Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6404
Gene name Gene Name - the full gene name approved by the HGNC.	Selectin P ligand
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SELPLG
Synonyms (NCBI Gene) Gene synonyms aliases	CD162, CLA, PSGL-1, PSGL1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte tr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017394	hsa-miR-335-5p	Microarray	18185580
MIRT637088	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT637087	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT637086	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT637085	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT637084	hsa-miR-612	HITS-CLIP	23824327
MIRT637083	hsa-miR-6860	HITS-CLIP	23824327
MIRT637082	hsa-miR-4486	HITS-CLIP	23824327
MIRT637081	hsa-miR-378g	HITS-CLIP	23824327
MIRT637080	hsa-miR-4284	HITS-CLIP	23824327
MIRT637079	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637078	hsa-miR-6877-5p	HITS-CLIP	23824327
MIRT637077	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT637076	hsa-miR-1268a	HITS-CLIP	23824327
MIRT637075	hsa-miR-1268b	HITS-CLIP	23824327
MIRT637074	hsa-miR-4314	HITS-CLIP	23824327
MIRT637073	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT618520	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT618519	hsa-miR-4532	HITS-CLIP	23824327
MIRT618518	hsa-miR-1470	HITS-CLIP	23824327
MIRT618517	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618516	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618515	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT637088	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT637087	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT637086	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT637085	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT637084	hsa-miR-612	HITS-CLIP	23824327
MIRT637083	hsa-miR-6860	HITS-CLIP	23824327
MIRT637082	hsa-miR-4486	HITS-CLIP	23824327
MIRT637081	hsa-miR-378g	HITS-CLIP	23824327
MIRT637080	hsa-miR-4284	HITS-CLIP	23824327
MIRT637079	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637078	hsa-miR-6877-5p	HITS-CLIP	23824327
MIRT637077	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT637076	hsa-miR-1268a	HITS-CLIP	23824327
MIRT637075	hsa-miR-1268b	HITS-CLIP	23824327
MIRT637074	hsa-miR-4314	HITS-CLIP	23824327
MIRT637073	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT618520	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT618519	hsa-miR-4532	HITS-CLIP	23824327
MIRT618518	hsa-miR-1470	HITS-CLIP	23824327
MIRT618517	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618516	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618515	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT1334342	hsa-miR-185	CLIP-seq
MIRT1334343	hsa-miR-3123	CLIP-seq
MIRT1334344	hsa-miR-3126-5p	CLIP-seq
MIRT1334345	hsa-miR-3148	CLIP-seq
MIRT1334346	hsa-miR-3190	CLIP-seq
MIRT1334347	hsa-miR-4306	CLIP-seq
MIRT1334348	hsa-miR-4419a	CLIP-seq
MIRT1334349	hsa-miR-4428	CLIP-seq
MIRT1334350	hsa-miR-4434	CLIP-seq
MIRT1334351	hsa-miR-4497	CLIP-seq
MIRT1334352	hsa-miR-4510	CLIP-seq
MIRT1334353	hsa-miR-4516	CLIP-seq
MIRT1334354	hsa-miR-4531	CLIP-seq
MIRT1334355	hsa-miR-4534	CLIP-seq
MIRT1334356	hsa-miR-4644	CLIP-seq
MIRT1334357	hsa-miR-4793-3p	CLIP-seq
MIRT1334358	hsa-miR-671-5p	CLIP-seq
MIRT1334359	hsa-miR-1343	CLIP-seq
MIRT1334360	hsa-miR-3074-5p	CLIP-seq
MIRT2323740	hsa-miR-3929	CLIP-seq
MIRT2323741	hsa-miR-4419b	CLIP-seq
MIRT2323742	hsa-miR-4438	CLIP-seq
MIRT2323743	hsa-miR-4478	CLIP-seq
MIRT2323744	hsa-miR-4687-5p	CLIP-seq
MIRT2323745	hsa-miR-513a-5p	CLIP-seq
MIRT2690348	hsa-miR-1252	CLIP-seq
MIRT1334349	hsa-miR-4428	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0001931	Component	Uropod	IDA	21696602
GO:0005102	Function	Signaling receptor binding	NAS	7505206
GO:0005515	Function	Protein binding	IPI	11081633, 18196517, 19118202, 26627825, 28011641
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	21696602
GO:0005886	Component	Plasma membrane	TAS	7505206
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	7505206
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7505206, 7541799
GO:0044853	Component	Plasma membrane raft	IDA	25425738
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0050900	Process	Leukocyte migration	IDA	25425738
GO:0050901	Process	Leukocyte tethering or rolling	IBA
GO:0050901	Process	Leukocyte tethering or rolling	IDA	25425738
GO:0050902	Process	Leukocyte adhesive activation	ISS
GO:0071354	Process	Cellular response to interleukin-6	IDA	9486531

MIM	HGNC	e!Ensembl
600738	10722	ENSG00000110876

Protein

UniProt ID

Q14242

Protein name

P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)

Protein function

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial l

PDB

1G1S

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed on neutrophils, monocytes and most lymphocytes.

Sequence

MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP

Sequence length

412

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules Neutrophil extracellular trap formation Staphylococcus aureus infection		Cell surface interactions at the vascular wall

SELPLG (selectin P ligand)