Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64061
Gene name Gene Name - the full gene name approved by the HGNC.	TSPY like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TSPYL2
Synonyms (NCBI Gene) Gene synonyms aliases	CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp11.22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle pr

Show/Hide all(41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004680	hsa-miR-15a-5p	Luciferase reporter assay	19478946
MIRT016836	hsa-miR-335-5p	Microarray	18185580
MIRT044649	hsa-miR-320a	CLASH	23622248
MIRT1460238	hsa-miR-15a	CLIP-seq
MIRT1460239	hsa-miR-15b	CLIP-seq
MIRT1460240	hsa-miR-16	CLIP-seq
MIRT1460241	hsa-miR-195	CLIP-seq
MIRT1460242	hsa-miR-424	CLIP-seq
MIRT1460243	hsa-miR-4524	CLIP-seq
MIRT1460244	hsa-miR-4706	CLIP-seq
MIRT1460245	hsa-miR-4734	CLIP-seq
MIRT1460246	hsa-miR-4749-5p	CLIP-seq
MIRT1460247	hsa-miR-497	CLIP-seq
MIRT1460248	hsa-miR-503	CLIP-seq
MIRT1460249	hsa-miR-582-5p	CLIP-seq
MIRT1460250	hsa-miR-596	CLIP-seq
MIRT1460251	hsa-miR-646	CLIP-seq
MIRT1460252	hsa-miR-744	CLIP-seq
MIRT2138174	hsa-miR-3150b-3p	CLIP-seq
MIRT2138175	hsa-miR-4784	CLIP-seq
MIRT1460238	hsa-miR-15a	CLIP-seq
MIRT1460239	hsa-miR-15b	CLIP-seq
MIRT1460240	hsa-miR-16	CLIP-seq
MIRT1460241	hsa-miR-195	CLIP-seq
MIRT2359153	hsa-miR-3180	CLIP-seq
MIRT2359154	hsa-miR-3180-3p	CLIP-seq
MIRT2359155	hsa-miR-3196	CLIP-seq
MIRT2359156	hsa-miR-3926	CLIP-seq
MIRT1460242	hsa-miR-424	CLIP-seq
MIRT2359157	hsa-miR-4488	CLIP-seq
MIRT1460243	hsa-miR-4524	CLIP-seq
MIRT2359158	hsa-miR-4697-5p	CLIP-seq
MIRT1460244	hsa-miR-4706	CLIP-seq
MIRT1460245	hsa-miR-4734	CLIP-seq
MIRT1460246	hsa-miR-4749-5p	CLIP-seq
MIRT1460247	hsa-miR-497	CLIP-seq
MIRT1460248	hsa-miR-503	CLIP-seq
MIRT1460250	hsa-miR-596	CLIP-seq
MIRT1460251	hsa-miR-646	CLIP-seq
MIRT2359159	hsa-miR-658	CLIP-seq
MIRT1460252	hsa-miR-744	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000182	Function	RDNA binding	NAS	11395479
GO:0000785	Component	Chromatin	IBA	21873635
GO:0003682	Function	Chromatin binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	26496610, 28514442, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	11395479
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	11395479
GO:0005737	Component	Cytoplasm	IEA
GO:0006334	Process	Nucleosome assembly	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0008156	Process	Negative regulation of DNA replication	IDA	11395479
GO:0009966	Process	Regulation of signal transduction	NAS	11395479
GO:0030308	Process	Negative regulation of cell growth	IDA	11395479
GO:0036498	Process	IRE1-mediated unfolded protein response	TAS
GO:0042393	Function	Histone binding	IBA	21873635
GO:0045786	Process	Negative regulation of cell cycle	NAS	11395479
GO:0045859	Process	Regulation of protein kinase activity	IDA	11395479

MIM	HGNC	e!Ensembl
300564	24358	ENSG00000184205

Protein

UniProt ID

Q9H2G4

Protein name

Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear prot

Protein function

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A express

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00956	NAP	259 → 426	Nucleosome assembly protein (NAP)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:12393179, ECO:0000269|PubMed:15241014}.

Sequence

MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD
MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT
PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER
ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL
KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLR
HISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDA
SHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCE
VVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSE
NPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYG
NNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDD
RDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSED
VWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG

Sequence length

693

Interactions

View interactions

	Reactome
			XBP1(S) activates chaperone genes

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077 View all (247 more)	23104009

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Inhibit	28169398
Carcinoma Hepatocellular	Associate	21829568
Developmental Disabilities	Associate	26059843
Endometrial Neoplasms	Associate	23104009
Gonadoblastoma	Associate	28169398
Leiomyoma	Associate	24291816
Lupus Erythematosus Discoid	Associate	11395479
Neoplasms	Associate	21829568, 25119594
Neoplasms	Inhibit	28169398, 36918555
Prostatic Neoplasms	Associate	28169398

TSPYL2 (TSPY like 2)