CCL17 (C-C motif chemokine ligand 17)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 6361
Gene name C-C motif chemokine ligand 17
Gene symbol CCL17
Synonyms (NCBI Gene)
A-152E5.3ABCD-2SCYA17TARC
Chromosome 16
Chromosome location 16q21
Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
miRNA miRNA information provided by mirtarbase database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (2)
miRTarBase ID miRNA Experiments Reference
MIRT019326 hsa-miR-148b-3p Microarray 17612493
MIRT021928 hsa-miR-128-3p Microarray 17612493
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (1)
Transcription factor Regulation Reference
STAT6 Activation 18191727
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding TAS 8702936
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 28381538
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
601520 10615 ENSG00000102970
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92583
Protein name C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Protein function Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:
PDB 1NR2 , 1NR4 , 5WK3 , 7S4N , 7SCV , 8FJ2 , 8SKK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine (PubMed:8702936). Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells (PubMed:8702936). {ECO:0000269|P
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway 		  Chemokine receptors bind chemokines