Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	637
Gene name	BH3 interacting domain death agonist
Gene symbol	BID
Synonyms (NCBI Gene)	FP497
Chromosome	22
Chromosome location	22q11.21
Summary	This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced

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Show/Hide all (228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006072	hsa-miR-492	MicroarrayqRT-PCR	21319197
MIRT006072	hsa-miR-492	MicroarrayqRT-PCR	21319197
MIRT006072	hsa-miR-492	MicroarrayqRT-PCR	21319197
MIRT049655	hsa-miR-92a-3p	CLASH	23622248
MIRT045661	hsa-miR-149-5p	CLASH	23622248
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT647841	hsa-miR-16-2-3p	HITS-CLIP	23824327
MIRT647840	hsa-miR-195-3p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT728203	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT728202	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT647841	hsa-miR-16-2-3p	HITS-CLIP	23824327
MIRT647840	hsa-miR-195-3p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT626406	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT626405	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT626404	hsa-miR-623	HITS-CLIP	23824327
MIRT626403	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT626402	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT626401	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT626400	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT626399	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626398	hsa-miR-507	HITS-CLIP	23824327
MIRT626397	hsa-miR-557	HITS-CLIP	23824327
MIRT626396	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626395	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT821468	hsa-miR-103a	CLIP-seq
MIRT821469	hsa-miR-107	CLIP-seq
MIRT821470	hsa-miR-1227	CLIP-seq
MIRT821471	hsa-miR-1302	CLIP-seq
MIRT821472	hsa-miR-1343	CLIP-seq
MIRT821473	hsa-miR-21	CLIP-seq
MIRT821474	hsa-miR-216b	CLIP-seq
MIRT821475	hsa-miR-3682-3p	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT821477	hsa-miR-4298	CLIP-seq
MIRT821478	hsa-miR-4502	CLIP-seq
MIRT821479	hsa-miR-4658	CLIP-seq
MIRT821480	hsa-miR-4659a-5p	CLIP-seq
MIRT821481	hsa-miR-4659b-5p	CLIP-seq
MIRT821482	hsa-miR-4758-5p	CLIP-seq
MIRT821483	hsa-miR-4762-3p	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821486	hsa-miR-548g	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT821488	hsa-miR-579	CLIP-seq
MIRT821489	hsa-miR-590-5p	CLIP-seq
MIRT821490	hsa-miR-556-3p	CLIP-seq
MIRT1942825	hsa-miR-1255a	CLIP-seq
MIRT1942826	hsa-miR-1255b	CLIP-seq
MIRT1942827	hsa-miR-1264	CLIP-seq
MIRT1942828	hsa-miR-1297	CLIP-seq
MIRT1942829	hsa-miR-1298	CLIP-seq
MIRT1942830	hsa-miR-147	CLIP-seq
MIRT1942831	hsa-miR-190	CLIP-seq
MIRT1942832	hsa-miR-190b	CLIP-seq
MIRT1942833	hsa-miR-199a-5p	CLIP-seq
MIRT1942834	hsa-miR-199b-5p	CLIP-seq
MIRT1942835	hsa-miR-2277-5p	CLIP-seq
MIRT1942836	hsa-miR-26a	CLIP-seq
MIRT1942837	hsa-miR-26b	CLIP-seq
MIRT1942838	hsa-miR-2964a-5p	CLIP-seq
MIRT1942839	hsa-miR-3607-5p	CLIP-seq
MIRT821475	hsa-miR-3682-3p	CLIP-seq
MIRT1942840	hsa-miR-3691-5p	CLIP-seq
MIRT1942841	hsa-miR-3911	CLIP-seq
MIRT1942842	hsa-miR-3935	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT1942843	hsa-miR-4465	CLIP-seq
MIRT1942844	hsa-miR-4479	CLIP-seq
MIRT1942845	hsa-miR-4493	CLIP-seq
MIRT1942846	hsa-miR-4752	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT1942847	hsa-miR-4775	CLIP-seq
