hsa-miR-144-5p	PAR-CLIP	21572407
MIRT559222	hsa-miR-3201	PAR-CLIP	21572407
MIRT559221	hsa-miR-4791	PAR-CLIP	21572407
MIRT559220	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT559219	hsa-miR-374a-3p	PAR-CLIP	21572407
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT624555	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT624554	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT559226	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT559225	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT559224	hsa-miR-2115-3p	PAR-CLIP	21572407
MIRT559223	hsa-miR-144-5p	PAR-CLIP	21572407
MIRT559222	hsa-miR-3201	PAR-CLIP	21572407
MIRT559221	hsa-miR-4791	PAR-CLIP	21572407
MIRT559220	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT559219	hsa-miR-374a-3p	PAR-CLIP	21572407
MIRT821927	hsa-miR-103a	CLIP-seq
MIRT821928	hsa-miR-107	CLIP-seq
MIRT821929	hsa-miR-1229	CLIP-seq
MIRT821930	hsa-miR-1295	CLIP-seq
MIRT821931	hsa-miR-132	CLIP-seq
MIRT821932	hsa-miR-144	CLIP-seq
MIRT821933	hsa-miR-1470	CLIP-seq
MIRT821934	hsa-miR-15a	CLIP-seq
MIRT821935	hsa-miR-15b	CLIP-seq
MIRT821936	hsa-miR-16	CLIP-seq
MIRT821937	hsa-miR-195	CLIP-seq
MIRT821938	hsa-miR-198	CLIP-seq
MIRT821939	hsa-miR-2117	CLIP-seq
MIRT821940	hsa-miR-212	CLIP-seq
MIRT821941	hsa-miR-29a	CLIP-seq
MIRT821942	hsa-miR-29b	CLIP-seq
MIRT821943	hsa-miR-29c	CLIP-seq
MIRT821944	hsa-miR-3065-3p	CLIP-seq
MIRT821945	hsa-miR-3161	CLIP-seq
MIRT821946	hsa-miR-323b-5p	CLIP-seq
MIRT821947	hsa-miR-338-3p	CLIP-seq
MIRT821948	hsa-miR-3670	CLIP-seq
MIRT821949	hsa-miR-3914	CLIP-seq
MIRT821950	hsa-miR-424	CLIP-seq
MIRT821951	hsa-miR-4272	CLIP-seq
MIRT821952	hsa-miR-4273	CLIP-seq
MIRT821953	hsa-miR-4469	CLIP-seq
MIRT821954	hsa-miR-4496	CLIP-seq
MIRT821955	hsa-miR-4530	CLIP-seq
MIRT821956	hsa-miR-4652-3p	CLIP-seq
MIRT821957	hsa-miR-4667-3p	CLIP-seq
MIRT821958	hsa-miR-4677-5p	CLIP-seq
MIRT821959	hsa-miR-4717-5p	CLIP-seq
MIRT821960	hsa-miR-4756-3p	CLIP-seq
MIRT821961	hsa-miR-4778-5p	CLIP-seq
MIRT821962	hsa-miR-4786-5p	CLIP-seq
MIRT821963	hsa-miR-497	CLIP-seq
MIRT821964	hsa-miR-576-3p	CLIP-seq
MIRT821965	hsa-miR-591	CLIP-seq
MIRT821966	hsa-miR-630	CLIP-seq
MIRT821967	hsa-miR-659	CLIP-seq
MIRT821968	hsa-miR-767-5p	CLIP-seq
MIRT821969	hsa-miR-769-5p	CLIP-seq
MIRT1942941	hsa-miR-1587	CLIP-seq
MIRT1942942	hsa-miR-4645-3p	CLIP-seq
MIRT1942943	hsa-miR-4674	CLIP-seq
MIRT1942944	hsa-miR-4714-3p	CLIP-seq
MIRT1942945	hsa-miR-514	CLIP-seq
MIRT1942946	hsa-miR-514b-3p	CLIP-seq
MIRT1942947	hsa-miR-548u	CLIP-seq
MIRT1942948	hsa-miR-635	CLIP-seq
MIRT821927	hsa-miR-103a	CLIP-seq
MIRT821928	hsa-miR-107	CLIP-seq
MIRT2181677	hsa-miR-153	CLIP-seq
MIRT821934	hsa-miR-15a	CLIP-seq
MIRT821935	hsa-miR-15b	CLIP-seq
MIRT821936	hsa-miR-16	CLIP-seq
MIRT2181678	hsa-miR-186	CLIP-seq
MIRT821937	hsa-miR-195	CLIP-seq
MIRT821938	hsa-miR-198	CLIP-seq
MIRT2181679	hsa-miR-2114	CLIP-seq
MIRT821941	hsa-miR-29a	CLIP-seq
