Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6317
Gene name Gene Name - the full gene name approved by the HGNC.
Serpin family B member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERPINB3
Synonyms (NCBI Gene) Gene synonyms aliases
HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, SSCA1, T4-A
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT443662 hsa-miR-4517 PAR-CLIP 22100165
MIRT443661 hsa-miR-3123 PAR-CLIP 22100165
MIRT443660 hsa-miR-556-5p PAR-CLIP 22100165
MIRT443659 hsa-miR-6807-5p PAR-CLIP 22100165
MIRT443662 hsa-miR-4517 PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IDA 12975381
GO:0002020 Function Protease binding IPI 21383048
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA 21873635
GO:0004867 Function Serine-type endopeptidase inhibitor activity NAS 7724531
GO:0004869 Function Cysteine-type endopeptidase inhibitor activity IMP 21383048
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600517 10569 ENSG00000057149
Protein
UniProt ID P29508
Protein name Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)
Protein function May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:000
PDB 2ZV6 , 4ZK0 , 4ZK3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 6 390 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269|PubMed:14970861}.
Sequence
Sequence length 390
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Amoebiasis   Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 15274141
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Esophagus neoplasm Esophageal Neoplasms, Squamous cell carcinoma of esophagus, Malignant neoplasm of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 15986332, 21517111
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 30825353
Arthritis Psoriatic Associate 9008232
Asthma Associate 23199842
Autoimmune Diseases Associate 22829702
Bowen's Disease Associate 36085041
Breast Neoplasms Associate 25213322
Carcinogenesis Associate 17291250, 25213322
Carcinogenesis Stimulate 17638865
Carcinoma Hepatocellular Associate 14970861, 21383048, 24809782, 25544768
Carcinoma Non Small Cell Lung Associate 24389432