Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	637
Gene name Gene Name - the full gene name approved by the HGNC.	BH3 interacting domain death agonist
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BID
Synonyms (NCBI Gene) Gene synonyms aliases	FP497
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced

Show/Hide all(228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006072	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006072	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006072	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT049655	hsa-miR-92a-3p	CLASH	23622248
MIRT045661	hsa-miR-149-5p	CLASH	23622248
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT647841	hsa-miR-16-2-3p	HITS-CLIP	23824327
MIRT647840	hsa-miR-195-3p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT728203	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT728202	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT647841	hsa-miR-16-2-3p	HITS-CLIP	23824327
MIRT647840	hsa-miR-195-3p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT821468	hsa-miR-103a	CLIP-seq
MIRT821469	hsa-miR-107	CLIP-seq
MIRT821470	hsa-miR-1227	CLIP-seq
MIRT821471	hsa-miR-1302	CLIP-seq
MIRT821472	hsa-miR-1343	CLIP-seq
MIRT821473	hsa-miR-21	CLIP-seq
MIRT821474	hsa-miR-216b	CLIP-seq
MIRT821475	hsa-miR-3682-3p	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT821477	hsa-miR-4298	CLIP-seq
MIRT821478	hsa-miR-4502	CLIP-seq
MIRT821479	hsa-miR-4658	CLIP-seq
MIRT821480	hsa-miR-4659a-5p	CLIP-seq
MIRT821481	hsa-miR-4659b-5p	CLIP-seq
MIRT821482	hsa-miR-4758-5p	CLIP-seq
MIRT821483	hsa-miR-4762-3p	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821486	hsa-miR-548g	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT821488	hsa-miR-579	CLIP-seq
MIRT821489	hsa-miR-590-5p	CLIP-seq
MIRT821490	hsa-miR-556-3p	CLIP-seq
MIRT1942825	hsa-miR-1255a	CLIP-seq
MIRT1942826	hsa-miR-1255b	CLIP-seq
MIRT1942827	hsa-miR-1264	CLIP-seq
MIRT1942828	hsa-miR-1297	CLIP-seq
MIRT1942829	hsa-miR-1298	CLIP-seq
MIRT1942830	hsa-miR-147	CLIP-seq
MIRT1942831	hsa-miR-190	CLIP-seq
MIRT1942832	hsa-miR-190b	CLIP-seq
MIRT1942833	hsa-miR-199a-5p	CLIP-seq
MIRT1942834	hsa-miR-199b-5p	CLIP-seq
MIRT1942835	hsa-miR-2277-5p	CLIP-seq
MIRT1942836	hsa-miR-26a	CLIP-seq
MIRT1942837	hsa-miR-26b	CLIP-seq
MIRT1942838	hsa-miR-2964a-5p	CLIP-seq
MIRT1942839	hsa-miR-3607-5p	CLIP-seq
MIRT821475	hsa-miR-3682-3p	CLIP-seq
MIRT1942840	hsa-miR-3691-5p	CLIP-seq
MIRT1942841	hsa-miR-3911	CLIP-seq
MIRT1942842	hsa-miR-3935	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT1942843	hsa-miR-4465	CLIP-seq
MIRT1942844	hsa-miR-4479	CLIP-seq
MIRT1942845	hsa-miR-4493	CLIP-seq
MIRT1942846	hsa-miR-4752	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT1942847	hsa-miR-4775	CLIP-seq
MIRT1942848	hsa-miR-490-5p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT1942849	hsa-miR-590-3p	CLIP-seq
MIRT1942850	hsa-miR-644	CLIP-seq
MIRT1942851	hsa-miR-656	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT1942828	hsa-miR-1297	CLIP-seq
MIRT1942829	hsa-miR-1298	CLIP-seq
MIRT1942836	hsa-miR-26a	CLIP-seq
MIRT1942837	hsa-miR-26b	CLIP-seq
