CXCL11 (C-X-C motif chemokine ligand 11)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6373
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine ligand 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCL11
Synonyms (NCBI Gene) Gene synonyms aliases
H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chem
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(38)
miRTarBase ID miRNA Experiments Reference
MIRT530625 hsa-miR-6835-3p PAR-CLIP 22012620
MIRT530624 hsa-miR-548b-3p PAR-CLIP 22012620
MIRT530623 hsa-miR-4511 PAR-CLIP 22012620
MIRT530622 hsa-miR-30a-5p PAR-CLIP 22012620
MIRT530621 hsa-miR-30b-5p PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18275857, 21314817, 25416956, 28381538
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006935 Process Chemotaxis IDA 12782716
GO:0006954 Process Inflammatory response IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604852 10638 ENSG00000169248
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O14625
Protein name C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
Protein function Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May
PDB 1RJT , 8HNK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 28 → 89 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin diso
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Show/Hide Text Mining Associations (153)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 22247499, 31960110
Adenocarcinoma of Lung Associate 36991099
Alzheimer Disease Inhibit 39929297
Angioedemas Hereditary Associate 36142237
Arthritis Juvenile Associate 34963488
Arthritis Psoriatic Associate 35095831
Arthritis Rheumatoid Associate 21255008
Asthma Stimulate 18684970
Astrocytoma Associate 8798467
Atherosclerosis Associate 17991878