MIRT1942848	hsa-miR-490-5p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT1942849	hsa-miR-590-3p	CLIP-seq
MIRT1942850	hsa-miR-644	CLIP-seq
MIRT1942851	hsa-miR-656	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT1942828	hsa-miR-1297	CLIP-seq
MIRT1942829	hsa-miR-1298	CLIP-seq
MIRT1942836	hsa-miR-26a	CLIP-seq
MIRT1942837	hsa-miR-26b	CLIP-seq
MIRT2181595	hsa-miR-3618	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2181597	hsa-miR-3936	CLIP-seq
MIRT1942843	hsa-miR-4465	CLIP-seq
MIRT2181598	hsa-miR-4685-5p	CLIP-seq
MIRT2181599	hsa-miR-4755-3p	CLIP-seq
MIRT2181600	hsa-miR-567	CLIP-seq
MIRT1942851	hsa-miR-656	CLIP-seq
MIRT2181601	hsa-miR-942	CLIP-seq
MIRT2485122	hsa-miR-1208	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT2485123	hsa-miR-140-5p	CLIP-seq
MIRT1942833	hsa-miR-199a-5p	CLIP-seq
MIRT1942834	hsa-miR-199b-5p	CLIP-seq
MIRT2485124	hsa-miR-2117	CLIP-seq
MIRT2485125	hsa-miR-296-5p	CLIP-seq
MIRT2485126	hsa-miR-3065-5p	CLIP-seq
MIRT2485127	hsa-miR-3145-5p	CLIP-seq
MIRT2485128	hsa-miR-3177-5p	CLIP-seq
MIRT2485129	hsa-miR-320a	CLIP-seq
MIRT2485130	hsa-miR-320b	CLIP-seq
MIRT2485131	hsa-miR-320c	CLIP-seq
MIRT2485132	hsa-miR-320d	CLIP-seq
MIRT2485133	hsa-miR-3661	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2485134	hsa-miR-4263	CLIP-seq
MIRT2485135	hsa-miR-4273	CLIP-seq
MIRT2485136	hsa-miR-4325	CLIP-seq
MIRT2485137	hsa-miR-4429	CLIP-seq
MIRT2485138	hsa-miR-4496	CLIP-seq
MIRT2485139	hsa-miR-4509	CLIP-seq
MIRT2485140	hsa-miR-452	CLIP-seq
MIRT2485141	hsa-miR-4676-3p	CLIP-seq
MIRT2485142	hsa-miR-4680-3p	CLIP-seq
MIRT2485143	hsa-miR-4684-3p	CLIP-seq
MIRT2485144	hsa-miR-4744	CLIP-seq
MIRT2485145	hsa-miR-4768-5p	CLIP-seq
MIRT2485146	hsa-miR-4799-5p	CLIP-seq
MIRT2485147	hsa-miR-491-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT2485148	hsa-miR-576-5p	CLIP-seq
MIRT2485149	hsa-miR-628-5p	CLIP-seq
MIRT2485150	hsa-miR-631	CLIP-seq
MIRT2485151	hsa-miR-649	CLIP-seq
MIRT2485152	hsa-miR-922	CLIP-seq
MIRT2485153	hsa-miR-938	CLIP-seq
MIRT821468	hsa-miR-103a	CLIP-seq
MIRT821469	hsa-miR-107	CLIP-seq
MIRT2181594	hsa-miR-1228	CLIP-seq
MIRT1942827	hsa-miR-1264	CLIP-seq
MIRT2485123	hsa-miR-140-5p	CLIP-seq
MIRT2485124	hsa-miR-2117	CLIP-seq
MIRT821474	hsa-miR-216b	CLIP-seq
MIRT1942838	hsa-miR-2964a-5p	CLIP-seq
MIRT2485125	hsa-miR-296-5p	CLIP-seq
MIRT2485126	hsa-miR-3065-5p	CLIP-seq
MIRT2485127	hsa-miR-3145-5p	CLIP-seq
MIRT2485128	hsa-miR-3177-5p	CLIP-seq
MIRT2485133	hsa-miR-3661	CLIP-seq
MIRT2675965	hsa-miR-3688-3p	CLIP-seq
MIRT2181596	hsa-miR-377	CLIP-seq
MIRT2675966	hsa-miR-3925-3p	CLIP-seq
MIRT821476	hsa-miR-3944-5p	CLIP-seq
MIRT2675967	hsa-miR-3978	CLIP-seq
MIRT2485135	hsa-miR-4273	CLIP-seq
MIRT2675968	hsa-miR-4311	CLIP-seq
MIRT2485138	hsa-miR-4496	CLIP-seq
MIRT821479	hsa-miR-4658	CLIP-seq
MIRT2485142	hsa-miR-4680-3p	CLIP-seq
MIRT2675969	hsa-miR-4743	CLIP-seq
MIRT821482	hsa-miR-4758-5p	CLIP-seq
MIRT821484	hsa-miR-4766-3p	CLIP-seq
MIRT2485145	hsa-miR-4768-5p	CLIP-seq
MIRT1942848	hsa-miR-490-5p	CLIP-seq
MIRT2485147	hsa-miR-491-3p	CLIP-seq
MIRT821485	hsa-miR-511	CLIP-seq
MIRT821487	hsa-miR-548p	CLIP-seq
MIRT2675970	hsa-miR-548t	CLIP-seq
MIRT821488	hsa-miR-579	CLIP-seq
MIRT2675971	hsa-miR-617	CLIP-seq
MIRT2485149	hsa-miR-628-5p	CLIP-seq
MIRT2485150	hsa-miR-631	CLIP-seq
MIRT2485151	hsa-miR-649	CLIP-seq
MIRT2675972	hsa-miR-766	CLIP-seq
MIRT2485153	hsa-miR-938	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
HIF1A	Repression	15024076
ZBTB16	Repression	20731660