MIRT821942	hsa-miR-29b	CLIP-seq
MIRT821943	hsa-miR-29c	CLIP-seq
MIRT821944	hsa-miR-3065-3p	CLIP-seq
MIRT2181680	hsa-miR-3074-5p	CLIP-seq
MIRT821947	hsa-miR-338-3p	CLIP-seq
MIRT821950	hsa-miR-424	CLIP-seq
MIRT2181681	hsa-miR-448	CLIP-seq
MIRT821954	hsa-miR-4496	CLIP-seq
MIRT821955	hsa-miR-4530	CLIP-seq
MIRT2181682	hsa-miR-4722-3p	CLIP-seq
MIRT2181683	hsa-miR-4769-3p	CLIP-seq
MIRT2181684	hsa-miR-4780	CLIP-seq
MIRT821963	hsa-miR-497	CLIP-seq
MIRT2181685	hsa-miR-623	CLIP-seq
MIRT821968	hsa-miR-767-5p	CLIP-seq
MIRT821927	hsa-miR-103a	CLIP-seq
MIRT821928	hsa-miR-107	CLIP-seq
MIRT821934	hsa-miR-15a	CLIP-seq
MIRT821935	hsa-miR-15b	CLIP-seq
MIRT821936	hsa-miR-16	CLIP-seq
MIRT821937	hsa-miR-195	CLIP-seq
MIRT821938	hsa-miR-198	CLIP-seq
MIRT821947	hsa-miR-338-3p	CLIP-seq
MIRT821950	hsa-miR-424	CLIP-seq
MIRT821954	hsa-miR-4496	CLIP-seq
MIRT821955	hsa-miR-4530	CLIP-seq
MIRT821963	hsa-miR-497	CLIP-seq
MIRT821927	hsa-miR-103a	CLIP-seq
MIRT821928	hsa-miR-107	CLIP-seq
MIRT2485249	hsa-miR-1200	CLIP-seq
MIRT821929	hsa-miR-1229	CLIP-seq
MIRT2485250	hsa-miR-1252	CLIP-seq
MIRT821930	hsa-miR-1295	CLIP-seq
MIRT2485251	hsa-miR-1303	CLIP-seq
MIRT2485252	hsa-miR-136	CLIP-seq
MIRT2485253	hsa-miR-143	CLIP-seq
MIRT821933	hsa-miR-1470	CLIP-seq
MIRT1942941	hsa-miR-1587	CLIP-seq
MIRT821934	hsa-miR-15a	CLIP-seq
MIRT821935	hsa-miR-15b	CLIP-seq
MIRT821936	hsa-miR-16	CLIP-seq
MIRT821937	hsa-miR-195	CLIP-seq
MIRT821938	hsa-miR-198	CLIP-seq
MIRT821939	hsa-miR-2117	CLIP-seq
MIRT2485254	hsa-miR-3150b-3p	CLIP-seq
MIRT2485255	hsa-miR-3160-3p	CLIP-seq
MIRT821945	hsa-miR-3161	CLIP-seq
MIRT2485256	hsa-miR-3200-3p	CLIP-seq
MIRT821946	hsa-miR-323b-5p	CLIP-seq
MIRT821947	hsa-miR-338-3p	CLIP-seq
MIRT2485257	hsa-miR-345	CLIP-seq
MIRT2485258	hsa-miR-3661	CLIP-seq
MIRT2485259	hsa-miR-3662	CLIP-seq
MIRT821948	hsa-miR-3670	CLIP-seq
MIRT2485260	hsa-miR-371-5p	CLIP-seq
MIRT821949	hsa-miR-3914	CLIP-seq
MIRT2485261	hsa-miR-3935	CLIP-seq
MIRT821950	hsa-miR-424	CLIP-seq
MIRT821952	hsa-miR-4273	CLIP-seq
MIRT2485262	hsa-miR-4275	CLIP-seq
MIRT2485263	hsa-miR-4324	CLIP-seq
MIRT821953	hsa-miR-4469	CLIP-seq
MIRT2485264	hsa-miR-4476	CLIP-seq
MIRT2485265	hsa-miR-4487	CLIP-seq
MIRT821954	hsa-miR-4496	CLIP-seq
MIRT821955	hsa-miR-4530	CLIP-seq
MIRT2485266	hsa-miR-4533	CLIP-seq
MIRT2485267	hsa-miR-4639-5p	CLIP-seq
MIRT1942942	hsa-miR-4645-3p	CLIP-seq
MIRT821957	hsa-miR-4667-3p	CLIP-seq
MIRT1942943	hsa-miR-4674	CLIP-seq
MIRT821958	hsa-miR-4677-5p	CLIP-seq
MIRT2485268	hsa-miR-4689	CLIP-seq
MIRT1942944	hsa-miR-4714-3p	CLIP-seq
MIRT821959	hsa-miR-4717-5p	CLIP-seq
MIRT2485269	hsa-miR-4724-3p	CLIP-seq
MIRT2485270	hsa-miR-4735-5p	CLIP-seq
MIRT821960	hsa-miR-4756-3p	CLIP-seq
MIRT2485271	hsa-miR-4768-5p	CLIP-seq
MIRT2485272	hsa-miR-4770	CLIP-seq
MIRT2485273	hsa-miR-4773	CLIP-seq
MIRT2485274	hsa-miR-4784	CLIP-seq
MIRT821962	hsa-miR-4786-5p	CLIP-seq
MIRT821963	hsa-miR-497	CLIP-seq
MIRT1942945	hsa-miR-514	CLIP-seq
