SELENOW (selenoprotein W)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 6415
Gene name Selenoprotein W
Gene symbol SELENOW
Synonyms (NCBI Gene)
SEPW1selW
Chromosome 19
Chromosome location 19q13.33
Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3` UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (8)
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
GO:0006950 Process Response to stress IEA
GO:0010269 Process Response to selenium ion IBA
GO:0016209 Function Antioxidant activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
603235 10752 ENSG00000178980
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63302
Protein name Selenoprotein W (SelW)
Protein function Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10262 Rdx 4 → 78 Rdx family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node. {ECO:0000269|PubMed
Sequence
Sequence length 87
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
EPILEPSY — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (5)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 26199857
★★★★★
★☆☆☆☆
Found in Text Mining only
Epilepsy Associate 39849427
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Epilepsy Familial Mesial Temporal Lobe Associate 19499324
★★★★★
★☆☆☆☆
Found in Text Mining only
Multiple Myeloma Associate 19690192
★★★★★
★☆☆☆☆
Found in Text Mining only
Oligodendroglioma Associate 29890994
★★★★★
★☆☆☆☆
Found in Text Mining only