Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6352
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL5
Synonyms (NCBI Gene) Gene synonyms aliases
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005677 hsa-miR-98-5p ELISA 20589685
MIRT005678 hsa-miR-125a-5p ELISA 20589685
MIRT053786 hsa-miR-214-3p ELISA, Immunohistochemistry, Luciferase reporter assay, qRT-PCR 23171795
MIRT437504 hsa-miR-146a-5p Luciferase reporter assay 24996260
MIRT685370 hsa-miR-106a-5p HITS-CLIP 23313552
Transcription factors
Transcription factor Regulation Reference
ATF3 Unknown 10760799
CREB1 Unknown 11413310
IRF1 Unknown 10385645
IRF3 Unknown 10385645;20483755
IRF7 Unknown 10385645
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IMP 21147091
GO:0002407 Process Dendritic cell chemotaxis TAS 18337562
GO:0002548 Process Monocyte chemotaxis IBA 21873635
GO:0002548 Process Monocyte chemotaxis IC 10660125
GO:0002676 Process Regulation of chronic inflammatory response TAS 10488085
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
187011 10632 ENSG00000271503
Protein
UniProt ID P13501
Protein name C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Protein function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major
PDB 1B3A , 1EQT , 1HRJ , 1RTN , 1RTO , 1U4L , 1U4M , 1U4P , 1U4R , 2L9H , 2VXW , 5CMD , 5COY , 5DNF , 5L2U , 5UIW , 6AEZ , 6C6D , 6FGP , 6LOG , 6STK , 7F1R , 7O7F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the follicular fluid (at protein level). T-cell and macrophage specific. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2456327}.
Sequence
Sequence length 91
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
TNF signaling pathway
Prion disease
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease
Human cytomegalovirus infection
Influenza A
Herpes simplex virus 1 infection
Rheumatoid arthritis
Lipid and atherosclerosis
  Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437
Glomerulonephritis Glomerulonephritis rs778043831 10385480
Hyperoxaluria Hyperoxaluria, Oxalosis rs397509360, rs138207257, rs2041105506, rs267606763, rs267606764, rs80356708, rs119490108, rs121908520, rs121908521, rs121908522, rs121908523, rs121908524, rs121908525, rs121908526, rs121908527
View all (238 more)
16284884
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)
17620002
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 8534483 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 12114533, 18391751, 20531015, 29641325, 8570619, 8986820
Acro Osteolysis Associate 29480835
Acute On Chronic Liver Failure Associate 36626090, 37816833
Addison Disease Stimulate 29498364
Addison Disease Associate 29498364
Adenocarcinoma Associate 27513329
Adenocarcinoma of Lung Associate 17207890, 17653092, 27513329, 31221150, 32549766, 35240266
Adenoma Associate 21249124
Adenomatous Polyposis Coli Associate 38073344
adult multisystem inflammatory disease COVID 19 related Associate 36102684