MIRT1942946	hsa-miR-514b-3p	CLIP-seq
MIRT2485275	hsa-miR-544b	CLIP-seq
MIRT1942947	hsa-miR-548u	CLIP-seq
MIRT2485276	hsa-miR-558	CLIP-seq
MIRT821964	hsa-miR-576-3p	CLIP-seq
MIRT821965	hsa-miR-591	CLIP-seq
MIRT2485277	hsa-miR-593	CLIP-seq
MIRT2485278	hsa-miR-631	CLIP-seq
MIRT1942948	hsa-miR-635	CLIP-seq
MIRT821967	hsa-miR-659	CLIP-seq
MIRT821969	hsa-miR-769-5p	CLIP-seq
MIRT2485279	hsa-miR-877	CLIP-seq
MIRT2485280	hsa-miR-888	CLIP-seq
MIRT821927	hsa-miR-103a	CLIP-seq
MIRT821928	hsa-miR-107	CLIP-seq
MIRT2485249	hsa-miR-1200	CLIP-seq
MIRT821929	hsa-miR-1229	CLIP-seq
MIRT2485250	hsa-miR-1252	CLIP-seq
MIRT821930	hsa-miR-1295	CLIP-seq
MIRT2485251	hsa-miR-1303	CLIP-seq
MIRT2485253	hsa-miR-143	CLIP-seq
MIRT821933	hsa-miR-1470	CLIP-seq
MIRT1942941	hsa-miR-1587	CLIP-seq
MIRT821934	hsa-miR-15a	CLIP-seq
MIRT821935	hsa-miR-15b	CLIP-seq
MIRT821936	hsa-miR-16	CLIP-seq
MIRT821937	hsa-miR-195	CLIP-seq
MIRT821938	hsa-miR-198	CLIP-seq
MIRT821939	hsa-miR-2117	CLIP-seq
MIRT2485254	hsa-miR-3150b-3p	CLIP-seq
MIRT2485255	hsa-miR-3160-3p	CLIP-seq
MIRT821945	hsa-miR-3161	CLIP-seq
MIRT2485256	hsa-miR-3200-3p	CLIP-seq
MIRT821946	hsa-miR-323b-5p	CLIP-seq
MIRT821947	hsa-miR-338-3p	CLIP-seq
MIRT2485257	hsa-miR-345	CLIP-seq
MIRT2485258	hsa-miR-3661	CLIP-seq
MIRT2485259	hsa-miR-3662	CLIP-seq
MIRT821948	hsa-miR-3670	CLIP-seq
MIRT2485260	hsa-miR-371-5p	CLIP-seq
MIRT821949	hsa-miR-3914	CLIP-seq
MIRT2485261	hsa-miR-3935	CLIP-seq
MIRT821950	hsa-miR-424	CLIP-seq
MIRT821952	hsa-miR-4273	CLIP-seq
MIRT2485262	hsa-miR-4275	CLIP-seq
MIRT2485263	hsa-miR-4324	CLIP-seq
MIRT821953	hsa-miR-4469	CLIP-seq
MIRT2485264	hsa-miR-4476	CLIP-seq
MIRT2485265	hsa-miR-4487	CLIP-seq
MIRT821954	hsa-miR-4496	CLIP-seq
MIRT821955	hsa-miR-4530	CLIP-seq
MIRT2485266	hsa-miR-4533	CLIP-seq
MIRT2485267	hsa-miR-4639-5p	CLIP-seq
MIRT1942942	hsa-miR-4645-3p	CLIP-seq
MIRT821957	hsa-miR-4667-3p	CLIP-seq
MIRT1942943	hsa-miR-4674	CLIP-seq
MIRT821958	hsa-miR-4677-5p	CLIP-seq
MIRT2485268	hsa-miR-4689	CLIP-seq
MIRT1942944	hsa-miR-4714-3p	CLIP-seq
MIRT821959	hsa-miR-4717-5p	CLIP-seq
MIRT2485269	hsa-miR-4724-3p	CLIP-seq
MIRT2485270	hsa-miR-4735-5p	CLIP-seq
MIRT821960	hsa-miR-4756-3p	CLIP-seq
MIRT2485272	hsa-miR-4770	CLIP-seq
MIRT2485273	hsa-miR-4773	CLIP-seq
MIRT2485274	hsa-miR-4784	CLIP-seq
MIRT821962	hsa-miR-4786-5p	CLIP-seq
MIRT821963	hsa-miR-497	CLIP-seq
MIRT1942945	hsa-miR-514	CLIP-seq
MIRT1942946	hsa-miR-514b-3p	CLIP-seq
MIRT2485275	hsa-miR-544b	CLIP-seq
MIRT1942947	hsa-miR-548u	CLIP-seq
MIRT2485276	hsa-miR-558	CLIP-seq
MIRT821964	hsa-miR-576-3p	CLIP-seq
MIRT821965	hsa-miR-591	CLIP-seq
MIRT2485277	hsa-miR-593	CLIP-seq
MIRT2485278	hsa-miR-631	CLIP-seq
MIRT1942948	hsa-miR-635	CLIP-seq
MIRT821967	hsa-miR-659	CLIP-seq
MIRT821969	hsa-miR-769-5p	CLIP-seq
MIRT2485279	hsa-miR-877	CLIP-seq
MIRT2485280	hsa-miR-888	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
MZF1	Activation	21190945
SP1	Activation	21190945

