SELENOW (selenoprotein W)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6415
Gene name Gene Name - the full gene name approved by the HGNC.
Selenoprotein W
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SELENOW
Synonyms (NCBI Gene) Gene synonyms aliases
SEPW1, selW
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3` UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
GO ID Ontology Definition Evidence Reference
GO:0005829 Component Cytosol IBA 21873635
GO:0010269 Process Response to selenium ion IBA 21873635
GO:0016209 Function Antioxidant activity IEA
GO:0098869 Process Cellular oxidant detoxification IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
603235 10752 ENSG00000178980
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID P63302
Protein name Selenoprotein W (SelW)
Protein function Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10262 Rdx 4 → 78 Rdx family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node. {ECO:0000269|PubMed
Sequence
Sequence length 87
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Epilepsy, Cryptogenic, Awakening Epilepsy rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)		 19499324
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 26199857
Epilepsy Associate 39849427
Epilepsy Familial Mesial Temporal Lobe Associate 19499324
Multiple Myeloma Associate 19690192
Oligodendroglioma Associate 29890994