MIRT2181595	hsa-miR-3618	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2181597	hsa-miR-3936	CLIP-seq
MIRT1942843	hsa-miR-4465	CLIP-seq
MIRT2181598	hsa-miR-4685-5p	CLIP-seq
MIRT2181599	hsa-miR-4755-3p	CLIP-seq
MIRT2181600	hsa-miR-567	CLIP-seq
MIRT1942851	hsa-miR-656	CLIP-seq
MIRT2181601	hsa-miR-942	CLIP-seq
MIRT2485122	hsa-miR-1208	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT2485123	hsa-miR-140-5p	CLIP-seq
MIRT1942833	hsa-miR-199a-5p	CLIP-seq
MIRT1942834	hsa-miR-199b-5p	CLIP-seq
MIRT2485124	hsa-miR-2117	CLIP-seq
MIRT2485125	hsa-miR-296-5p	CLIP-seq
MIRT2485126	hsa-miR-3065-5p	CLIP-seq
MIRT2485127	hsa-miR-3145-5p	CLIP-seq
MIRT2485128	hsa-miR-3177-5p	CLIP-seq
MIRT2485129	hsa-miR-320a	CLIP-seq
MIRT2485130	hsa-miR-320b	CLIP-seq
MIRT2485131	hsa-miR-320c	CLIP-seq
MIRT2485132	hsa-miR-320d	CLIP-seq
MIRT2485133	hsa-miR-3661	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2485134	hsa-miR-4263	CLIP-seq
MIRT2485135	hsa-miR-4273	CLIP-seq
MIRT2485136	hsa-miR-4325	CLIP-seq
MIRT2485137	hsa-miR-4429	CLIP-seq
MIRT2485138	hsa-miR-4496	CLIP-seq
MIRT2485139	hsa-miR-4509	CLIP-seq
MIRT2485140	hsa-miR-452	CLIP-seq
MIRT2485141	hsa-miR-4676-3p	CLIP-seq
MIRT2485142	hsa-miR-4680-3p	CLIP-seq
MIRT2485143	hsa-miR-4684-3p	CLIP-seq
MIRT2485144	hsa-miR-4744	CLIP-seq
MIRT2485145	hsa-miR-4768-5p	CLIP-seq
MIRT2485146	hsa-miR-4799-5p	CLIP-seq
MIRT2485147	hsa-miR-491-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT2485148	hsa-miR-576-5p	CLIP-seq
MIRT2485149	hsa-miR-628-5p	CLIP-seq
MIRT2485150	hsa-miR-631	CLIP-seq
MIRT2485151	hsa-miR-649	CLIP-seq
MIRT2485152	hsa-miR-922	CLIP-seq
MIRT2485153	hsa-miR-938	CLIP-seq
MIRT821468	hsa-miR-103a	CLIP-seq
MIRT821469	hsa-miR-107	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT1942827	hsa-miR-1264	CLIP-seq
MIRT2485123	hsa-miR-140-5p	CLIP-seq
MIRT2485124	hsa-miR-2117	CLIP-seq
MIRT821474	hsa-miR-216b	CLIP-seq
MIRT1942838	hsa-miR-2964a-5p	CLIP-seq
MIRT2485125	hsa-miR-296-5p	CLIP-seq
MIRT2485126	hsa-miR-3065-5p	CLIP-seq
MIRT2485127	hsa-miR-3145-5p	CLIP-seq
MIRT2485128	hsa-miR-3177-5p	CLIP-seq
MIRT2485133	hsa-miR-3661	CLIP-seq
MIRT2675965	hsa-miR-3688-3p	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2675966	hsa-miR-3925-3p	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT2675967	hsa-miR-3978	CLIP-seq
MIRT2485135	hsa-miR-4273	CLIP-seq
MIRT2675968	hsa-miR-4311	CLIP-seq
MIRT2485138	hsa-miR-4496	CLIP-seq
MIRT821479	hsa-miR-4658	CLIP-seq
MIRT2485142	hsa-miR-4680-3p	CLIP-seq
MIRT2675969	hsa-miR-4743	CLIP-seq
MIRT821482	hsa-miR-4758-5p	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT2485145	hsa-miR-4768-5p	CLIP-seq
MIRT1942848	hsa-miR-490-5p	CLIP-seq
MIRT2485147	hsa-miR-491-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT2675970	hsa-miR-548t	CLIP-seq
MIRT821488	hsa-miR-579	CLIP-seq
MIRT2675971	hsa-miR-617	CLIP-seq
MIRT2485149	hsa-miR-628-5p	CLIP-seq
MIRT2485150	hsa-miR-631	CLIP-seq
MIRT2485151	hsa-miR-649	CLIP-seq
MIRT2675972	hsa-miR-766	CLIP-seq
MIRT2485153	hsa-miR-938	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
HIF1A	Repression	15024076
ZBTB16	Repression	20731660

