XPNPEP3 (X-prolyl aminopeptidase 3)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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63929 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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X-prolyl aminopeptidase 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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XPNPEP3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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APP3, ICP55, NPHPL1 |
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Chromosome
Chromosome number
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22 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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22q13.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize t |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q9NQH7 | |||||||||||||||
| Protein name | Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) | |||||||||||||||
| Protein function | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). {ECO:000 | |||||||||||||||
| PDB | 5X49 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant. {ECO:0000269|PubMed:15708373}. | |||||||||||||||
| Sequence |
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| Sequence length | 507 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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