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0004177	Function	Aminopeptidase activity	EXP	9668046, 11062501
GO:0004177	Function	Aminopeptidase activity	IBA
GO:0004177	Function	Aminopeptidase activity	TAS	9546396
GO:0004180	Function	Carboxypeptidase activity	TAS	9546396
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	8639621
GO:0005515	Function	Protein binding	IPI	11350084, 25416956, 25910212, 28514442, 31515488, 31875550, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	TAS	8639621
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	31875550
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8639621
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	9546396
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IBA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	TAS	8639621
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009636	Process	Response to toxic substance	IBA
GO:0009636	Process	Response to toxic substance	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 31515488, 32296183
GO:0043418	Process	Homocysteine catabolic process	IBA
GO:0070005	Function	Cysteine-type aminopeptidase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
602403	1059	ENSG00000108578

Q13867

Protein name

Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)

Protein function

The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cel

PDB

1CB5 , 2CB5 , 7V5L , 7V5S , 7V5T , 7XF9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03051	Peptidase_C1_2	5 → 451	Peptidase C1-like family	Family

Sequence

MSSSGLNSEKVAALIQKLNSDPQFVLAQNVGTTHDLLDICLKRATVQRAQHVFQHAVPQE
GKPITNQKSSGRCWIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFWDKVERCYFFLSAFVD
TAQRKEPEDGRLVQFLLMNPANDGGQWDMLVNIVEKYGVIPKKCFPESYTTEATRRMNDI
LNHKMREFCIRLRNLVHSGATKGEISATQDVMMEEIFRVVCICLGNPPETFTWEYRDKDK
NYQKIGPITPLEFYREHVKPLFNMEDKICLVNDPRPQHKYNKLYTVEYLSNMVGGRKTLY
NNQPIDFLKKMVAASIKDGEAVWFGCDVGKHFNSKLGLSDMNLYDHELVFGVSLKNMNKA
ERLTFGESLMTHAMTFTAVSEKDDQDGAFTKWRVENSWGEDHGHKGYLCMTDEWFSEYVY
EVVVDRKHVPEEVLAVLEQEPIILPAWDPMGALAE

Sequence length

455

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Alzheimer disease type 1	Benign	rs1050565	RCV004821958

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	10530514
Dermatitis	Associate	31892708
Dermatitis Atopic	Associate	21190945
Dermatitis Atopic	Inhibit	31892708
Hodgkin Disease	Associate	27327270
Ichthyosis Lamellar	Inhibit	25219105
Inflammation	Associate	31892708
Lung Diseases	Associate	27327270
Neoplasms	Associate	10404591
Neuroblastoma	Associate	19556859
Parkinson Disease	Associate	38176938
Psoriasis	Inhibit	31892708

BLMH (bleomycin hydrolase)