Show/Hide all(63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001836	Process	Release of cytochrome c from mitochondria	IDA	17052454
GO:0001836	Process	Release of cytochrome c from mitochondria	IEA
GO:0005123	Function	Death receptor binding	TAS	8918887
GO:0005515	Function	Protein binding	IPI	9463381, 12624108, 14963330, 15694340, 16697956, 17052454, 17123957, 17289999, 17485524, 19074266, 19074440, 20956295, 21036904, 21382479, 23374347, 23604079, 23782464, 24814347, 25241761, 25416956, 29531808, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	9727491
GO:0005741	Component	Mitochondrial outer membrane	IDA	29531808
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	8918887
GO:0006626	Process	Protein targeting to mitochondrion	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	TAS	9727491
GO:0008637	Process	Apoptotic mitochondrial changes	IBA
GO:0008637	Process	Apoptotic mitochondrial changes	TAS	9727492
GO:0010918	Process	Positive regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8918887
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	19074440, 21041309
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033554	Process	Cellular response to stress	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042129	Process	Regulation of T cell proliferation	IEA
GO:0042770	Process	Signal transduction in response to DNA damage	TAS	18309324
GO:0042775	Process	Mitochondrial ATP synthesis coupled electron transport	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043028	Function	Cysteine-type endopeptidase regulator activity involved in apoptotic process	TAS	15661737
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	17289999, 21525171
GO:0050678	Process	Regulation of epithelial cell proliferation	IEA
GO:0051402	Process	Neuron apoptotic process	TAS	16167175
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0090150	Process	Establishment of protein localization to membrane	IDA	21041309
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IBA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	9727491, 32029622
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IEA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IGI	21041309
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IMP	17289999, 21262771
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:0097284	Process	Hepatocyte apoptotic process	IDA	32029622
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:0097345	Process	Mitochondrial outer membrane permeabilization	IEA
GO:0097435	Process	Supramolecular fiber organization	IDA	33106313
GO:1902108	Process	Regulation of mitochondrial membrane permeability involved in apoptotic process	IEA
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:1902531	Process	Regulation of intracellular signal transduction	IEA
GO:2000045	Process	Regulation of G1/S transition of mitotic cell cycle	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IEA
GO:2001233	Process	Regulation of apoptotic signaling pathway	IEA
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IEA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	21459798
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IBA
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IMP	21262771

MIM	HGNC	e!Ensembl
601997	1050	ENSG00000015475

Protein

UniProt ID

P55957

Protein name

BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]

Protein function

Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). ; [BH3-interacting domain death agonist p15]: Induces caspase activat

PDB

1ZY3 , 2BID , 2KBW , 2M5B , 2M5I , 4BD2 , 4QVE , 4ZEQ , 4ZIG , 4ZII , 5AJJ , 5C3F , 7M5A , 7M5B , 7P33 , 7QTW , 8SM5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06393	BID	3 → 192	BH3 interacting domain (BID)	Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level). {ECO:0000269|PubMed:14583606}.; TISSUE SPECIFICITY: [Isoform 3]: Expressed in lung, pancreas and spleen (at protein level). {ECO:0000269|PubMed:14583606}.; TIS

Sequence

MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTD
GNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSE
EDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQ
NLRTYVRSLARNGMD

Sequence length

195

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance Sphingolipid signaling pathway p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Natural killer cell mediated cytotoxicity Non-alcoholic fatty liver disease Alzheimer disease Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral myocarditis Lipid and atherosclerosis		Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria

BID (BH3 interacting domain death agonist)