Show/Hide all (63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001836	Process	Release of cytochrome c from mitochondria	IDA	17052454
GO:0001836	Process	Release of cytochrome c from mitochondria	IEA
GO:0005123	Function	Death receptor binding	TAS	8918887
GO:0005515	Function	Protein binding	IPI	9463381, 12624108, 14963330, 15694340, 16697956, 17052454, 17123957, 17289999, 17485524, 19074266, 19074440, 20956295, 21036904, 21382479, 23374347, 23604079, 23782464, 24814347, 25241761, 25416956, 29531808, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	9727491
GO:0005741	Component	Mitochondrial outer membrane	IDA	29531808
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	8918887
GO:0006626	Process	Protein targeting to mitochondrion	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	TAS	9727491
GO:0008637	Process	Apoptotic mitochondrial changes	IBA
GO:0008637	Process	Apoptotic mitochondrial changes	TAS	9727492
GO:0010918	Process	Positive regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8918887
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	19074440, 21041309
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033554	Process	Cellular response to stress	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042129	Process	Regulation of T cell proliferation	IEA
GO:0042770	Process	Signal transduction in response to DNA damage	TAS	18309324
GO:0042775	Process	Mitochondrial ATP synthesis coupled electron transport	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043028	Function	Cysteine-type endopeptidase regulator activity involved in apoptotic process	TAS	15661737
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	17289999, 21525171
GO:0050678	Process	Regulation of epithelial cell proliferation	IEA
GO:0051402	Process	Neuron apoptotic process	TAS	16167175
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0090150	Process	Establishment of protein localization to membrane	IDA	21041309
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IBA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	9727491, 32029622
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IEA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IGI	21041309
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IMP	17289999, 21262771
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:0097284	Process	Hepatocyte apoptotic process	IDA	32029622
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:0097345	Process	Mitochondrial outer membrane permeabilization	IEA
GO:0097435	Process	Supramolecular fiber organization	IDA	33106313
GO:1902108	Process	Regulation of mitochondrial membrane permeability involved in apoptotic process	IEA
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:1902531	Process	Regulation of intracellular signal transduction	IEA
GO:2000045	Process	Regulation of G1/S transition of mitotic cell cycle	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IEA
GO:2001233	Process	Regulation of apoptotic signaling pathway	IEA
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IEA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	21459798
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IBA
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IMP	21262771

MIM	HGNC	e!Ensembl
601997	1050	ENSG00000015475

P55957

Protein name

BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]

Protein function

Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). ; [BH3-interacting domain death agonist p15]: Induces caspase activat

PDB

1ZY3 , 2BID , 2KBW , 2M5B , 2M5I , 4BD2 , 4QVE , 4ZEQ , 4ZIG , 4ZII , 5AJJ , 5C3F , 7M5A , 7M5B , 7P33 , 7QTW , 8SM5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06393	BID	3 → 192	BH3 interacting domain (BID)	Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level). {ECO:0000269|PubMed:14583606}.; TISSUE SPECIFICITY: [Isoform 3]: Expressed in lung, pancreas and spleen (at protein level). {ECO:0000269|PubMed:14583606}.; TIS

Sequence

MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTD
GNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSE
EDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQ
NLRTYVRSLARNGMD

Sequence length

195

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance Sphingolipid signaling pathway p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Natural killer cell mediated cytotoxicity Non-alcoholic fatty liver disease Alzheimer disease Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral myocarditis Lipid and atherosclerosis		Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria

BID (BH3 interacting domain death agonist)