Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6344
Gene name Gene Name - the full gene name approved by the HGNC.
Secretin receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SCTR
Synonyms (NCBI Gene) Gene synonyms aliases
SECR, SR
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its r
Transcription factors
Transcription factor Regulation Reference
SP1 Unknown 14645499
SP3 Unknown 14645499
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002024 Process Diet induced thermogenesis ISS
GO:0005881 Component Cytoplasmic microtubule IDA 23264731
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0007166 Process Cell surface receptor signaling pathway IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
182098 10608 ENSG00000080293
Protein
UniProt ID P47872
Protein name Secretin receptor (SCT-R) (SECR)
Protein function G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973, PubMed:32811827, PubMed:33008599, PubMed:7
PDB 6WI9 , 6WZG , 7D3S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 63 126 Hormone receptor domain Family
PF00002 7tm_2 139 384 7 transmembrane receptor (Secretin family) Family
Sequence
Sequence length 440
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Pancreatic secretion
Bile secretion
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
30718926
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Biliary Atresia Associate 35508528
Carcinoid Tumor Associate 18223557
Carcinoma Non Small Cell Lung Associate 18223557
Carotid Artery Thrombosis Inhibit 34543480
Cholangiocarcinoma Associate 18223557
Cholestasis Associate 35508528
Colorectal Neoplasms Associate 18403637, 32970347
Constriction Pathologic Inhibit 34543480
Fibrosis Associate 35508528
Gastrinoma Associate 17711922