CCL17 (C-C motif chemokine ligand 17)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6361
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL17
Synonyms (NCBI Gene) Gene synonyms aliases
A-152E5.3, ABCD-2, SCYA17, TARC
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q21
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT019326 hsa-miR-148b-3p Microarray 17612493
MIRT021928 hsa-miR-128-3p Microarray 17612493
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
STAT6 Activation 18191727
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002548 Process Monocyte chemotaxis IBA 21873635
GO:0005102 Function Signaling receptor binding TAS 8702936
GO:0005515 Function Protein binding IPI 28381538
GO:0005615 Component Extracellular space IBA 21873635
GO:0006935 Process Chemotaxis TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601520 10615 ENSG00000102970
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q92583
Protein name C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Protein function Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:
PDB 1NR2 , 1NR4 , 5WK3 , 7S4N , 7SCV , 8FJ2 , 8SKK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine (PubMed:8702936). Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells (PubMed:8702936). {ECO:0000269|P
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway 		  Chemokine receptors bind chemokines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437
Show/Hide Text Mining Associations (122)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Stimulate 37532692
Adenocarcinoma of Lung Associate 37532692
Airway Obstruction Associate 15944327
Allergic Fungal Sinusitis Associate 26047816
Alzheimer Disease Stimulate 33803478
Amyotrophic Lateral Sclerosis Associate 36768220
Arthritis Psoriatic Associate 11310827
Arthritis Rheumatoid Associate 15331393, 30619268
Arthritis Rheumatoid Stimulate 27250804
Asthma Stimulate 18684970